公开(公告)号：US12054788B2

公开(公告)日：2024-08-06

申请号：US18156014

申请日：2023-01-18

Applicant: Washington University

Inventor： Eric Claude Leuthardt ,  Gavin P. Dunn ,  Hong Chen ,  Allegra Petti

IPC: A61B5/00 ,  A61B5/055 ,  A61B10/00 ,  A61B90/11 ,  A61N7/00 ,  C12Q1/6851 ,  C12Q1/6886

CPC classification number: C12Q1/6886 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/6803 ,  A61B10/0045 ,  A61B90/11 ,  A61N7/00 ,  C12Q1/6851 ,  A61B2010/0077 ,  A61B2010/008 ,  A61N2007/0039 ,  A61N2007/006 ,  A61N2007/0078 ,  C12Q2600/156

Abstract: Among the various aspects of the present disclosure is the provision of a noninvasive and localized brain liquid biopsy using focused ultrasound. Briefly, therefore, the present disclosure is directed to methods and systems to identify brain lesion or tumor characteristics without the need for a solid brain biopsy.

公开(公告)号：US20240019562A1

公开(公告)日：2024-01-18

申请号：US18352700

申请日：2023-07-14

Applicant: Washington University

Inventor： Zhongtao Hu ,  Hong Chen

IPC: G01S7/524 ,  B33Y50/00 ,  B29C64/386

CPC classification number: G01S7/524 ,  B33Y50/00 ,  B29C64/386 ,  B33Y70/00

Abstract: A method of fabricating a binary metasurface for producing an ultrasound Airy beam for underwater ultrasound applications is provided. The method includes generating an amplitude distribution of an Airy beam at a frequency, and converting the amplitude distribution into a binary phase profile. The method also includes generating a 3D printing design of a binary metasurface based on the binary phase profile, wherein the binary metasurface includes ridges and grooves defined by neighboring ridges, a ridge having a thickness corresponding to a phase delay of π/2 of the Airy beam between water and a 3D-printable material. The method further includes additively manufacturing the binary metasurface with the 3D-printable material based on the 3D printing design.

公开(公告)号：US20230287513A1

公开(公告)日：2023-09-14

申请号：US18156014

申请日：2023-01-18

Applicant: Washington University

Inventor： Eric Claude Leuthardt ,  Gavin P. Dunn ,  Hong Chen ,  Allegra Petti

IPC: C12Q1/6886 ,  A61B10/00 ,  A61N7/00 ,  A61B5/055 ,  A61B5/00 ,  C12Q1/6851 ,  A61B90/11

CPC classification number: C12Q1/6886 ,  A61B10/0045 ,  A61N7/00 ,  A61B5/055 ,  A61B5/0042 ,  A61B5/6803 ,  C12Q1/6851 ,  A61B90/11 ,  C12Q2600/156 ,  A61B2010/0077 ,  A61B2010/008 ,  A61N2007/006 ,  A61N2007/0078 ,  A61N2007/0039

Abstract: Among the various aspects of the present disclosure is the provision of a noninvasive and localized brain liquid biopsy using focused ultrasound. Briefly, therefore, the present disclosure is directed to methods and systems to identify brain lesion or tumor characteristics without the need for a solid brain biopsy.

公开(公告)号：US20220386872A1

公开(公告)日：2022-12-08

申请号：US17819815

申请日：2022-08-15

Applicant: Washington University

Inventor： Hong Chen ,  Arash Nazeri ,  Christopher Pacia ,  Eric Leuthardt

IPC: A61B5/00 ,  A61B8/08 ,  A61B5/055 ,  C12Q1/6806 ,  G01N33/574

Abstract: Among the various aspects of the present disclosure is the provision of a noninvasive and localized brain liquid biopsy using focused ultrasound. Briefly, therefore, the present disclosure is directed to methods and systems to identify brain lesion or tumor characteristics without the need for a solid brain biopsy.

公开(公告)号：US20240344148A1

公开(公告)日：2024-10-17

申请号：US18750459

申请日：2024-06-21

Applicant: Washington University

Inventor： Eric Claude Leuthardt ,  Gavin P. Dunn ,  Hong Chen ,  Allegra Petti

IPC: C12Q1/6886 ,  A61B5/00 ,  A61B5/055 ,  A61B10/00 ,  A61B90/11 ,  A61N7/00 ,  C12Q1/6851

CPC classification number: C12Q1/6886 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/6803 ,  A61B10/0045 ,  A61B90/11 ,  A61N7/00 ,  C12Q1/6851 ,  A61B2010/0077 ,  A61B2010/008 ,  A61N2007/0039 ,  A61N2007/006 ,  A61N2007/0078 ,  C12Q2600/156

Abstract: Among the various aspects of the present disclosure is the provision of a noninvasive and localized brain liquid biopsy using focused ultrasound. Briefly, therefore, the present disclosure is directed to methods and systems to identify brain lesion or tumor characteristics without the need for a solid brain biopsy.

公开(公告)号：US11667975B2

公开(公告)日：2023-06-06

申请号：US16393322

申请日：2019-04-24

Applicant: Washington University

Inventor： Eric Leuthardt ,  Gavin Dunn ,  Hong Chen ,  Allegra Petti

IPC: A61B5/05 ,  C12Q1/6886 ,  A61B10/00 ,  A61N7/00 ,  A61B5/055 ,  A61B5/00 ,  C12Q1/6851 ,  A61B90/11

CPC classification number: C12Q1/6886 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/6803 ,  A61B10/0045 ,  A61B90/11 ,  A61N7/00 ,  C12Q1/6851 ,  A61B2010/008 ,  A61B2010/0077 ,  A61N2007/006 ,  A61N2007/0039 ,  A61N2007/0078 ,  C12Q2600/156

Abstract: Among the various aspects of the present disclosure is the provision of a noninvasive and localized brain liquid biopsy using focused ultrasound. Briefly, therefore, the present disclosure is directed to methods and systems to identify brain lesion or tumor characteristics without the need for a solid brain biopsy.