公开(公告)号：US20240344148A1

公开(公告)日：2024-10-17

申请号：US18750459

申请日：2024-06-21

Applicant: Washington University

Inventor： Eric Claude Leuthardt ,  Gavin P. Dunn ,  Hong Chen ,  Allegra Petti

IPC: C12Q1/6886 ,  A61B5/00 ,  A61B5/055 ,  A61B10/00 ,  A61B90/11 ,  A61N7/00 ,  C12Q1/6851

CPC classification number: C12Q1/6886 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/6803 ,  A61B10/0045 ,  A61B90/11 ,  A61N7/00 ,  C12Q1/6851 ,  A61B2010/0077 ,  A61B2010/008 ,  A61N2007/0039 ,  A61N2007/006 ,  A61N2007/0078 ,  C12Q2600/156

Abstract: Among the various aspects of the present disclosure is the provision of a noninvasive and localized brain liquid biopsy using focused ultrasound. Briefly, therefore, the present disclosure is directed to methods and systems to identify brain lesion or tumor characteristics without the need for a solid brain biopsy.

公开(公告)号：US10596014B2

公开(公告)日：2020-03-24

申请号：US15644201

申请日：2017-07-07

Applicant: Washington University

Inventor： Eric Claude Leuthardt ,  Kimberly Kreines ,  Nick Anderson

IPC: A61F2/72 ,  A61B5/00 ,  A61B5/04 ,  A61F2/04 ,  A61F2/50 ,  A61F2/68 ,  A61F2/70 ,  A61F2/76 ,  A61N1/36 ,  A61F2/48

Abstract: A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain. A prosthetic device receives the command signal from the signal translating unit and manipulates the body part in response to the command signal.

公开(公告)号：US20190275318A1

公开(公告)日：2019-09-12

申请号：US16410684

申请日：2019-05-13

Applicant: Washington University

Inventor： Eric Claude Leuthardt ,  Daniel W. Moran ,  Matthew R. MacEwan

IPC: A61N1/05 ,  A61N1/20

Abstract: A system to deliver current to an area of interest of a subject is described that includes a power source, a controller electrically coupled to the power source, at least one first electrode electrically coupled to the controller, and at least one second electrode electrically coupled to one of the power source and the controller, with the area of interest positioned between the at least one first electrode and the at least one second electrode. A method of stimulating at least one of bone growth, tissue healing and pain control within an area of interest of a patient is described that includes inserting first and second electrode spaced at a predetermined distance, and further includes directing an electric current between the first and second electrodes so that at least a portion of the electric current passes through the area of interest positioned between the first electrode and the second electrode.

公开(公告)号：US09730816B2

公开(公告)日：2017-08-15

申请号：US14291603

申请日：2014-05-30

Applicant: Washington University

Inventor： Eric Claude Leuthardt ,  Kim Wisneski ,  Nick Anderson

IPC: A61B5/0476 ,  A61B5/0484 ,  A61N1/05 ,  A61N1/36 ,  A61F2/72 ,  A61B5/04 ,  A61B5/00 ,  A61F2/04 ,  A61F2/50 ,  A61F2/68 ,  A61F2/70 ,  A61F2/76 ,  A61F2/48

CPC classification number: A61F2/72 ,  A61B5/04001 ,  A61B5/4076 ,  A61B5/4836 ,  A61F2/042 ,  A61F2/50 ,  A61F2002/482 ,  A61F2002/6872 ,  A61F2002/704 ,  A61F2002/7615 ,  A61N1/36003 ,  A61N1/36025 ,  A61N1/36082

Abstract: A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain. A prosthetic device receives the command signal from the signal translating unit and manipulates the body part in response to the command signal.

公开(公告)号：US12054788B2

公开(公告)日：2024-08-06

申请号：US18156014

申请日：2023-01-18

Applicant: Washington University

Inventor： Eric Claude Leuthardt ,  Gavin P. Dunn ,  Hong Chen ,  Allegra Petti

IPC: A61B5/00 ,  A61B5/055 ,  A61B10/00 ,  A61B90/11 ,  A61N7/00 ,  C12Q1/6851 ,  C12Q1/6886

CPC classification number: C12Q1/6886 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/6803 ,  A61B10/0045 ,  A61B90/11 ,  A61N7/00 ,  C12Q1/6851 ,  A61B2010/0077 ,  A61B2010/008 ,  A61N2007/0039 ,  A61N2007/006 ,  A61N2007/0078 ,  C12Q2600/156

Abstract: Among the various aspects of the present disclosure is the provision of a noninvasive and localized brain liquid biopsy using focused ultrasound. Briefly, therefore, the present disclosure is directed to methods and systems to identify brain lesion or tumor characteristics without the need for a solid brain biopsy.

公开(公告)号：US20230287513A1

公开(公告)日：2023-09-14

申请号：US18156014

申请日：2023-01-18

Applicant: Washington University

Inventor： Eric Claude Leuthardt ,  Gavin P. Dunn ,  Hong Chen ,  Allegra Petti

IPC: C12Q1/6886 ,  A61B10/00 ,  A61N7/00 ,  A61B5/055 ,  A61B5/00 ,  C12Q1/6851 ,  A61B90/11

CPC classification number: C12Q1/6886 ,  A61B10/0045 ,  A61N7/00 ,  A61B5/055 ,  A61B5/0042 ,  A61B5/6803 ,  C12Q1/6851 ,  A61B90/11 ,  C12Q2600/156 ,  A61B2010/0077 ,  A61B2010/008 ,  A61N2007/006 ,  A61N2007/0078 ,  A61N2007/0039

Abstract: Among the various aspects of the present disclosure is the provision of a noninvasive and localized brain liquid biopsy using focused ultrasound. Briefly, therefore, the present disclosure is directed to methods and systems to identify brain lesion or tumor characteristics without the need for a solid brain biopsy.

公开(公告)号：US10363412B2

公开(公告)日：2019-07-30

申请号：US15807152

申请日：2017-11-08

Applicant: Washington University

Inventor： Eric Claude Leuthardt ,  Daniel W. Moran ,  Matthew R. MacEwan

IPC: A61N1/05 ,  A61N1/20 ,  A61N1/32 ,  A61N1/36 ,  A61B17/70

Abstract: A system to deliver current to an area of interest of a subject is described that includes a power source, a controller electrically coupled to the power source, at least one first electrode electrically coupled to the controller, and at least one second electrode electrically coupled to one of the power source and the controller, with the area of interest positioned between the at least one first electrode and the at least one second electrode. A method of stimulating at least one of bone growth, tissue healing and pain control within an area of interest of a patient is described that includes inserting first and second electrode spaced at a predetermined distance, and further includes directing an electric current between the first and second electrodes so that at least a portion of the electric current passes through the area of interest positioned between the first electrode and the second electrode.

公开(公告)号：US11167132B2

公开(公告)日：2021-11-09

申请号：US16410684

申请日：2019-05-13

Applicant: Washington University

Inventor： Eric Claude Leuthardt ,  Daniel W. Moran ,  Matthew R. MacEwan

IPC: A61N1/05 ,  A61N1/32 ,  A61N1/20 ,  A61B17/56 ,  A61N1/36 ,  A61B17/70

Abstract: A system to deliver current to an area of interest of a subject is described that includes a power source, a controller electrically coupled to the power source, at least one first electrode electrically coupled to the controller, and at least one second electrode electrically coupled to one of the power source and the controller, with the area of interest positioned between the at least one first electrode and the at least one second electrode. A method of stimulating at least one of bone growth, tissue healing and pain control within an area of interest of a patient is described that includes inserting first and second electrode spaced at a predetermined distance, and further includes directing an electric current between the first and second electrodes so that at least a portion of the electric current passes through the area of interest positioned between the first electrode and the second electrode.

公开(公告)号：US20180064932A1

公开(公告)日：2018-03-08

申请号：US15807152

申请日：2017-11-08

Applicant: Washington University

Inventor： Eric Claude Leuthardt ,  Daniel W. Moran ,  Matthew R. MacEwan

IPC: A61N1/05 ,  A61N1/20 ,  A61N1/36 ,  A61N1/32 ,  A61B17/70

CPC classification number: A61N1/0558 ,  A61B17/7037 ,  A61B17/7059 ,  A61B17/7061 ,  A61N1/205 ,  A61N1/326 ,  A61N1/36071 ,  A61N1/36103

Abstract: A system to deliver current to an area of interest of a subject is described that includes a power source, a controller electrically coupled to the power source, at least one first electrode electrically coupled to the controller, and at least one second electrode electrically coupled to one of the power source and the controller, with the area of interest positioned between the at least one first electrode and the at least one second electrode. A method of stimulating at least one of bone growth, tissue healing and pain control within an area of interest of a patient is described that includes inserting first and second electrode spaced at a predetermined distance, and further includes directing an electric current between the first and second electrodes so that at least a portion of the electric current passes through the area of interest positioned between the first electrode and the second electrode.

公开(公告)号：US20170304084A1

公开(公告)日：2017-10-26

申请号：US15644201

申请日：2017-07-07

Applicant: Washington University

Inventor： Eric Claude Leuthardt ,  Kimberly Kreines ,  Nick Anderson

IPC: A61F2/72 ,  A61B5/00 ,  A61F2/04 ,  A61F2/50 ,  A61B5/04 ,  A61F2/68 ,  A61F2/70 ,  A61F2/76 ,  A61N1/36 ,  A61F2/48

CPC classification number: A61F2/72 ,  A61B5/04001 ,  A61B5/4076 ,  A61B5/4836 ,  A61F2/042 ,  A61F2/50 ,  A61F2002/482 ,  A61F2002/6872 ,  A61F2002/704 ,  A61F2002/7615 ,  A61N1/36003 ,  A61N1/36025 ,  A61N1/36082

Abstract: A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain. A prosthetic device receives the command signal from the signal translating unit and manipulates the body part in response to the command signal.