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公开(公告)号：US20220031831A1
公开(公告)日：2022-02-03
申请号：US17309272
申请日：2019-11-13
Applicant: Kansas State University Research Foundation
Inventor： Waithaka Mwangi , Shehnaz Lokhandwala
Abstract: The present disclosure provides immunogenic compositions or vaccines against African Swine Fever Virus (ASFV), methods of making and using such immunogenic compositions or vaccines, and methods of administering such immunogenic compositions or vaccines. In some forms, a plurality of ASFV antigens are combined together into a live-vectored multivalent immunogenic composition. In some forms, the live-vectored multivalent immunogenic composition is a multicistronic expression cassette.
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92.发明授权公开(公告)号：US11208499B2
公开(公告)日：2021-12-28
申请号：US16728400
申请日：2019-12-27
Applicant: Kansas State University Research Foundation
Inventor： Yong-Cheng Shi , Yanjie Bai , Zhenhua Sun
IPC: C08B31/04
Abstract: Water soluble, lipophilic starches are provided, which comprise a mixture of functionalized high and low molecular weight maltodextrin molecules. The starches may be formed by dispersing a granular starch in a liquid medium to form a slurry that is simultaneously cooked and subjected to enzyme hydrolysis. Following hydrolysis, the starch is functionalized with an organic acid anhydride reagent, such as octenylsuccinic anhydride. The organic acid anhydride substitution occurs randomly and at various locations within the maltodextrin molecules.
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公开(公告)号：US20210251689A1
公开(公告)日：2021-08-19
申请号：US17251592
申请日：2019-06-12
Applicant: HOLOGIC, INC. , KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
Inventor： Punit Prakash , Hojjatollah Fallahi , Jessica T. Schenck , Eric A. Frattura
IPC: A61B18/18 , A61B5/0507 , A61B5/00
Abstract: A tissue ablation system includes an antenna, a microwave energy source, measurement apparatus including a signal generator and a detector, a controller, and a switch assembly arranged to alternatively electrically couple the antenna to the microwave energy source or to the measurement apparatus, wherein the controller is configured to cause the switch assembly to alternate between assessment mode and ablation mode, and wherein the controller is configured to control the delivery of ablative microwave energy during an ablation mode based at least in part on a difference between a then-current broadband reflection coefficient spectrum and a previously measured broadband reflection coefficient spectrum obtained by delivery of a spectrum of individual non-ablative microwave signals and detecting the reflection of same during respective assessment modes.
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公开(公告)号：US20210193343A1
公开(公告)日：2021-06-24
申请号：US17270537
申请日：2019-08-23
Applicant: Kansas State University Research Foundation
Inventor： Walter McNeil , Amir Bahadori , Diego Laramore
Abstract: Microsized devices operable to emit neutrons in a selective manner are provided. The devices are configured so that the rate of neutron emission can be varied, either actively or passively. The devices comprise an a-particle emitting material and a neutron producing target material that when aligned and/or positioned a predetermined distance apart emit neutrons. The rate of neutron emission can be slowed or stopped by taking the materials out of alignment and/or attenuating the α-particles being directed toward the neutron producing target material.
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公开(公告)号：US20210189418A1
公开(公告)日：2021-06-24
申请号：US16098680
申请日：2017-05-04
Inventor： Dorith Rotenberg , Anna E. Whitfield , William W. Bockus , Forrest G. Chumley , Rodolfo Acosta-Leal
IPC: C12N15/82
Abstract: Isolated cDNA sequences encoding for highly conserved domains of plant viral pathogen genomes. The cDNA sequences are selected from the group consisting of those listed in Table I (SEQ ID NOs: 1-68). cDNA fusion constructs or chimeric transgene constructs comprising at least two different cDNA sequences selected from the list in Table I, and more specifically cDNA corresponding to at least two different viruses is described, along with methods of creating transgenic plants with broad-spectrum, durable resistance to multiple viral pathogens using these cDNA sequences.
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Patent Agency Ranking
公开(公告)号：US11033600B2
公开(公告)日：2021-06-15
申请号：US16320681
申请日：2017-07-28
Inventor： Kyeong-Ok Chang , William C. Groutas
IPC: A61K38/00 , A61K38/05 , A61K31/4015 , A61K31/662 , A61K31/223 , C07K5/06 , A61K31/225 , A61K31/5375 , A61K47/50 , A61P31/14 , A61K47/10 , A61K45/06
Abstract: Disclosed herein are protease transition state inhibitor/analogue prodrug compounds selected from the group consisting of esters, carbamates, ester phosphates, and pharmaceutically acceptable salts thereof. Compositions containing such prodrugs are also disclosed, along with methods of using such compounds therapeutically or prophylactically against calicivirus, picornavirus, and/or coronavirus infection, as well as other conditions, such as malaria, cancer, stroke, heart attack, neural degeneration, cataracts, and glaucoma through inhibition of the variety of proteases associated with progression of such conditions.
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公开(公告)号：US20210046144A1
公开(公告)日：2021-02-18
申请号：US16977353
申请日：2019-03-01
Applicant: Kansas State University Research Foundation
Inventor： Megan C. Niederwerder , Raymond R.R. Rowland , Cassandra Jones , Steven S. Dritz , Jason C. Woodworth
IPC: A61K36/9066 , A61K31/20 , A61K36/88 , A61K36/81 , A61K36/537 , A61P31/20 , A23K20/158 , A23K50/42 , A23K20/22 , A23K50/30
Abstract: Methods of inhibiting the spread of African swine fever virus and/or classical swine fever virus in animal feed, feed ingredients, and pet food are provided. The methods utilize generally safe chemical mitigants, such as medium chain fatty acids. The chemical mitigants are effective when introduced to the feed or feed ingredients at inclusion rates much lower than previous methods for inhibiting other microbes. The methods are particularly suitable for use in post-processing treatment of animal feed, feed ingredients, or pet food that will be transported and stored for multiple days or weeks.
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公开(公告)号：US10881722B2
公开(公告)日：2021-01-05
申请号：US16334885
申请日：2017-09-18
Applicant: Kansas State University Research Foundation , The United States of America, as represented by The Secretary of Agriculture
Inventor： Juergen A. Richt , Igor Morozov , Sun Young Sunwoo , William C. Wilson
Abstract: The present disclosure provides for an immunogenic composition against epizootic hemorrhagic disease virus (EHDV). The immunogenic composition has been shown to be efficacious in inducing serum neutralizing antibodies against EHDV and intended to be used to prevent or reduce clinical symptoms associated with EHDV infection in susceptible animals. The disclosure provides for composition and methods that represent an improvement over previous strategies for treating and preventing EHDV.
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公开(公告)号：US20200306737A1
公开(公告)日：2020-10-01
申请号：US16089609
申请日：2017-03-28
Applicant: Kansas State University Research Foundation
Inventor： Duy H. Hua
Abstract: Chiral polyvinylpyrrolidinone (CSPVP), complexes of CSPVP with a core species, such as a metallic nanocluster catalyst, and enantioselective oxidation reactions utilizing such complexes are disclosed. The CSPVP complexes can be used in asymmetric oxidation of diols, enantioselective oxidation of alkenes, and carbon-carbon bond forming reactions, for example. The CSPVP can also be complexed with biomolecules such as proteins, DNA, and RNA, and used as nanocarriers for siRNA or dsRNA delivery.
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公开(公告)号：US10674690B2
公开(公告)日：2020-06-09
申请号：US15416521
申请日：2017-01-26
Applicant: Kansas State University Research Foundation
Inventor： Mitchell R. Tuinstra , Kassim Al-Khatib
Abstract: The present invention provides for compositions and methods for producing sorghum crop plants that are resistant to herbicides. In particular, the present invention provides for sorghum plants, plant tissues and plant seeds that contain altered acetolactate synthase (ALS) genes and proteins that are resistant to inhibition by herbicides that normally inhibit the activity of the ALS protein.
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