公开(公告)号：US09186329B2

公开(公告)日：2015-11-17

申请号：US13749612

申请日：2013-01-24

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Paul M. Consigny

IPC: A61K9/14 ,  A61K9/127 ,  A61K9/16 ,  A61K31/335

CPC classification number: A61K9/146 ,  A61K9/127 ,  A61K9/1273 ,  A61K9/14 ,  A61K9/1629 ,  A61K31/335

Abstract: This invention is directed to methods of treating solid tumor cancers, particularly refractory cancers by administration of a drug capable of inhibiting mTOR and/or inhibiting an efflux pump and/or inhibiting HIF-1α and VEGF, the drug in particular being selected from the group consisting of sirolimus, everolimus, zotarolimus, tacrolimus, iolimus A9, deforolimus, AP23572, tacrolimus, temsirolimus, pimecrolimus, novolimus, 40-O-(3-hydroxypropyl), 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin and 40-O-tetrazolylrapamycin, the drug being administered along with a chemotherapeutic agent and/or radiation therapy.

Abstract translation: 本发明涉及通过施用能够抑制mTOR和/或抑制外排泵和/或抑制HIF-1α和VEGF的药物来治疗实体瘤癌症，特别是难治性癌症的方法，该药物特别是选自组 由西罗莫司，依维莫司，佐他莫司，他克莫司，依维莫司A9，deforolimus，AP23572，他克莫司，替西罗莫司，吡美莫司，诺罗维司40-O-（3-羟丙基），40-O- [2-（2-羟基）乙氧基] 雷帕霉素和40-O-四唑基雷帕霉素，该药物与化学治疗剂和/或放射治疗一起施用。

公开(公告)号：US09381325B2

公开(公告)日：2016-07-05

申请号：US13898027

申请日：2013-05-20

Applicant: Abbott Cardiovascular Systems, Inc.

Inventor： Thomas Haslinger ,  Jeong S. Lee ,  Neftali Fernandez ,  John A. Simpson

IPC: A61M5/00 ,  A61M25/00 ,  A61M29/00 ,  A61M25/10 ,  A61L29/04 ,  A61L29/06 ,  A61L29/08

CPC classification number: A61L29/14 ,  A61L29/041 ,  A61L29/06 ,  A61L29/085 ,  A61M25/0009 ,  A61M25/0045 ,  A61M25/005 ,  A61M25/10 ,  A61M25/1006 ,  A61M25/104 ,  A61M2025/1061 ,  C08L23/06 ,  C08L77/00

Abstract: A balloon catheter having a multilayer catheter shaft is formed to have an inner layer and an outer layer, where the inner layer and outer layer are selected from materials that enhance the pushability of the catheter while preserving the flexibility. Using a combination of a high Shore D duromater value material and a lower Shore D duromater value material, various combinations of multilayer catheter shafts are disclosed utilizing different glass transition temperatures and block copolyamides to obtain the desired characteristics.

公开(公告)号：US08170657B1

公开(公告)日：2012-05-01

申请号：US12191124

申请日：2008-08-13

Applicant: Kevin J. Ehrenreich

Inventor： Kevin J. Ehrenreich

IPC: A61N1/30

CPC classification number: A61N5/062 ,  A61N5/0601

Abstract: A delivery catheter for delivery, then photo-activation of photo sensitive material has a photo-sensitive substance-delivery part and an activation part. The catheter delivers substances such as biomaterials to a target site, followed by illumination of the target using optics located at the distal tip of the catheter which are optically coupled to an extracorporeal light source. In another aspect a deployable light-delivery catheter is disclosed that can illuminate a large area of tissue.

Abstract translation: 用于递送的输送导管，然后感光材料的光激活具有光敏物质递送部分和激活部分。 该导管将诸如生物材料的物质输送到目标部位，随后使用位于导管的远侧末端的光学器件照射目标，其光学耦合到体外光源。 在另一方面，公开了可以照射大面积组织的可部署的光输送导管。