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公开(公告)号：US5834467A
公开(公告)日：1998-11-10
申请号：US482504
申请日：1995-06-07
申请人： Vincent J. Kalish , Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriquez
发明人： Vincent J. Kalish , Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriquez
IPC分类号： C07D295/20 , A61K31/00 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/435 , A61K31/4353 , A61K31/4365 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/4738 , A61K31/4743 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/675 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C237/42 , C07C323/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/56 , C07D213/81 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D233/66 , C07D233/90 , C07D295/205 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07F9/12 , C07F9/62 , C07K5/00 , A61K31/50
CPC分类号： C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要： HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
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公开(公告)号：US06693199B2
公开(公告)日：2004-02-17
申请号：US10300638
申请日：2002-11-21
申请人： Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
发明人： Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
IPC分类号： C07D51502
CPC分类号： C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要： A method of making HIV protease inhibitors of general formula (1): These HIV compounds inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optically other antiviral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
摘要翻译： 制备通式（1）的HIV蛋白酶抑制剂的方法：这些HIV化合物抑制或阻断HIV蛋白酶的生物活性，导致HIV病毒的复制终止。 这些化合物以及含有这些化合物和光学其它抗病毒剂作为活性成分的药物组合物适用于治疗已知导致AIDS的HIV病毒感染的患者或宿主。
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公开(公告)号：US5827891A
公开(公告)日：1998-10-27
申请号：US478599
申请日：1995-06-07
申请人： Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
发明人： Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
IPC分类号： C07D295/20 , A61K31/00 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/435 , A61K31/4353 , A61K31/4365 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/4738 , A61K31/4743 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/675 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C237/42 , C07C323/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/56 , C07D213/81 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D233/66 , C07D233/90 , C07D295/205 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07F9/12 , C07F9/62 , C07K5/00 , A61K31/16 , C07C233/00
CPC分类号： C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要： HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
摘要翻译： 可通过化学合成获得的HIV蛋白酶抑制剂抑制或阻断HIV蛋白酶的生物活性，导致HIV病毒的复制终止。 这些化合物以及含有这些化合物和任选的其它抗病毒剂作为活性成分的药物组合物适用于治疗已知导致AIDS的HIV病毒感染的患者或宿主。
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公开(公告)号：US06525215B2
公开(公告)日：2003-02-25
申请号：US09885056
申请日：2001-06-21
申请人： Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
发明人： Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
IPC分类号： C07C6532
CPC分类号： C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要： Compounds useful as intermediates in the preparation of HIV protease inhibitors. These compounds have the following general formula:
摘要翻译： 可用作制备HIV蛋白酶抑制剂的中间体的化合物。 这些化合物具有以下通式：
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5.发明授权Pharmaceutical compositions containing HIV protease inhibitors and methods of their use 有权含有HIV蛋白酶抑制剂的药物组合物及其使用方法
公开(公告)号：US6162812A
公开(公告)日：2000-12-19
申请号：US283152
申请日：1999-04-01
申请人： Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
发明人： Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
IPC分类号： C07D295/20 , A61K31/00 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/435 , A61K31/4353 , A61K31/4365 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/4738 , A61K31/4743 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/675 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C237/42 , C07C323/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/56 , C07D213/81 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D233/66 , C07D233/90 , C07D295/205 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07F9/12 , C07F9/62 , C07K5/00
CPC分类号： C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要： HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optically other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
摘要翻译： 可通过化学合成获得的HIV蛋白酶抑制剂抑制或阻断HIV蛋白酶的生物活性，导致HIV病毒的复制终止。 这些化合物以及含有这些化合物和光学其它抗病毒剂作为活性成分的药物组合物适用于治疗已知导致AIDS的HIV病毒感染的患者或宿主。
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公开(公告)号：US5952343A
公开(公告)日：1999-09-14
申请号：US481831
申请日：1995-06-07
申请人： Bruce A. Dressman , James E. Fritz , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
发明人： Bruce A. Dressman , James E. Fritz , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
IPC分类号： C07D295/20 , A61K31/00 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/435 , A61K31/4353 , A61K31/4365 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/4738 , A61K31/4743 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/675 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C237/42 , C07C323/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/56 , C07D213/81 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D233/66 , C07D233/90 , C07D295/205 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07F9/12 , C07F9/62 , C07K5/00 , C07D217/12 , C07D471/02
CPC分类号： C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要： HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
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公开(公告)号：US06271235B1
公开(公告)日：2001-08-07
申请号：US08478600
申请日：1995-06-07
申请人： Bruce A. Dressman , James E. Fritz , Stephen W. Kaldor , Vincent J. Kalish , Siegfried Heinz Reich , Michael J. Rodriguez , Timothy A. Shepherd , John H. Tatlock , Louis Nickolaus Jungheim
发明人： Bruce A. Dressman , James E. Fritz , Stephen W. Kaldor , Vincent J. Kalish , Siegfried Heinz Reich , Michael J. Rodriguez , Timothy A. Shepherd , John H. Tatlock , Louis Nickolaus Jungheim
IPC分类号： A61K31495
CPC分类号： C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要： HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
摘要翻译： 可通过化学合成获得的HIV蛋白酶抑制剂抑制或阻断HIV蛋白酶的生物活性，导致HIV病毒的复制终止。 这些化合物以及含有这些化合物和任选的其它抗病毒剂作为活性成分的药物组合物适用于治疗已知导致AIDS的HIV病毒感染的患者或宿主。
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公开(公告)号：US5846993A
公开(公告)日：1998-12-08
申请号：US481833
申请日：1995-06-07
申请人： Bruce A. Dressman , James E. Fritz , Stephen W. Kaldor , Vincent J. Kalish , Siegfried Heinz Reich , John H. Tatlock , Michael J. Rodriguez
发明人： Bruce A. Dressman , James E. Fritz , Stephen W. Kaldor , Vincent J. Kalish , Siegfried Heinz Reich , John H. Tatlock , Michael J. Rodriguez
IPC分类号： C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D233/66 , C07D233/90 , C07D401/06 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62 , A61K31/40
CPC分类号： C07D213/40 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/06 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要： HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
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公开(公告)号：US5837710A
公开(公告)日：1998-11-17
申请号：US479765
申请日：1995-06-07
申请人： William J. Hornback , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
发明人： William J. Hornback , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
IPC分类号： C07D295/20 , A61K31/00 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/435 , A61K31/4353 , A61K31/4365 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/4738 , A61K31/4743 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/675 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C237/42 , C07C323/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/56 , C07D213/81 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D233/66 , C07D233/90 , C07D295/205 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07F9/12 , C07F9/62 , C07K5/00 , A61K31/38
CPC分类号： C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要： HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
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公开(公告)号：US5827858A
公开(公告)日：1998-10-27
申请号：US478020
申请日：1995-06-07
IPC分类号： C07D295/20 , A61K31/00 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/435 , A61K31/4353 , A61K31/4365 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/4738 , A61K31/4743 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/675 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C237/42 , C07C323/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/56 , C07D213/81 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D233/66 , C07D233/90 , C07D295/205 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07F9/12 , C07F9/62 , C07K5/00 , A61K31/44
CPC分类号： C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要： HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
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