公开(公告)号：US20180134808A1

公开(公告)日：2018-05-17

申请号：US15865479

申请日：2018-01-09

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Tamar DANON ,  Netta SELA ,  Abraham SHANZER ,  Rina ARAD-YELLIN ,  Raghavendra KIKKERI

IPC: C07K16/44 ,  C07F3/06 ,  C07D233/61 ,  C07K16/40

CPC classification number: C07K16/44 ,  C07D233/61 ,  C07F3/06 ,  C07K16/40 ,  C07K2317/565 ,  C07K2317/76

Abstract: An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12.

公开(公告)号：US20170210823A1

公开(公告)日：2017-07-27

申请号：US15328036

申请日：2014-07-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Moran GROSSMAN ,  Nir BEN-CHETRIT

IPC: C07K16/40 ,  A61K45/06 ,  A61K33/24 ,  A61K39/395

CPC classification number: C07K16/40 ,  A61K33/24 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

Abstract: An article of manufacture is disclosed which comprises at least two active agents, wherein a first of the two active agents comprises an anti-cancer agent or an antifibrotic agent and a second of the at least two active agents downregulates the activity and/or expression of lysyl-oxidase like protein-2 (LOXL-2) and which is capable of altering the structure of the extracellular matrix.

公开(公告)号：US20240166768A1

公开(公告)日：2024-05-23

申请号：US18430696

申请日：2024-02-02

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Roei David MAZOR ,  Ziv SHULMAN

IPC: C07K16/40 ,  A61K39/00 ,  A61K39/395 ,  A61P35/00 ,  C07K14/725 ,  G01N33/573 ,  G01N33/574

CPC classification number: C07K16/40 ,  A61K39/3955 ,  A61K39/4613 ,  A61P35/00 ,  C07K14/7051 ,  G01N33/573 ,  G01N33/57492 ,  C07K2319/30 ,  G01N2333/96486

Abstract: Monoclonal antibodies for the treatment of ovarian cancer are provided also provide are uses of same. Such uses include characterizing the tumor, diagnosing it and treatment of same.

公开(公告)号：US20220106405A1

公开(公告)日：2022-04-07

申请号：US17429672

申请日：2020-02-10

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Vishnu MOHAN

IPC: C07K16/40 ,  C07K16/30 ,  A61P35/00 ,  A61K31/282 ,  A61K31/7068

Abstract: An antibody comprising an antigen recognition region which binds a catalytic site of MMP-7, having complementarity determining region (CDR) amino acid sequences as set forth in: SEQ ID NOs: 3 (CDR1), 4 (CDR2) and 5 (CDR3), sequentially arranged from N to C on a light chain of the antibody; and SEQ ID NOs: 6 (CDR1), 7 (CDR2) and 8 (CDR3), sequentially arranged from N to C on a heavy chain of the antibody.

公开(公告)号：US20130224225A1

公开(公告)日：2013-08-29

申请号：US13872265

申请日：2013-04-29

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Irit SAGI ,  Tamar Danon ,  Netta Sela ,  Abraham Shanzer ,  Rina Arad-Yellin ,  Raghavendra Kikkeri

IPC: C07K16/44 ,  C07F3/06

CPC classification number: C07K16/44 ,  C07D233/61 ,  C07F3/06 ,  C07K16/40 ,  C07K2317/565 ,  C07K2317/76

Abstract: An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12.

Abstract translation: 包含抗原识别区的抗体，其包含SEQ ID NO：7,8,9,10,11和12所示的CDR氨基酸序列。

公开(公告)号：US20210162025A1

公开(公告)日：2021-06-03

申请号：US17166060

申请日：2021-02-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Eitan WONG ,  Ran AFIK

IPC: A61K38/48 ,  C12N9/64

Abstract: A method of treating an inflammatory disease is disclosed. The method comprises administering to the subject a therapeutically effective amount of a polypeptide comprising a pro-domain of TNF-alpha converting enzyme (TACE), said polypeptide being devoid of a catalytic domain of said TACE, said polypeptide comprising a modification at a site selected from the group consisting of R58, R56 and K57 which renders said polypeptide resistant to furin degradation said polypeptide being capable of downregulating an activity of TACE, thereby treating the inflammatory disease.

公开(公告)号：US20200261577A1

公开(公告)日：2020-08-20

申请号：US16830461

申请日：2020-03-26

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Dalit TALMI-FRANK ,  Inna SOLOMONOV ,  Ido AMIT

IPC: A61K39/395 ,  A61K45/06 ,  A61K31/351 ,  A61K31/196 ,  C07K16/40 ,  A61K31/215

Abstract: A method of treating or preventing a disease associated with a secondary infection in a subject infected with a pathogen is provided. The method comprises administering to the subject a therapeutically effective amount of an anti-pathogenic agent directed towards the pathogen and a therapeutically effective amount of an agent which down-regulates at least one extracellular matrix-associated polypeptide.

公开(公告)号：US20160257765A1

公开(公告)日：2016-09-08

申请号：US15161375

申请日：2016-05-23

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Tamar DANON ,  Netta SELA ,  Abraham SHANZER ,  Rina ARAD-YELLIN ,  Raghavendra KIKKERI

IPC: C07K16/44 ,  C07K16/40 ,  C07F3/06

CPC classification number: C07K16/44 ,  C07D233/61 ,  C07F3/06 ,  C07K16/40 ,  C07K2317/565 ,  C07K2317/76

Abstract: An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12.

公开(公告)号：US20240398906A1

公开(公告)日：2024-12-05

申请号：US18804150

申请日：2024-08-14

Applicant: Yeda Research and Development Co. Ltd. ,  Ramot at Tel-Aviv University Ltd.

Inventor： Irit SAGI ,  Nikolaos A. AFRATIS ,  Inna SOLOMONOV ,  Carmit LEVY ,  Shivang PARIKH

IPC: A61K38/44 ,  A61K38/17 ,  A61K45/06 ,  A61P35/00

Abstract: A method of treating a cancer which is characterized by an up-regulation of expression of lysyl oxidase (LOX) and heat shock protein 70 (HSP70) is disclosed. The method comprises administering to the subject a therapeutically effective amount of a polypeptide comprising a propeptide of lysyl oxidase (LOX), said polypeptide being devoid of LOX catalytic activity, wherein said polypeptide binds to both LOX and heat shock protein 70 (HSP70) with a EC50 of less than 100 nM.

公开(公告)号：US20180028650A1

公开(公告)日：2018-02-01

申请号：US15549161

申请日：2016-02-09

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Dalit TALMI - FRANK ,  Inna SOLOMONOV ,  Ido AMIT

IPC: A61K39/395 ,  A61K31/196 ,  A61K31/215 ,  C07K16/40 ,  A61K31/351

CPC classification number: A61K39/3955 ,  A61K31/196 ,  A61K31/215 ,  A61K31/351 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/40 ,  A61K2300/00

Abstract: A method of treating or preventing a disease associated with a secondary infection in a subject infected with a pathogen is provided. The method comprises administering to the subject a therapeutically effective amount of an anti-pathogenic agent directed towards the pathogen and a therapeutically effective amount of an agent which down-regulates at least one extracellular matrix-associated polypeptide.