公开(公告)号：US20210380650A1

公开(公告)日：2021-12-09

申请号：US17392137

申请日：2021-08-02

Applicant: The Board of Regents of the University of Texas System

Inventor： Eric N. OLSON ,  Rhonda S. BASSEL-DUBY ,  Catherine A. MAKAREWICH ,  Benjamin R. NELSON

IPC: C07K14/47 ,  A61K38/17 ,  A61K45/06 ,  A61K48/00

Abstract: The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.

公开(公告)号：US20210371508A1

公开(公告)日：2021-12-02

申请号：US17332790

申请日：2021-05-27

Applicant: The Board of Regents of the University of Texas System

Inventor： Ningyan ZHANG ,  Zhiqiang AN ,  Zhiqiang KU ,  Yihong WAN ,  Jing KRZESZINSKI

IPC: C07K16/18 ,  A61K45/06 ,  G01N33/574 ,  A61K47/68

Abstract: Provided herein are methods for treating cancer, such as breast cancer, by administering an inhibitor of NMES1. Further provided herein are NMES1 monoclonal antibodies which may be used to detect or treat cancer.

公开(公告)号：US11162063B2

公开(公告)日：2021-11-02

申请号：US16855831

申请日：2020-04-22

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Charles S. Cox, Jr. ,  Brijesh S. Gill ,  Kevin Aroom ,  Pamela Wenzel

IPC: C12M1/42 ,  C12M1/12 ,  C12M1/00 ,  C12M3/00 ,  A61K35/28 ,  C12N5/0775 ,  A61P25/00

Abstract: A bioreactor system for conditioning of pluripotent cells or cell media is provided. In further aspects, conditioned pluripotent cells and methods for making such cells are provided.

公开(公告)号：US11111278B2

公开(公告)日：2021-09-07

申请号：US16743831

申请日：2020-01-15

Applicant: The Board of Regents of the University of Texas System

Inventor： Eric N. Olson ,  Rhonda S. Bassel-Duby ,  Catherine A. Makarewich ,  Benjamin R. Nelson

IPC: C07K14/47 ,  A61K45/06 ,  A61K38/17 ,  A61K48/00

Abstract: The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.

公开(公告)号：US11093787B2

公开(公告)日：2021-08-17

申请号：US16312983

申请日：2017-06-30

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Darin T Okuda ,  Braeden D Newton

IPC: G06K9/62 ,  G06K9/34 ,  G06T7/11 ,  G06T15/08 ,  G06T17/00 ,  G16H30/40 ,  A61B5/055

Abstract: Methods, apparatuses, systems, and implementations for creating 3-dimensional (3D) representations exhibiting geometric and surface characteristics of brain lesions are disclosed. 2D and/or 3D MRI images of the brain may be acquired. Brain lesions and other abnormalities may be identified and isolated with each lesion serving as a region of interest (ROI). Saved ROI may be converted into stereolithography format, maximum intensity projection (MIP) images, and/or orthographic projection images. Data corresponding to these resulting 3D brain lesion images may be used to create 3D printed models of the isolated brain lesions using 3D printing technology. Analysis of the 3D brain lesion images and the 3D printed brain lesion models may enable a more efficient and accurate way of determining brain lesion etiologies.

公开(公告)号：US20210238564A1

公开(公告)日：2021-08-05

申请号：US17273880

申请日：2019-09-03

Applicant: The Board of Regents of the University of Texas System

Inventor： Jerry W. SHAY ,  Enzo TEDONE ,  Mohammed E. SAYED

IPC: C12N9/12 ,  G01N33/50

Abstract: The present disclosure describes purified telomerase holoenzyme and its delivery to cells, such as T cells, for increasing telomere length, increasing cell proliferation, and impeding cell senescence.

公开(公告)号：US20210236018A1

公开(公告)日：2021-08-05

申请号：US17051770

申请日：2019-04-30

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Daniel T. DeArmond ,  Lucas M. Holt ,  Andrew P. Wang

IPC: A61B5/085 ,  A61M1/04 ,  A61B5/00 ,  A61B5/11 ,  A61B5/03

Abstract: The present invention relates to systems and methods for monitoring impedance from a sensor in the chest of a subject to determine the status of lung inflation or presence of pneumothorax in the subject, the presence of pulmonary edema, the status of regional lung ventilation, and the status of cardiac contractility.

公开(公告)号：US11054423B2

公开(公告)日：2021-07-06

申请号：US16790658

申请日：2020-02-13

Applicant: VANDERBILT UNIVERSITY ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： James E. Crowe, Jr. ,  Andrew I. Flyak ,  Alexander Bukreyev ,  Philipp Ilinykh

IPC: G01N33/569 ,  A61K39/42 ,  C07K16/10 ,  G01N33/577 ,  A61K39/395 ,  G01N33/68 ,  A61K39/00

Abstract: The present disclosure is directed to antibodies binding to and neutralizing ebolavirus and methods for use thereof. The present disclosure is directed to a method of detecting an ebolavirus infection in a subject comprising (a) contacting a sample from said subject with an antibody or antibody fragment having clone-paired heavy and light chain CDR sequences from Table 2, or an antibody fragment thereof; and (b) detecting ebolavirus glycoprotein in said sample by binding of said antibody or antibody fragment to antigen in said sample. In still further embodiments, the present disclosure concerns immunodetection kits for use with the iminunodetection methods described above.

公开(公告)号：US20210196676A1

公开(公告)日：2021-07-01

申请号：US17058380

申请日：2019-05-30

Applicant: The Board of Regents of the University of Texas System

Inventor： Ellen S. VITETTA

IPC: A61K31/365 ,  A61K9/00 ,  A61K9/06 ,  A61K31/60 ,  A61K31/19 ,  A61K31/513 ,  A61K45/06 ,  A61K31/122 ,  A61K31/4745 ,  A61K31/4164 ,  A61K9/70 ,  A61P31/22 ,  A61F13/40 ,  A61M35/00 ,  A61B18/02 ,  A61B18/20 ,  A61B18/14 ,  A61B17/3205

Abstract: The present disclosure relates to the use of the sequiterpene lactones and Helenalin (H. tox) or its derivatives to treat viral infection and virally induced lesions, such as warts or wart-associated skin or mucosal lesion. A topical application, optionally using a skin covering such as gauze, a bandage, or a patch, can substantially reduce and even eliminate persistent, recurrent and/or treatment-resistant warts.

公开(公告)号：US11040959B2

公开(公告)日：2021-06-22

申请号：US16303043

申请日：2017-06-29

Applicant: The Scripps Research Institute ,  The Board of Regents of the University of Texas System ,  Bruce Beutler ,  Dale L. Boger

Inventor： Bruce Beutler ,  Dale L. Boger

IPC: C07D403/10 ,  A61P37/04

Abstract: A diprovocim compound that corresponds in structure to structural Formula V is disclosed, wherein A, W, Z, R1, R2, R3 and R4 (when present) are defined within. A diprovocim compound has immune-adjuvant properties on human and mouse cells in culture and on in vivo immunization of mice. A composition containing a diprovocim and a method of using a compound are also disclosed. The immunostimulatory activity of a diprovocim compound is similar to that of LPS, to which there is no apparent structural similarity. A contemplated compound bears no structural similarity to either the TLR1/TLR2 lipoprotein agonists nor to any other synthetic TLR agonist, and is remarkably easy to prepare and synthetically modify.