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    Carbamate caspase inhibitors and uses thereof
    91.
    发明授权
    Carbamate caspase inhibitors and uses thereof 失效
    氨基甲酸酯半胱天冬酶抑制剂及其用途

    公开(公告)号：US06689784B2

    公开(公告)日：2004-02-10

    申请号：US09821161

    申请日：2001-03-29

    Applicant: David Bebbington ,  Ronald Knegtel ,  Michael Mortimore ,  David Kay ,  Julian M. C. Golec

    Inventor： David Bebbington ,  Ronald Knegtel ,  Michael Mortimore ,  David Kay ,  Julian M. C. Golec

    IPC: C07D20982

    CPC classification number: C07D403/12 ,  C07D209/08 ,  C07D209/86 ,  C07D221/12 ,  C07D223/26 ,  C07D223/28 ,  C07D279/30

    Abstract: This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R1 is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; Y is an electronegative leaving group; R2 is CO2H, CH2CO2H, or esters, amides or isosteres thereof; R3 is a group capable of fitting into the S2 subsite of a caspase enzyme; R4 and R5 are taken together with the intervening nitrogen to form heterocyclic ring and R is as described in the specification. The compounds are effective inhibitors of apoptosis and IL-1&bgr; secretion.

    Abstract translation: 本发明提供了式I的半胱天冬酶抑制剂：其中Z是氧或硫; R 1是氢，-CHN 2，R 1，CH 2 OR，CH 2 SR或-CH 2 Y; Y是电负离子团; R 2是CO 2 H，CH 2 CO 2 H或其酯，酰胺或等体积体; R 3是能够适应半胱天冬酶的S2亚位点的基团; R 4和R 5与中间的氮一起形成杂环，R如说明书中所述。 这些化合物是凋亡和IL-1β分泌的有效抑制剂。

    Analyzer of a vehicle's evaporative emissions
    93.
    发明授权
    Analyzer of a vehicle's evaporative emissions 失效
    车辆蒸发排放分析仪

    公开(公告)号：US06401528B1

    公开(公告)日：2002-06-11

    申请号：US09397326

    申请日：1999-09-16

    Applicant: David Kay Lambert ,  Dean A. Drake ,  Peter John Groblicki

    Inventor： David Kay Lambert ,  Dean A. Drake ,  Peter John Groblicki

    IPC: G01M1900

    CPC classification number: F02M25/0809 ,  F02D41/042

    Abstract: A process and apparatus are disclosed for estimating evaporative fuel emission losses from a vehicle having a hydrocarbon-fueled engine operating under control of a microprocessor-based powertrain controller, a fuel tank with an evaporated fuel emission control system comprising a fuel vapor adsorbtion means connected to the tank and engine, and a diagnostic system that detects malfunctions in the vapor adsorbtion means. The process and apparatus measures temperature inside the vehicle passenger compartment at successive times when the engine is not running and determines the lowest temperature during partial diurnal and diurnal cooling cycles and uses such temperature along with any malfunction data to estimate evaporated fuel loss during a test period.

    Abstract translation: 公开了一种用于估计来自具有在基于微处理器的动力系统控制器的控制下操作的烃燃料发动机的车辆的蒸发燃料排放损失的过程和装置，具有蒸发燃料排放控制系统的燃料箱，所述蒸发燃料排放控制系统包括连接到 罐和发动机，以及检测蒸汽吸附装置中的故障的诊断系统。 该过程和设备在发动机未运行的连续时间内测量车辆乘客舱内的温度，并确定部分日间和昼间冷却循环期间的最低温度，并使用这种温度以及任何故障数据来估计测试期间的蒸发燃料损失 。

    Engine emissions analyzer with diagnostic
    94.
    发明授权
    Engine emissions analyzer with diagnostic 失效
    发动机排放分析仪带诊断

    公开(公告)号：US5750886A

    公开(公告)日：1998-05-12

    申请号：US672159

    申请日：1996-06-27

    Applicant: David Kay Lambert ,  Peter John Groblicki

    Inventor： David Kay Lambert ,  Peter John Groblicki

    IPC: G01M15/10 ,  G01M15/00

    CPC classification number: G01M15/102

    Abstract: A method for analyzing automotive vehicle emissions detects and logs significant engine events over a test period, and applies the logged events to a model defining the emissions impact of such events to yield a vehicle emissions estimate for the test period. The method includes a diagnostic for diagnosing a deviation in performance of emissions control systems away from an expected performance and for correcting the vehicle emissions estimated to reflect the operating condition of the emissions control systems.

    Abstract translation: 用于分析机动车辆排放的方法在测试期间检测和记录重要的发动机事件，并将记录的事件应用于定义这种事件的排放影响的模型，以产生测试期间的车辆排放估计。 该方法包括用于诊断排放控制系统的性能偏离远离预期性能的诊断，以及用于校正估计的反映排放控制系统的运行状况的车辆排放。

    Hybrid refractive/diffractive achromatic lens for optical data storage systems
    95.
    发明授权
    Hybrid refractive/diffractive achromatic lens for optical data storage systems 失效
    用于光学数据存储系统的混合折射/衍射消色差透镜

    公开(公告)号：US5349471A

    公开(公告)日：1994-09-20

    申请号：US17712

    申请日：1993-02-16

    Applicant: G. Michael Morris ,  David Kay ,  Dale Buralli ,  David Kubalak

    Inventor： G. Michael Morris ,  David Kay ,  Dale Buralli ,  David Kubalak

    IPC: G02B5/18 ,  G02B27/00 ,  G11B7/135 ,  G02B3/08 ,  G02B27/44

    CPC classification number: G02B5/1895 ,  G02B27/0037 ,  G02B27/4238 ,  G02B5/1876 ,  G11B7/1374 ,  G11B2007/13722

    Abstract: A diffractive/refractive hybrid lens for use in an optical data storage system as an objective is provided by a convex-plano singlet having a refractive element defined by plano-convex surfaces and a diffractive element defined by a Fresnel zone-like pattern on the plano surface which together provide the total power of the lens. The refractive lens is made of a high index, high dispersion glass so that the curvature and thickness of the refractive lens is minimized while providing a large numerical aperture (at least 0.45) at the expense of increased longitudinal chromatic aberration, which are compensated by the diffractive element and without the need for one or more additional curved surfaces as in low index biaspheric glass objective lenses for chromatic and mono-chromatic aberration reduction, which increases the thickness and curvatures of the lens. The invention enables longitudinal chromatic aberration to be corrected for at least a 10 nm band width around a center wavelength over a 20 nm range, as results when different lasers are used and as laser power varies during optical data storage on an optical data storage device (an optical disk). The thin, light weight low curvature achromat has maximum tolerance for various possible manufacturing errors such as decentering, variations in thickness of the lens, tilt and focal length especially for on-axis field of view less than 2.degree. while providing a very high quality spot (Strehl ratio of at least 0.9.).

    Abstract translation: 用作光学数据存储系统作为目的的衍射/折射混合透镜由具有由平凸表面限定的折射元件和由平面上的菲涅耳带状图案限定的衍射元件的凸平面单重晶片提供 一起提供透镜的总功率的表面。 折射透镜由高折射率高分散玻璃制成，使得折射透镜的曲率和厚度最小化，同时以增加的纵向色差为代价提供大的数值孔径（至少为0.45），其由 并且不需要一个或多个附加的弯曲表面，如在用于彩色和单色像差降低的低折射率偏置玻璃物镜中，这增加了透镜的厚度和曲率。 本发明使得能够在20nm范围内围绕中心波长的至少10nm带宽校正纵向色差，这是因为当使用不同的激光器并且在​​光学数据存储装置中的光学数据存储期间激光功率变化时的结果 光盘）。 薄的，重量轻的低曲率消色差对于各种可能的制造误差具有最大公差，例如偏心，透镜厚度变化，倾斜和焦距，特别是对于小于2°的轴上视场，同时提供非常高的质量点 （Strehl比至少为0.9）。

    Gate valve
    98.
    发明授权
    Gate valve 有权
    闸阀

    公开(公告)号：US08672295B2

    公开(公告)日：2014-03-18

    申请号：US12900682

    申请日：2010-10-08

    Applicant: Samir Dhawan ,  Jason Neal Whaley ,  David Kay ,  Randall Ferrain Weaver ,  Neil Colin Kennedy

    Inventor： Samir Dhawan ,  Jason Neal Whaley ,  David Kay ,  Randall Ferrain Weaver ,  Neil Colin Kennedy

    IPC: F16K3/00 ,  F16K25/00

    CPC classification number: F16K3/0236 ,  F16K3/0209 ,  F16K3/20

    Abstract: A gate valve comprises a valve body having an internal working fluid passage and an internal gate chamber extending transverse to the working fluid passage. In addition, the gate valve comprises a gate disposed in the internal gate chamber and movable within the gate chamber between a closed position obstructing fluid flow through the working fluid passage and an open position allowing fluid flow through the working fluid passage. Further, the gate valve comprises an internal sealing arrangement coaxially disposed in the working fluid passage and extending between the valve body and the gate to form a barrier between the internal working fluid passage and the gate chamber. The internal sealing arrangement includes a frustoconical metal sealing surface adapted to sealingly engage an opposed mating frustoconical metal sealing surface on the valve body to form a first tapered metal-to-metal seal between the sealing arrangement and the valve body.

    Abstract translation: 闸阀包括具有内部工作流体通道的阀体和横向于工作流体通道延伸的内部门室。 此外，闸阀包括设置在内部门室中的门，并且可在门室内在阻塞流过工作流体通道的流体的关闭位置和允许流体流过工作流体通道的打开位置之间移动。 此外，闸阀包括同轴地设置在工作流体通道中并在阀体和门之间延伸的内部密封装置，以在内部工作流体通道和门室之间形成阻挡层。 内部密封装置包括截头圆锥形金属密封表面，其适于密封地接合阀体上相对的配合截头圆锥形金属密封表面，以在密封装置和阀体之间形成第一锥形金属对金属密封。

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