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公开(公告)号：US20100099997A1
公开(公告)日：2010-04-22
申请号：US12645906
申请日：2009-12-23
IPC分类号： A61B5/02
CPC分类号： A61B7/04 , A61B5/1116 , A61B8/0883 , A61N1/3627 , A61N1/36535 , A61N1/36578 , A61N1/36585
摘要： A system to monitor heart sounds. The system comprises an implantable heart sound sensor configured to produce an electrical signal representative of at least one heart sound, an implantable posture sensor operable to produce an electrical signal representative of a patient's posture, and a controller circuit. The controller circuit is configured to determine a patient posture, measure at least one heart sound in correspondence with at least one corresponding patient posture, adjust the heart sound measurement by using the corresponding determined patient posture to reduce or remove variation in the heart sound measurement due to patient posture, detect a change in the adjusted heart sound measurement, and provide an indication of congestive heart failure to a user or an automated process in response to the detected change.
摘要翻译： 监听心音的系统 该系统包括被配置为产生表示至少一个心音的电信号的可植入心音传感器，可操作以产生表示患者姿势的电信号的可植入姿态传感器和控制器电路。 控制器电路被配置为确定患者姿势，测量与至少一个对应的患者姿势相对应的至少一个心音，通过使用相应的确定的患者姿势来调整心脏声音测量，以减少或消除心音测量中的变化 到患者姿势，检测调整后的心音测量的变化，并响应于检测到的变化向用户或自动化过程提供充血性心力衰竭的指示。
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公开(公告)号：US20090018461A1
公开(公告)日：2009-01-15
申请号：US12283760
申请日：2008-09-16
IPC分类号： A61B5/02
CPC分类号： A61B7/04
摘要： A cardiac rhythm management system includes a heart sound detector providing for detection of the third heart sounds (S3). An implantable sensor such as an accelerometer or a microphone senses an acoustic signal indicative heart sounds including the second heart sounds (S2) and S3. The heart sound detector detects occurrences of S2 and starts S3 detection windows each after a predetermined delay after a detected occurrence of S2. The occurrences of S3 are then detected from the acoustic signal within the S3 detection windows.
摘要翻译： 心律管理系统包括提供检测第三心音的心音检测器（S3）。 诸如加速度计或麦克风的可植入传感器感测指示包括第二心音（S2）和S3的心音的声信号。 心音检测器检测到S2的发生，并且在检测到S2发生之后经过预定延迟之后开始S3检测窗口。 然后从S3检测窗口内的声信号检测S3的出现。
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公开(公告)号：US07431699B2
公开(公告)日：2008-10-07
申请号：US10746853
申请日：2003-12-24
IPC分类号： A61B5/02
CPC分类号： A61B7/04
摘要： A cardiac rhythm management system includes a heart sound detector providing for detection of the third heart sounds (S3). An implantable sensor such as an accelerometer or a microphone senses an acoustic signal indicative heart sounds including the second heart sounds (S2) and S3. The heart sound detector detects occurrences of S2 and starts S3 detection windows each after a predetermined delay after a detected occurrence of S2. The occurrences of S3 are then detected from the acoustic signal within the S3 detection windows.
摘要翻译： 心律管理系统包括用于检测第三心音的心音检测器（S 3）。 诸如加速度计或麦克风的可植入传感器感测到指示包括第二心音（S 2）和S 3的心音的声信号。 心音检测器检测到S 2的发生，并且在检测到的S 2发生之后，在预定延迟之后开始S 3检测窗口。 然后从S 3检测窗口内的声信号检测出S 3的出现。
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94.发明申请MONITORING OF CHRONOBIOLOGICAL RHYTHMS FOR DISEASE AND DRUG MANAGEMENT USING ONE OR MORE IMPLANTABLE DEVICE 有权使用一个或多个可植入装置监测疾病和药物管理的血液生殖系统公开(公告)号：US20080114219A1
公开(公告)日：2008-05-15
申请号：US11554986
申请日：2006-10-31
申请人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
发明人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
IPC分类号： A61B5/00
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G06F19/00
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译： 使用至少一个可植入装置自动评价或预测受试者的健康状况。 在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。 也可以使用昼夜节律以外的其他时间生理节律。 可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。 预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。 还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。
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公开(公告)号：US08636669B2
公开(公告)日：2014-01-28
申请号：US12985055
申请日：2011-01-05
IPC分类号： A61B5/02
CPC分类号： A61B5/02028 , A61B7/00 , A61N1/36514 , A61N1/36528
摘要： A cardiac rhythm management system provides for ambulatory monitoring of hemodynamic performance based on quantitative measurements of heart sound related parameters for diagnostic and therapeutic purposes. Monitoring of such heart sound related parameters allows the cardiac rhythm management system to determine a need for delivering a therapy and/or therapy parameter adjustments based on conditions of a heart. This monitoring also allows a physician to observe or assess the hemodynamic performance for diagnosing and making therapeutic decisions. Because the conditions of the heart may fluctuate and may deteriorate significantly between physician visits, the ambulatory monitoring, performed on a continuous or periodic basis, ensures a prompt response by the cardiac rhythm management system that may save a life, prevent hospitalization, or prevent further deterioration of the heart.
摘要翻译： 心律管理系统基于用于诊断和治疗目的的心音相关参数的定量测量，提供对血液动力学性能的动态监测。 监测这种心脏声音相关参数允许心律管理系统基于心脏的情况来确定递送治疗和/或治疗参数调整的需要。 该监测还允许医师观察或评估用于诊断和作出治疗决定的血液动力学性能。 由于心脏的状况可能波动，并且可能在医师访问之间显着恶化，所以在连续或周期性的基础上进行的动态监测可确保心律管理系统能够节省生命，预防住院或进一步防止心律失常的迅速反应 心脏恶化
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96.发明授权Biventricular-triggered pacing in the context of multi-site left ventricular pacing 有权在多局部左心室起搏背景下的双心室触发起搏公开(公告)号：US08600501B2
公开(公告)日：2013-12-03
申请号：US13327442
申请日：2011-12-15
申请人： Jeffrey E. Stahmann , James O. Gilkerson , Krzysztof Z. Siejko , James Kalgren , Yinghong Yu , Kenneth L. Baker
发明人： Jeffrey E. Stahmann , James O. Gilkerson , Krzysztof Z. Siejko , James Kalgren , Yinghong Yu , Kenneth L. Baker
IPC分类号： A61N1/365
CPC分类号： A61N1/36592 , A61N1/3627 , A61N1/3684
摘要： Biventricular-triggered pacing is a pacing mode that can employ in cardiac resynchronization pacing at elevated heart rates. Described herein are methods and devices for implementing biventricular pacing in the context of multi-site left ventricular pacing.
摘要翻译： 双心室触发起搏是起搏模式，可以在升高的心率下采用心脏再同步起搏。 本文描述了在多局部左心室起搏背景下实现双心室起搏的方法和装置。
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公开(公告)号：US08478392B2
公开(公告)日：2013-07-02
申请号：US13168481
申请日：2011-06-24
IPC分类号： A61B5/04
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods for rhythm discrimination using the motion of an implantable lead are described. In an example, an implantable medical device can include a receiver circuit configured to be electrically coupled to an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The device can include an arrhythmia detection circuit configured to determine an arrhythmia status using the information indicative of the movement of the implantable lead and an arrhythmia classification circuit configured to determine one or more of a location or a type of an arrhythmia, using the information indicative of the movement of the implantable lead, when the arrhythmia status indicates that an arrhythmia is occurring or has occurred.
摘要翻译： 描述使用可植入引线的运动进行节律辨别的系统和方法。 在一个示例中，可植入医疗设备可以包括被配置为电耦合到可植入引线的接收器电路，并且被配置为获得至少部分地基于心脏的运动而指示可植入引线的运动的信息。 该装置可以包括心律失常检测电路，其被配置为使用指示可植入引线的移动的信息来确定心律失常状态，以及心律失常分类电路，其被配置为使用所述信息指示来确定心律不齐的位置或类型中的一个或多个 当心律失常状态表示发生心律失常或发生心律失常时，可植入性铅的运动。
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公开(公告)号：US20130096451A1
公开(公告)日：2013-04-18
申请号：US13708196
申请日：2012-12-07
IPC分类号： A61B7/00
CPC分类号： A61B7/04 , A61B7/00 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36585 , A61N1/368
摘要： A system and method provide heart sound tracking, including an input circuit, configured to receive heart sound information, and a heart sound recognition circuit. The heart sound recognition circuit can be coupled to the input circuit and can be configured to recognize, within a particular heart sound of a particular heart sound waveform, a first intra heart sound energy indication and a corresponding first intra heart sound time indication using the heart sound information from the particular heart sound waveform and the heart sound information from at least one other heart sound waveform. The particular heart sound can include at least a portion of one of S1, S2, S3, and S4. Further, the first intra heart sound energy indication and the corresponding first intra heart sound time indication can correspond to the at least a portion of one of S1, S2, S3, and S4, respectively.
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公开(公告)号：US08346360B2
公开(公告)日：2013-01-01
申请号：US13214564
申请日：2011-08-22
IPC分类号： A61N1/362
CPC分类号： A61B5/0205 , A61B5/0031 , A61B5/0215 , A61B5/02158 , A61B5/0402 , A61B5/0488 , A61N1/36114 , A61N1/36117 , A61N1/36128 , A61N1/36139 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/372 , A61N1/37288
摘要： Various system embodiments comprise a stimulator adapted to deliver a stimulation signal for a heart failure therapy, a number of sensors adapted to provide at least a first measurement of a heart failure status and a second measurement of the heart failure status, and a controller. The controller is connected to the stimulator and to the number of sensors. The controller is adapted to use the first and second measurements to create a heart failure status index, and control the stimulator to modulate the signal using the index. Other aspects and embodiments are provided herein.
摘要翻译： 各种系统实施例包括适于递送用于心力衰竭治疗的刺激信号的刺激器，适于提供心力衰竭状态的至少第一测量和心力衰竭状态的第二测量的多个传感器以及控制器。 控制器连接到刺激器和传感器的数量。 控制器适于使用第一和第二测量来创建心力衰竭状态指数，并且使用该索引来控制刺激器来调制信号。 本文提供了其它方面和实施例。
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公开(公告)号：US08332034B2
公开(公告)日：2012-12-11
申请号：US12964902
申请日：2010-12-10
IPC分类号： A61N1/365
CPC分类号： A61B7/04 , A61B7/00 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36585 , A61N1/368
摘要： A system and method provide heart sound tracking, including an input circuit, configured to receive heart sound information, and a heart sound recognition circuit. The heart sound recognition circuit can be coupled to the input circuit and can be configured to recognize, within a particular heart sound of a particular heart sound waveform, a first intra heart sound energy indication and a corresponding first intra heart sound time indication using the heart sound information from the particular heart sound waveform and the heart sound information from at least one other heart sound waveform. The particular heart sound can include at least a portion of one of S1, S2, S3, and S4. Further, the first intra heart sound energy indication and the corresponding first intra heart sound time indication can correspond to the at least a portion of one of S1, S2, S3, and S4, respectively.
摘要翻译： 一种系统和方法提供心脏跟踪，包括被配置为接收心脏声音信息的输入电路和心脏声音识别电路。 心脏声音识别电路可以耦合到输入电路，并且可以被配置为在特定心脏声音波形的特定心脏声音内识别第一心脏心脏声能指示和使用心脏的对应的第一心脏心脏音频指示 来自特定心脏声音波形的声音信息和来自至少一个其他心脏声音波形的心脏声音信息。 特定的心音可以包括S1，S2，S3和S4中的一个的至少一部分。 此外，第一心内心音能量指示和对应的第一心脏心音时间指示可以分别对应于S1，S2，S3和S4中的一个的至少一部分。
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