公开(公告)号：US4042594A

公开(公告)日：1977-08-16

申请号：US701015

申请日：1976-06-30

申请人： Tsutomu Irikura

发明人： Tsutomu Irikura

IPC分类号： C07D213/65 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/455 ,  A61P3/06 ,  C07D213/80 ,  C07D213/55

CPC分类号： C07D213/80

摘要： This invention relates to novel 4-(4'-chloro-benzyloxy)benzyl nicotinate and its salts, and to methods of preparing thereof.

摘要翻译： 本发明涉及新型4-（4'-氯 - 苄氧基）苄基烟酸酯及其盐，以及其制备方法。

公开(公告)号：US11952387B2

公开(公告)日：2024-04-09

申请号：US15734655

申请日：2019-08-20

申请人： KYORIN PHARMACEUTICAL CO., LTD.

发明人： Masahiko Kinebuchi ,  Takekazu Kondou ,  Koji Ochiai ,  Yosuke Nishigaya

IPC分类号： C07D513/04 ,  A61P31/16

CPC分类号： C07D513/04 ,  A61P31/16 ,  C07B2200/05

摘要： [Problem] To provide a compound having an antiviral action on a virus belonging to the picornavirus genus, specifically, a rhinovirus.
[Solution] Provided are a compound represented by general formula (1), a pharmaceutically acceptable salt thereof, or a hydrate thereof.

公开(公告)号：US20220088057A1

公开(公告)日：2022-03-24

申请号：US17424004

申请日：2019-01-25

申请人： KYORIN PHARMACEUTICAL CO., LTD.

发明人： Kazuhisa NAKAO ,  Junichi ISHIYAMA ,  Wataru ICHIKAWA ,  Atsushi MASUI ,  Yunike AKASAKA ,  Aya HONDA

IPC分类号： A61K31/7105 ,  A61P1/16 ,  A61P11/00 ,  A61P13/12

摘要： Disclosed is an antisense nucleic acid that suppresses NEK6 gene expression.

公开(公告)号：US20200157607A1

公开(公告)日：2020-05-21

申请号：US16782794

申请日：2020-02-05

申请人： NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY ,  KYORIN PHARMACEUTICAL CO., LTD.

发明人： Hidenori NAGAI ,  Shunsuke FURUTANI ,  Yoshihisa HAGIHARA ,  Yusuke FUCHIWAKI

IPC分类号： C12Q1/686 ,  C12N15/09 ,  C12M1/00 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/6851

摘要： The present invention provides a reciprocal-flow-type nucleic acid amplification device comprising: heaters capable of forming a denaturation temperature zone and an extension/annealing temperature zone; a fluorescence detector capable of detecting movement of a sample solution between the two temperature zones; a pair of liquid delivery mechanisms that allow the sample solution to move between the two temperature zones and that are configured to be open to atmospheric pressure when liquid delivery stops; a substrate on which the chip for nucleic acid amplification according to claim 2 can be placed; and a control mechanism that controls driving of each liquid delivery mechanism by receiving an electrical signal from the fluorescence detector relating to movement of the sample solution from the control mechanism; the device being capable of performing real-time PCR by measuring fluorescence intensity for each thermal cycle.

公开(公告)号：US10525058B2

公开(公告)日：2020-01-07

申请号：US15576350

申请日：2016-05-26

申请人： KYORIN PHARMACEUTICAL CO., LTD.

发明人： Kiyoshi Fujii ,  Kentaro Umei ,  Hiroyasu Takahashi ,  Mitsuhito Shibasaki ,  Kohei Ohata

IPC分类号： C07D307/22 ,  C07D487/22 ,  A61K31/4985 ,  C07D487/04 ,  C07D263/26 ,  C07D207/273 ,  C07D498/04 ,  C07D211/76 ,  A61K31/343 ,  A61K31/381

摘要： The present invention provides a urea derivative or a pharmacologically acceptable salt thereof that has a formyl peptide receptor like 1 (hereinafter may be abbreviated as FPRL1) agonist effect, a pharmaceutical composition containing the urea derivative or the pharmacologically acceptable salt thereof, and a pharmaceutical use thereof. It has been found that a urea derivative represented by the general formula (I) below or a pharmacologically acceptable salt thereof has a superior FPRL1 agonist effect. Compound (I) or a pharmacologically acceptable salt thereof is highly useful for treatment, prevention, or suppression of inflammatory diseases, chronic airway diseases, cancers, septicemia, allergic symptoms, HIV retrovirus infection, circulatory disorders, neuroinflammation, nervous disorders, pains, prion diseases, amyloidosis, immune disorders and the like.

公开(公告)号：US10252992B2

公开(公告)日：2019-04-09

申请号：US16011050

申请日：2018-06-18

申请人： Kyorin Pharmaceutical Co. Ltd.

发明人： Hiroyasu Takahashi ,  Yoshifumi Saito ,  Kosuke Tsuda ,  Mitsuhito Shibasaki ,  Kohei Ohata

IPC分类号： A61K31/4015 ,  C07D207/12 ,  C07D207/273 ,  C07D403/12 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D209/54 ,  C07D405/14 ,  C07D413/14 ,  C07D401/06 ,  C07D403/04 ,  C07D409/14 ,  C07D413/06 ,  C07D207/22

摘要： Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect.The present invention relates to a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing the compound represented by the general formula (I) or a pharmacologically acceptable salt thereof.

公开(公告)号：US20190076421A1

公开(公告)日：2019-03-14

申请号：US16189461

申请日：2018-11-13

申请人： KYORIN PHARMACEUTICAL CO., LTD.

发明人： Kota KUME ,  Hisao YOSHIDA ,  Hirotaka ANDO ,  Yuta TANAKA

IPC分类号： A61K31/4709

摘要： [Problem] The present invention pertains to a safer and more effective respiratory infection treating agent.[Solution] A respiratory infection treating agent containing, as an active ingredient, 7-[(3S,4S)-3-{(cyclopropylamino)methyl}-4-fluoropyrrolidine-1-yl]-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or a pharmaceutically acceptable salt thereof.

公开(公告)号：US09920005B2

公开(公告)日：2018-03-20

申请号：US15281942

申请日：2016-09-30

申请人： Kyorin Pharmaceutical Co., Ltd.

发明人： Hidetaka Komatsu ,  Hiroya Satoh

IPC分类号： A61K31/138 ,  C07C319/28 ,  C07C213/10

CPC分类号： C07C319/28 ,  C07B2200/13 ,  C07C323/32

摘要： A method for highly efficiently preparing high purity crystals of 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chloro-phenyl]-ethyl]-1,3-propanediol hydrochloride. The method involves dissolving 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol in a mixed solvent comprising a solvent in which its hydrochloride is highly soluble and a solvent in which its hydrochloride is less soluble, to prepare a solution of 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol; and then adding hydrochloric acid to the resulting solution with stirring, to crystallize the hydrochloride of 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chloro-phenyl]ethyl]-1,3-propanediol.

公开(公告)号：US09687453B2

公开(公告)日：2017-06-27

申请号：US14786412

申请日：2014-04-24

申请人： KYORIN PHARMACEUTICAL CO., LTD.

发明人： Hiroshi Uchida ,  Masataka Hanada ,  Yoshikazu Miyazaki

IPC分类号： A61K31/47 ,  A61K9/20 ,  A61K31/4709 ,  A61K9/28

CPC分类号： A61K9/2054 ,  A61K9/2013 ,  A61K9/2853 ,  A61K9/2866 ,  A61K31/4709

摘要： [Problem] To provide a novel pharmaceutical composition which contains a medically active component and which can suppress delays in the release of said component due to gelling.[Solution] This solid pharmaceutical composition contains a compound represented by general formula (1), or a salt thereof, a cellulosic excipient, and a salting-out agent.

公开(公告)号：US09603804B2

公开(公告)日：2017-03-28

申请号：US14786394

申请日：2014-04-24

申请人： KYORIN PHARMACEUTICAL CO., LTD.

发明人： Hiroshi Uchida ,  Masataka Hanada

IPC分类号： A61K31/47 ,  A61K9/20 ,  A61K31/4709 ,  B01F3/04

CPC分类号： A61K9/2054 ,  A61K9/2013 ,  A61K9/2095 ,  A61K31/4709 ,  B01F3/04446

摘要： [Problem] To provide a solid pharmaceutical composition which contains a compound represented by general formula (1) or a salt thereof and suppresses decomposition of said compound or salt thereof, and a production method of said solid pharmaceutical composition.[Solution] This solid pharmaceutical composition contains a compound represented by general formula (1) or a salt thereof, a cellulosic excipient, and an acidic substance of pH 4.0 or less.