公开(公告)号：US3882234A

公开(公告)日：1975-05-06

申请号：US45745574

申请日：1974-04-03

Applicant: MILES LAB

Inventor： HAVERA HERBERT JOHN ,  STRYCKER WALLACE GLENN

IPC: C07D233/74 ,  A61K15/12

CPC classification number: C07D233/74 ,  Y10S514/821

Abstract: N-(2-diethylamino)ethyl- Alpha -(5,5-diphenylhydantoin-3yl)acetamide and nontoxic salts thereof exhibit antiarrhythmic activity in mammals.

Abstract translation: N-（2-二乙氨基）乙基-α-（5,5-二苯基乙内酰脲-3-基）乙酰胺及其无毒盐在哺乳动物中表现出抗心律失常活性。

公开(公告)号：US3882225A

公开(公告)日：1975-05-06

申请号：US78246768

申请日：1968-12-09

Applicant: MILES LAB

Inventor： PATEL VIRENDRA ,  FETTER MARION COOK ,  NAND SHRADHA

IPC: G01N33/554 ,  G01N31/00 ,  G01N31/02 ,  G01N33/10

CPC classification number: G01N33/554

Abstract: Immunological reagents capable of direct agglutination with antigens are prepared by pre-polymerizing the antibody to form an aggregate and then coupling this aggregate to a microbial cell carrier particle with a chemical coupling agent. The prepolymerization of the antibody can be accomplished by the use of the same or another coupling agent. The use of the microbial cell carrier particle allows the reagents formed to be used as immunological indicator particles in slide tests which permit a quick read-out of test results. The reagent formed may be prepared and shipped in dry form and then reconstituted with liquid for use.

Abstract translation: 通过使抗体预聚合形成骨料，然后用化学偶联剂将该骨料与微生物细胞载体颗粒偶联，可制备能够与抗原直接凝集的免疫试剂。 抗体的预聚合可以通过使用相同或另一种偶联剂来实现。 微生物细胞载体颗粒的使用允许所形成的试剂用作滑动试验中的免疫指示剂颗粒，其允许快速读出测试结果。 所形成的试剂可以制备并以干燥形式运输，然后用液体重构使用。

公开(公告)号：US3879393A

公开(公告)日：1975-04-22

申请号：US37127773

申请日：1973-06-18

Applicant: MILES LAB

Inventor： HAVERA HERBERT JOHN

IPC: C07D401/06 ,  C07D51/48

CPC classification number: C07D401/06 ,  Y10S514/929

Abstract: The disclosed derivatives of 1,3-disubstituted 2,4 (1H,3H)quinazolinediones produce vasodilation in experimental animals. The 1,3-disubstitutions include, among others, 1(alky(alkylamino))-, 1-(alkylpiperidyl)-, 3-(alkyl(alkylamino))-, 3-(alkyl(4-phenyl-1-piperidyl)-, and 3-(alkyl(4-phenyl-1piperazinyl))-moieties. In the latter two substituents the phenyl group optionally is substituted with halogeno or loweralkyl groups. Additionally, the compounds optionally are substituted at carbon atoms 5 through 8 of the quinazolinedione nucleus with halogeno, nitro, alkoxy, and alkylamido substituents.

Abstract translation: 公开的1,3-二取代的2,4（1H，3H） - 喹唑啉二酮的衍生物在实验动物中产生血管舒张。 1,3-二取代基包括1- [烷基（烷基氨基）] - ，1-（烷基哌啶基） - ，3- [烷基（烷基氨基）] - ，3- [烷基（4-苯基-1-哌啶基 ] - 和3- [烷基（4-苯基-1-哌嗪基）] - 部分，在后两个取代基中，苯基任选被卤代或低级烷基取代。另外，化合物任选地在碳原子5 8具有卤代，硝基，烷氧基和烷基酰氨基取代基的喹唑啉二酮核。

公开(公告)号：US3856649A

公开(公告)日：1974-12-24

申请号：US34199973

申请日：1973-03-16

Applicant: MILES LAB

Inventor： GENSHAW M ,  SMITH M

IPC: G01N27/333 ,  G01N27/30

CPC classification number: G01N27/3335

Abstract: A solid state electrode for use in determining ion concentration in an aqueous solution. The electrode comprises an electrically conductive inner element with a salt disposed on a surface portion thereof having as a cation a cation form of the element and also having an anion, a hydrophilic layer in intimate contact with the salt and including a water soluble salt of said anion and a hydrophobic layer in intimate contact with the hydrophilic layer whereby the hydrophilic layer is shielded from contact with the ion-containing aqueous solution. This electrode may function as a reference electrode as well as an electrode for identifying specific ions.

Abstract translation: 用于测定水溶液中离子浓度的固态电极。 所述电极包括导电内部元件，其具有盐，其设置在其表面部分上，其具有作为所述元件的阳离子形式的阳离子，并且还具有阴离子，与所述盐紧密接触的亲水层，并且包含所述 阴离子和与亲水层紧密接触的疏水层，从而使亲水层不被与含离子的水溶液接触。 该电极可以用作参考电极以及用于识别特定离子的电极。

公开(公告)号：US3843710A

公开(公告)日：1974-10-22

申请号：US33280573

申请日：1973-02-15

Applicant: MILES LAB

Inventor： BUCKLER R ,  HARTZLER H

IPC: C07K1/00 ,  C07C121/78

CPC classification number: C07K1/006 ,  Y10S514/869

Abstract: Certain substituted Beta -arylamidoacrylic acids and a method of preparing them are disclosed. These compounds are useful as antiinflammatory and diuretic agents.

公开(公告)号：US3836667A

公开(公告)日：1974-09-17

申请号：US34274173

申请日：1973-03-19

Applicant: MILES LAB

Inventor： OSWALD H ,  WARREN B

IPC: A61K31/19 ,  A61K31/557 ,  A61K27/00

CPC classification number: A61K31/557 ,  A61K31/19

Abstract: THE INVENTION RELATES TO THE USE OF PROSTAGLANDIN A1 AS A BRONCHODILATING AGENT; THE PROSTAGLANDIN CAN BE USED IN PARTICULAR IN ALLEVIATING THE SYMPTOMS OF STATUS ASTHMATICUS BY INJECTION.

公开(公告)号：US3835151A

公开(公告)日：1974-09-10

申请号：US35131973

申请日：1973-04-16

Applicant: MILES LAB

Inventor： HAVERA H ,  STRYCKER W

IPC: C07D233/72 ,  C07D233/74 ,  C07D49/36

CPC classification number: C07D233/74 ,  Y10S514/821

Abstract: N-(2-diethylamino)ethyl- Alpha -(5,5-diphenylhydantoin-3yl)acetamide and nontoxic salts thereof exhibit antiarrhythmic activity in mammals.

Abstract translation: N-（2-二乙氨基）乙基-α-（5,5-二苯基乙内酰脲-3-基）乙酰胺及其无毒盐在哺乳动物中表现出抗心律失常活性。

公开(公告)号：US3814767A

公开(公告)日：1974-06-04

申请号：US24222772

申请日：1972-04-07

Applicant: MILES LAB

Inventor： WARD F

IPC: C07C45/73 ,  C07D295/10 ,  C07D295/116 ,  C07D51/70

CPC classification number: C07D295/116 ,  C07D295/10

Abstract: A PROCESS FOR THE SYNTHESIS OF BICYCLO ALKYL DERIVATIVES OF THE STRUCTUAL FORMULA:

2,6-(-CH2-X-CH2-),2-R4,3-R1,4-R2,5-R5-CYCLOHEXANONE

IN WICH R1 IS H OR PHENYL, R2 IS H OR ALKYL, R4 IS H PHENYL OR SUBSTITUTED PHENYL IN WHICH THE SUBSTITUENTS ARE HALOGEN, ALKOXY, OR ALKYL, R5 IS

4-(R3-PHENYL)PIPERAZINO OR 4-(R3-PHENYL)PIPERIDINO,

R3 IS H, HALOGEN, ALKOXY OR CF3, AND X IS A POLYCARBON LOWER ALKYLENE RADICAL OF BETWEEN 0 AND 2 CARBON ATOMS INCLUSIVE, COMPRISING THE FOLLOWING REACTION SEQUENCE:

O=CH-CH(-R2)-CH(-R1)-C(-R4)
--> (- H2O) R5-CH=C(-R2)-CH(-R1)-C(-R4)
CH2-) --> (DELTA, DMF OR (I-PR-)OH, (ET-)3-N) 2,6-(-CH2-X-

CH2-),2-R4,3-R1,4-R2,5-R5-CYCLOHEXANONE

THE COMPOUNDS PREPARED ACCORDING TO THE PROCESS OF THIS INVENTION HAVE BENEFICIAL PHARMACOLOGICAL PROPERTIES.

公开(公告)号：US3814670A

公开(公告)日：1974-06-04

申请号：US24786872

申请日：1972-04-26

Applicant: MILES LAB

Inventor： FREAKE R ,  HADEN B

IPC: C12M1/34 ,  C12M1/16 ,  C12M1/20 ,  C12B1/00

CPC classification number: C12M23/04 ,  C12M25/14 ,  C12Q1/04 ,  G01N33/52 ,  Y10S435/805

Abstract: TEST ARTICLE FOR USE IN CULTURING, DETECTING AND ANALYZING MICROORGAISM COMPRISING AN ABSORBENT WEB AND A SUBSTANTIALLY DRY, STABLE, CONTINUOUS LAYER OF A GEL SUCH AS AGAR OR GELATIN JOINED IN LAMINAR RELATIONSHIP THEREWITH BY A CONTINUOUS INTERFACE INTERGAL WITH SAID WEB AND GEL LAYER AND COMPRISING A COMPOSITE OF THE WEB AND GEL LAYER SAID DEVICE MAY BE ADDITIONALLY COMPRISED OF ONE OR MORE SUBSTANTIALLY DRY, STABLE, CNTINUOUS OVERLAYERS OF A GEL POSITIONED IN LAMINAR RELATIONSHIP WITH THE INITIAL GEL LAYER. SUCH GEL OVERLAYER IS PREFERABLY INCORPORATED WITH A REAGENT WHICH INCLUDES MICROBIOLOGICAL NUTRIENT MEDIA, BACKGROUND DYES AND COLOR INDICATORS.

公开(公告)号：US3811840A

公开(公告)日：1974-05-21

申请号：US81193569

申请日：1969-04-01

Applicant: MILES LAB

Inventor： BAUER R ,  ROSENFIELD R ,  RUPE C

IPC: C12Q1/54 ,  G01N31/22 ,  G01N33/52 ,  G01N31/14 ,  G01N33/00 ,  G01N33/16

CPC classification number: C12Q1/54 ,  G01N31/22 ,  G01N33/521 ,  G01N33/525 ,  Y10T436/173845 ,  Y10T436/193333 ,  Y10T436/201666

Abstract: Test device for detecting low concentrations of substances in test fluids comprising an absorbent wick having a substantially flat surface portion enclosed in a fluid impervious sheath having an aperture of predetermined limited area formed therein, the aperture being contiguous to and exposing a predetermined limited area of the flat surface portion of the wick, which portion is incorporated with a reagent specifically reactable with the substance being detected. In use the device is immersed into the test fluid so that the aperture is submerged and the device, allowed to remain therein while the test fluid contacts the reagent area adjacent to the aperture and migrates into the remainder of the wick. The reagent is immobilized with respect to the liquid. The sheath adjacent to the wick is opaque.