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公开(公告)号：US09216218B2
公开(公告)日：2015-12-22
申请号：US13636277
申请日：2011-03-10
IPC分类号： A61K39/395 , C07K16/30 , C12N5/20 , C07K16/46 , C12N5/16 , C12N15/113 , A61K39/00
CPC分类号： C07K16/30 , A61K39/39558 , A61K2039/505 , C07K16/462 , C07K16/464 , C07K2317/14 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C12N5/163 , C12N15/1138 , C12N2310/14
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, hepatocellular cancer, colon cancer, pancreatic cancer, esophageal cancer, head & neck cancer, kidney cancer, in particular renal cell carcinoma, prostate cancer, liver cancer, melanoma, sarcoma, myeloma, neuroblastoma, placental choriocarcinoma, cervical cancer, and thyroid cancer, and the metastatic forms thereof. In one embodiment, the tumor disease is metastatic cancer in the lung.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达GT468的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如乳腺癌，肺癌，胃癌，卵巢癌，肝细胞癌，结肠癌，胰腺癌，食管癌 癌症，头颈癌，肾癌，特别是肾细胞癌，前列腺癌，肝癌，黑素瘤，肉瘤，骨髓瘤，成神经细胞瘤，胎盘绒毛膜癌，子宫颈癌和甲状腺癌及其转移形式。 在一个实施方案中，肿瘤疾病是肺中的转移性癌症。
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公开(公告)号：US20130071325A1
公开(公告)日：2013-03-21
申请号：US13636277
申请日：2011-03-10
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K39/39558 , A61K2039/505 , C07K16/462 , C07K16/464 , C07K2317/14 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C12N5/163 , C12N15/1138 , C12N2310/14
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, hepatocellular cancer, colon cancer, pancreatic cancer, esophageal cancer, head & neck cancer, kidney cancer, in particular renal cell carcinoma, prostate cancer, liver cancer, melanoma, sarcoma, myeloma, neuroblastoma, placental choriocarcinoma, cervical cancer, and thyroid cancer, and the metastatic forms thereof. In one embodiment, the tumor disease is metastatic cancer in the lung.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达GT468的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如乳腺癌，肺癌，胃癌，卵巢癌，肝细胞癌，结肠癌，胰腺癌，食管癌 癌症，头颈癌，肾癌，特别是肾细胞癌，前列腺癌，肝癌，黑素瘤，肉瘤，骨髓瘤，成神经细胞瘤，胎盘绒毛膜癌，子宫颈癌和甲状腺癌及其转移形式。 在一个实施方案中，肿瘤疾病是肺中的转移性癌症。
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3.发明申请公开(公告)号：US20120070430A1
公开(公告)日：2012-03-22
申请号：US13266368
申请日：2010-04-22
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
IPC分类号： A61K39/395 , C07K16/18 , C07K14/47 , C12N5/10 , C12N1/21 , A61P35/00 , C07H21/00 , A61K39/00 , C12Q1/68 , G01N33/53 , A61K35/12 , C07H21/04 , C12N1/19
CPC分类号： G01N33/57484 , A61K31/7088
摘要： The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
摘要翻译： 本发明涉及其表达与癌症疾病相关的遗传产物。 本发明还涉及遗传产物表达或异常表达，特别是癌症疾病的疾病的治疗和诊断。
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4.发明申请Methods Involving MS4A12 and Agents Targeting MS4A12 for Therapy, Diagnosis and Testing 审中-公开涉及MS4A12和靶向MS4A12的药物用于治疗，诊断和测试的方法公开(公告)号：US20110027297A1
公开(公告)日：2011-02-03
申请号：US12937178
申请日：2009-03-30
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
IPC分类号： A61K39/395 , C07H21/02 , C07H21/00 , C07K16/28 , A61K31/713 , A61K31/7088 , C12N5/071 , C12Q1/68 , C12Q1/02 , G01N33/566 , A61P35/00 , A61P35/04
CPC分类号： C12N15/1138 , A61K2039/505 , C12N2310/11 , C12N2310/111 , C12N2310/14 , G01N33/5011 , G01N33/57419 , G01N2333/485 , G01N2333/70596
摘要： The invention relates to methods involving MS4A12 and agents targeting MS4A12 which are useful for therapy, diagnosis and testing of disease states, in particular cancer diseases. In particular, the invention relates to agents which reduce or inhibit expression or activity of MS4A12, compositions containing these agents, and methods for reducing, determining, or increasing the responsiveness of a cell towards EGF.
摘要翻译： 本发明涉及涉及MS4A12和靶向MS4A12的试剂的方法，其可用于治疗，诊断和测试疾病状态，特别是癌症疾病。 特别地，本发明涉及减少或抑制MS4A12的表达或活性，含有这些试剂的组合物以及减少，测定或增加细胞对EGF的反应性的方法。
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5.发明申请Compositions and Methods for Therapy and Diagnosis of Cancer and Cancer Metastasis 审中-公开癌症和癌症转移治疗和诊断的组合和方法公开(公告)号：US20090253775A1
公开(公告)日：2009-10-08
申请号：US12420612
申请日：2009-04-08
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
IPC分类号： A61K31/7088 , G01N33/53 , C12Q1/68 , A61P35/00
CPC分类号： C12Q1/6886 , A61K31/7088 , A61K39/39558 , A61K47/6807 , C07K16/28 , C07K16/2866 , C07K16/40 , C07K2317/76 , C12N15/1138 , C12N15/8218 , C12N2310/11 , C12N2310/14 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , G01N33/57484 , G01N33/57492 , G01N2333/715 , G01N2333/7158 , G01N2333/916
摘要： The present invention relates to methods which make possible to assess and/or prognose a cancer disease, the metastatic behaviour of a cancer disease and/or the occurrence of a relapse of cancer. In particular, the methods of the invention make possible to assess and/or prognose the occurrence of cancer metastasis, in particular distant metastasis. Preferably, the methods of the invention allow to discriminate malign from benign conditions.
摘要翻译： 本发明涉及有可能评估和/或预测癌症疾病，癌症疾病的转移行为和/或癌症复发的方法。 特别地，本发明的方法使得有可能评估和/或预测癌症转移的发生，特别是远处转移。 优选地，本发明的方法允许区分恶性与良性状况。
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公开(公告)号：US20090081215A1
公开(公告)日：2009-03-26
申请号：US12197960
申请日：2008-08-25
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
IPC分类号： A61K39/395 , C07K16/30 , A61P35/04
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , A61K39/39558 , A61K48/00 , C07K14/4748 , C07K16/3015 , C07K16/3023 , C07K16/3053 , C07K16/3069 , C07K2317/34 , C07K2317/76 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/574
摘要： The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which said genetic products that are expressed in association with a tumor are expressed in an aberrant manner. The invention also relates to proteins, polypeptides, and peptides which are expressed in association with a tumor and the nucleic acids coding therefor.
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公开(公告)号：US20150337052A1
公开(公告)日：2015-11-26
申请号：US14821411
申请日：2015-08-07
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
IPC分类号： C07K16/30
CPC分类号： C07K16/3076 , A61K47/549 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K2317/30 , C07K2317/34 , G01N33/57484
摘要： The present technology relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the present technology also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for the polypeptides, peptides and proteins.
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公开(公告)号：US20140127219A1
公开(公告)日：2014-05-08
申请号：US14117118
申请日：2012-04-20
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Wöll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan , Michael Weichel
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Wöll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan , Michael Weichel
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K39/39591 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDN6, including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLDN6的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌，皮肤癌，恶性肿瘤 黑素瘤，头颈癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，子宫颈癌，睾丸癌和子宫癌。
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公开(公告)号：US20090208498A1
公开(公告)日：2009-08-20
申请号：US12423153
申请日：2009-04-14
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
IPC分类号： A61K39/395 , C07K16/30 , A61P35/00
CPC分类号： C07K16/3076 , A61K47/48569 , A61K47/549 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K2317/30 , C07K2317/34 , G01N33/57484
摘要： The present technology relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the present technology also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for the polypeptides, peptides and proteins.
摘要翻译： 本技术涉及与肿瘤相关表达的遗传产物的鉴定和用于表达产物的编码核酸。 本技术的一个实施方案还涉及其中遗传产物与肿瘤相关表达的肿瘤，蛋白质，多肽和肽异常表达的疾病的治疗和诊断，以及编码多肽的核酸 ，肽和蛋白质。
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公开(公告)号：US07429461B2
公开(公告)日：2008-09-30
申请号：US10506443
申请日：2003-03-12
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
IPC分类号： G01N33/574
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , A61K39/39558 , A61K48/00 , C07K14/4748 , C07K16/3015 , C07K16/3023 , C07K16/3053 , C07K16/3069 , C07K2317/34 , C07K2317/76 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/574
摘要： The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which said genetic products that are expressed in association with a tumor are expressed in an aberrant manner. The invention also relates to proteins, polypeptides, and peptides which are expressed in association with a tumor and the nucleic acids coding therefor.
摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定及其编码的核酸。 本发明涉及以异常方式表达与肿瘤相关表达的所述遗传产物的疾病的治疗和诊断。 本发明还涉及与肿瘤相关的表达的蛋白质，多肽和肽以及编码它们的核酸。
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