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公开(公告)号：US12016692B2
公开(公告)日：2024-06-25
申请号：US17379702
申请日：2021-07-19
发明人： Hadi Heidari , Siming Zuo
CPC分类号： A61B5/242 , A61B5/7203 , A61B5/725 , G01R33/0023 , G01R33/098 , A61B2562/0223
摘要： A readout integrated circuit (IC) architecture for a tunnelling magnetoresistive (TMR) sensor which uses common mode feedback to achieve a performance level suitable for accurate detection of biomagnetic signals. The architecture uses a three-operational amplifier configuration with chopper stabilization. The architecture may form part of a fully integrated biomagnetic sensor electronics package that includes an array of TMR sensors together with modules for signal amplification and conditioning, data conversion and communication.
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公开(公告)号：US20240158452A1
公开(公告)日：2024-05-16
申请号：US18500492
申请日：2023-11-02
发明人： Richard Maizels , Danielle Smyth , Henry McSorley
IPC分类号： C07K14/435 , A61K35/17 , A61P37/06 , C07K14/495 , C12N5/0783
CPC分类号： C07K14/4354 , A61K35/17 , A61P37/06 , C07K14/495 , C12N5/0637 , A61K38/00
摘要： The present invention concerns a structurally distinct immunosuppressive mimic of TGF-β that is a potent inducer of murine and human regulatory T cells and provides a therapeutic agent for the treatment of inflammatory disorders. Disclosed herein is a novel parasite TGF-β mimic which fully replicates the biological and functional properties of TGF-β, including binding to mammalian TGF-β receptors and inducing Foxp3+ Treg in both murine and human CD4+ T cells. This TGF-β mimic shares no homology to mammalian TGF-β or other members of the TGF-β family, but s distinctly related to the component control protein (CCP) superfamily.
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公开(公告)号：US11866467B2
公开(公告)日：2024-01-09
申请号：US16636215
申请日：2018-08-03
发明人： Richard Maizels , Danielle Smyth , Henry McSorley
IPC分类号： C07K14/435 , A61P37/06 , A61K35/17 , C07K14/495 , C12N5/0783 , A61K38/00
CPC分类号： C07K14/4354 , A61K35/17 , A61P37/06 , C07K14/495 , C12N5/0637 , A61K38/00 , C07K2319/00 , C12N2501/15
摘要： The present invention concerns a structurally distinct immunosuppressive mimic of TGF-β that is a potent inducer of murine and human regulatory T cells and provides a therapeutic agent for the treatment of inflammatory disorders. Disclosed herein is a novel parasite TGF-β mimic which fully replicates the biological and functional properties of TGF-β, including binding to mammalian TGF-β receptors and inducing Foxp3+ Treg in both murine and human CD4+ T cells. This TGF-β mimic shares no homology to mammalian TGF-β or other members of the TGF-β family, but s distinctly related to the component control protein (CCP) superfamily.
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公开(公告)号：US11851773B2
公开(公告)日：2023-12-26
申请号：US18086364
申请日：2022-12-21
发明人： Leroy Cronin , Mark Symes , Jia-Jia Chen
摘要： A method is disclosed of manufacturing a semiconductor structure comprising an (001) oriented zincblende structure group III-nitride layer, such as GaN. The layer is formed on a 3C-SiC layer on a silicon substrate. A nucleation layer is formed, recrystallized and then the zincblende structure group III-nitride layer is formed by MOVPE at temperature T3 in the range 750-1000° C., to a thickness of at least 0.5μ. There is also disclosed a corresponding semiconductor structure comprising a zincblende structure group III-nitride layer which, when characterized by XRD, shows that the substantial majority, or all, of the layer is formed of zincblende structure group III-nitride in preference to wurtzite structure group III-nitride.
The present invention provides methods for producing hydrogen using a mediator that is capable of reversibly donating and accepting four or more electrons. A method of the invention comprises the steps of reducing a mediator by four or more electrons to yield a reduced mediator, and oxidising a reduced mediator to yield a mediator, and reducing protons to yield hydrogen.-
5.发明授权公开(公告)号：US11742629B2
公开(公告)日：2023-08-29
申请号：US16966337
申请日：2019-02-05
申请人： THE UNIVERSITY OF SUSSEX , THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW , INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人： Benjamin Wetzel , Michael Kues , Christian Reimer , Robin Helsten , Piotr Roztocki , Yoann Jestin , Roberto Morandotti
CPC分类号： H01S3/10046 , G02F1/35 , H01S3/0057 , H01S3/0092 , H01S3/06791 , H01S3/1305 , H01S3/136 , G02F1/3503 , G02F1/3528
摘要： A method and a system for controlling an output of an optical system, the method comprising generating a plurality of optical signal components having different optical properties and passing the generated optical signal components as input to an optical system comprising an optical device and/or an optical medium; an output of the optical system being based on interactions of the signal components within the optical device and/or the optical medium; and relative proportions of the optical signal components that are generated and individual optical properties thereof being selected to control the output of the optical system.
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公开(公告)号：US20230160850A1
公开(公告)日：2023-05-25
申请号：US17917965
申请日：2021-04-08
IPC分类号： G01N27/414 , B01L3/00
CPC分类号： G01N27/4148 , B01L3/5027 , B01L2300/0663 , B01L2400/0406
摘要： A biomarker detection apparatus in which a CMOS-based chip is used to generate independent detection signals from a reaction zone that receives a biological sample, where the biological sample is provided to both a test region and positive and negative control regions within the reaction zone. The independent detection signals can be processed together (i.e. as a group of input parameters for an algorithm) to identify the presence of a biomarker (or a plurality of biomarkers) in a biological sample. The use of sample-specific, independently detectable positive and negative controls facilitates improved detection accuracy.
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公开(公告)号：US20230149882A1
公开(公告)日：2023-05-18
申请号：US17919508
申请日：2021-04-19
发明人： Leroy CRONIN
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J19/004 , B01J2219/00389 , B01J2219/00394 , B01J2219/00686 , B01J2219/00689 , B01J2219/00695 , B01J2219/00698 , B01J2219/00722 , B01J2219/00725
摘要： Provided is a fluid handling device having multiple flow pathways through the device. The device has a fluid directing manifold comprising an array of interconnected multi-directional valves, and a plurality of ports in fluid connection with the array. The device also has a controller to set the position of the multi-directional valves. The manifold is configured to provide at least two independent flow paths between a pair of ports within the manifold. Also provided is a method of using the device, and an automated chemical synthesis platform comprising the device.
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公开(公告)号：US11643442B2
公开(公告)日：2023-05-09
申请号：US15512548
申请日：2015-09-22
发明人： Daniel Walker , Laura McCaughey
CPC分类号： C07K14/21 , A61K38/164 , A61K9/0073 , A61K38/00
摘要： The treatment of bacterial respiratory infections using bacterially-originating antibiotics known as pyocins. In particular, S type pyocins are administered by pulmonary administration for the treatment of such infections.
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公开(公告)号：US11572629B2
公开(公告)日：2023-02-07
申请号：US16964557
申请日：2019-01-24
发明人： Leroy Cronin , Mark Symes , Jia-Jia Chen
摘要： The present invention provides methods for producing hydrogen using a mediator that is capable of reversibly donating and accepting four or more electrons. A method of the invention comprises the steps of reducing a mediator by four or more electrons to yield a reduced mediator, and oxidising a reduced mediator to yield a mediator, and reducing protons to yield hydrogen.
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公开(公告)号：US20220389414A1
公开(公告)日：2022-12-08
申请号：US17772169
申请日：2020-10-28
申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO , WISCONSIN ALUMNI RESEARCH FOUNDATION , THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , NORTHWESTERN UNIVERSITY
发明人： Alan ASPURU-GUZIK , Si Yue GUO , Tony Chang-Chi WU , Pascal Thomas FRIEDERICH , Randall Howard GOLDSMITH , Leroy CRONIN , Abhishek SHARMA , Yudong CAO , Nathan C. GIANNESCHI , Christopher James FORMAN
摘要： Molecular computer techniques for solving a computational problem using an array of reaction sites, for example, droplets, are disclosed. The problem may be represented as a Hamiltonian in terms of problem variables and problem parameters. The reaction sites may have a physicochemical property mapping to discrete site states corresponding to possible values of the problem variables. In a purely molecular approach, the reaction sites have intra-site and inter-site couplings enforced thereon representing the problem parameters, and the array is allowed to evolve, subjected to the enforced couplings, to a final configuration conveying a solution to the problem. In a hybrid classical-molecular approach, an iterative procedure may be performed that involves feeding read-out site states into a digital computer, determining, based on the problem parameters, perturbations to be applied to the states, and allowing the array to evolve under the perturbations to a final configuration conveying a solution to the problem.
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