公开(公告)号：US20230288238A1

公开(公告)日：2023-09-14

申请号：US18115525

申请日：2023-02-28

Applicant: MITSUBISHI HEAVY INDUSTRIES, LTD. ,  Tokyo University of Science Foundation

Inventor： Shunsuke MIZUMI ,  Naoto OMURA ,  Masahiro MOTOSUKE ,  Daiki SHIRAISHI ,  Koichi MURAKAMI

IPC: G01F1/684 ,  G01F1/688

CPC classification number: G01F1/6842 ,  G01F1/6888

Abstract: The sensor of a fluid sensor system includes an outer peripheral sensor unit including three or more sensor pairs to surround and sandwich the heating element. The computing device of the system includes a first identification unit identifies a sensor pair in which an output difference between an output value corresponding to a temperature detected by one temperature sensor of the sensor pair and an output value corresponding to a temperature detected by the other temperature sensor of the sensor pair is largest, a second identification unit identifies other sensor pairs adjacent to the identified sensor pair in the circumferential direction, and a flow direction estimation unit estimates the flow direction of the fluid on the basis of the output difference in the sensor pair having the largest output difference and output differences in the other sensor pairs adjacent to the sensor pair in the circumferential direction.

公开(公告)号：US11718590B2

公开(公告)日：2023-08-08

申请号：US17557751

申请日：2021-12-21

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION ,  JEOL Ltd.

Inventor： Tatsuya Higashi ,  Shoujiro Ogawa ,  Masaki Takiwaki ,  Seketsu Fukuzawa

IPC: C07D249/12

CPC classification number: C07D249/12

Abstract: A compound represented by Chemical formula 1:




wherein n is an integer of 2 or more, is provided. Also provided is a derivatization reagent for derivatizing a diene-containing compound, including a compound represented by Chemical formula 1. Further provided is a synthesis method for a compound, including a nucleophilic substitution reaction between an aryl halide and a heterocyclic amine compound being saturated, the compound being represented by Chemical formula 1.

公开(公告)号：US20230220022A1

公开(公告)日：2023-07-13

申请号：US18092737

申请日：2023-01-03

Applicant: The University of Tokyo ,  ONO PHARMACEUTICAL CO., LTD. ,  TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Kouji MATSUSHIMA ,  Satoshi UEHA ,  Shungo DESHIMARU ,  Chang-Yu CHEN ,  Shoji YOKOCHI ,  Yoshiro ISHIWATA ,  Shiro SHIBAYAMA

IPC: C07K14/47 ,  A61P35/00 ,  A61K38/00

CPC classification number: C07K14/47 ,  A61P35/00 ,  A61K38/00

Abstract: Disclosed are a novel therapeutic means effective and practical against cancer, and a novel substance useful as such a therapeutic means. Provided are novel peptides derived from a partial region of HMGN1, HMGN2, HMGN4 or HMGN5, and anti-cancer agents and anti-cancer effect enhancers containing the peptide as an active ingredient. The peptide of the present invention has an anti-tumor effect even independently, and exerts a remarkably excellent anti-tumor effect particularly when used in combination with an immune checkpoint regulator, or an anti-CD4 antibody or antigen-binding fragment thereof.

公开(公告)号：US20230037023A1

公开(公告)日：2023-02-02

申请号：US17794025

申请日：2020-12-23

Applicant: Tokyo University of Science Foundation ,  Nagase & Co., Ltd.

Inventor： Keiichi Iwamura ,  Kitahiro Kaneda

IPC: H04L9/08

Abstract: A registration device of an individual identification system that includes the registration device, a verification device, and an identification device and that identifies an individual identification target, the registration device including: a registration unit that outputs verification information enabling verification of an identification key that is unique to the identification target, by using, as inputs, an input signal that depends on at least one of a physical property and an image feature of the identification target, and non-physical information that does not depend on the physical property and that differs for each identification target.

公开(公告)号：US20220356462A1

公开(公告)日：2022-11-10

申请号：US17625918

申请日：2020-07-10

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Kouji MATSUSHIMA ,  Satoshi UEHA ,  Shigeyuki SHICHINO ,  Satoru ITO ,  Hiroyasu AOKI

IPC: C12N15/10 ,  C12Q1/6874

Abstract: A nucleic acid amplification method using a solid-phase carrier according to the present invention comprises: capturing a target nucleic acid comprising mRNA on a solid-phase carrier; carrying out complementary-strand synthesis on the solid phase; carrying out exonuclease treatment to degrade and remove unreacted target- capturing nucleic acid on the solid phase; and then carrying out mRNA degradation and homopolymer addition by TdT reaction in the presence of a chain-terminating nucleotide triphosphate. According to the method of the present invention, cDNA can be stably and highly efficiently amplified even from a small amount of sample even in cases where the ratio of the amount of enzyme to the DNA substrate on the solid phase is excessive, where the reaction time is excessive, and/or where reagents show lot-to-lot variation. Further, the amplification method of the present invention can broaden the range of applications of techniques in which analysis using a specific-binding molecule labeled with an oligonucleic acid such as a DNA-labeled antibody and analysis of transcripts are carried out simultaneously.

公开(公告)号：US11472109B2

公开(公告)日：2022-10-18

申请号：US16485711

申请日：2018-02-13

Applicant: Nihon University ,  Tokyo University of Science Foundation

Inventor： Masahito Ueda ,  Ryosuke Matsuzaki ,  Yoshiyasu Hirano

IPC: B29C64/336 ,  B33Y30/00 ,  B29C64/118 ,  B29C64/209

Abstract: A three-dimensional printing apparatus (1) allowing a linear filament (F) in which a fiber bundle (C) is impregnated with resin (P) to be continuously ejected includes twisting means (6) for allowing a total amount of twisting of the filament (F) or an amount of twisting of the fiber bundle (C) to be changed.

公开(公告)号：US20220146929A1

公开(公告)日：2022-05-12

申请号：US17452343

申请日：2021-10-26

Applicant: TOKYO OHKA KOGYO CO., LTD. ,  Tokyo University of Science Foundation

Inventor： Kunihiro Noda ,  Dai Shiota ,  Koji Arimitsu

IPC: G03F7/004 ,  G03F7/075 ,  C07D233/60 ,  C07D311/86 ,  C07F9/06

Abstract: An energy-sensitive composition including a polysilane, a base generator, and a solvent, the base generator including a compound represented by formula (b1) and a photo base generator: in which Rb1 to Rb3 each independently represents a hydrogen atom, halogen atom, hydroxyl group, mercapto group, sulfide group, silyl group, silanol group, nitro group, nitroso group, sulfonato group, phosphino group, phosphinyl group, phosphonato group or organic group; Rb4 and Rb5 each independently represent a hydrogen atom, halogen atom, hydroxyl group, mercapto group, sulfide group, silyl group, silanol group, nitro group, nitroso group, sulfino group, sulfo group, sulfonato group, phosphino group, phosphinyl group, phosphono group, phosphonato group or aliphatic group; and Rb6 represents a hydrogen atom, alkyl group or alkoxy group.

公开(公告)号：US20220022395A1

公开(公告)日：2022-01-27

申请号：US17309843

申请日：2019-12-25

Applicant: Tokyo University of Science Foundation

Inventor： Kazuyuki KUCHITSU ,  Nobutaka KITAHATA ,  Yuho SAITO ,  Koji KURAMOCHI

IPC: A01H3/04 ,  A01N37/34 ,  A01N43/82 ,  C07C255/54

Abstract: A jasmonic acid endogeny promoting agent and a method for promoting jasmonic acid endogeny using the same, the agent including a compound shown in formula (1) or a salt thereof as an active ingredient. In formula (1), R1 and R2 independently represent a monovalent organic group, cyano group, halogen atom or the like, and R1, of which there are n instances, contains at least a cyano group or halogen atom, n represents an integer between 1 and 5, and m represents an integer between 0 and 5

公开(公告)号：US11193948B2

公开(公告)日：2021-12-07

申请号：US15813542

申请日：2017-11-15

Applicant: Tokyo University of Science ,  National University Corporation Chiba University ,  JEOL Ltd.

Inventor： Tatsuya Higashi ,  Shoujiro Ogawa ,  Fumio Nomura ,  Mamoru Satoh ,  Masaki Takiwaki

IPC: G01N33/82 ,  G01N30/72

Abstract: Provided is a method for quantifying vitamin D, with the vitamin D contained in a biological sample being derivatized with a derivatization reagent and being measured with a mass spectrometer, the method including, a derivatization step of derivatizing n number of samples by using n types of 4-(4′-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione (DAPTAD) isotopologues respectively as derivatization reagents, a mixing step of mixing the n types of derivatization samples obtained in the derivatization step, and a quantitative analysis step of subjecting each of the n types of vitamin D derivatives contained in the mixed sample obtained in the mixing step to quantitative analysis using a mass spectrometer.

公开(公告)号：US20210358695A1

公开(公告)日：2021-11-18

申请号：US16479783

申请日：2018-01-19

Applicant: Tokyo University of Science Foundation

Inventor： Shinichi Komaba ,  Kei Kubota ,  Tomooki Hosaka

IPC: H01G11/06 ,  H01M10/054 ,  H01G11/32 ,  H01G11/60 ,  H01M10/0569

Abstract: An electrolyte solution for a potassium ion battery or a potassium ion capacitor, the electrolyte solution comprising at least one potassium salt compound selected from the group consisting of potassium bis(trifluoromethanesulfonyl)amide and potassium bis(fluorosulfonyl)amide and at least one solvent selected from the group consisting of ethylene glycol dimethyl ether, diethylene glycol dimethyl ether, triethylene glycol dimethyl ether, tetraethylene glycol dimethyl ether, pentaethylene glycol dimethyl ether, ethylene carbonate, and propylene carbonate, in which a concentration of the potassium salt compound in the electrolyte solution is from 1.5 mol/kg to 12.0 mol/kg.