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    STORAGE-STABLE LAMINATE SEGMENTS
    3.
    发明申请
    STORAGE-STABLE LAMINATE SEGMENTS 有权
    储存稳定的层压板

    公开(公告)号：US20100178343A1

    公开(公告)日：2010-07-15

    申请号：US12602172

    申请日：2008-05-27

    申请人： Hans-Dieter Sahm ,  Heinrich Thoeing ,  Wolfgang Laux

    发明人： Hans-Dieter Sahm ,  Heinrich Thoeing ,  Wolfgang Laux

    IPC分类号： A61K9/70 ,  B32B37/14 ,  B32B3/10 ,  B32B7/06 ,  B32B7/12

    CPC分类号： A61F13/0259 ,  A61F13/0008 ,  A61F13/02 ,  A61F13/025 ,  A61F13/0253 ,  A61K9/7023 ,  A61K9/703 ,  A61K9/7053 ,  Y10T428/15 ,  Y10T428/24314

    摘要： The invention relates to laminate segments equipped or coated with an adhesive matrix, particularly transdermal therapeutic systems having formulations strongly tending to leak adhesive. The inventive laminate segments include a matrix, with or without a back layer, a protective layer on the adhesive side of the matrix, provided with a cut as a peel-off aid, and a cover film partially coated with adhesive, applied to the protective film, which overlaps the cut in the protective film using the adhesive-free part thereof The cover film prevents a leakage of the adhesive through the cut, and therefore a gluing together of the laminate segments to the packaging material thereof, without having an adverse effect on the function of the cut as a peel-off aid. Such laminate segments can be produced without the use of any intermediate carriers.

    摘要翻译： 本发明涉及配备或涂覆有粘合剂基质的层压片段，特别是具有强烈倾向于泄漏粘合剂的制剂的经皮治疗系统。 本发明的层压片段包括具有或不具有背层的基质，在基质的粘合剂侧上设置有作为剥离助剂的切口的保护层和部分涂覆有粘合剂的覆盖膜，施加到保护层 膜，其与不含粘合剂的部分重叠在保护膜上的切口。覆盖膜防止粘合剂通过切口泄漏，因此将层压片段粘合到其包装材料上而不产生不利影响 关于作为剥离助剂的切割功能。 可以在不使用任何中间载体的情况下制造这种层压片段。

    Method for producing individually dosed active substance-containing and, in particular, aromatics-containing film-shaped administration forms rapidly disintegrating upon contact with liquid
    5.
    发明授权
    Method for producing individually dosed active substance-containing and, in particular, aromatics-containing film-shaped administration forms rapidly disintegrating upon contact with liquid 有权
    用于生产单独计量的含活性物质的方法，特别是含芳族化合物的膜状给药形式在与液体接触时迅速崩解

    公开(公告)号：US08883191B2

    公开(公告)日：2014-11-11

    申请号：US10745889

    申请日：2003-12-26

    申请人： Michael Horstmann ,  Wolfgang Laux

    发明人： Michael Horstmann ,  Wolfgang Laux

    IPC分类号： A61F13/00 ,  A61K47/00 ,  A61K9/70 ,  A61K9/00 ,  A61K9/20

    CPC分类号： A61K9/0056 ,  A61K9/2072 ,  A61K9/70 ,  A61K9/7007

    摘要： A method for producing individually dosed active substance-containing and, in particular, aromatic-containing, film-shaped administration form, rapidly disintegrating upon contact with a liquid, wherein the aromatic is present as an internal, liposoluble phase in the form of liquid droplets distributed within an outer, solid but water-soluble phase, is characterized in that the said outer phase contains: at least 40% (w/w) polyvinyl alcohol 0 to 30% (w/w), of a surface-active substance, and that the constituent amount of the inner phase, relative to the outer phase, is between 0.1 and 30% (w/w), in each case relative to the water-free portions.

    摘要翻译： 一种用于生产单独计量的含活性物质，特别是含芳族化合物的膜状施用形式的方法，其与液体接触时迅速崩解，其中所述芳族化合物作为液滴形式的内部脂溶性相存在 分布在外部固体但水溶性相中的特征在于，所述外相包含：至少40％（w / w）的聚乙烯醇0至30％（w / w）的表面活性物质， 并且相对于外相的内相的组成量相对于无水部分为0.1〜30％（w / w）。

    Rapidly disintegrating dosage form for releasing active ingredients in the oral cavity or in body cavities
    8.
    发明授权
    Rapidly disintegrating dosage form for releasing active ingredients in the oral cavity or in body cavities 有权
    用于释放口腔或体腔中活性成分的快速崩解剂型

    公开(公告)号：US08313769B2

    公开(公告)日：2012-11-20

    申请号：US13194881

    申请日：2011-07-29

    申请人： Christian Von Falkenhausen ,  Markus Krumme ,  Wolfgang Laux

    发明人： Christian Von Falkenhausen ,  Markus Krumme ,  Wolfgang Laux

    IPC分类号： A61K9/22 ,  A61J3/00

    CPC分类号： A61K9/0056 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/7007

    摘要： A dosage form which is, in particular, sheet-like and rapidly disintegrating or soluble in an aqueous environment for rapid release of active ingredients in the oral cavity, in body orifices or in body cavities, where the dosage form comprises a matrix which comprises one or more water -soluble polymers as base substances, and comprises at least one active ingredient, is characterized in that the dosage form is provided with spaces or cavities which are present in the polymeric matrix and whose contents differ in terms of the state of aggregation from the matrix.

    摘要翻译： 一种剂型，其特别是片状并且在水性环境中快速分解或溶解以便快速释放口腔，体内孔或体腔中的活性成分，其中剂型包含基质，其包含一个 或更多的水溶性聚合物作为基础物质，并且包含至少一种活性成分，其特征在于，所述剂型具有存在于所述聚合物基质中的空间或空腔，并且其含量在聚集状态方面不同 矩阵。

    Rapidly-decomposing administrable form for releasing active ingredients in the oral cavity or in bodily cavities
    10.
    发明授权
    Rapidly-decomposing administrable form for releasing active ingredients in the oral cavity or in bodily cavities 有权
    快速分解的可口服形式用于释放口腔或身体腔中的活性成分

    公开(公告)号：US07988997B2

    公开(公告)日：2011-08-02

    申请号：US10332064

    申请日：2001-06-22

    申请人： Christian Von Falkenhausen ,  Markus Krumme ,  Wolfgang Laux

    发明人： Christian Von Falkenhausen ,  Markus Krumme ,  Wolfgang Laux

    IPC分类号： A61K9/22

    CPC分类号： A61K9/0056 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/7007

    摘要： A dosage form which is, in particular, sheet-like and rapidly disintegrating or soluble in an aqueous environment for rapid release of active ingredients in the oral cavity, in body orifices or in body cavities, where the dosage form comprises a matrix which comprises one or more water-soluble polymers as base substances, and comprises at least one active ingredient, is characterized in that the dosage form is provided with spaces or cavities which are present in the polymeric matrix and whose contents differ in terms of the state of aggregation from the matrix.

    摘要翻译： 一种剂型，其特别是片状并且在水性环境中快速分解或溶解以便快速释放口腔，体内孔或体腔中的活性成分，其中剂型包含基质，其包含一个 或更多的水溶性聚合物作为基础物质，并且包含至少一种活性成分，其特征在于，所述剂型具有存在于所述聚合物基质中的空间或空腔，并且其含量在聚集状态方面不同 矩阵。