公开(公告)号：US20080246962A1

公开(公告)日：2008-10-09

申请号：US12063410

申请日：2006-08-08

Applicant: Yongwu Yang

Inventor： Yongwu Yang

IPC: G01J3/28

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/0289 ,  G01J3/0291 ,  G02B6/3885 ,  G02B6/4226 ,  G02B6/4292

Abstract: A coupler for coupling a linear fiber array to a spectrometer is provided, the coupler having a tube, a linear fiber bundle array inserted through the tube, an alignment mechanism for aligning the linear fiber bundle array with a slit on the spectrometer, and a locking mechanism for locking the linear fiber bundle array to the tube. Further, a method for coupling a linear fiber array to a spectrometer is provided, the method having the steps of inserting a linear fiber bundle array through a tube, aligning the linear fiber bundle array with a slit on the spectrometer, and locking the linear fiber bundle array to the tube once it is aligned with the slit on the spectrometer.

Abstract translation: 提供了一种用于将线性光纤阵列耦合到光谱仪的耦合器，耦合器具有管，插入穿过管的线性光纤束阵列，用于使线性光纤束阵列与光谱仪上的狭缝对准的对准机构，以及锁定 将线性纤维束阵列锁定到管的机构。 此外，提供了将线性光纤阵列耦合到光谱仪的方法，该方法具有以下步骤：通过管插入线性光纤束阵列，将线性光纤束阵列与光谱仪上的狭缝对准，并将线性光纤 一旦它与光谱仪上的狭缝对准，则将束阵列连接到管。

公开(公告)号：US07898657B2

公开(公告)日：2011-03-01

申请号：US11972849

申请日：2008-01-11

Applicant: Peter A. Klein ,  Wang-Long Zhou ,  Yongwu Yang ,  Victor Sapirstein ,  Jesse Samuel Eberdt, III ,  W. L. Douglas Townsend, Jr.

Inventor： Peter A. Klein ,  Wang-Long Zhou ,  Yongwu Yang ,  Victor Sapirstein ,  Jesse Samuel Eberdt, III ,  W. L. Douglas Townsend, Jr.

IPC: G01J3/44

CPC classification number: G01N21/65 ,  G01N21/9508

Abstract: A probe for a system for determining the chemical signature of a pharmaceutical compound. The probe comprises: a housing; an inlet in the housing adapted to be connected to a transmitting optical fiber; a scanning aperture in the housing; a receiving outlet in the housing adapted to be connected to a receiving optical fiber; at least one transmission reflector positioned in the housing to receive laser light from the transmitting optical fiber and reflect the laser light through the detection outlet to a pharmaceutical vial containing a pharmaceutical compound positioned outside the housing, and at least one receiving reflector positioned in the housing to receive light reflected by the pharmaceutical compound and reflect the light to the receiving outlet. This configuration can enable rapid and accurate scanning of a pharmaceutical contained in a vial positioned adjacent the detection outlet.

Abstract translation: 用于确定药物化合物的化学特征的系统的探针。 探针包括：壳体; 壳体中的入口适于连接到发射光纤; 壳体中的扫描孔; 壳体中的接收出口适于连接到接收光纤; 位于外壳中的至少一个透射反射器，用于接收来自发射光纤的激光，并将激光反射通过检测出口到包含定位在外壳外部的药物化合物的药物小瓶，以及至少一个位于壳体中的接收反射器 以接收由药物化合物反射的光并将光反射到接收出口。 这种配置可以快速准确地扫描包含在邻近检测出口的小瓶中的药物。

公开(公告)号：US06265151B1

公开(公告)日：2001-07-24

申请号：US09224141

申请日：1998-12-31

Applicant: Joseph M. Canter ,  Yongwu Yang ,  Wanglong Zhou

Inventor： Joseph M. Canter ,  Yongwu Yang ,  Wanglong Zhou

IPC: C12Q100

CPC classification number: G01N21/6486 ,  G01N2021/6423

Abstract: A process for detecting HIV infection, Hepatitis A, B and C, and other similar infections in a plasma sample, wherein the process involves the use of an excitation laser source to irradiate upon the plasma sample an excitation laser beam to obtain a fluorescence emission spectrum of the plasma sample. The invention uses an excitation laser wavelength of about 355 nanometers. Detection of the fluorescence is made in the wavelength range from about 380 to 600 nanometers. The resulting spectrum of the sample is compared with the spectrum of a control which is free from infection. Analysis of the parameters of the emission spectra including, but not limited to, peak intensity wavelength, amplitude at the peak intensity, area ratio of left and right portions of the emission spectra, and shifts of the peak intensity wavelength, allows determination of HIV infection, Hepatitis A, B and C, and other similar infection in the plasma. Selective absorbents, such as C-M Affi Gel Blue and activated charcoal, may be used to treat the samples before fluorescence measurements, which is found to improve discrimination of infected and uninfected samples. The present invention is capable of detecting HIV infection at the stage when it is still undetectable by conventional diagnosis methods.

Abstract translation: 一种在血浆样品中检测HIV感染，甲型肝炎，乙型和丙型肝炎以及其他类似感染的方法，其中该方法包括使用激发激光源照射等离子体样品激发激光束以获得荧光发射光谱 的血浆样品。 本发明使用约355纳米的激发激光波长。 在约380-600纳米的波长范围内进行荧光的检测。 将所得样品的光谱与无感染对照的光谱进行比较。 包括但不限于峰强度波长，峰强度下的振幅，发射光谱的左右部分的面积比和峰强度波长的偏移的发射光谱参数的分析允许测定HIV感染 ，甲型肝炎，乙型和丙型肝炎等血浆中类似的感染。 选择性吸收剂，如C-M Affi凝胶蓝和活性炭可用于在荧光测量之前处理样品，这被发现可改善感染和未感染样品的鉴别。 本发明能够在通过常规诊断方法仍然不可检测的阶段检测HIV感染。

公开(公告)号：US6159159A

公开(公告)日：2000-12-12

申请号：US224182

申请日：1998-12-31

Applicant: Joseph M. Canter ,  Yongwu Yang ,  Wanglong Zhou ,  Victor S. Sapirstein ,  Melvin P. Ehrlich ,  James S. Harrison ,  Eugene Katsman ,  Omanand Koul ,  Michael Y. Lu ,  Michael A. Greenwald

Inventor： Joseph M. Canter ,  Yongwu Yang ,  Wanglong Zhou ,  Victor S. Sapirstein ,  Melvin P. Ehrlich ,  James S. Harrison ,  Eugene Katsman ,  Omanand Koul ,  Michael Y. Lu ,  Michael A. Greenwald

IPC: A61B10/00

CPC classification number: A61B10/0012 ,  A61B2010/0025 ,  Y10S436/906

Abstract: A quantitative process for monitoring female fertility cycle wherein the process involves directing a laser beam, preferably generated by a diode laser, onto an area of a slide containing an air-dried sample of a female body fluid. The diffraction pattern resulting from the sample is detected by a two-dimensional photo diode array and analyzed by a microprocessor. If a ferning pattern exists, such pattern will generate a characteristic structure in the diffraction pattern which is then detected by the photo diode array. If no ferning occurs, the corresponding diffraction pattern will be structureless. The microprocessor is programmed with an algorithm to produce a quantitative index of ferning indicating quantitatively the ferning level. Preferably, a plurality of spots on the sample are measured to determine the ferning level at each spot, and the microprocessor then makes a final determination as to final ferning level on the basis of the test results of all of the spots. This significantly increases the reliability of the final test result, since a defect at one test spot or anomaly of one test result will not be fatal to the final result.

Abstract translation: 一种用于监测雌性生育周期的定量过程，其中该方法包括将优选由二极管激光产生的激光束引导到含有女性体液的空气干燥样品的载玻片的区域上。 由样品产生的衍射图由二维光电二极管阵列检测并由微处理器分析。 如果存在镀层图案，则这种图案将产生衍射图案中的特征结构，然后由光电二极管阵列检测。 如果没有发生发光，相应的衍射图将是无结构的。 微处理器用一种算法进行编程，以产生定量指定的定量指标。 优选地，测量样品上的多个点以确定每个点处的熨烫水平，然后微处理器基于所有点的测试结果对最终熨烫水平进行最终确定。 这显着增加了最终测试结果的可靠性，因为一个测试点的缺陷或一个测试结果的异常对最终结果不会是致命的。

公开(公告)号：US08083385B1

公开(公告)日：2011-12-27

申请号：US11924619

申请日：2007-10-26

Applicant: Yongwu Yang

Inventor： Yongwu Yang

IPC: B60Q1/00 ,  F21V1/00 ,  F21V17/02 ,  G02F1/1335

CPC classification number: G02F1/1313 ,  G02F1/13318

Abstract: An apparatus for attenuating the intensity of light transmitted through the apparatus is provided. In one embodiment, the apparatus may comprise a first polarizer having a first polarizing orientation and a second polarizer having a polarizing orientation perpendicular to the first polarizer. First and second electrodes are disposed between the polarizers and a nematic liquid crystal layer is disposed between the electrodes. At least one light detector positioned for measuring the intensity of the transmitted light may be positioned on an outer side of the second polarizer. A voltage controller in electrical communication with the light detector is provided for controlling the voltage level applied to the electrodes based on the intensity of the measured light wherein the voltage determines the amount of light transmitted through the apparatus.

Abstract translation: 提供一种用于衰减透过该装置的光强度的装置。 在一个实施例中，该装置可以包括具有第一偏振方向的第一偏振器和具有垂直于第一偏振器的偏振方向的第二偏振器。 第一和第二电极设置在偏振器之间，向列型液晶层设置在电极之间。 定位用于测量透射光的强度的至少一个光检测器可以位于第二偏振器的外侧。 提供与光检测器电连通的电压控制器，用于基于测量光的强度来控制施加到电极的电压电平，其中电压确定透射通过设备的光量。

公开(公告)号：US06944204B2

公开(公告)日：2005-09-13

申请号：US10766373

申请日：2004-01-28

Applicant: Wang Long Zhou ,  Yongwu Yang ,  Victor S. Sapirstein ,  Shaoqing Peng

Inventor： Wang Long Zhou ,  Yongwu Yang ,  Victor S. Sapirstein ,  Shaoqing Peng

IPC: G01N21/71 ,  H01S3/00 ,  G01J3/00 ,  G01J3/28

CPC classification number: G01N21/718

Abstract: A laser system comprising a laser for providing a laser beam, a non-linear optical crystal in the laser beam path creating a second order light, a laser beam expander in the beam path after the non-linear crystal, a dichromatic mirror in the beam path after the beam expander, an objective lens that focuses the laser beam on a sample and collects transmission from the sample before the sample transmission impacts the dichromatic mirror, a partial reflector of the second order light in the transmission path after the dichromatic mirror, and a coupler for coupling an optical component to the sample transmission.

Abstract translation: 一种激光系统，包括用于提供激光束的激光器，在产生二阶光的激光束路径中的非线性光学晶体，在非线性晶体之后的光束路径中的激光束扩展器，光束中的二色镜 光束扩展器之后的路径，物镜，其将激光束聚焦在样本上，并且在样品透射冲击二色镜之前收集来自样品的透射，在二色镜之后的传输路径中的第二级光的部分反射器，以及 用于将光学部件耦合到样品传输器的耦合器。

公开(公告)号：US11185270B1

公开(公告)日：2021-11-30

申请号：US15888009

申请日：2018-02-03

Applicant: Yongwu Yang

Inventor： Yongwu Yang

IPC: A61B5/00 ,  A61B5/22 ,  A61B5/0205 ,  A61B5/11

Abstract: A wearable band configured to fit human limbs receives muscle tension data via sensors housed within the device. The processing circuitry generates statistical models for each physical state of a user and compares the received data with the statistical model. The user is alerted when the processing circuitry detects a change in the data that is outside the predetermined range. The sampling rate of measurements increases when a change is detected to confirm the abnormal data.

公开(公告)号：US20170363896A1

公开(公告)日：2017-12-21

申请号：US15187769

申请日：2016-06-20

Applicant: Yongwu Yang ,  Canwen Liu

Inventor： Yongwu Yang ,  Canwen Liu

IPC: G02F1/133 ,  G02F1/1335 ,  G02F1/1368 ,  G02F1/137 ,  G02F1/1343

CPC classification number: G02F1/13318 ,  G02F1/1313 ,  G02F1/133528 ,  G02F1/134336 ,  G02F1/1368 ,  G02F1/137 ,  G02F2001/13312 ,  G02F2001/133531 ,  G02F2001/13756 ,  G02F2203/48

Abstract: A light attenuation apparatus for adjusting the intensity of light transmitted through the apparatus, comprises: a light detector array for measuring light intensity incident on the light attenuation apparatus; and LCD filter panel, comprising: a first polarizer having a polarizing orientation; a second polarizer; a first substrate with a plurality of electrodes, a second substrate having a plurality of electrodes perpendicular to the first substrate. The first and second substrates disposed between the polarizers. An LCD filter grid has nematic liquid crystals inside the grid to form a plurality of pixels. Each pixel comprises a filter and the LCD filter grid is disposed between the substrates with a plurality of electrodes. A voltage driver controls the voltage level applied to the electrodes based on the intensity of the measured light wherein the voltage determines the amount of light transmitted through the apparatus. Each pixel is independently addressed by the voltage driver.

公开(公告)号：US07728972B2

公开(公告)日：2010-06-01

申请号：US12063410

申请日：2006-08-08

Applicant: Yongwu Yang

Inventor： Yongwu Yang

IPC: G01J3/02 ,  G02B6/36

CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/0289 ,  G01J3/0291 ,  G02B6/3885 ,  G02B6/4226 ,  G02B6/4292

Abstract: A coupler for coupling a linear fiber array to a spectrometer is provided, the coupler having a tube, a linear fiber bundle array inserted through the tube, an alignment mechanism for aligning the linear fiber bundle array with a slit on the spectrometer, and a locking mechanism for locking the linear fiber bundle array to the tube. Further, a method for coupling a linear fiber array to a spectrometer is provided, the method having the steps of inserting a linear fiber bundle array through a tube, aligning the linear fiber bundle array with a slit on the spectrometer, and locking the linear fiber bundle array to the tube once it is aligned with the slit on the spectrometer.

Abstract translation: 提供了一种用于将线性光纤阵列耦合到光谱仪的耦合器，耦合器具有管，插入穿过管的线性光纤束阵列，用于使线性光纤束阵列与光谱仪上的狭缝对准的对准机构，以及锁定 将线性纤维束阵列锁定到管的机构。 此外，提供了将线性光纤阵列耦合到光谱仪的方法，该方法具有以下步骤：通过管插入线性光纤束阵列，将线性光纤束阵列与光谱仪上的狭缝对准，并将线性光纤 一旦它与光谱仪上的狭缝对准，则将束阵列连接到管。

公开(公告)号：US20080183410A1

公开(公告)日：2008-07-31

申请号：US11972849

申请日：2008-01-11

Applicant: Peter A. Klein ,  Jesse Samuel Eberdt ,  W.L. Douglas Townsend ,  Victor Sapirstein ,  Wang-Long Zhou ,  Yongwu Yang

Inventor： Peter A. Klein ,  Jesse Samuel Eberdt ,  W.L. Douglas Townsend ,  Victor Sapirstein ,  Wang-Long Zhou ,  Yongwu Yang

IPC: G06F19/00 ,  G02B7/182

CPC classification number: G01N21/65 ,  G01N21/9508

Abstract: A probe for a system for determining the chemical signature of a pharmaceutical compound. The probe comprises: a housing; an inlet in the housing adapted to be connected to a transmitting optical fiber; a scanning aperture in the housing; a receiving outlet in the housing adapted to be connected to a receiving optical fiber; at least one transmission reflector positioned in the housing to receive laser light from the transmitting optical fiber and reflect the laser light through the detection outlet to a pharmaceutical vial containing a pharmaceutical compound positioned outside the housing, and at least one receiving reflector positioned in the housing to receive light reflected by the pharmaceutical compound and reflect the light to the receiving outlet. This configuration can enable rapid and accurate scanning of a pharmaceutical contained in a vial positioned adjacent the detection outlet.

Abstract translation: 用于确定药物化合物的化学特征的系统的探针。 探针包括：壳体; 壳体中的入口适于连接到发射光纤; 壳体中的扫描孔; 壳体中的接收出口适于连接到接收光纤; 位于外壳中的至少一个透射反射器，用于接收来自发射光纤的激光，并将激光反射通过检测出口到包含定位在外壳外部的药物化合物的药物小瓶，以及至少一个位于壳体中的接收反射器 以接收由药物化合物反射的光并将光反射到接收出口。 这种配置可以快速准确地扫描包含在邻近检测出口的小瓶中的药物。