-
1.发明申请公开(公告)号：US20130310336A1
公开(公告)日：2013-11-21
申请号：US13675937
申请日：2012-11-13
IPC分类号： C07H19/23 , C07H19/10 , C07H19/073
CPC分类号： A61K31/7072 , A61K31/7052 , A61K31/7056 , A61K31/7064 , A61K31/7076 , A61K38/21 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/16 , C07H19/20 , C07H19/23 , Y02A50/385 , Y02A50/387 , Y02A50/389
摘要： A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.
摘要翻译： 提供用于治疗感染黄病毒或瘟病毒的宿主的方法和组合物，其包括施用有效的黄病毒或瘟病毒处理量的所述1'，2'或3'-修饰的核苷或其药学上可接受的盐或前药。
-
公开(公告)号：US20130315863A1
公开(公告)日：2013-11-28
申请号：US13956287
申请日：2013-07-31
IPC分类号： C07H19/10 , A61K31/7072 , A61K31/7064 , C07H19/06 , A61K31/7056 , A61K38/21
CPC分类号： A61K31/7072 , A61K31/7052 , A61K31/7056 , A61K31/7064 , A61K31/7076 , A61K38/21 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/16 , C07H19/20 , C07H19/23 , Y02A50/385 , Y02A50/387 , Y02A50/389
摘要： A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.
摘要翻译： 提供用于治疗感染黄病毒或瘟病毒的宿主的方法和组合物，其包括施用有效的黄病毒或瘟病毒处理量的所述1'，2'或3'-修饰的核苷或其药学上可接受的盐或前药。
-
公开(公告)号：US20140213540A1
公开(公告)日：2014-07-31
申请号：US14220534
申请日：2014-03-20
申请人： IDENIX PHARMACEUTICALS, INC. , L'UNIVERSITE MONTPELLIER II , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITA DEGLI STUDI DI CAGLIARI
IPC分类号： C07H19/16 , C07H19/056 , C07H19/06
CPC分类号： C07H19/16 , A61K9/20 , A61K9/48 , A61K31/675 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/21 , A61K38/212 , A61K45/06 , A61K47/60 , C07H19/00 , C07H19/04 , C07H19/048 , C07H19/056 , C07H19/06 , C07H19/22 , A61K2300/00
摘要： 2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branched nucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.
-
4.发明申请MODIFIED 2' AND 3'-NUCLEOSIDE PRODRUGS FOR TREATING FLAVIVIRIDAE INFECTIONS 审中-公开用于治疗感冒的改良的2'和3'-核苷酸产物公开(公告)号：US20150017124A1
公开(公告)日：2015-01-15
申请号：US14334381
申请日：2014-07-17
申请人： IDENIX PHARMACEUTICALS, INC. , UNIVERSITA DEGLI STUDI DI CAGLIARI , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , L'UNIVERSITE MONTPELLIER II
IPC分类号： C07H19/16 , A61K38/21 , A61K31/7072 , A61K31/7076 , C07H19/06 , A61K31/7068 , A61K31/7056 , A61K47/48
CPC分类号： C07H19/16 , A61K9/20 , A61K9/48 , A61K31/675 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/21 , A61K38/212 , A61K45/06 , A61K47/60 , C07H19/00 , C07H19/04 , C07H19/048 , C07H19/056 , C07H19/06 , C07H19/22 , A61K2300/00
摘要： 2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branched nucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.
摘要翻译： 描述了1'，2'，3'或4'-支化核苷的2'和/或3'前药及其药学上可接受的盐和衍生物。 这些前药可用于预防和治疗黄病毒科感染，包括HCV感染和其他相关病症。 描述本发明前药的化合物和组合物。 还提供了包括施用有效量的本发明前药或其药学上可接受的盐或衍生物的方法和用途。 这些药物可以任选地与另外的抗病毒剂组合或改变来施用，以预防或治疗黄病毒科感染和其他相关病症。
-
公开(公告)号：US20170088577A1
公开(公告)日：2017-03-30
申请号：US15379415
申请日：2016-12-14
申请人： Idenix Pharmaceuticals LLC , Universita degli Studi di Cagliari , Centre National De La Recherche Scientifique , Universite de Montpellier
IPC分类号： C07H19/16 , A61K38/21 , A61K9/20 , A61K9/48 , C07H19/056 , A61K31/7068 , A61K31/7076 , A61K31/7072 , A61K31/7056 , A61K31/708 , A61K45/06 , C07H19/06
CPC分类号： C07H19/16 , A61K9/20 , A61K9/48 , A61K31/675 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/21 , A61K38/212 , A61K45/06 , A61K47/60 , C07H19/00 , C07H19/04 , C07H19/048 , C07H19/056 , C07H19/06 , C07H19/22 , A61K2300/00
摘要： 2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.
-
公开(公告)号：US20160166597A1
公开(公告)日：2016-06-16
申请号：US14972009
申请日：2015-12-16
IPC分类号： A61K31/7072 , C12Q1/70 , C12Q1/18 , A61K38/21
摘要： The present invention discloses a method for the treatment of Flaviviridae infection that includes the administration of a 2′-branched nucleoside, or a pharmaceutically acceptable prodrug and/or salt thereof, to a human in need of therapy in combination or alternation with a drug that directly or indirectly induces a mutation in the viral genome at a location other than a mutation of a nucleotide that results in a change from serine to a different amino acid in the highly conserved consensus sequence, XRXSGXXXT (SEQ ID NO: 63), of domain B of the RNA polymerase region, or is associated with such a mutation. The invention also includes a method to detect a mutant strain of Flaviviridae and a method for its treatment.
摘要翻译： 本发明公开了一种治疗黄病毒科感染的方法，其包括将2支支链核苷或其药学上可接受的前药和/或盐给予需要与药物组合或替代的药物， 在高度保守的共有序列（XRXSGXXXT（SEQ ID NO：63））中，在导致从丝氨酸到不同氨基酸的变化的核苷酸突变以外的位置直接或间接诱导病毒基因组中的突变 B的RNA聚合酶区域，或与这样的突变有关。 本发明还包括检测黄病毒科突变菌株的方法及其治疗方法。
-
公开(公告)号：US20140286900A1
公开(公告)日：2014-09-25
申请号：US14183438
申请日：2014-02-18
CPC分类号： A61K31/7072 , A61K31/7052 , A61K38/21 , A61K38/212 , A61K38/215 , A61K38/217 , A61K45/06 , C07H19/06 , C07H19/16 , C07K14/005 , C12N2770/24022 , C12N2770/24122 , C12N2770/24222 , C12Q1/04 , C12Q1/18 , C12Q1/701 , C12Q1/707 , C12Q2600/156 , C12Q2600/158 , G01N2333/186 , A61K2300/00
摘要： The present invention discloses a method for the treatment of Flaviviridae infection that includes the administration of a 2′-branched nucleoside, or a pharmaceutically acceptable prodrug and/or salt thereof, to a human in need of therapy in combination or alternation with a drug that directly or indirectly induces a mutation in the viral genome at a location other than a mutation of a nucleotide that results in a change from serine to a different amino acid in the highly conserved consensus sequence, XRXSGXXXT (SEQ ID NO: 63), of domain B of the RNA polymerase region, or is associated with such a mutation. The invention also includes a method to detect a mutant strain of Flaviviridae and a method for its treatment.
摘要翻译： 本发明公开了一种治疗黄病毒科感染的方法，其包括将2支支链核苷或其药学上可接受的前药和/或盐给予需要与药物组合或替代的药物， 在高度保守的共有序列（XRXSGXXXT（SEQ ID NO：63））中，在导致从丝氨酸到不同氨基酸的变化的核苷酸突变以外的位置直接或间接诱导病毒基因组中的突变 B的RNA聚合酶区域，或与这样的突变有关。 本发明还包括检测黄病毒科突变菌株的方法及其治疗方法。
-
8.发明申请公开(公告)号：US20140255339A1
公开(公告)日：2014-09-11
申请号：US14197078
申请日：2014-03-04
申请人： Idenix Pharmaceuticals, Inc. , Universite Montpellier II , Centre National de la Recherche Scientifique
发明人： Jean-Pierre SOMMADOSSI , Gilles GOSSELIN , Claire PIERRA , Christian PERIGAUD , Suzanne PEYROTTES
IPC分类号： C07H17/02 , A61K31/7068 , A61K31/708 , A61K31/7064 , C07F9/6561 , A61K31/675 , A61K31/7056 , A61K31/7076 , A61K31/7072
CPC分类号： C07H17/02 , A61K31/675 , A61K31/7056 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07F9/65586 , C07F9/65616 , C07H19/00
摘要： Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.
摘要翻译： 本文提供了用于治疗肝脏疾病（包括HCV和/或HBV感染）的化合物，组合物和方法。 具体地，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.03 秒)
