公开(公告)号：US11814685B2

公开(公告)日：2023-11-14

申请号：US16758624

申请日：2018-10-24

申请人： UNIVERSITÉ PARIS CITÉ ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)

发明人： Sandrine Bourdoulous ,  Anaïs Domingot ,  Camille Faure

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

摘要： This invention relates to a method for diagnosing and/or prognosticating HER2-dependent cancer in a subject, comprising a) measuring the amount of one or more miRNA selected from the group consisting of miRNA 429-3p, miRNA 29c-3p, miRNA 29a-3p, miRNA 29b-3p, miRNA 200a-3p, miRNA 200b-3p, miRNA 200c-3p, miRNA 141-3p, miRNA 15a-5p, miRNA 15b-5p, miRNA 16-5p, miRNA 424-5p, miRNA 497-5p, miRNA 615-3p, miRNA 451a-3p and miRNA 542-5p in a sample from the subject; b) comparing the amount of one or more miRNA measured in step a) to a reference value; c) finding a deviation or no deviation of the amount of one or more miRNA measured in step a) from the reference value; and d) attributing said finding of deviation or no deviation to a particular diagnosis and/or prognosis of HER2-dependent cancer in the subject.

公开(公告)号：US20220220316A1

公开(公告)日：2022-07-14

申请号：US17655717

申请日：2022-03-21

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  UNIVERSITE PAUL SABATIER TOULOUSE III

发明人： Christophe LE ROUX ,  Francois MARTIN ,  Pierre MICOUD ,  Angela DUMAS

IPC分类号： C09C1/30 ,  C01B33/44 ,  C09C1/00

摘要： A method for preparing a composition including mineral particles functionalized by at least one organic group and having a specific surface defined according to the BET method greater than 500 m2/g, involves: —choosing a phyllosilicate composition, including mineral particles having a thickness of less than 100 nm, a largest dimension of less than 10 μm and belonging to the family of lamellar silicates; —choosing at least one functionalizing agent, from the group formed from the oxysilanes and oxygermanes having at least one organic group, —bringing the phyllosilicate composition into contact with a functionalizing solution including the functionalizing agent, so as to obtain a phyllosilicate composition including mineral particles functionalized by the organic group, while choosing the organic group from the group formed from the cationic heteroaryl groups, the quaternary ammonium groups and the salts of same. The phyllosilicate composition obtained by the method is also described.

公开(公告)号：US20220196538A1

公开(公告)日：2022-06-23

申请号：US17606101

申请日：2020-04-24

申请人： HORIBA ABX SAS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) ,  UNIVERSITE DE MONTPELLIER

发明人： Pierre TARACONAT ,  Damien ISEBE ,  Simon MENDEZ ,  Franck NlCOUD

IPC分类号： G01N15/10 ,  G01N15/12 ,  G01N15/02

摘要： A device for medical analyses with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarized opening, a computer (6) arranged to process a pulse data set by determining a rotation value indicating whether the cell from which this pulse data set has been taken has undergone a rotation during its passage through the polarized opening, and a classifier (8) arranged to retrieve from the computer (6) a given pulse data set, and to use the resulting rotation value to classify the given pulse data set in a rotation pulse data set group (10) or a rotationless pulse data set group (12).

公开(公告)号：US20210230009A1

公开(公告)日：2021-07-29

申请号：US15733291

申请日：2018-12-21

申请人： IMERTECH SAS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  UNIVERSITÉ PAUL SABATIER TOULOUSE III

发明人： Christophe LE ROUX ,  François MARTIN ,  Pierre MICOUD ,  Suzanne FÉRY-FORGUES ,  Mathilde POIRIER ,  Cyril AYMONIER ,  Christel CARÊME ,  Marie CLAVERIE

IPC分类号： C01B33/40 ,  A61K8/25 ,  A61Q17/04

摘要： The present invention relates to methods for producing mixtures comprising noble metal and phyllomineral, and compositions obtained from said methods.

公开(公告)号：US10906016B2

公开(公告)日：2021-02-02

申请号：US14382200

申请日：2013-02-28

申请人： ISL—Institut franco-allemand de recherches de Saint-Louis ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)

发明人： Denis Spitzer ,  Vincent Pichot ,  Benedikt Risse

IPC分类号： B01J3/08 ,  C06B25/04 ,  C06B25/34 ,  C01B32/26

摘要： The present invention relates to the field of manufacturing nanoparticles, and specifically to a method for manufacturing diamond nanoparticles, or nanodiamonds, by detonation at least one explosive charge, wherein said at least one explosive charge is nanostructured.

公开(公告)号：US10722813B2

公开(公告)日：2020-07-28

申请号：US14377161

申请日：2013-02-07

申请人： Centre National De La Recherche Scientifique (C.N.R.S) ,  ISL—Institut franco-allemand de recherches de Saint-Louis

发明人： Benedikt Risse ,  Dominique Hassler ,  Denis Spitzer

IPC分类号： B01D9/00 ,  B01D1/18 ,  B01J2/04 ,  B04C9/00

摘要： A method of preparing organic or inorganic nanoparticles is useful in the manufacture of of fertilizers, pharmaceutical or phytopharmaceutical active ingredients, or insensitive energy materials. The method includes preparing a solution of a compound in a solvent, heating the solution under a pressure ranging from 3 to 300 bars at a temperature higher than the boiling point of the solvent, atomizing the solution in an spray drying chamber using at least one dispersion device and at an angle ranging from 30 to 150° under pressure ranging from 0.0001 to 2 bars, separating the solvent in gaseous form, and recovering the nanoparticles.

公开(公告)号：US10577251B2

公开(公告)日：2020-03-03

申请号：US15840901

申请日：2017-12-13

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  UNIVERSITE PAUL SABATIER (TOULOUSE III)

发明人： Christophe Le Roux ,  Francois Martin ,  Pierre Micoud ,  Angela Dumas

IPC分类号： C01B33/24 ,  C01B33/20 ,  C01B33/22 ,  C01B33/38

摘要： A composition comprising synthetic mineral particles, such as silicate or phyllosilicate mineral particles, is presented. The composition can be prepared by a process in which a hydrogel precursor of the synthetic mineral particles is produced by a coprecipitation reaction between at least one compound comprising silicon, such as sodium metasilicate, and at least one compound comprising at least one metal element, such as a dicarboxylate salt of the formula M(R1—COO)2, wherein R1 is H or an alkyl group having 1 to 4 carbon atoms. The coprecipitation reaction also takes place in the presence of at least one carboxylate salt of formula R2—COOM′ wherein M′ is Na or K, and R2 is H or an alkyl group having 1 to 4 carbon atoms.

公开(公告)号：US10465012B2

公开(公告)日：2019-11-05

申请号：US13739421

申请日：2013-01-11

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)

发明人： Yasemin Ataman-Onal ,  Thierry Delair ,  Genevieve Inchauspe ,  Pascale Jeannin ,  Glaucia Paranhos-Baccala ,  Bernard Verrier

IPC分类号： A61K47/69 ,  A61K9/16 ,  A61K9/51 ,  A61K47/34 ,  G01N33/543 ,  C07K14/005 ,  C07K16/10 ,  C07K16/40 ,  A61K47/48 ,  A61K39/00

摘要： Nonlamellar bioresorbable microparticles to which protein substances are bonded, and a method for preparing the microparticles, comprising: (i) preparing the microparticles from at least one bioresorbable polymer without stabilizer and without surfactant; and (ii) bonding the protein substances to the microparticles obtained in step (i) without surfactant.

公开(公告)号：US10166530B2

公开(公告)日：2019-01-01

申请号：US15325733

申请日：2015-07-15

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  UNIVERSITE DE MONTPELLIER

发明人： Claude Grison ,  Vincent Escande

IPC分类号： B01J23/755 ,  C07C29/14 ,  C07C29/143 ,  C07C29/17 ,  C07C201/12 ,  C07C253/30 ,  B01J37/08 ,  B01J21/18 ,  B01J35/10 ,  C07C29/156 ,  C07C33/02 ,  C07J1/00

摘要： Disclosed is a method for reducing organic compounds using catalysts containing nickel (0) from metal hyperaccumulator plants. The method can be implemented in a green manner and is advantageous compared to methods using the known catalysts.

公开(公告)号：US10059704B2

公开(公告)日：2018-08-28

申请号：US14112864

申请日：2012-04-20

申请人： Sylvain Routier ,  Franck Suzenet ,  Frederic Pin ,  Sylvie Chalon ,  Johnny Vercouillie ,  Denis Guilloteau

发明人： Sylvain Routier ,  Franck Suzenet ,  Frederic Pin ,  Sylvie Chalon ,  Johnny Vercouillie ,  Denis Guilloteau

IPC分类号： C07D451/04 ,  A61K51/04 ,  C07D453/02 ,  C07D455/02

CPC分类号： C07D451/04 ,  A61K51/0453 ,  A61K51/0455 ,  A61K51/0459 ,  A61K51/0463 ,  C07D453/02 ,  C07D455/02 ,  G01N2333/70571 ,  G01N2800/28 ,  G01N2800/2821

摘要： A compound having the following general formula (I): wherein: X is a nitrogen atom and Y is a carbon atom; or X is a carbon atom and Y is a nitrogen atom; the Ar group is an aryl or heteroaryl group; and the RN and RN′ groups, together with the carbon atoms to which they are bound, form a monocyclic or bicyclic azacycloalkane group. The pharmaceutically acceptable salts thereof, the hydrates or polymorphic crystalline structures thereof, and to the racemates, diastereoisomers, or enantiomers thereof are also described.