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公开(公告)号：US08110201B2
公开(公告)日：2012-02-07
申请号：US12698976
申请日：2010-02-02
申请人： Yasir Skeiky , Jeff Guderian , Steven Reed
发明人： Yasir Skeiky , Jeff Guderian , Steven Reed
CPC分类号： C07K14/35 , A61K39/00 , A61K2039/53 , A61K2039/55566 , A61K2039/55577 , C07K2319/02
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种分枝杆菌属的组合物和融合蛋白。 抗原和编码这些组合物的核酸和融合蛋白。 本发明的组合物增加来自感染结核病的个体的血清的血清学敏感性，以及用于诊断，治疗和预防结核病感染的方法。
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公开(公告)号：US07678375B2
公开(公告)日：2010-03-16
申请号：US11342364
申请日：2006-01-26
申请人： Yasir Skeiky , Jeff Guderian , Steven Reed
发明人： Yasir Skeiky , Jeff Guderian , Steven Reed
CPC分类号： C07K14/35 , A61K39/00 , A61K2039/53 , A61K2039/55566 , A61K2039/55577 , C07K2319/02
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种分枝杆菌属的组合物和融合蛋白。 抗原和编码这些组合物的核酸和融合蛋白。 本发明的组合物增加来自感染结核病的个体的血清的血清学敏感性，以及用于诊断，治疗和预防结核病感染的方法。
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公开(公告)号：US20080242630A1
公开(公告)日：2008-10-02
申请号：US11982179
申请日：2007-10-31
申请人： Yasir Skeiky , Jeff Guderian , Steven Reed
发明人： Yasir Skeiky , Jeff Guderian , Steven Reed
IPC分类号： A61K31/711 , C07H21/04 , C12N15/00 , A61P31/06 , C12N1/20
CPC分类号： C07K14/35 , A61K39/00 , A61K2039/53 , A61K2039/55566 , A61K2039/55577 , C07K2319/02
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种分枝杆菌属的组合物和融合蛋白。 抗原和编码这些组合物的核酸和融合蛋白。 本发明的组合物增加来自感染结核病的个体的血清的血清学敏感性，以及用于诊断，治疗和预防结核病感染的方法。
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公开(公告)号：US08110200B2
公开(公告)日：2012-02-07
申请号：US12698893
申请日：2010-02-02
申请人： Yasir Skeiky , Jeff Guderian , Steven Reed
发明人： Yasir Skeiky , Jeff Guderian , Steven Reed
CPC分类号： C07K14/35 , A61K39/00 , A61K2039/53 , A61K2039/55566 , A61K2039/55577 , C07K2319/02
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种分枝杆菌属的组合物和融合蛋白。 抗原和编码这些组合物的核酸和融合蛋白。 本发明的组合物增加来自感染结核病的个体的血清的血清学敏感性，以及用于诊断，治疗和预防结核病感染的方法。
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公开(公告)号：US20100183677A1
公开(公告)日：2010-07-22
申请号：US12698976
申请日：2010-02-02
申请人： Yasir Skeiky , Jeff Guderian , Steven Reed
发明人： Yasir Skeiky , Jeff Guderian , Steven Reed
IPC分类号： A61K39/04 , A61K31/7088 , A61P31/06 , A61K45/00
CPC分类号： C07K14/35 , A61K39/00 , A61K2039/53 , A61K2039/55566 , A61K2039/55577 , C07K2319/02
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种分枝杆菌属的组合物和融合蛋白。 抗原和编码这些组合物的核酸和融合蛋白。 本发明的组合物增加来自感染结核病的个体的血清的血清学敏感性，以及用于诊断，治疗和预防结核病感染的方法。
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公开(公告)号：US07691993B2
公开(公告)日：2010-04-06
申请号：US11982179
申请日：2007-10-31
申请人： Yasir Skeiky , Jeff Guderian , Steven Reed
发明人： Yasir Skeiky , Jeff Guderian , Steven Reed
CPC分类号： C07K14/35 , A61K39/00 , A61K2039/53 , A61K2039/55566 , A61K2039/55577 , C07K2319/02
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
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公开(公告)号：US20070184074A1
公开(公告)日：2007-08-09
申请号：US11342364
申请日：2006-01-26
申请人： Yasir Skeiky , Jeff Guderian , Steven Reed
发明人： Yasir Skeiky , Jeff Guderian , Steven Reed
IPC分类号： A61K39/04 , G01N33/554 , C07H21/04 , C12N15/74 , G01N33/569 , C12N1/21 , C07K14/36
CPC分类号： C07K14/35 , A61K39/00 , A61K2039/53 , A61K2039/55566 , A61K2039/55577 , C07K2319/02
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
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公开(公告)号：US07026465B2
公开(公告)日：2006-04-11
申请号：US10369983
申请日：2003-02-18
申请人： Yasir Skeiky , Jeff Guderian , Steven Reed
发明人： Yasir Skeiky , Jeff Guderian , Steven Reed
CPC分类号： C07K14/35 , A61K39/00 , A61K2039/53 , A61K2039/55566 , A61K2039/55577 , C07K2319/02
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
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9.发明申请公开(公告)号：US20050232941A1
公开(公告)日：2005-10-20
申请号：US11109468
申请日：2005-04-19
IPC分类号： A61K35/12 , A61K39/00 , A61K39/02 , A61K39/118 , C07H21/04 , C07K14/295 , C12N1/21 , C12N5/0783 , C12Q1/68 , G01N33/554 , G01N33/569
CPC分类号： C12N5/0636 , A61K39/00 , A61K39/118 , A61K2035/124 , A61K2039/505 , A61K2039/515 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/57 , C07K14/295 , C07K2319/00 , G01N33/56927
摘要： Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.
摘要翻译： 公开了用于诊断和治疗衣原体感染的化合物和方法。 提供的化合物包括含有衣原体抗原的至少一个抗原部分的多肽和编码这些多肽的DNA序列。 还提供了包含此类多肽或DNA序列的药物组合物和疫苗以及针对这些多肽的抗体。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的衣原体感染。
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10.发明申请COMPOUNDS AND METHODS FOR TREATMENT AND DIAGNOSIS OF CHLAMYDIAL INFECTION 失效用于治疗和诊断CHLAMYDIAL感染的化合物和方法公开(公告)号：US20050084499A1
公开(公告)日：2005-04-21
申请号：US10197220
申请日：2002-07-15
IPC分类号： A61K35/12 , A61K39/00 , A61K39/02 , A61K39/118 , C07H21/04 , C07K14/295 , C12N1/21 , C12N5/0783 , C12Q1/68 , G01N33/554 , G01N33/569
CPC分类号： C12N5/0636 , A61K39/00 , A61K39/118 , A61K2035/124 , A61K2039/505 , A61K2039/515 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/57 , C07K14/295 , C07K2319/00 , G01N33/56927
摘要： Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.
摘要翻译： 公开了用于诊断和治疗衣原体感染的化合物和方法。 提供的化合物包括含有衣原体抗原的至少一个抗原部分的多肽和编码这些多肽的DNA序列。 还提供了包含此类多肽或DNA序列的药物组合物和疫苗以及针对这些多肽的抗体。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的衣原体感染。
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