公开(公告)号：US06649162B1

公开(公告)日：2003-11-18

申请号：US09155569

申请日：2000-03-29

申请人： Wolfgang Biering ,  Hamza Mansour ,  Guenther Schlag ,  Thomas Seelich ,  Edgar Scheel ,  Georg Habison

发明人： Wolfgang Biering ,  Hamza Mansour ,  Guenther Schlag ,  Thomas Seelich ,  Edgar Scheel ,  Georg Habison

IPC分类号： A61K3848

CPC分类号： A61L15/425 ,  A61L15/225 ,  A61L15/325 ,  A61L2400/04 ,  Y10S128/08 ,  Y10S128/22 ,  C08L89/06

摘要： The invention relates to a hemostatic sponge based on collagen and an activator or proactivator of blood coagulation homogeneously distributed therein, which is dried and contains a water content of at least 2%, preferably in the range of 2 to 25%, more preferred 10 to 20%, and a method for producing this sponge.

摘要翻译： 本发明涉及一种基于胶原的止血海绵和均匀分布在其中的凝血活化剂或预活化剂，其干燥并含有至少2％，优选2至25％，更优选10至 20％，以及该海绵的制造方法。

公开(公告)号：US4735616A

公开(公告)日：1988-04-05

申请号：US875080

申请日：1986-06-17

申请人： Johann Eibl ,  Thomas Seelich ,  Heinz Redl ,  Georg Habison

发明人： Johann Eibl ,  Thomas Seelich ,  Heinz Redl ,  Georg Habison

IPC分类号： A61B17/00 ,  A61B17/115 ,  A61M5/19 ,  A61M5/31 ,  A61M31/00 ,  A61M35/00 ,  A61M5/18

CPC分类号： A61B17/00491 ,  A61M5/19 ,  A61B2017/00495 ,  A61M5/284

摘要： An arrangement for applying a tissue adhesive based on human or animal proteins, to seamlessly or seam-supportingly connect human or animal tissue or organ parts by uniting with blood-clot-promoting coagulation factors (thrombin). The arrangement includes a plurality of syringe bodies commonly actuatable by pistons and to which a connecting head is attachable. The syringe bodies have equal effective strokes, yet one of them, i.e., that destined to contain the protein solution, has a cross sectional area that is two to nine times larger than the other one(s). There may be applied tissue adhesives having a fibrinogen content of from 2 to 12%.

摘要翻译： 用于施加基于人或动物蛋白质的组织粘合剂的装置，通过与促凝血促凝血因子（凝血酶）结合而无缝地或缝合地连接人或动物组织或器官部分。 该装置包括通常由活塞致动的多个注射器体，并且可连接头部。 注射器本体具有相同的有效冲程，但是其中一个，即注定含有蛋白质溶液的横截面面积的横截面面积比另一个的横截面积大2至9倍。 可以使用纤维蛋白原含量为2至12％的组织粘合剂。

公开(公告)号：US06718735B2

公开(公告)日：2004-04-13

申请号：US10101490

申请日：2002-03-19

申请人： James D. Lewis, Jr. ,  William Baccia ,  Josef Schmidt ,  Johan Vandersande ,  John Carl Card ,  Theodor Langer ,  Georg Habison ,  Helmut Eder

发明人： James D. Lewis, Jr. ,  William Baccia ,  Josef Schmidt ,  Johan Vandersande ,  John Carl Card ,  Theodor Langer ,  Georg Habison ,  Helmut Eder

IPC分类号： B65B5510

CPC分类号： B65D75/5883 ,  B65B9/20 ,  B65B55/103 ,  B65B61/186

摘要： A flexible polymeric container for holding albumin. The container is made of a sheet of flexible polymeric film formed into a bag having a cavity enclosed by a first wall, an opposing second wall, and seals about a periphery of the first and second walls. The seals join an interior portion of the opposing first and second walls and create a fluid-tight chamber within the cavity of the container for storing a concentration of the albumin. A method of packaging the albumin protein into a flexible polymeric container is also provided. Therein a flexible polymeric material is converted into bags, the bags are filled with a quantity of albumin by a filler, and a seal area of the bags is sealed to enclose the albumin within the bag.

摘要翻译： 用于保持白蛋白的柔性聚合物容器。 容器由形成为袋的柔性聚合物薄膜制成，其具有被第一壁，相对的第二壁包围的空腔，并围绕第一和第二壁的周边密封。 密封件连接相对的第一和第二壁的内部，并在容器的空腔内产生流体密封的腔室，用于储存白蛋白的浓度。 还提供了将白蛋白包装到柔性聚合物容器中的方法。 其中将柔性聚合物材料转化成袋，袋中填充有一定数量的白蛋白，并且将袋的密封区域密封以将白蛋白包裹在袋内。

公开(公告)号：US4631055A

公开(公告)日：1986-12-23

申请号：US705725

申请日：1985-02-26

申请人： Heinz Redl ,  Georg Habison

发明人： Heinz Redl ,  Georg Habison

IPC分类号： A61L24/00 ,  A61B17/00 ,  A61B17/04 ,  A61L26/00 ,  A61M3/00 ,  A61M5/178 ,  A61M35/00 ,  B05B7/04 ,  A61M5/00

CPC分类号： A61B17/00491 ,  A61M3/005 ,  A61B2017/00495

摘要： There is disclosed an arrangement for applying a tissue adhesive based on human or animal proteins to seamlessly or seam-supportingly connect human or animal tissue or organ parts, to seal wounds, stop bleedings and the like. The tissue adhesive is formed in situ by combining solutions of the proteins and of blood-clot-promoting coagulation factors. The arrangement includes a plurality of containers ending in joining pieces for accommodating the components to be applied. A connecting head is attachable to the joining pieces of the containers, which includes a separate conveying channel for each of the components to be applied. In order to design an arrangement of the above defined kind to be troublefree and to render it usable even for hardly accessible application sites, without requiring an exchange of parts of the arrangement at an interruption of the component flow, and to be able to use it with and without the help of an endoscope, the connecting head includes an additional conveying channel for a medicinal gas. This channel leads to the front side of the connecting head parallel and closely adjacent the remaining conveying channels. The connecting head is continued in either a multi-lumen catheter containing a gas-conveying channel or in a mixing needle.

摘要翻译： 公开了一种用于施用基于人或动物蛋白质的组织粘合剂以无缝或缝合支撑地连接人或动物组织或器官部分，以密封伤口，停止出血等的布置。 组合粘合剂通过组合蛋白质溶液和促凝血凝血因子在原位形成。 该装置包括多个容器，其以接合件结束，以容纳要施加的部件。 连接头可附接到容器的连接件，其包括用于要施加的每个部件的单独输送通道。 为了设计上述定义类型的布置是无故障的，并且即使对于难以访问的应用场所也可使其可用，而不需要在部件流程中断时更换部件，并且能够使用它 在没有内窥镜的帮助下，连接头包括用于医用气体的附加输送通道。 该通道通向连接头的前侧平行并紧邻其余输送通道。 连接头在包含气体输送通道的多腔导管中或在混合针中连续。

公开(公告)号：US5665067A

公开(公告)日：1997-09-09

申请号：US394039

申请日：1995-02-24

申请人： Albert Linder ,  Andreas Kellner ,  Georg Habison ,  Guenther Zuelow

发明人： Albert Linder ,  Andreas Kellner ,  Georg Habison ,  Guenther Zuelow

IPC分类号： A61B17/00 ,  A61B17/11 ,  A61B17/12 ,  A61M35/00 ,  B05B7/06 ,  A61M37/00

CPC分类号： A61B17/00491 ,  A61M35/00 ,  B05B7/061 ,  A61B2017/00495

摘要： There is disclosed an apparatus for applying a multiple component tissue adhesive, which apparatus has component conveying channels for the components of the tissue adhesive, extending in a one-piece construction part from a connecting part to a delivery part, and a gas conveying channel for a medicinal gas serving for atomizing the tissue adhesive components, wherein all the conveying channels end in separate exit openings at a front side of the delivery part and extend parallel to one another over at least that part of their longitudinal extension which is immediately upstream of the exit openings, and wherein the component conveying channels together are enclosed by the gas conveying channel at least on that part of their longitudinal extension immediately in front of their exit openings.

摘要翻译： 公开了一种用于施加多组分组织粘合剂的装置，该装置具有用于组织粘合剂的部件的部件输送通道，其从连接部分到输送部分以一体式结构部件延伸，并且气体输送通道用于 用于雾化组织粘合剂组分的药用气体，其中所有输送通道在输送部分的前侧处分开的出口开口延伸并且在它们的纵向延伸部分的至少一部分上彼此平行延伸，该部分的紧靠上游 出口开口，并且其中输送通道的部件一起被气体输送通道封闭，其至少在其纵向延伸部分的那一部分上紧靠其出口开口的前方。

公开(公告)号：US5464396A

公开(公告)日：1995-11-07

申请号：US310404

申请日：1994-09-22

申请人： Helmut Barta ,  Helmut Eder ,  Manfred Granser ,  Georg Habison ,  Edith Hantak ,  Franz Moser ,  Peter Pfaffenbichler

发明人： Helmut Barta ,  Helmut Eder ,  Manfred Granser ,  Georg Habison ,  Edith Hantak ,  Franz Moser ,  Peter Pfaffenbichler

IPC分类号： A61M5/178 ,  A61B17/00 ,  A61M5/145 ,  A61M5/19 ,  A61M5/31 ,  A61M5/315 ,  A61M5/50 ,  B65D81/32 ,  A61M5/00

CPC分类号： A61B17/00491 ,  A61M5/19 ,  A61M5/5066 ,  B05C17/00593 ,  B65D81/325 ,  A61B2017/00495 ,  A61M2005/3104 ,  A61M2005/31508 ,  A61M2207/00 ,  B05C17/00516

摘要： There is disclosed a syringe assembly for the storage and application of a biological multi-component material. Its assembly parts are a syringe device including several parallel syringe bodies interconnected by a connection part, which syringe bodies are filled with the individual components of the multi-component material, include coni and are closed by pistons; an actuation device for this syringe device, which includes piston rods associated with the pistons and a common grip element; and a dispensing element to be attached to the coni of the syringe bodies. The filled syringe bodies, which are closed by separate piston plugs, constitute a one-piece syringe unit with the connection part. The connection part leaves a recess between the syringe bodies on one of the ends of the syringe unit for receiving a protection means shielding off the other syringe body/ies when filling the syringe bodies. The grip element is connected in one piece with the piston rods, thereby forming a one-piece piston rod unit separate from the syringe unit including the piston plugs.

摘要翻译： 公开了一种用于存储和应用生物多组分材料的注射器组件。 其组装部件是包括通过连接部分互连的几个平行的注射器体的注射器装置，该注射器主体被多组分材料的各个部件填充，包括圆锥形并且被活塞封闭; 用于该注射器装置的致动装置，其包括与活塞相关联的活塞杆和公共夹持元件; 以及附接到注射器主体的锥体的分配元件。 填充的注射器主体由单独的活塞塞封闭，构成具有连接部件的一体式注射器单元。 连接部分在注射器单元的一个端部上的注射器主体之间留下凹槽，用于在填充注射器主体时接收屏蔽其它注射器主体的保护装置。 夹紧元件与活塞杆一体地连接，从而形成与包括活塞塞的注射器单元分离的一体式活塞杆单元。