公开(公告)号：US20100248926A1

公开(公告)日：2010-09-30

申请号：US12813103

申请日：2010-06-10

Applicant: Jerry Wayne Pipes ,  Wesley Steven Jones ,  Randy Lee McKnight

Inventor： Jerry Wayne Pipes ,  Wesley Steven Jones ,  Randy Lee McKnight

IPC: B31B1/62

CPC classification number: B65D85/1045 ,  B31B50/006 ,  B65B19/223 ,  B65B19/228 ,  B65B51/026 ,  B65D2301/20 ,  Y10S493/911

Abstract: Systems and methods are provided for making a hard pack cigarette package composed of a transparent material that includes an inner frame that is also composed of a transparent material. The package is assembled using a hot-melt adhesive material to bind the package together as well as to bind the inner frame insert and a foil wrapped assemblage of smoking articles to the package. The hot-melt adhesive material is applied by an electronically controlled hot-melt adhesive applicator working in conjunction with a uniform contrast roller.

Abstract translation: 提供了用于制造由透明材料构成的硬包装香烟包装的系统和方法，该透明材料包括也由透明材料构成的内框架。 使用热熔粘合剂材料组装包装，以将包装件结合在一起，并将内框架插入件和箔包裹的吸烟物品组合件结合到包装上。 热熔粘合剂材料通过电子控制的热熔粘合剂涂布器施加，其与均匀的对比辊结合使用。

公开(公告)号：US07678449B2

公开(公告)日：2010-03-16

申请号：US11548361

申请日：2006-10-11

Applicant: Steven Jones

Inventor： Steven Jones

IPC: B05D1/38 ,  B05D3/02 ,  B32B5/16

CPC classification number: C09C1/0015 ,  C01G49/0018 ,  C01P2002/72 ,  C01P2004/20 ,  C01P2006/42 ,  C01P2006/60 ,  C09C1/0021 ,  C09C2200/1004 ,  C09C2200/102 ,  C09C2200/1087 ,  C09C2200/407 ,  C09C2200/408 ,  C09C2220/103 ,  Y10S428/90 ,  Y10T428/2911 ,  Y10T428/2991 ,  Y10T428/2993

Abstract: Iridescent magnetic pigments are produced by depositing a ferrite layer and a second metal oxide layer in succession on a substrate. The substrate may be platy and is coated with the ferrite, which is then coated with the second metal oxide layer to provide interference color effect. At least one of the layers is magnetic. The magnetic pigment may be used in coatings such as paints.

Abstract translation: 彩色磁性颜料通过在衬底上相继沉积铁素体层和第二金属氧化物层来制备。 衬底可以是板状的并且被铁氧体涂覆，然后用第二金属氧化物层涂覆以提供干涉色彩效果。 至少一层是磁性的。 磁性颜料可用于涂料如油漆。

公开(公告)号：US07622112B2

公开(公告)日：2009-11-24

申请号：US10581613

申请日：2004-12-06

Applicant: Jody Berry ,  Steven Jones ,  Xin Yong Yuan ,  Mike Gubbins ,  Anton Andonov ,  Hana Weingartl ,  Mike Drebot ,  Frank Plummer

Inventor： Jody Berry ,  Steven Jones ,  Xin Yong Yuan ,  Mike Gubbins ,  Anton Andonov ,  Hana Weingartl ,  Mike Drebot ,  Frank Plummer

IPC: A61K39/42 ,  C12N15/09 ,  C12N15/13 ,  C12P21/08 ,  C12P21/00 ,  C07K16/10 ,  C07K16/46

CPC classification number: C07K16/10 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/76 ,  G01N33/56983

Abstract: Monoclonal antibody reagents that recognize the SARS-coronavirus (SARS-HCoV) are needed urgently. In this report we describe the development and immunochemical characterization of mAbs against the SARS-HCoV based upon their specificity, binding requirements, and biological activity. Initial screening by ELISA, using highly purified virus as the coating antigen, resulted in the selection of seventeen mAbs. Five mAbs exhibited Western immunoblot reactivity with the denatured spike protein, of which two demonstrated the ability to neutralize SARS-HCoV in vitro. Another four Western immunoblot-negative mAbs also neutralize the virus. These antibodies will be useful for the development of diagnostic tests, pathogenicity and vaccine studies.

Abstract translation: 迫切需要识别SARS冠状病毒（SARS-HCoV）的单克隆抗体试剂。 在本报告中，我们根据其特异性，结合要求和生物活性，描述mAb对SARS-HCoV的发展和免疫化学表征。 通过ELISA进行初步筛选，使用高度纯化的病毒作为包被抗原，导致17个mAb的选择。 5个mAb显示出与变性穗蛋白的Western免疫印迹反应性，其中两个显示出在体外中和SARS-HCoV的能力。 另外四种Western免疫印迹阴性mAb也中和了病毒。 这些抗体可用于诊断测试，致病性和疫苗研究的开发。

公开(公告)号：US20080230410A1

公开(公告)日：2008-09-25

申请号：US11726713

申请日：2007-03-22

Applicant: Wesley Steven Jones ,  Pankaj Patel

Inventor： Wesley Steven Jones ,  Pankaj Patel

IPC: B65D85/10

CPC classification number: B65D85/1045 ,  B65D5/4291 ,  B65D5/6691 ,  B65D2203/12

Abstract: A hard pack cigarette package includes an inner frame with fold-over tabs at the top of the inner frame shoulders that overlap an opposing flap in the hinged lid of the package. When the lid is opened or closed, the tabs and opposing flap disengage with an audible click sound. The force required to disengage the tabs and flap help to retain the lid in a secured closed position.

Abstract translation: 硬包装香烟包装件包括内框架，其内侧框架顶部具有与包装铰链盖中的相对的折叠片重叠的折叠突出部。 当盖打开或关闭时，突舌和相对的舌片与可听见的咔嗒声一起脱离。 解除接头和挡板所需的力有助于将盖子保持在固定的关闭位置。

公开(公告)号：US07390796B2

公开(公告)日：2008-06-24

申请号：US11599124

申请日：2006-11-14

Applicant: Mark G. Currie ,  Steven Jones ,  Charles M. Zepp

Inventor： Mark G. Currie ,  Steven Jones ,  Charles M. Zepp

IPC: A61K31/56 ,  C07J5/00

CPC classification number: C07J5/00 ,  C07J5/0076 ,  C07J5/0092 ,  C07J71/0031 ,  Y10S514/826 ,  Y10S514/886

Abstract: Compounds are disclosed of the formula in which R3 is C8 to C24 hydrocarbon or the residue of misoprostol. The compounds are useful for treating rhinitis and asthma, particularly by inhalation, and for treating inflammation, particularly by local or topical administration.

Abstract translation: 公开了下列化学式的化合物，其中R 3为C 8 -C 24烃或米索前列醇的残基。 该化合物可用于治疗鼻炎和哮喘，特别是通过吸入治疗和治疗炎症，特别是通过局部或局部给药治疗炎症。

公开(公告)号：US20080093233A1

公开(公告)日：2008-04-24

申请号：US11717585

申请日：2007-03-12

Applicant: Wesley Steven Jones ,  Pankaj Patel

Inventor： Wesley Steven Jones ,  Pankaj Patel

IPC: A24F15/02

CPC classification number: B65D77/042 ,  B65D85/1072

Abstract: An assembled container for smoking articles includes an outer sleeve that includes a front wall, a rear wall, a right side wall, and a left side wall. Packets of cigarettes are positioned within the outer sleeve. For example, two packets, each containing ten cigarettes, are positioned within the outer sleeve. The packets, and the outer sleeve, may include mechanisms that interact during movement of the individual packets within the outer sleeve.

Abstract translation: 用于吸烟物品的组装容器包括外套筒，其包括前壁，后壁，右侧壁和左侧壁。 卷烟被定位在外套筒内。 例如，每个包含十支香烟的两个包被定位在外套筒内。 分组和外套筒可以包括在外套筒内的各个分组的移动期间相互作用的机构。

公开(公告)号：US20080025980A1

公开(公告)日：2008-01-31

申请号：US11854160

申请日：2007-09-12

Applicant: Britta Hardy ,  Steven Jones ,  Leah Klapper

Inventor： Britta Hardy ,  Steven Jones ,  Leah Klapper

IPC: A61K39/395 ,  A61P37/02

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/73

Abstract: The present invention provides to a humanized monoclonal antibody having immunostimulatory effects. This antibody binds specifically to B lymphoblastoid cells, induces proliferation and activation of peripheral blood lymphocytes, particularly T cells, and is capable of eliciting an anti-tumor effect upon administration to subjects suffering from cancer.

Abstract translation: 本发明提供具有免疫刺激作用的人源化单克隆抗体。 该抗体特异性结合B淋巴母细胞，诱导外周血淋巴细胞，特别是T细胞的增殖和激活，并且能够在给予患有癌症的受试者时引发抗肿瘤作用。

公开(公告)号：US20080004327A1

公开(公告)日：2008-01-03

申请号：US11772798

申请日：2007-07-02

Applicant: Michele Heffernan ,  Robert Foglesong ,  Seth Hopkins ,  Mustapha Soukri ,  Steven Jones ,  Kerry Spear ,  Mark Varney

Inventor： Michele Heffernan ,  Robert Foglesong ,  Seth Hopkins ,  Mustapha Soukri ,  Steven Jones ,  Kerry Spear ,  Mark Varney

IPC: A61K31/407 ,  C07D491/02

CPC classification number: C07D495/04 ,  C07D491/04

Abstract: This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. The invention also provides methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure: wherein A is NH or S. Q is a member selected from CR1 and N. X and Y are members independently selected from O, S, CR2, N and NH. R1, R2 and R4 are members independently selected from H and F, provided that at least one member selected from R1, R2 and R4 is F. R6 is a member selected from O−X+ and OH, wherein X+ is a positive ion, which is a member selected from inorganic positive ions and organic positive ions.

Abstract translation: 本发明提供了D-氨基酸氧化酶酶的新型抑制剂以及包含本发明化合物的药物组合物。 本发明还提供了治疗和预防神经系统疾病如神经精神和神经退行性疾病以及疼痛，共济失调和惊厥的方法。 本发明的化合物具有以下一般结构：其中A是NH或S.Q是选自CR 1和N的成员.X和Y是独立地选自O，S，CR < > 2，N和NH。 R 1，R 2和R 4都是独立地选自H和F的成员，条件是选自R 1，R 2， R 1，R 2，R 4和R 4是F.R 6是选自O - >其中X + +为​​正离子，其为选自无机正离子和有机正离子的成员。

公开(公告)号：US20070093438A1

公开(公告)日：2007-04-26

申请号：US10572004

申请日：2004-09-15

Applicant: Christophe Echeverri ,  Anthony Hyman ,  Pierre Gonczy ,  Birte Sonnichsen ,  Steven Jones ,  Andrew Walsh ,  Liisa Koski

Inventor： Christophe Echeverri ,  Anthony Hyman ,  Pierre Gonczy ,  Birte Sonnichsen ,  Steven Jones ,  Andrew Walsh ,  Liisa Koski

IPC: A61K48/00 ,  C40B40/08 ,  C40B30/06

CPC classification number: A01K67/0336 ,  A01K2217/058 ,  A01K2227/703 ,  A01K2267/0331 ,  C07K14/4738 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/12

Abstract: The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in spindle formation or microtubule function during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.

Abstract translation: 本发明涉及几种秀丽隐杆线虫基因及其相应基因产物在细胞分裂期间纺锤体形成或微管功能中的重要功能作用，可通过RNA介导的干扰（RNAi）和鉴定和分离鉴定 所述基因的功能直系同源物包括所有生物功能衍生物本发明还涉及所述基因和基因产物（包括所述直系同源物）在抗增殖剂的开发或分离中的用途，特别是其在适当的筛选测定中的用途，以及 它们用于诊断和治疗增殖性和其他疾病。 特别地，本发明涉及从所述基因衍生的小干扰RNA用于治疗增殖性疾病的用途。

公开(公告)号：US20060193872A1

公开(公告)日：2006-08-31

申请号：US10522134

申请日：2003-07-28

Applicant: Steven Jones ,  Heinz Feldman ,  Ute Stroeher

Inventor： Steven Jones ,  Heinz Feldman ,  Ute Stroeher

IPC: A61K39/12 ,  C07K14/145 ,  C07H21/04

CPC classification number: C12N7/00 ,  A61K39/12 ,  A61K2039/5256 ,  C07K14/005 ,  C12N2760/10034 ,  C12N2760/14134 ,  C12N2760/14234 ,  C12N2760/20221 ,  C12N2760/20222 ,  C12N2760/20232 ,  C12N2760/20243 ,  Y02A50/386

Abstract: Recombinant VSV viral particles and the use thereof as vaccines for immunization are described.

Abstract translation: 描述了重组VSV病毒颗粒及其作为免疫疫苗的用途。