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公开(公告)号：US09840546B2
公开(公告)日：2017-12-12
申请号：US12936164
申请日：2008-04-03
Applicant: Weidong Zhou , Xiaojin Liao , Li Sun , Linzhong Zhang , Qingsong Lu , Shiye Shen , Lishan Yang , Defang Zhang , Huihuang Lin , Ping Zhang
Inventor： Weidong Zhou , Xiaojin Liao , Li Sun , Linzhong Zhang , Qingsong Lu , Shiye Shen , Lishan Yang , Defang Zhang , Huihuang Lin , Ping Zhang
CPC classification number: C07K14/61 , A61K38/27 , A61K47/60 , Y02A50/473
Abstract: The growth hormone with high biological activity modified by the double-stranded polyethylene glycol at a single site and the preparation method thereof are provided. The PEGylated growth hormone has a higher biological activity and a longer half-life than the unmodified growth hormone. The composition comprising the PEGylated growth hormone is useful in the treatment of the growth or development disorder such as growth hormone deficiency, Turner syndrome etc.
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Patent Agency Ranking
2.发明授权Interferon alpha-2B modified by polyethylene glycol and methods of preparation thereof 有权由聚乙二醇改性的干扰素α-2B及其制备方法公开(公告)号：US08597635B2
公开(公告)日：2013-12-03
申请号：US12676525
申请日：2007-09-04
Applicant: Weidong Zhou , Qingjiang Xiao , Li Sun , Tiebing Wang , Fenghong Yin , Shihong Luo , Lu Zhuang , Min Liu , Tianle Xu , Yong Zhang
Inventor： Weidong Zhou , Qingjiang Xiao , Li Sun , Tiebing Wang , Fenghong Yin , Shihong Luo , Lu Zhuang , Min Liu , Tianle Xu , Yong Zhang
IPC: A61K38/21 , A61K38/00 , A61K39/385 , C07K14/56
CPC classification number: C07K14/56 , A61K38/00 , A61K47/60 , Y02A50/473
Abstract: The present invention relates to interferon-α2b modified with Y-shaped branched polyethylene glycol (PEG) at a single Lys residue and the preparation thereof. The peglated IFN-α2b can be used for the preparation of a medicament for treating a disease, e.g. viral infections such as Hepatitis C.
Abstract translation: 本发明涉及在单个Lys残基处用Y型支化聚乙二醇（PEG）修饰的干扰素-α2b及其制备。 聚乙二醇化IFN-α2b可用于制备用于治疗疾病的药物，例如， 病毒感染如丙型肝炎
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3.发明授权Interferon alpha-2a modified by polyethylene glycol and methods of preparation thereof 有权由聚乙二醇修饰的干扰素α-2a及其制备方法公开(公告)号：US08597634B2
公开(公告)日：2013-12-03
申请号：US12676511
申请日：2007-09-04
Applicant: Weidong Zhou , Qingjiang Xiao , Li Sun , Tiebing Wang , Bin Liu , Song Lin , Min Liu , Fenghong Yin , Lu Zhuang , Lifang Lei
Inventor： Weidong Zhou , Qingjiang Xiao , Li Sun , Tiebing Wang , Bin Liu , Song Lin , Min Liu , Fenghong Yin , Lu Zhuang , Lifang Lei
IPC: A61K38/21 , A61K38/00 , A61K39/385 , C07K14/56
CPC classification number: C07K14/56 , A61K38/00 , A61K47/60 , Y02A50/473
Abstract: The present invention relates to interferon (IFN)-α2a modified at a specific Lys residue with Y-shaped branched polyethylene glycol (PEG) derivative and the preparation thereof, as well as the use of the prepared IFN-α2a modified by PEG at a single amino acid residue in medicines.
Abstract translation: 本发明涉及在具有Y型支链聚乙二醇（PEG）衍生物的特定Lys残基修饰的干扰素（IFN）-α2a及其制备方法，以及使用经单PEG修饰的IFN-α2a 药物中的氨基酸残基。
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4.发明授权Y-shaped polyethylene glycol modified G-CSF, the preparation and use thereof 有权Y型聚乙二醇改性G-CSF，的制备及应用公开(公告)号：US08530417B2
公开(公告)日：2013-09-10
申请号：US12811103
申请日：2007-12-29
Applicant: Shiyuan Wang , Jianhua Zheng , Li Sun , Huili Cai , Meihua Yang , Yan He , Ping Chen , Hongyuan Deng , Liping Zhong , Shuying Huang
Inventor： Shiyuan Wang , Jianhua Zheng , Li Sun , Huili Cai , Meihua Yang , Yan He , Ping Chen , Hongyuan Deng , Liping Zhong , Shuying Huang
CPC classification number: C07K1/1077 , A61K47/60 , C07K14/535
Abstract: The present invention relates to granulocyte colony stimulating factor (G-CSF) modified with Y-shaped branched polyethylene glycol (YPEG-G-CSF) at a specific lysine (Lys 17) and the preparation thereof, as well as the pharmaceutical composition comprising YPEG-G-CSF and use thereof.
Abstract translation: 本发明涉及用特定赖氨酸（Lys 17）Y型支链聚乙二醇（YPEG-G-CSF）修饰的粒细胞集落刺激因子（G-CSF）及其制备方法，以及包含YPEG的药物组合物 -G-CSF及其用途。
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5.发明申请Y-SHAPED POLYETHYLENE GLYCOL MODIFIED G-CSF, THE PREPARATION AND USE THEREOF 有权Y型聚乙烯甘油改性G-CSF，的制备及其用途公开(公告)号：US20110280826A1
公开(公告)日：2011-11-17
申请号：US12811103
申请日：2007-12-29
Applicant: Shiyuan Wang , Jianhua Zheng , Li Sun , Huili Cai , Meihua Yang , Yan He , Ping Chen , Hongyuan Deng , Liping Zhong , Shuying Huang
Inventor： Shiyuan Wang , Jianhua Zheng , Li Sun , Huili Cai , Meihua Yang , Yan He , Ping Chen , Hongyuan Deng , Liping Zhong , Shuying Huang
CPC classification number: C07K1/1077 , A61K47/60 , C07K14/535
Abstract: The present invention relates to granulocyte colony stimulating factor (G-CSF) modified with Y-shaped branched polyethylene glycol (YPEG-G-CSF) at a specific lysine (Lys 17) and the preparation thereof, as well as the pharmaceutical composition comprising YPEG-G-CSF and use thereof.
Abstract translation: 本发明涉及用特定赖氨酸（Lys 17）Y型支链聚乙二醇（YPEG-G-CSF）修饰的粒细胞集落刺激因子（G-CSF）及其制备方法，以及包含YPEG的药物组合物 -G-CSF及其用途。
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6.发明申请INTERFERON ALPHA2A MODIFIED BY POLYETHYLENE GLYCOL, THE PREPARATION AND USE THEREOF 有权由聚乙二醇改性的干燥素ALPHA2A，其制备及使用公开(公告)号：US20100239532A1
公开(公告)日：2010-09-23
申请号：US12676511
申请日：2007-09-04
Applicant: Weidong Zhou , Qingjing Xiao , Li Sun , Tlebing Wang , Bin Liu , Song Lin , Min Liu , Fenghong Yin , Lu Zhuang , Lifang Lei
Inventor： Weidong Zhou , Qingjing Xiao , Li Sun , Tlebing Wang , Bin Liu , Song Lin , Min Liu , Fenghong Yin , Lu Zhuang , Lifang Lei
IPC: A61K38/21 , C07K17/06 , A61P29/00 , A61P35/00 , A61P31/20 , A61P31/14 , A61P19/02 , A61P11/06 , A61P11/00
CPC classification number: C07K14/56 , A61K38/00 , A61K47/60 , Y02A50/473
Abstract: The present invention relates to interferon (IFN)-α2a modified at a specific Lys residue with Y-shaped branched polyethylene glycol (PEG) derivative and the preparation thereof, as well as the use of the prepared IFN-α2a modified by PEG at a single amino acid residue in medicines.
Abstract translation: 本发明涉及在具有Y型支链聚乙二醇（PEG）衍生物的特定Lys残基上修饰的干扰素（IFN）-α2a及其制备方法，以及在单次使用由PEG修饰的制备的IFN-α2a 药物中的氨基酸残基。
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