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公开(公告)号：US20230167159A1
公开(公告)日：2023-06-01
申请号：US17906825
申请日：2021-03-22
发明人： Waithaka Mwangi , Huldah Sang
IPC分类号： C07K14/165 , C12N15/86
CPC分类号： C07K14/165 , C12N15/86 , C12N2770/20034 , A61K2039/53
摘要： A new species of coronavirus, SARS-CoV-2, is the cause of a worldwide pandemic and has resulted in hundreds of thousands of deaths. The present disclosure provides immunological compositions and methods related to the production and administration of such compositions to reduce the severity of, incidence of and transmissibility of SARS-CoV-2.
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公开(公告)号：US11600399B2
公开(公告)日：2023-03-07
申请号：US17270537
申请日：2019-08-23
发明人： Walter McNeil , Amir Bahadori , Diego Laramore
摘要： Microsized devices operable to emit neutrons in a selective manner are provided. The devices are configured so that the rate of neutron emission can be varied, either actively or passively. The devices comprise an a-particle emitting material and a neutron producing target material that when aligned and/or positioned a predetermined distance apart emit neutrons. The rate of neutron emission can be slowed or stopped by taking the materials out of alignment and/or attenuating the α-particles being directed toward the neutron producing target material.
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公开(公告)号：US20220356492A1
公开(公告)日：2022-11-10
申请号：US17635036
申请日：2020-08-14
发明人： Kristopher Silver , Yoonseong Park
摘要： Nucleic acid delivery vehicles for delivering nucleic acid, e.g., for RNAi to cells that are typically refractory to RNAi by using extracellular vesicles (EVs) from cultured beetle cells as delivery vehicles. Instead of using high levels of long dsRNA and transfection reagents to accomplish suppression of an mRNA target in cells that don't respond to treatment with naked dsRNA, this approach applies the dsRNA to cultured beetle cells, collects nucleic-acid loaded EVs from the culture, then treats our target cells with the intracellularly loaded EVs, which results in significant enhancement of the RNAi response and greater suppression of transcript levels.
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公开(公告)号：US20220073999A1
公开(公告)日：2022-03-10
申请号：US17514724
申请日：2021-10-29
发明人： Mei He
IPC分类号： C12Q1/6886 , A61K47/69 , G01N33/574 , G01N33/543 , B03C1/015 , B03C1/30 , B01L3/00 , A61K49/00
摘要： Methods for producing engineered exosomes and other vesicle-like biological targets, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments.
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公开(公告)号：US20220024877A1
公开(公告)日：2022-01-27
申请号：US17277631
申请日：2019-09-20
发明人： Stefan H. Bossmann , Madumali Kalubowilage , Man Zhang , Anjana Delpe-Acharige , Kayla Eschliman , Frank Wolschendorf , Olaf Kutsch , Alex Dalecki , Whitney Narmore
IPC分类号： C07D231/42 , C07D231/22 , A61K45/06 , A61P31/04
摘要： Heterocyclic compounds with a novel pyrazole thioamide-based NNSN structural motif, having highly effective zinc- or copper-activated toxicity against microbial infections at micromolar or nanomolar minimum inhibitory concentrations (MIC), and methods of making and using same.
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公开(公告)号：US20210393328A1
公开(公告)日：2021-12-23
申请号：US17465169
申请日：2021-09-02
IPC分类号： A61B18/18
摘要： An electrosurgical device (10) is provided that is operable to deliver microwave energy within a controlled angular expanse to cause targeted tissue ablation. The device (10) comprises a blocking or reflecting material such as cylindrical members (34) that are laterally spaced from the antenna (20) that is operable to emit the microwave energy. The reflecting material creates regions in and/or surrounding the device into which sensors (51), such as thermocouple wires, may be placed to monitor a condition associated with the device or the patient's body.
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公开(公告)号：US11162143B2
公开(公告)日：2021-11-02
申请号：US17236561
申请日：2021-04-21
发明人： Mei He
IPC分类号： G01N27/00 , B03C5/00 , G01N27/12 , C12Q1/6886 , A61K47/69 , G01N33/574 , G01N33/543 , B03C1/015 , B03C1/30 , B01L3/00 , A61K49/00
摘要： Methods for producing engineered exosomes and other vesicle-like biological targets, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments.
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公开(公告)号：US20210298827A1
公开(公告)日：2021-09-30
申请号：US16477490
申请日：2018-01-26
发明人： Punit Prakash , Austin Pfannenstiel
摘要： A novel monitoring method evaluates tissue ablation progress. An antenna in a distal portion of an ablation applicator sends and receives electrical information from the target tissue during ablation. The information is used to determine ablation progress. A related ablation monitoring system includes a power monitor and processor operable to evaluate ablation progress based on reflected electrical properties during the ablation. The invention has particular benefits when used in endoscopic-based microwave ablation.
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公开(公告)号：US11122758B2
公开(公告)日：2021-09-21
申请号：US16339212
申请日：2017-10-07
发明人： Bikram S. Gill , Bernd Friebe , Dal-Hoe Koo
摘要： Wheat lines comprising homoeologous pairing promoter genes from chromosome 5Mg from Ae. geniculata and methods of inducing homoeologous recombination in plant breeding from these lines.
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公开(公告)号：US20210100265A1
公开(公告)日：2021-04-08
申请号：US17116928
申请日：2020-12-09
IPC分类号： A23K30/00 , A23K50/42 , A23L3/3472 , A23L3/358 , A23L3/3508 , A23K20/158 , A23K20/22 , A23K50/30
摘要： Methods of preventing or decreasing PEDv and/or Salmonella bacteria in animal feed, feed ingredients, and pet food are provided. The methods utilize generally safe chemical mitigants, such as medium chain fatty acids, essential oils, and sodium bisulfate. The chemical mitigants are introduced to the feed or feed ingredients at inclusion rates selected so as to prevent or decrease PEDv and/or Salmonella bacteria in the animal feed, feed ingredients, or pet rood. The methods are particularly suitable for use in post-processing treatment of animal feed, feed ingredients, or pet food that will be transported and stored for multiple days or weeks.
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