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91.发明申请公开(公告)号：US20160367360A1
公开(公告)日：2016-12-22
申请号：US15189786
申请日：2016-06-22
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2436 , A61F2220/0016 , A61F2230/0006 , A61F2230/0034 , A61F2230/0052 , A61F2250/001 , A61F2250/0039 , A61F2250/0048
摘要： A mitral valve implant includes a force-expanding mitral valve lattice having an interior orifice and a self-expanding valve trampoline attached at the interior orifice of the force-expanding mitral valve lattice. The mitral valve lattice is self-expandable to a first configuration and force expandable from the first configuration to a second configuration. The configurations can be circular or D-shaped. The mitral valve lattice comprises jack screws adjusting configurations of the mitral valve lattice. The valve trampoline has a cylindrical central region comprising valve leaflets. An outwardly flaring implant skirt is attached to the mitral valve lattice exterior. Wall-retaining wires are attached to the mitral valve lattice, are petal-shaped, and have a pre-set, radially outward, memory shape. The wires and skirt impart a force on a respective side of the native mitral valve when the mitral valve lattice is expanded within an annulus of the native mitral valve.
摘要翻译： 二尖瓣植入物包括力扩张二尖瓣网格，其具有连接在力扩张二尖瓣网格的内孔处的内孔和自膨胀阀蹦床。 二尖瓣网格可自膨胀至第一构型，并且力可从第一构型扩展至第二构型。 配置可以是圆形或D形。 二尖瓣格子包括调整二尖瓣格结构的千斤顶螺钉。 阀蹦床具有包括瓣叶的圆柱形中心区域。 向外扩张的植入物裙缘连接到二尖瓣格架外部。 护壁线连接到二尖瓣格子，呈花瓣状，并且具有预设的径向向外的记忆形状。 当二尖瓣网格在天然二尖瓣的环形区域内扩张时，电线和裙部在天然二尖瓣的相应侧上施加力。
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公开(公告)号：US09339380B2
公开(公告)日：2016-05-17
申请号：US14186989
申请日：2014-02-21
发明人： Arshad Quadri , J. Brent Ratz
CPC分类号： A61F2/2409 , A61F2/24 , A61F2/2418 , A61F2/243 , A61F2/2436 , A61F2/2439 , A61F2/95 , A61F2002/9522 , A61F2002/9534 , A61F2220/0016 , A61F2220/0033 , A61F2220/0075 , A61F2230/0013 , A61F2250/001
摘要： A vascular implant for replacing a native heart valve comprises a self expanding stent supporting a valve body having leaflets. The stent preferably comprises an anchoring structure configured to prevent the implant from passing through the valve annulus. For delivery, the implant is compacted within a delivery device and secured at one end. During delivery the implant is partially released from the delivery device, and positioning of the implant can be verified prior to full release. The implant can be at least partially resheathed and repositioned if desired.
摘要翻译： 用于替换天然心脏瓣膜的血管植入物包括支撑具有传单的阀体的自扩张支架。 支架优选地包括构造成防止植入物通过瓣膜环的锚定结构。 为了交付，植入物在输送装置内压实并固定在一端。 在输送期间，植入物部分地从输送装置释放，并且可以在完全释放之前验证植入物的定位。 如果需要，植入物可以至少部分地重新固定并重新定位。
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公开(公告)号：USD755384S1
公开(公告)日：2016-05-03
申请号：US29484001
申请日：2014-03-05
设计人： Luca Pesce , J. Brent Ratz
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公开(公告)号：US12083011B2
公开(公告)日：2024-09-10
申请号：US17357816
申请日：2021-06-24
CPC分类号： A61F2/2418 , A61F2/2445 , A61F2220/0008 , A61F2220/005 , A61F2220/0075 , A61F2250/0039 , A61F2250/0069
摘要： A prosthesis for placement within a native heart valve preferably includes an expandable frame having locking tabs disposed along a proximal end. A plurality of distal anchors is disposed along a distal end of the frame. Each distal anchor is provided with a cushion cover. An outer fabric member surrounds the frame and may extend outwardly from the frame in an expanded condition for providing an improved seal in the region of a native annulus. A valve body is positioned within an interior of the expandable from for allowing blood flow in only one direction. In preferred embodiments, the cushions are positioned over enlarged head portions of the distal anchors for further reducing trauma on surrounding tissue.
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公开(公告)号：US20240197471A1
公开(公告)日：2024-06-20
申请号：US18595011
申请日：2024-03-04
发明人： J. Brent Ratz , Arshad Quadri , Luca Pesce
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2220/0008 , A61F2250/0039 , A61F2250/006 , A61F2250/0069
摘要： A prosthesis can comprise an expandable frame, a plurality of distal anchors and a plurality of proximal anchors. The anchors can extend outwardly from the frame. The frame can be configured to radially expand and contract for deployment within a body cavity. The frame and anchors can have one of many different shapes and configurations. For example, when the frame is in an expanded configuration, the proximal anchors can extend a significant distance away from the exterior of the frame, such as a length equal to or greater than about one half the diameter of the frame. As another example, the anchors can have looped ends.
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公开(公告)号：US20240122705A1
公开(公告)日：2024-04-18
申请号：US18391575
申请日：2023-12-20
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2436 , A61F2002/9505
摘要： A prosthetic cardiac valve comprises an anchor having an atrial skirt, an annular region, and a ventricular skirt. The prosthetic valve also has a plurality of prosthetic valve leaflets each having a first end and a free end. The first end is coupled with the anchor and the free end is opposite the first end. The prosthetic cardiac valve has an open configuration in which the free ends of the prosthetic valve leaflets are disposed away from one another to allow antegrade blood flow therepast, and a closed configuration in which the free ends of the prosthetic valve leaflets engage one another and substantially prevent retrograde blood flow therepast. The anchor has a collapsed configuration for delivery to the heart and an expanded configuration for anchoring the prosthetic cardiac valve to a patient's heart.
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公开(公告)号：US11589983B2
公开(公告)日：2023-02-28
申请号：US16867206
申请日：2020-05-05
发明人： Arshad Quadri , J. Brent Ratz
摘要： A heart valve includes a valve body made of a flexible material such as pericardium. The valve body is made of two layers of material, an outer layer, and an inner layer that defines a plurality of leaflets. The leaflets of the inner layer are attached to the outer layer. In some embodiments the valve body is made by cutting a single piece of flat source tissue, folding the cut tissue and forming it into a tubular pattern having the inner and outer layers. The multi-layer valve body can be mounted on a stent for delivery within a patient's heart.
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公开(公告)号：US20230014100A1
公开(公告)日：2023-01-19
申请号：US17951855
申请日：2022-09-23
发明人： Arshad Quadri , J. Brent Ratz
IPC分类号： A61F2/24
摘要： A replacement heart valve includes an expandable frame for engaging a native valve annulus and a valve body positioned within the expandable frame. The valve body has an upstream end and a downstream end, wherein a diameter at the downstream end is greater than a diameter at the upstream end. The replacement heart valve also includes an elongate upstream portion having an inflow diameter, a transition portion that flares outwardly, and a downstream portion configured to engage a native valve annulus.
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公开(公告)号：US11419720B2
公开(公告)日：2022-08-23
申请号：US16559191
申请日：2019-09-03
摘要： A prosthetic cardiac valve comprises an anchor having an atrial skirt, an annular region, and a ventricular skirt. The prosthetic valve also has a plurality of prosthetic valve leaflets each having a first end and a free end. The first end is coupled with the anchor and the free end is opposite the first end. The prosthetic cardiac valve has an open configuration in which the free ends of the prosthetic valve leaflets are disposed away from one another to allow antegrade blood flow therepast, and a closed configuration in which the free ends of the prosthetic valve leaflets engage one another and substantially prevent retrograde blood flow therepast. The anchor has a collapsed configuration for delivery to the heart and an expanded configuration for anchoring the prosthetic cardiac valve to a patient's heart.
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公开(公告)号：US20220249225A1
公开(公告)日：2022-08-11
申请号：US17733914
申请日：2022-04-29
发明人： J. Brent Ratz , Arshad Quadri , Luca Pesce
IPC分类号： A61F2/24
摘要： A prosthesis can comprise an expandable frame, a plurality of distal anchors and a plurality of proximal anchors. The anchors can extend outwardly from the frame. The frame can be configured to radially expand and contract for deployment within a body cavity. The frame and anchors can have one of many different shapes and configurations. For example, when the frame is in an expanded configuration, the frame can have a larger cross-sectional dimension in a middle portion of the frame and a smaller cross-sectional dimension in a proximal portion and a distal portion of the frame, wherein the middle portion is between the proximal and distal portions. As another example, the anchors can have looped ends, the entire anchor may loop out from the frame.
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