公开(公告)号：US20220299520A1

公开(公告)日：2022-09-22

申请号：US17636396

申请日：2020-08-19

Applicant: The University of Warwick

Inventor： Jan Brosens

IPC: G01N33/68 ,  C12N15/10

Abstract: The invention relates to methods for assessing the risk of miscarriage or embryo implantation failure, and also for monitoring or evaluating the effect of a treatment to reduce the risk of miscarriage or embryo implantation failure using specific biomarkers. The invention also relates to the use of these biomarkers in methods of diagnosing a reproductive disorder in an individual, and also to methods of treating a reproductive disorder. In addition, the biomarkers can further be used in methods of selecting patients for treatment to reduce risk of embryo implantation failure or miscarriage. The invention also relates to kits for use in any of the methods described herein.

公开(公告)号：US20220192809A1

公开(公告)日：2022-06-23

申请号：US17604249

申请日：2020-04-15

Applicant: The University of Warwick

Inventor： Vasily KANTSLER ,  Max MEISSNER ,  Anton BUKATIN ,  Petr DENISSENKO

IPC: A61D19/02 ,  C12M1/00 ,  C12M1/12

Abstract: A motile cell sorting device is disclosed. The device comprises a chamber, an inlet and an outlet in fluid communication with the chamber, and a plurality of discrete barriers disposed in the chamber. Each discrete barrier comprises at least one wall and at least one acute edge orientated towards the outlet.

公开(公告)号：US20210387187A1

公开(公告)日：2021-12-16

申请号：US17330986

申请日：2021-05-26

Applicant: University of Warwick

Inventor： Matthew Ian Gibson ,  Sarah-Jane RICHARDS ,  Alexander Neil BAKER

IPC: B01L3/00 ,  G01N33/543 ,  G01N33/58 ,  G01N33/569

Abstract: The present invention relates to methods for the detection of an analyte, such as coronavirus (e.g. SARS-CoV-2) or other virus particles and proteins, in a test sample. The invention also provides a flow device for use in such methods. Additionally, there is provided a coronavirus-binding reagent having the structure [sialic acid]-[linker]-[polymer]-[gold nanoparticle] for use in the devices and methods of the invention.

公开(公告)号：US20210360915A1

公开(公告)日：2021-11-25

申请号：US16981373

申请日：2019-03-15

Applicant: UNIVERSITY OF WARWICK

Inventor： Matthew GIBSON ,  Muhammad HASSAN ,  Alice FAYTER

IPC: A01N1/02

Abstract: The present invention relates to cryopreserving compositions which are suitable for the cryopreservation of biological materials, e.g. cells and proteins. The cryopreserving compositions comprise specified concentrations of polyvinyl alcohol (PVA) and poly-ethylene glycol (PEG). The invention also relates to process for producing cryopreserved biological materials.

公开(公告)号：US20210072058A1

公开(公告)日：2021-03-11

申请号：US16982398

申请日：2019-03-18

Applicant: The University of Warwick

Inventor： Steve DIXON ,  David GREENSHIELDS

IPC: G01F1/66

Abstract: Disclosed is a method of inferring fluid flow speed through a passage. The method comprises receiving a first signal having a frequency and phase corresponding to that of a detected first ultrasonic wave, the first ultrasonic wave having been detected after passing through the fluid in a direction with a component opposed or aligned to a main direction of the fluids flow. Further, receiving a second signal having a frequency and phase corresponding to that of a detected second ultrasonic wave, the second ultrasonic wave having been detected after passing through the fluid in a direction with a component different to that of the first ultrasonic wave with respect to the main direction of the fluids flow. Further, inferring the fluid flow speed through the passage in accordance with the relative phase shift between the first and second signals. The frequencies of the first and second ultrasonic waves are substantially the same or are substantially harmonics of one another.

公开(公告)号：US20210024579A1

公开(公告)日：2021-01-28

申请号：US17042489

申请日：2019-03-28

Applicant: UNIVERSITY OF WARWICK

Inventor： Michael SHIPMAN

IPC: C07K7/54 ,  G01N33/68

Abstract: The invention provides an improved method of macrocyclization of peptidomimetics, as measured by isolated yields and product distribution, which comprises substitution of one or more of the backbone amide C═O bonds with a turn-inducing motif. The method is general with enhancements seen across a range of ring sizes (e.g. tri-, tetra-, penta- and hexapeptides). Specifically, the invention provides a peptidomimetic macrocycle comprising a carbonylbioisosteric turn-inducing element having the structure: (I) wherein X is a heteroatom; and wherein R1 to R6 are each independently selected from alkyl, aryl, heteroaryl and H.

公开(公告)号：US20210007349A1

公开(公告)日：2021-01-14

申请号：US16981421

申请日：2019-03-15

Applicant: UNIVERSITY OF WARWICK

Inventor： Matthew GIBSON ,  Christopher STUBBS ,  Trisha BAILEY

IPC: A01N1/02

Abstract: The present invention relates to processes for producing compositions for the cryopreservation of biological materials, e.g. cells and proteins. The compositions comprise a polyampholyte polymer. The invention also provides certain cryopreserving compositions comprising the polyampholyte polymer.

公开(公告)号：US20190331512A1

公开(公告)日：2019-10-31

申请号：US16463843

申请日：2017-11-23

Applicant: The University of Warwick

Inventor： Steven Dixon ,  Foz Hughes

IPC: G01F1/66 ,  G01K13/02 ,  G01F15/00 ,  G01F15/14

Abstract: An ultrasonic clamp-on flow meter is disclosed. The flow meter comprises a moulded coupling element (9).

公开(公告)号：US10006935B2

公开(公告)日：2018-06-26

申请号：US14398707

申请日：2013-05-01

Applicant: The University of Warwick

Inventor： Patrick Robert Unwin ,  Kim Martin McKelvey

IPC: G01Q60/60 ,  G01Q40/00 ,  B82Y35/00

CPC classification number: G01Q60/60 ,  B82Y35/00

Abstract: A method of controlling a scanning electrochemical microscopy probe tip comprising the following steps: oscillating the scanning electrochemical microscopy probe tip relative to the surface of interest; moving the oscillating scanning electrochemical microscopy probe tip towards the surface of interest; detecting damping of an amplitude of the oscillation of the scanning electrochemical microscopy probe tip resulting from the scanning electrochemical microscopy probe tip coming into contact with the surface of interest at the first location; using the detected damping to detect the surface of interest; retracting the scanning electrochemical microscopy probe tip away from the surface of interest without first translating the scanning electrochemical microscopy probe tip along the surface of interest while the scanning electrochemical microscopy probe tip is in intermittent contact with the surface of interest. The method further comprises measuring electrochemical signals produced at the oscillating scanning electrochemical microscopy probe tip while moving the oscillating scanning electrochemical microscopy probe tip towards and/or away from the surface of interest.

公开(公告)号：US09964446B2

公开(公告)日：2018-05-08

申请号：US15035182

申请日：2014-11-04

Applicant: The University of Warwick

Inventor： David Gunnarsson ,  Evan Parker ,  Martin Prest ,  Mika Prunnila ,  Terence Whall

IPC: G01J5/20 ,  G01J5/04 ,  H01L39/22 ,  H01L39/24 ,  G01J5/02 ,  H01L31/09 ,  G01J5/10

CPC classification number: G01J5/046 ,  G01J5/024 ,  G01J5/20 ,  G01J2005/106 ,  G01J2005/208 ,  H01L31/09 ,  H01L39/22 ,  H01L39/24

Abstract: A bolometer is described. A bolometer includes a superconductor-insulator-semiconductor-superconductor structure or a superconductor-insulator-semiconductor-insulator-superconductor structure. The semiconductor comprises an electron gas in a layer of silicon, germanium or silicon-germanium alloy in which valley degeneracy is at least partially lifted. The insulator or a one or both of the insulators may comprise a layer of dielectric material. The insulator or a one or both of the insulators may comprise a layer of non-degenerately doped semiconductor.