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91.发明申请Method and system for updating data on an information appliance based on changes in local and remote data sources 审中-公开根据本地和远程数据源的变化更新信息设备上的数据的方法和系统公开(公告)号：US20030187964A1
公开(公告)日：2003-10-02
申请号：US10002897
申请日：2001-10-31
发明人： Meurig Sage , Philip D. Gray
IPC分类号： G06F015/177
CPC分类号： H04L67/1095 , G06F16/273 , G06F16/951 , H04L67/34 , H04L69/329
摘要： A method and system for updating data on an information appliance based on changes in local and remote data sources. The information appliance contains a set of rules These rules allow it to define links between its existing data and local and remote data sources. Using these links it can automatically gather data from these sources using context sensitive queries that are directly relevant to the current state of the information appliance. These updates can modify any data items within the system. These updates can either directly alter these data items or modify metadata about the data items, such as the set of possible values for the item. They can do this implicitly and immediately, or explicitly after the user reviews a summary of the new data and chooses to add the information using a single action. The links themselves are data items within the system. These links are defined using a structured representation and so can themselves be sent around the network. The application can therefore use the same mechanism to ask for both basis data and link specifications which can be used to gather further data. Embodiments of the invention are described.
摘要翻译： 一种基于本地和远程数据源的变化更新信息设备上的数据的方法和系统。 信息设备包含一组规则这些规则允许它定义其现有数据与本地和远程数据源之间的链接。 使用这些链接，它可以使用与信息设备的当前状态直接相关的上下文相关查询来自动收集来自这些来源的数据。 这些更新可以修改系统内的任何数据项。 这些更新可以直接更改这些数据项或修改关于数据项的元数据，例如项目的可能值集合。 他们可以在用户查看新数据的摘要之后隐含地立即或明确地执行此操作，并选择使用单个操作添加信息。 链接本身是系统内的数据项。 这些链接使用结构化表示进行定义，因此本身可以在网络周围发送。 因此，应用程序可以使用相同的机制来询问可用于收集更多数据的基础数据和链接规范。 对本发明的实施例进行说明。
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公开(公告)号：US20030053789A1
公开(公告)日：2003-03-20
申请号：US10047308
申请日：2002-01-15
发明人： John Haig Marsh , Craig James Hamilton , Olek Peter Kowalski , Stuart Duncan McDougall , Xuefeng Liu , Bo-Cang Qui
IPC分类号： G02B006/10 , C23C014/32 , G02B006/00
CPC分类号： B82Y20/00 , H01L21/182 , H01S5/3413
摘要： There is disclosed an improved method of manufacturing an optical device using impurity induced Quantum Well Intermixing (QWI) process. Reported QWI, and particularly Impurity Free Vacancy Diffusional (IFVD) methods, suffer from a number of disadvantages, eg the temperature at which Gallium Arsenide (GaAs) out-diffuses from the semiconductor material to the Silica (SiO2) film. Accordingly, the present invention provides a method of manufacturing an optical device, a device body portion (5a) from which the device is to be made including at least on Quantum Well (QW) (10a), the method including the steps of: causing an impurity material to intermix with the at least one Quantum Well (QW) (10a), wherein the impurity material at least includes Copper (Cu).
摘要翻译： 公开了使用杂质诱导量子阱混合（QWI）工艺制造光学器件的改进方法。 报告的QWI，特别是无杂质空闲扩散（IFVD）方法存在许多缺点，例如砷化镓（GaAs）从半导体材料扩散到二氧化硅（SiO 2）膜的温度。 因此，本发明提供了一种制造光学器件的方法，至少包括量子阱（QW）（10a））的器件本体部分（5a），该器件主体部分（5a）包括以下步骤：引起 与所述至少一个量子阱（QW）（10a）混合的杂质材料，其中所述杂质材料至少包括铜（Cu）。
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公开(公告)号：US12129235B2
公开(公告)日：2024-10-29
申请号：US17251712
申请日：2019-06-21
申请人： The University Court of the University of Glasgow , The University Court of the University of Edinburgh
IPC分类号： C07D215/48 , A61K51/04
CPC分类号： C07D215/48 , A61K51/04 , C07B2200/05
摘要： The invention provides a compound of formula (I), and salts, solvates and radiolabelled forms thereof, together with complexes of the compound of formula (I) with TSPO, and methods for forming such complexes, and methods for detecting the compound of formula (I), such as in complex with TSPO.
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公开(公告)号：US20240350162A1
公开(公告)日：2024-10-24
申请号：US18292766
申请日：2022-07-29
发明人： Nicola Giuseppe FENU , Sandy COCHRAN , Margaret LUCAS , Rupert SHINGLETON , Rebecca Shirley CLEARY
CPC分类号： A61B17/320068 , A61B2017/00137 , A61B2017/320074
摘要： An ultrasonic transducer for surgical applications is disclosed. The ultrasonic transducer comprises: a back mass; a front mass; an ultrasonic actuator arrangement held between the back mass and the front mass; and an ultrasonic horn arrangement forward of the front mass. The back mass, ultrasonic actuator arrangement, front mass and ultrasonic horn arrangement are arranged along a longitudinal axis of the transducer. Vibrations generated by the ultrasonic actuator arrangement are conducted into the front mass and into the ultrasonic horn arrangement along a vibrational energy transfer path and are amplitude amplified by the ultrasonic horn arrangement. One or more of the back mass, front mass and ultrasonic horn arrangement includes a plurality of openings opening towards the longitudinal axis and intersecting the vibrational energy transfer path and configured to provide an increased mechanical compliance in a direction along the vibrational energy transfer path.
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95.发明公开公开(公告)号：US20240344149A1
公开(公告)日：2024-10-17
申请号：US18290974
申请日：2022-07-15
IPC分类号： C12Q1/6888 , G16H20/40
CPC分类号： C12Q1/6888 , G16H20/40 , C12Q2600/106 , C12Q2600/158
摘要： The invention relates to a method of predicting a response of a prostate cancer subject to radiotherapy, comprising determining or receiving the result of a determination of a gene expression profile for each of three or more PDE4D7 knockdown differentially expressed genes selected from the group consisting of: ACPP, AR, CDH1, EHF, ETV1, FOLH1, FOXA1, HOXB13, KLK2, KLK3, MAOA, MLH1, MME, MYO6, NAALADL2, NKX3-1, NQO1, NRP1, SLC45A3, SPDEF, ATM, ATR, BRCA1, BR-CA2, CDK12, FANCA, MRE11 and PALB2, said gene expression profiles being determined in a biological sample obtained from the subject, and determining the prediction of the radiotherapy response based on the gene expression profiles for the three or more PDE4D7 knockdown genes, wherein the radiotherapy is radical radiotherapy or salvage radiotherapy.
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公开(公告)号：US20240165270A1
公开(公告)日：2024-05-23
申请号：US18503439
申请日：2023-11-07
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH , THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW
CPC分类号： A61K48/0066 , A61K9/0019 , A61K9/0085 , A61P25/14 , C07K14/001 , C07K14/4703 , C12N7/00 , C12N15/86 , A61K38/00 , C12N2750/14143
摘要： MECP2 EXPRESSION CASSETTES. The present invention provides nucleic acid molecules comprising a MeCP2 expression cassette, the expression cassette comprising, in operable linkage from 5′ to 3′: a 5′ transcriptional control region comprising a promoter capable of driving transcription in neural cells; an open reading frame encoding a MeCP2 protein; translation control signals; a 3′ untranslated region (3′UTR) comprising one or more of: (i) a binding site for mir-22; (ii) a binding site for mir-19; (iii) a binding site for miR-132; (iv) a binding site for miR124; and (v) an AU-rich element; and transcriptional termination signals; wherein the MeCP2 expression cassette is not more than about 5 kb in length. The invention further provides viral vectors, especially vectors derived from adeno-associated virus (AAV), for use in therapeutic delivery of such expression cassettes. The nucleic acid molecules and viral vectors disclosed herein provide novel tools for expressing MeCP2 and are of particular value in the treatment of disorders associated with reduced MeCP2 activity, including Rett syndrome.
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公开(公告)号：US20230296645A1
公开(公告)日：2023-09-21
申请号：US18014715
申请日：2021-07-05
发明人： Thomas McMullen , Richard Bates
CPC分类号： G01R1/06744 , C23F4/00 , G01R1/06755 , G01R3/00
摘要： The present invention relates primarily to a method of fabrication of one or more free-standing micromachined parts. The method includes performing reactive ion etching of photoresist and tungsten-based layers supported on a carrier substrate to thereby define one or more micromachined parts, followed by separating the resulting one or more micromachined parts from the carrier substrate such that the parts are free-standing. The invention also relates to tungsten-based microprobe obtainable by such a method, wherein the microprobe has a substantially square or rectangular cross-section in a direction perpendicular to a longitudinal axis of the microprobe, and to probe cards comprising a plurality of such microprobes.
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公开(公告)号：US20230184924A1
公开(公告)日：2023-06-15
申请号：US17766760
申请日：2020-10-07
申请人： ECOLE NATIONALE SUPERIEURE DE L'ELECTRONIQUE ET DE SES APPLICATIONS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW , CY CERGY PARIS UNIVERSITÉ
IPC分类号： G01S13/89 , G06V10/764 , G08B21/04
CPC分类号： G01S13/89 , G06V10/764 , G08B21/0446
摘要： The invention discloses a device (1) for characterizing in real time the actimetry of a subject, having: a radar (2) emitting and receiving radar signals, and having a software interface for configuring the shape of the signal emitted; processing and computing means (3) coupled to the radar (2), having a trained classifier (3a) using a database, said processing and computing means (3) being configured to perform in real time: —a capture of color micro-Doppler images (6) having several color channels (R, V, B), each having micro-Doppler signatures (6a) with color pixels the value of which is a function of a reflectivity and a speed of the subject; —a processing of the micro-Doppler images (6) for: computing a so-called monochromatic image having monochromatic pixels, each having a given monochromatic intensity, on the basis of the color pixels of each color micro-Doppler image; transforming the monochromatic image into a binary image by segmentation, according to a binary luminous intensity threshold, of the monochromatic pixels, producing binary pixels, the value of which is dependent on the chromatic intensity of the monochromatic pixel associated with the binary pixel, with respect to the threshold.
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公开(公告)号：US20230183868A1
公开(公告)日：2023-06-15
申请号：US18086364
申请日：2022-12-21
发明人： Leroy Cronin , Mark Symes , Jia-Jia Chen
摘要： A method is disclosed of manufacturing a semiconductor structure comprising an (001) oriented zincblende structure group III-nitride layer, such as GaN. The layer is formed on a 3C-SiC layer on a silicon substrate. A nucleation layer is formed, recrystallized and then the zincblende structure group III-nitride layer is formed by MOVPE at temperature T3 in the range 750-1000° C., to a thickness of at least 0.5μ. There is also disclosed a corresponding semiconductor structure comprising a zincblende structure group III-nitride layer which, when characterized by XRD, shows that the substantial majority, or all, of the layer is formed of zincblende structure group III-nitride in preference to wurtzite structure group III-nitride.
The present invention provides methods for producing hydrogen using a mediator that is capable of reversibly donating and accepting four or more electrons. A method of the invention comprises the steps of reducing a mediator by four or more electrons to yield a reduced mediator, and oxidising a reduced mediator to yield a mediator, and reducing protons to yield hydrogen.-
公开(公告)号：US20230129380A1
公开(公告)日：2023-04-27
申请号：US17912382
申请日：2021-03-19
发明人： Leroy Cronin
摘要： The present invention provides a method for estimating the molecular complexity of a sample, for example to determine whether biotic or synthetic components are present in the sample. The method comprises the steps of (a) performing one of MS/MS, NMR or IR on a sample; (b) determining the unique peaks in the resulting spectrum; and (c) calculating the molecular assembly index of the sample based on the number of unique peaks in the spectrum.
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