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公开(公告)号:US06271235B1
公开(公告)日:2001-08-07
申请号:US08478600
申请日:1995-06-07
申请人: Bruce A. Dressman , James E. Fritz , Stephen W. Kaldor , Vincent J. Kalish , Siegfried Heinz Reich , Michael J. Rodriguez , Timothy A. Shepherd , John H. Tatlock , Louis Nickolaus Jungheim
发明人: Bruce A. Dressman , James E. Fritz , Stephen W. Kaldor , Vincent J. Kalish , Siegfried Heinz Reich , Michael J. Rodriguez , Timothy A. Shepherd , John H. Tatlock , Louis Nickolaus Jungheim
IPC分类号: A61K31495
CPC分类号: C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要: HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
摘要翻译: 可通过化学合成获得的HIV蛋白酶抑制剂抑制或阻断HIV蛋白酶的生物活性,导致HIV病毒的复制终止。 这些化合物以及含有这些化合物和任选的其它抗病毒剂作为活性成分的药物组合物适用于治疗已知导致AIDS的HIV病毒感染的患者或宿主。
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公开(公告)号:US06693199B2
公开(公告)日:2004-02-17
申请号:US10300638
申请日:2002-11-21
申请人: Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
发明人: Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
IPC分类号: C07D51502
CPC分类号: C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要: A method of making HIV protease inhibitors of general formula (1): These HIV compounds inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optically other antiviral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
摘要翻译: 制备通式(1)的HIV蛋白酶抑制剂的方法:这些HIV化合物抑制或阻断HIV蛋白酶的生物活性,导致HIV病毒的复制终止。 这些化合物以及含有这些化合物和光学其它抗病毒剂作为活性成分的药物组合物适用于治疗已知导致AIDS的HIV病毒感染的患者或宿主。
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公开(公告)号:US5952343A
公开(公告)日:1999-09-14
申请号:US481831
申请日:1995-06-07
申请人: Bruce A. Dressman , James E. Fritz , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
发明人: Bruce A. Dressman , James E. Fritz , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
IPC分类号: C07D295/20 , A61K31/00 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/435 , A61K31/4353 , A61K31/4365 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/4738 , A61K31/4743 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/675 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C237/42 , C07C323/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/56 , C07D213/81 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D233/66 , C07D233/90 , C07D295/205 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07F9/12 , C07F9/62 , C07K5/00 , C07D217/12 , C07D471/02
CPC分类号: C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要: HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
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公开(公告)号:US5827891A
公开(公告)日:1998-10-27
申请号:US478599
申请日:1995-06-07
申请人: Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
发明人: Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
IPC分类号: C07D295/20 , A61K31/00 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/435 , A61K31/4353 , A61K31/4365 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/4738 , A61K31/4743 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/675 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C237/42 , C07C323/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/56 , C07D213/81 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D233/66 , C07D233/90 , C07D295/205 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07F9/12 , C07F9/62 , C07K5/00 , A61K31/16 , C07C233/00
CPC分类号: C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要: HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
摘要翻译: 可通过化学合成获得的HIV蛋白酶抑制剂抑制或阻断HIV蛋白酶的生物活性,导致HIV病毒的复制终止。 这些化合物以及含有这些化合物和任选的其它抗病毒剂作为活性成分的药物组合物适用于治疗已知导致AIDS的HIV病毒感染的患者或宿主。
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5.Pharmaceutical compositions containing HIV protease inhibitors and methods of their use 有权
标题翻译: 含有HIV蛋白酶抑制剂的药物组合物及其使用方法公开(公告)号:US6162812A
公开(公告)日:2000-12-19
申请号:US283152
申请日:1999-04-01
申请人: Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
发明人: Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
IPC分类号: C07D295/20 , A61K31/00 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/435 , A61K31/4353 , A61K31/4365 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/4738 , A61K31/4743 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/675 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C237/42 , C07C323/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/56 , C07D213/81 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D233/66 , C07D233/90 , C07D295/205 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07F9/12 , C07F9/62 , C07K5/00
CPC分类号: C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要: HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optically other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
摘要翻译: 可通过化学合成获得的HIV蛋白酶抑制剂抑制或阻断HIV蛋白酶的生物活性,导致HIV病毒的复制终止。 这些化合物以及含有这些化合物和光学其它抗病毒剂作为活性成分的药物组合物适用于治疗已知导致AIDS的HIV病毒感染的患者或宿主。
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公开(公告)号:US06525215B2
公开(公告)日:2003-02-25
申请号:US09885056
申请日:2001-06-21
申请人: Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
发明人: Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
IPC分类号: C07C6532
CPC分类号: C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要: Compounds useful as intermediates in the preparation of HIV protease inhibitors. These compounds have the following general formula:
摘要翻译: 可用作制备HIV蛋白酶抑制剂的中间体的化合物。 这些化合物具有以下通式:
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公开(公告)号:US5834467A
公开(公告)日:1998-11-10
申请号:US482504
申请日:1995-06-07
申请人: Vincent J. Kalish , Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriquez
发明人: Vincent J. Kalish , Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , John E. Munroe , Siegfried Heinz Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriquez
IPC分类号: C07D295/20 , A61K31/00 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/435 , A61K31/4353 , A61K31/4365 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/4738 , A61K31/4743 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/675 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C237/42 , C07C323/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/56 , C07D213/81 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D233/66 , C07D233/90 , C07D295/205 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07F9/12 , C07F9/62 , C07K5/00 , A61K31/50
CPC分类号: C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要: HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
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公开(公告)号:US5846993A
公开(公告)日:1998-12-08
申请号:US481833
申请日:1995-06-07
申请人: Bruce A. Dressman , James E. Fritz , Stephen W. Kaldor , Vincent J. Kalish , Siegfried Heinz Reich , John H. Tatlock , Michael J. Rodriguez
发明人: Bruce A. Dressman , James E. Fritz , Stephen W. Kaldor , Vincent J. Kalish , Siegfried Heinz Reich , John H. Tatlock , Michael J. Rodriguez
IPC分类号: C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D233/66 , C07D233/90 , C07D401/06 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62 , A61K31/40
CPC分类号: C07D213/40 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/06 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要: HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
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公开(公告)号:US5484926A
公开(公告)日:1996-01-16
申请号:US190764
申请日:1994-02-02
申请人: Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried H. Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
发明人: Bruce A. Dressman , James E. Fritz , Marlys Hammond , William J. Hornback , Stephen W. Kaldor , Vincent J. Kalish , John E. Munroe , Siegfried H. Reich , John H. Tatlock , Timothy A. Shepherd , Michael J. Rodriguez
IPC分类号: C07D295/20 , A61K31/00 , A61K31/165 , A61K31/33 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/435 , A61K31/4353 , A61K31/4365 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/4738 , A61K31/4743 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/675 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P43/00 , C07C237/42 , C07C323/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/56 , C07D213/81 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D233/66 , C07D233/90 , C07D295/205 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07F9/12 , C07F9/62 , C07K5/00 , C07D217/20
CPC分类号: C07D401/06 , C07C237/42 , C07C323/60 , C07D207/16 , C07D209/08 , C07D211/60 , C07D213/40 , C07D215/48 , C07D215/50 , C07D217/02 , C07D217/06 , C07D217/26 , C07D401/12 , C07D403/14 , C07D409/12 , C07D417/12 , C07D495/04 , C07F9/62
摘要: HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
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10.Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting &bgr;-amyloid peptide release and/or its synthesis by use of such compounds 失效
标题翻译: 包含其的环状氨基酸化合物药物组合物和通过使用这些化合物抑制β-淀粉样肽释放和/或其合成的方法公开(公告)号:US06528505B1
公开(公告)日:2003-03-04
申请号:US09338180
申请日:1999-06-22
申请人: James E. Audia , Bruce A. Dressman , Qing Shi
发明人: James E. Audia , Bruce A. Dressman , Qing Shi
IPC分类号: C07D22314
CPC分类号: C07D401/12 , A61K38/00 , C07D403/12 , C07K5/0821 , C07K5/0823
摘要: Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
摘要翻译: 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物,因此具有治疗阿尔茨海默病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。
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