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5433 条记录 (耗时 0.064 秒)

    DROPLET DISPENSING DEVICE AND SYSTEM
    92.
    发明申请
    DROPLET DISPENSING DEVICE AND SYSTEM 有权

    公开(公告)号：US20210401621A1

    公开(公告)日：2021-12-30

    申请号：US16760289

    申请日：2018-11-02

    申请人： HOFFMANN-LA ROCHE INC.

    发明人： Maxime GAILLOT ,  Roberta LEAH ,  Declan REILLY ,  Thomas THUEER ,  Jack CARROLL ,  James COOP ,  Edward SIMS ,  Mark TEUCHER

    IPC分类号： A61F9/00

    摘要： A device for providing a droplet of a liquid stored in an interior of a vial is disclosed that includes a support body and a resilient dome portion mounted to the support body to form a chamber having air, with the dome portion being configured to create an air flow when activated by compression. The support body includes a vial seat, a nozzle, and air flow and transfer conduits. The support body is arranged, when the vial is received by the vial seat, such that the air flow conduit establishes an air connection between the vial interior and the chamber, the transfer conduit establishes a fluid connection between the vial and the nozzle, and, upon activation of the dome portion, the air flow delivers air into the vial that causes liquid to be transferred from the vial to the nozzle through the transfer conduit.

    VALVE FOR TRANSFERRING AT LEAST ONE FLUID
    94.
    发明申请
    VALVE FOR TRANSFERRING AT LEAST ONE FLUID 有权

    公开(公告)号：US20210381608A1

    公开(公告)日：2021-12-09

    申请号：US17406782

    申请日：2021-08-19

    申请人： Hoffmann-La Roche Inc.

    发明人： Jennifer Römer ,  Christian Neusüss

    IPC分类号： F16K11/074 ,  G01N30/20 ,  F16K31/04

    摘要： A fluid transfer valve has ports arranged in groups. The valve has a rotor having channels and an actuator is operably connectable to the rotor. The actuator is positionable in a loading orientation in which the first channel is connected to one or two of the ports to transfer fluid into the first channel and/or the second channel is connected to one or two of the ports to transfer a second fluid into the second channel. The actuator also is positionable into first and second injection orientations in which various ones of the channels and ports are connected for different fluid flow configurations. Each channel has two ends located on a virtual circle whose center coincides with the rotor's axis of rotation. The channels can have a semicircular shape, a semi-oval shape or a U-shape. An analytical system and method that use the inventive valve are also disclosed.

    PROCESS FOR THE PURIFICATION OF OLIGONUCLEOTIDES
    96.
    发明申请
    PROCESS FOR THE PURIFICATION OF OLIGONUCLEOTIDES 有权

    公开(公告)号：US20210347800A1

    公开(公告)日：2021-11-11

    申请号：US17236501

    申请日：2021-04-21

    申请人： Hoffmann-La Roche Inc.

    发明人： Joerg LILL ,  Filippo SLADOJEVICH

    IPC分类号： C07H1/06 ,  C07H21/00 ,  B01D69/02

    摘要： The invention relates to a new process for the purification of oligonucleotides which comprises the removal of the acid labile 5′hydroxy protecting group at the 5′-O-oligonucleotide terminus of the oligonucleotide by way of tangential flow filtration with an acidic buffer solution. The process requires less steps and allows a higher degree of automation.

    METHOD FOR SEEDING CELLS ON A SENSOR SURFACE
    100.
    发明申请
    METHOD FOR SEEDING CELLS ON A SENSOR SURFACE 有权

    公开(公告)号：US20210270828A1

    公开(公告)日：2021-09-02

    申请号：US17324985

    申请日：2021-05-19

    申请人： Hoffmann-La Roche Inc. ,  NCL New Concept Lab GmbH

    发明人： Stephen FOWLER ,  Na Hong QIU ,  Guojun CHEN

    IPC分类号： G01N33/543 ,  G01N33/50

    摘要： The present invention provides a method for attaching cells to a biosensor surface (5) of a biosensor (4) comprising: providing a cell suspension in a liquid receiving unit (1), wherein the cell suspension forms a surface (7) to the exterior of the liquid receiving unit (1); contacting the biosensor surface (5) with the surface (7) of the cell suspension in the liquid receiving unit (1); and allowing the cells to settle on the biosensor surface (5) by gravity, and allowing the cells to adhere to the biosensor surface (5).