公开(公告)号：US20240226818A1

公开(公告)日：2024-07-11

申请号：US18530437

申请日：2023-12-06

申请人： Giner, Inc.

发明人： Derek J. STRASSER ,  Hui XU ,  Judith LATTIMER

IPC分类号： B01D71/26 ,  B01D69/12

CPC分类号： B01D71/262 ,  B01D69/1251 ,  B01D2323/30 ,  B01D2325/16 ,  B01D2325/42

摘要： Anion exchange membrane and methods of making and using the same. In one embodiment, the anion exchange membrane may be made by a method that includes a two-step polymerization. In the first step, an α-olefin monomer containing a pendant halide, such as 8-bromo-1-octene, may be polymerized by Ziegler-Natta polymerization to form a first polymer portion, the first polymer portion being a homopolymer. In the second step, the polymerization is charged with a non-functionalized α-olefin monomer, such as ethylene, thereby forming a second polymer portion, the second polymer being a copolymer made up predominantly of the non-functionalized olefin monomer. If desired, a small amount of an α-olefin monomer containing a crosslinking functionality may be included in the first and/or second steps. Following the two-step polymerization, the polymer is fabricated into a thin film. Thereafter, the thin film may be functionalized by replacing the pendant halides with pendant cations.

公开(公告)号：US11701215B2

公开(公告)日：2023-07-18

申请号：US16266687

申请日：2019-02-04

申请人： Giner, Inc.

发明人： Linda Tempelman ,  Simon Stone ,  Klearchos Papas

IPC分类号： A61F2/02 ,  A61M5/142 ,  A61M5/00 ,  A61K48/00

CPC分类号： A61F2/022 ,  A61K48/0075 ,  A61M2005/006 ,  A61M2005/14204 ,  A61M2202/0208 ,  A61M2205/7536

摘要： System for gas treatment of cellular implants. The system enhances the viability and function of cellular implants, particularly those with high cellular density, for use in human or veterinary medicine. The system utilizes a miniaturized electrochemical gas generator subsystem that continuously supplies oxygen and/or hydrogen to cells within an implantable and immunoisolated cell containment subsystem to facilitate cell viability and function at high cellular density while minimizing overall implant size. The cell containment subsystem is equipped with features to allow gas delivery through porous tubing or gas-only permeable internal gas compartments within the implantable cell containment subsystem. Furthermore, the gas generator subsystem includes components that allow access to water for electrolysis while implanted, thereby promoting long-term implantability of the gas generator subsystem. An application of the system is a pancreatic islet (or pancreatic islet analogue) implant for treatment of Type 1 diabetes (T1D) that would be considered a bio-artificial pancreas.

公开(公告)号：US20220367895A1

公开(公告)日：2022-11-17

申请号：US17743303

申请日：2022-05-12

申请人： Giner, Inc.

发明人： Derek J. Strasser ,  Hui Xu

IPC分类号： H01M8/1004 ,  H01M8/1041

摘要： Membrane electrode assembly and method for fabricating the same. In one embodiment, the method may involve providing an anion exchange membrane and then applying catalyst coatings to opposing surfaces of the anion exchange membrane, whereby a membrane electrode assembly may be formed. Next, the membrane electrode assembly may be subjected to a two-part treatment process. In a first part of the process, the membrane electrode assembly may be swelled, at room temperature, by exposure to an aqueous ethanol solution vapor while being retained under tension in a frame. The aqueous ethanol solution vapor may be, for example, 80:20 by volume ethanol and water. In a second part of the process, the swollen membrane electrode assembly may be removed from the frame and then pressed, at room temperature, between two plates. A layer of rubber and a layer polytetrafluoroethylene may be placed between each plate and the swollen membrane electrolyte assembly.

公开(公告)号：US11092585B2

公开(公告)日：2021-08-17

申请号：US16287431

申请日：2019-02-27

申请人： Giner, Inc.

发明人： Badawi M. Dweik ,  Avni A. Argun ,  Katherine E. Harrison

IPC分类号： G01N33/18 ,  G01N27/327 ,  G01N27/42

摘要： Method and system for detection and quantification of oxidizable organics in water. The method involves the partial electrolytic decomposition of the oxidizable organics in a short time frame, preferably less than five seconds, and does not involve the use of toxic reagents. The system includes an electrochemical sensor probe that, in turn, includes a boron-doped diamond microelectrode array. The system additionally includes an electronic transducer and a computing device. The system utilizes an analysis technique to convert sensor signal to a result that can be correlated with COD or BOD values obtained by standard methods. The method and system are particularly suitable for, but not limited to, use in monitoring of water quality at wastewater treatment plants. By employing the method before and after adding aerobic microorganisms to the sample, the method may be used to distinguish biologically oxidizable organics from total oxidizable organics.

公开(公告)号：US08361308B2

公开(公告)日：2013-01-29

申请号：US12878504

申请日：2010-09-09

申请人： Mourad Manoukian ,  Anthony B. Laconti ,  Linda A. Tempelman ,  John Forchione

发明人： Mourad Manoukian ,  Anthony B. Laconti ,  Linda A. Tempelman ,  John Forchione

IPC分类号： G01N27/417

CPC分类号： G01N27/4074

摘要： A method for the detection of carbon dioxide gas using an electrochemical sensor. The method includes exposing a gas to a sensor, which includes a non-conductive solid substrate and at least one each of a metal oxide sensing electrode, a reference electrode and a counter electrode positioned on the substrate. A solid polymer electrolyte anion-exchange membrane is in intimate contact with the sensing electrode, reference electrode and counter electrode. The method is highly sensitive and selective to carbon dioxide with a very rapid response time.

摘要翻译： 一种使用电化学传感器检测二氧化碳气体的方法。 该方法包括将气体暴露于传感器，该传感器包括非导电固体基底和位于基底上的金属氧化物感测电极，参考电极和对置电极中的至少一个。 固体聚合物电解质阴离子交换膜与感测电极，参比电极和对电极紧密接触。 该方法对二氧化碳具有高度敏感性和选择性，反应时间非常快。

公开(公告)号：US5079107A

公开(公告)日：1992-01-07

申请号：US780587

申请日：1985-09-26

申请人： Vinod M. Jalan

发明人： Vinod M. Jalan

IPC分类号： B01J23/40 ,  B01J23/56 ,  B01J23/89 ,  H01M4/86 ,  H01M4/92

CPC分类号： H01M4/926 ,  B01J23/40 ,  B01J23/56 ,  B01J23/89 ,  H01M4/92 ,  H01M2004/8689 ,  H01M2300/0008

摘要： Ternary alloy electrocatalysts comprising platinum and at least two less noble elements are described. The ternary alloy electrocatalysts when employed in the cathode of a fuel cell utilizing a phosphoric acid electrolyte provide improved oxygen activity and stability in comparison to unalloyed platinum. The cost of the electrocatalysts is also reduced in comparison to an unalloyed platinum electrocatalyst.

摘要翻译： 描述了包含铂和至少两种较低贵族元素的三元合金电催化剂。 当使用磷酸电解质的燃料电池的阴极中使用三元合金电极催化剂时，与非合金铂相比提供了改进的氧活性和稳定性。 与非合金铂电极催化剂相比，电催化剂的成本也降低。

公开(公告)号：US4820386A

公开(公告)日：1989-04-11

申请号：US151937

申请日：1988-02-03

申请人： Anthony B. LaConti ,  Arthur E. Griffith

发明人： Anthony B. LaConti ,  Arthur E. Griffith

IPC分类号： G01N27/49 ,  G01N27/28 ,  G01N27/54

CPC分类号： G01N27/4074

摘要： A fast response diffusion-type sensor cell for the detection of carbon monoxide and other oxidizable or reducible gases comprising a three-electrode hydrated proton-conducting membrane cell configuration, with all electrodes in intimate contact with the same proton-conducting membrane is described. The liquid electrolyte-free system has a porous gas-diffusion sensing electrode and a counter electrode located on the same side of and in intimate contact with the proton-conducting membrane. The reference electrode is spatially located on the same or opposite side of the membrane as are the sensing and counter electrodes. The cell configuration is advantageous in that (1) the ionic resistance value between the sensing/reference electrodes is lower than that between the sensing/counter electrodes, and (2) the sensing and counter electrodes being on the same side of the membrane and connected by one or more hydrated proton-exchange membrane channels leads to faster response times and greater immunity to interference from counter electrode reaction products.

摘要翻译： 描述了用于检测一氧化碳和其他可氧化或可还原气体的快速响应扩散型传感器单元，其包括三电极水合质子传导膜电池结构，其中所有电极与相同的质子传导膜紧密接触。 不含液体电解质的系统具有多孔气体扩散感测电极和位于与质子传导膜相同侧并与质子传导膜紧密接触的对电极。 参考电极在空间上位于膜的相同或相对侧上，如感测和对电极。 电池结构的优点在于（1）感测/参考电极之间的离子电阻值低于感测/对电极之间的离子电阻值，和（2）感测和对电极位于膜的同一侧并连接 通过一个或多个水合质子交换膜通道导致更快的响应时间和更大的抗反电极反应产物的干扰。

公开(公告)号：US11978912B2

公开(公告)日：2024-05-07

申请号：US17531461

申请日：2021-11-19

申请人： The Research Foundation for The State University of New York ,  Giner, Inc.

发明人： Gang Wu ,  Hui Xu ,  Shengwen Liu ,  Shuo Ding

IPC分类号： H01M4/90 ,  H01M8/10

CPC分类号： H01M4/9075 ,  H01M4/9016 ,  H01M2008/1095

摘要： Atomically dispersed platinum-group metal-free catalyst and method for synthesizing the same. According to one embodiment, the catalyst is made by a method in which, in a first step, a metal oxide/zeolitic imidazolate frameworks (ZIF) composite is formed by combining (i) nanoparticles of an oxide of at least one of iron, cobalt, nickel, manganese, and copper, (ii) a hydrated zinc salt, and (iii) an imidazole. Then, in a second step, the metal oxide/ZIF composite is thermally activated, i.e., carbonized, to form an M-N—C catalyst. Thereafter, the M-N—C catalyst may be mixed with a quantity of ammonium chloride, and then the M-N—C/NH4Cl mixture may be pyrolyzed. The foregoing NH4Cl treatment may improve the intrinsic activity of the catalyst. Then, a thin layer of nitrogen-doped carbon may be added to NH4Cl-treated M-N—C catalyst by chemical vapor deposition (CVD). Such CVD treatment may improve the stability of the catalyst.

公开(公告)号：US20230374570A1

公开(公告)日：2023-11-23

申请号：US18295613

申请日：2023-04-04

申请人： Giner, Inc.

发明人： Avni A. Argun ,  Muhit Rana

IPC分类号： C12Q1/6834 ,  C12Q1/04

CPC分类号： C12Q1/6834 ,  C12Q1/04

摘要： Method and system for detecting a fungal gene and kit for use with same. According to one embodiment, a nucleotide capture probe is coupled to a surface, such as a well of a 96-well plate, using a biotin-streptavidin interaction. The capture probe is preferably specific for a portion of a target sequence of a fungal gene of interest. Upon capture, additional portions of the target sequence of the fungal gene of interest are tagged with nucleotide labeling probes. An enzyme label, which is preferably a poly-horseradish peroxidase conjugate, is then attached to each of the labeling probes, for example, by a biotin-streptavidin interaction. The enzyme label catalyzes the oxidation of a substrate, such as 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide. The oxidized substrate may then be detected photonically, by visually detecting a colorimetric change or by absorbance readings, and/or detected electrochemically in the presence of an acid.

公开(公告)号：US11773496B2

公开(公告)日：2023-10-03

申请号：US16415977

申请日：2019-05-17

申请人： Giner Life Sciences, Inc.

发明人： Melissa N. Schwenk ,  Simon G. Stone

IPC分类号： C25B1/01 ,  C25B1/04 ,  A61M5/142 ,  C25B9/73 ,  A61M5/00

CPC分类号： C25B1/04 ,  A61M5/14276 ,  C25B9/73 ,  A61M2005/006 ,  A61M2005/14204 ,  A61M2202/0208

摘要： Electrolytic gas generator and multi-functional current collector for use in same. In one embodiment, the current collector is constructed both to conduct current from an electrode to a conductive lead and to conduct gas generated at the electrode to external tubing. Accordingly, the current collector may be formed by bonding together a top metal plate and a bottom metal plate of similar profiles, each of which may be shaped to include a main portion and a lateral extension. The bottom metal plate may have central through hole in the main portion for receiving gas from the anode. The top metal plate may have a recess on its bottom surface. The recess may have a first end aligned with the through hole on the bottom metal plate and may have a second end at the end of the lateral extension. A lead and tubing may be attached to the lateral extension.