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1.发明申请DEVICES, METHODS AND SYSTEMS FOR MEASURING ONE OR MORE CHARACTERISTICS OF A BIOMATERIAL IN A SUSPENSION 审中-公开用于测量悬浮物中生物体的一个或更多特征的装置，方法和系统公开(公告)号：US20090158822A1
公开(公告)日：2009-06-25
申请号：US11962219
申请日：2007-12-21
CPC分类号： G01N15/06 , G01N29/024 , G01N29/222 , G01N2291/02466 , G01N2291/02809 , G01N2291/045
摘要： A system for measuring one or more ultrasound parameters of a suspension comprising particulate biomaterial dispersed in a liquid carrier comprising, a bioprocessor for processing the particulate biomaterial; an immersible device comprising an ultrasound probes and a reflector; a housing, that fixes the probe and the reflector at positions with a space in between the probe surface and the reflective surface, comprising an opening into the housing that is of a size sufficient to allow the suspension to flow into the space between the probe surface and the reflective surface; an ultrasound wave generator/receiver device; and a signal processing device.
摘要翻译： 一种用于测量包含分散在液体载体中的颗粒生物材料的悬浮液的一个或多个超声参数的系统，包括用于处理颗粒生物材料的生物处理器; 包括超声探头和反射器的浸入式装置; 壳体，其将探针和反射器固定在探针表面和反射表面之间的空间的位置处，包括到壳体中的开口，其尺寸足以允许悬浮液流入探针表面和反射表面之间的空间 和反射面; 超声波发生器/接收器装置; 和信号处理装置。
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公开(公告)号：US07205385B2
公开(公告)日：2007-04-17
申请号：US10987662
申请日：2004-11-12
CPC分类号： C07D263/44 , A61K49/085 , A61K49/146
摘要： A method for synthesizing extended poly(amino acids) conjugated to imaging agents, such as DTPA, is disclosed. The amino acid is initially conjugated to the imaging agent at the monomer stage, followed by formation of the corresponding N-carboxyanhydride. The method utilizes catalyzed ring opening polymerization of the N-carboxyanhydride of the amino acid-imaging agent monomer allowing the formation of a poly(amino acid) backbone having 100% imaging agent conjugation if desired. However, the present method also permits the degree of conjugation to be controlled by copolymerizing the N-carboxyanhydride of the amino acid-imaging agent monomer with one or more unconjugated monomers, i.e. N-carboxyanhydrides of the same or of other amino acids. Various imaging agents may be employed, and new hybrid random, block, and mixed copolymers may be prepared.
摘要翻译： 公开了用于合成与显影剂缀合的延伸的聚（氨基酸）的方法，例如DTPA。 氨基酸最初在单体阶段与成像剂缀合，然后形成相应的N-羧酸酐。 该方法利用氨基酸显影剂单体的N-羧酸酐的催化开环聚合，如果需要，允许形成具有100％成像剂共轭的聚（氨基酸）主链。 然而，本方法还允许通过使氨基酸显影剂单体的N-羧酸酐与一种或多种非共轭单体，即相同或其它氨基酸的N-羧酸酐共聚来控制缀合度。 可以使用各种成像剂，并且可以制备新的杂化随机，嵌段和混合共聚物。
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公开(公告)号：US20110070596A1
公开(公告)日：2011-03-24
申请号：US12705828
申请日：2010-02-15
申请人： Nichole Lea Wood , Mohan Mark Amaratunga , Hans Grade , Faisal Ahmed Syud , Anup Sood , Reginald Donovan Smith , Ayse Betul Dinc , Amy Casey Williams , Anthony John Murray , Gregory Daryll Goddard
发明人： Nichole Lea Wood , Mohan Mark Amaratunga , Hans Grade , Faisal Ahmed Syud , Anup Sood , Reginald Donovan Smith , Ayse Betul Dinc , Amy Casey Williams , Anthony John Murray , Gregory Daryll Goddard
IPC分类号： G01N33/68 , C07D403/12 , G01N33/53
CPC分类号： G01N33/6845 , G01N33/6848
摘要： Agents and methods for qualitative and quantitative analysis a protein complex or protein complexes using isotope-labeled symmetrical bifunctional crosslinkers and mass spectrometry are provided. Targeting moieties, cell permeability moieties, or affinity moieties, may be appended to the bifunctional crosslinkers. The isotope-labeled symmetrical bifunctional crosslinkers may be used in a kit or as a library.
摘要翻译： 提供了使用同位素标记的对称双功能交联剂和质谱定性和定量分析蛋白质复合物或蛋白质复合物的试剂和方法。 靶向部分，细胞渗透性部分或亲和部分可附加到双功能交联剂上。 同位素标记的对称双功能交联剂可用于试剂盒或文库。
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公开(公告)号：US20070259330A1
公开(公告)日：2007-11-08
申请号：US11739890
申请日：2007-04-25
申请人： Gregory Daryll Goddard , Mohan Mark Amaratunga , Cyndy D. Sanberg , James van Alstine , Oleg Kuzmenok
发明人： Gregory Daryll Goddard , Mohan Mark Amaratunga , Cyndy D. Sanberg , James van Alstine , Oleg Kuzmenok
CPC分类号： C12N5/0605
摘要： The present invention relates to the isolation of human stem cells for use e.g. in cell therapy. More specifically, the invention is a method of separating mononuclear cells from human blood, which method comprises providing a human blood sample together with density gradient media (DGM) in a container; spinning the container comprising blood and DGM; and collecting the DGM fraction that comprises mononuclear cells; wherein the DGM has a density which is >1.080 and
摘要翻译： 本发明涉及人类干细胞的分离，例如使用。 在细胞疗法中。 更具体地说，本发明是从人血液中分离单核细胞的方法，该方法包括在容器中提供人血液样品以及密度梯度介质（DGM）; 旋转包含血液和DGM的容器; 并收集包含单核细胞的DGM级分; 其中DGM具有在25℃下测量的> 1.080和<1.090G / CM 3的密度。本发明还涉及包含密度梯度介质的袋和管，其中密度和重量摩尔渗透压浓度具有 已被优化用于本方法，优选用作试剂盒。
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5.发明授权Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism 失效生物体内生物化学活性高分辨率体内成像的系统和方法公开(公告)号：US07303741B2
公开(公告)日：2007-12-04
申请号：US10252311
申请日：2002-09-23
申请人： Ileana Hancu , Mohan Mark Amaratunga , Denyce Kramer Wicht , Paritosh Dhawale , Nadeem Ishaque , Faisal Ahmed Syud , Bruce Fletcher Johnson , Amy Casey Williams
发明人： Ileana Hancu , Mohan Mark Amaratunga , Denyce Kramer Wicht , Paritosh Dhawale , Nadeem Ishaque , Faisal Ahmed Syud , Bruce Fletcher Johnson , Amy Casey Williams
IPC分类号： A61B5/055
CPC分类号： A61K49/0056 , A61K49/0002 , A61K49/0032 , A61K49/085 , A61K49/10 , A61K49/14
摘要： This invention relates to bifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these bifunctional detection agents may comprise administering them into a living organism, and then estimating the localization of the detection agent using one modality (i.e., MRI), while concurrently estimating the level of biological activity using a second modality (i.e., optical imaging). One of the bifunctional detection agents comprises a magnetic resonance component and an optical imaging component. The magnetic resonance component comprises a contrast agent that is always activated or “on”. The optical imaging component comprises an activatable contrast agent or dye that is activated or turned “on” only in the presence of a particular event. For example, the optical imaging component may be activated by a certain wavelength of light and (1) by the presence of a particular biochemical marker, (2) by enzyme cleavage, or (3) by a change in the temperature or pH of the surrounding medium. These bifunctional detection agents allow both anatomical and functional/metabolic information to be obtained simultaneously.
摘要翻译： 本发明涉及用于提供生物体内生化活性的高分辨率体内成像的双功能检测剂。 使用这些双功能检测剂的方法可以包括将它们施用于活生物体中，然后使用一种模态（即，MRI）估计检测剂的定位，同时使用第二模态估计生物活性的水平（即，光学 成像）。 双功能检测剂之一包括磁共振成分和光学成像成分。 磁共振成分包括始终被激活或“开启”的造影剂。 光学成像组件包括可激活的造影剂或染料，其仅在特定事件的存在下被激活或变为“开启”。 例如，光学成像组件可以被一定波长的光激活，并且（1）存在特定的生物化学标记，（2）通过酶切割，或（3）通过温度或pH的变化 周围介质。 这些双功能检测剂允许同时获得解剖学和功能性/代谢信息。
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公开(公告)号：US06498271B2
公开(公告)日：2002-12-24
申请号：US10041996
申请日：2002-01-10
IPC分类号： C07C5500
CPC分类号： C08G64/20 , C08G64/0216 , C08G64/14 , C08G64/1616
摘要： Aliphatic tricarboxylic acids, as exemplified by 9-carboxy-1,18-octadecanedioic acid, may be prepared by the biotransformation of an olefinic monocarboxylic acid such as oleic acid to the corresponding olefinic dicarboxylic acid, preferably 1,18-octadec-9-enedioic acid, in the presence of a strain of yeast, such as a strain of Candida tropicalis, followed by the carboxylation of the olefinic dicarboxylic acid by reaction with carbon monoxide and water in the presence of a catalyst. The product tricarboxylic acids are useful as branching agents for polycarbonates.
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7.发明授权公开(公告)号：US06458899B1
公开(公告)日：2002-10-01
申请号：US09814484
申请日：2001-03-20
申请人： David Paul Mobley , Mohan Mark Amaratunga , John Henry Lobos , Sukhendu Bikash Hait , Andrew James Caruso
发明人： David Paul Mobley , Mohan Mark Amaratunga , John Henry Lobos , Sukhendu Bikash Hait , Andrew James Caruso
IPC分类号： C08G6416
CPC分类号： C08G64/20 , C08G64/0216 , C08G64/14 , C08G64/1616
摘要： Aliphatic tricarboxylic acids, as exemplified by 9-carboxy-1,18-octadecanedioic acid, may be prepared by the biotransformation of an olefinic monocarboxylic acid such as oleic acid to the corresponding olefinic dicarboxylic acid, preferably 1,18-octadec-9-enedioic acid, in the presence of a strain of yeast, such as a strain of Candida tropicalis, followed by the carboxylation of the olefinic dicarboxylic acid by reaction with carbon monoxide and water in the presence of a catalyst. The product tricarboxylic acids are useful as branching agents for polycarbonates.
摘要翻译： 脂肪族三羧酸，例如9-羧基-1,18-十八烷二酸，可以通过将烯属单羧酸如油酸生物转化成相应的烯属二羧酸，优选的是1,18-十八碳-9-烯酸 在酵母菌株例如热带假丝酵母菌株的存在下，然后在催化剂存在下与一氧化碳和水反应，使烯属二羧酸羧化。 产物三羧酸可用作聚碳酸酯的支化剂。
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8.发明申请SYSTEMS AND METHODS FOR HIGH-RESOLUTION IN VIVO IMAGING OF BIOCHEMICAL ACTIVITY IN A LIVING ORGANISM 审中-公开生活有机体生物活性成像高分辨率的系统与方法公开(公告)号：US20080118439A1
公开(公告)日：2008-05-22
申请号：US11875245
申请日：2007-10-19
申请人： Ileana Hancu , Mohan Mark Amaratunga , Denyce Kramer Wicht , Paritosh Dhawale , Nadeem Ishaque , Faisal Ahmed Syud , Bruce Fletcher Johnson , Amy Casey Williams
发明人： Ileana Hancu , Mohan Mark Amaratunga , Denyce Kramer Wicht , Paritosh Dhawale , Nadeem Ishaque , Faisal Ahmed Syud , Bruce Fletcher Johnson , Amy Casey Williams
CPC分类号： A61K49/0056 , A61K49/0002 , A61K49/0032 , A61K49/085 , A61K49/10 , A61K49/14
摘要： This invention relates to multifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these multifunctional detection agents may comprise administering them into a living organism, and then estimating the localization of the detection agent using one modality (i.e., MRI), while concurrently estimating the level of biological activity using a second modality (i.e., optical imaging). One of the multifunctional detection agents comprises a magnetic resonance component and an optical imaging component. The magnetic resonance component comprises a contrast agent that is always activated or “on”. The optical imaging component comprises a plurality of activatable contrast agents or dyes, at least two of which are different from one another, wherein at least one of the activatable contrast agents can be activated or turned “on” only in the presence of a particular event.
摘要翻译： 本发明涉及可用于提供活体内生物化学活性的高分辨率，体内成像的多功能检测剂。 使用这些多功能检测剂的方法可以包括将其施用于活生物体中，然后使用一种模态（即，MRI）估计检测剂的定位，同时使用第二模态估计生物活性的水平（即，光学 成像）。 多功能检测剂之一包括磁共振成分和光学成像元件。 磁共振成分包括始终被激活或“开启”的造影剂。 光学成像组件包括多个可激活的造影剂或染料，其中至少两个不同于其中，其中可激活的造影剂中的至少一个可以在特定事件的存在下被激活或“打开” 。
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9.发明授权Polyestercarbonates and methods for the direct incorporation of acids into polycarbonate chains by SSP 有权聚酯碳酸酯和通过SSP将酸直接引入聚碳酸酯链中的方法公开(公告)号：US06365702B1
公开(公告)日：2002-04-02
申请号：US09681747
申请日：2001-05-31
IPC分类号： C08G6400
摘要： A method for preparing a polyestercarbonate copolymer using solid state polymerization and polyestercarbonates prepared thereby is described. The method comprises preparing a mixture comprising partially crystalline bisphenol A polycarbonate oligomer and hydroxy acids, aliphatic diacids, cycloaliphatic diacids, aromatic diacids or aromatic triacids and subjecting that mixture to solid state polymerization to afford a polyestercarbonate copolymer.
摘要翻译： 描述了使用固态聚合制备聚酯碳酸酯共聚物的方法和由此制备的聚酯碳酸酯。 该方法包括制备包含部分结晶双酚A聚碳酸酯低聚物和羟基酸，脂族二酸，脂环族二酸，芳族二酸或芳族三酸的混合物，并使该混合物进行固态聚合以得到聚酯碳酸酯共聚物。
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