Preparation of Magnetic Core-Shell Particles

    公开(公告)号:US20230127156A1

    公开(公告)日:2023-04-27

    申请号:US17906787

    申请日:2021-03-30

    摘要: The invention relates to a process for preparing core-shell particles comprising the steps of (i) providing a dispersion of primary magnetic particles having a mean diameter lower than 200 nm in a solvent; (ii) adding one or more (semi-)metal (oxyhydr)oxide(s) and/or one or more precursor(s) of a (semi-)metal (oxyhydr)oxide to said dispersion; (iii) optionally adding a hydrolysis agent for said one or more precursor(s); (iv) injecting the dispersion in a spray dryer; whereby a (semi-)metal (oxyhydr)oxide shell is formed on the magnetic particles during spray drying. The invention also relates to particles obtainable by said process, to a formulation of said particles in a solvent and to the use of said particles or said formulation for RNA or DNA extraction.

    Aged spirit preservation systems and devices

    公开(公告)号:US11628992B2

    公开(公告)日:2023-04-18

    申请号:US16682832

    申请日:2019-11-13

    摘要: Many embodiments described herein prevent an aged spirit from degrading due to the oxygen trapped in the headspace without the use of a pump. The aged spirit preservation system may have a cork with an open top, an open bottom, and a channel extending from the open top to the open bottom. The cork may be sized couple to an internal portion of a bottle. The system may even include a sealing device coupled to an outer portion of the cork between the open top and the open bottom. Additionally, the system may include a replaceable cartridge containing an adsorbent media, iron, a salt, and a color-changing indicator. Oxygen from the bottle may be allowed to enter the cartridge and react with the iron via a non-reversible reaction, thereby preventing the degradation of the spirit.

    Cationic composite silicate filter aids

    公开(公告)号:US11596921B2

    公开(公告)日:2023-03-07

    申请号:US15776420

    申请日:2016-11-18

    申请人: Imerys USA, Inc.

    摘要: A cationic composite filter aid may include a silicate substrate, a silica precipitated on the silicate substrate, and a cationic surface modification of the precipitated silica. A method for making a cationic composite filter aid may include providing a silicate substrate, precipitating a silica onto the silicate substrate to form a composite filter aid, and cationically modifying the precipitated silica to form a cationic composite filter aid. A method for filtering a liquid may include providing a liquid for filtering and filtering the liquid through a cationically modified composite filter aid. The cationically modified composite filter aid may include a silicate substrate, a precipitated silica, and a cationic surface modification of the precipitated silica.

    High-loading and alkali-resistant protein a magnetic bead and method of use thereof

    公开(公告)号:US11577218B2

    公开(公告)日:2023-02-14

    申请号:US16475784

    申请日:2018-01-04

    摘要: Provided is a high-loading and alkali-resistant protein A magnetic bead. The magnetic bead can maintain chemical stability under pH 2-14 and has an immunoglobulin G (IgG) binding capacity greater than 50 mg/mL. Further provided is a method for purifying and/or detecting an immunoglobulin, comprising a step of contacting a sample containing the immunoglobulin with the high-loading and alkali-resistant protein A magnetic bead. The alkali-resistant protein A magnetic bead can realize rapid purification of immunoglobulin, saving about 80% of treatment time and reducing total purification costs by 50%. In addition, the alkali-resistant protein A magnetic bead has high alkali resistance. An alkaline method for in situ cleaning can be performed to regenerate the magnetic bead after use. The magnetic bead has rapid magnetic response and good dispersiveness, realizing rapid magnetic bead enrichment, cleaning, and elution. The magnetic bead facilitates automated, high-throughput, and large volume purification of a sample.

    Preparation of new aldehyde and/or ketone traps and filters

    公开(公告)号:US11571650B2

    公开(公告)日:2023-02-07

    申请号:US16634633

    申请日:2018-07-27

    摘要: A method for preparing a nanoporous silica sol-gel matrix containing at least one amine reactant selected from hydroxylamine, methylhydroxylamine, tertbutylhydroxylamine, methoxyamine, tetraethylenepentamine, dicarboxylic acid dihydrazides, particularly adipic acid dihydrazide, and the salts thereof, said method including the following steps: a) synthesising a gel from tetramethoxysilane or from a mixture of tetramethoxysilane and another organosilicon precursor selected from among phenyltrimethoxysilane, phenyltriethoxysilane, a fluoroalkyltrimethoxysilane, a fluoroalkyltriethoxysilane, a chloroalkylmethoxysilane, a chloroalkylethoxysilane, an alkyltrimethoxysilane, an alkyltriethoxysilane, an aminopropyltriethoxysilane and the mixtures thereof, the synthesis being performed in an aqueous medium at a temperature ranging from 10 to 70° C. in the presence of at least one amine reactant selected from among hydroxylamine, methylhydroxylamine, tertbutylhydroxylamine, methoxyamine, dicarboxylic acid dihydrazides, particularly adipic acid dihydrazide, and the salts thereof; b) drying the gel obtained during step a) so as to obtain a sol-gel matrix containing at least one amine reactant.