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    Ultrasonic detection measurement system using a tunable digital filter with 4x interpolator
    93.
    发明授权
    Ultrasonic detection measurement system using a tunable digital filter with 4x interpolator 有权
    超声波检测测量系统使用带4x内插器的可调数字滤波器

    公开(公告)号：US07757557B2

    公开(公告)日：2010-07-20

    申请号：US11490334

    申请日：2006-07-20

    申请人： Andrew Thomas ,  Steven Besser ,  Jason Toomey

    发明人： Andrew Thomas ,  Steven Besser ,  Jason Toomey

    IPC分类号： G01N29/38

    CPC分类号： G01N29/262 ,  G01N29/043 ,  G01N29/42 ,  G01N29/44 ,  G01N29/4463 ,  G01N29/449 ,  G01N2291/044 ,  G01N2291/102

    摘要： An ultrasonic inspection system utilizes a tunable digital filter with 4× interpolation. The system is used for scanning objects to be tested and includes a transmit/receive device to generate a test signal and receive an echo signal. A signal processing circuit processes the echo signal with one or more analog to digital converters for converting an analog version of the echo signal to a digital echo signal in the form of streaming digital data which is stored in a memory. The data is stored at a first data rate and read out at the second, slower data rate. An averaging decimator receives and processes the data from the memory and supplies it to an IIR filter and subsequently to an FIR filter and ultimately to a box car filter to effect processing thereon which increases the perceived resolution of the data by a given factor, preferably by a factor of 4.

    摘要翻译： 超声波检测系统采用4×内插的可调数字滤波器。 该系统用于扫描要测试的对象，并且包括发射/接收装置以产生测试信号并接收回波信号。 信号处理电路用一个或多个模拟数字转换器处理回波信号，用于将回波信号的模拟版本转换成存储在存储器中的流式数字数据形式的数字回波信号。 数据以第一数据速率存储，并以第二个较慢的数据速率读出。 平均抽取器接收并处理来自存储器的数据并将其提供给IIR滤波器并随后提供给FIR滤波器并且最终提供给盒式汽车滤波器以对其进行处理，从而将数据的感知分辨率提高给定因子，优选地通过 一个因素4。

    ULTRASONIC DETECTION MEASUREMENT SYSTEM USING A TUNABLE DIGITAL FILTER WITH 4X INTERPOLATOR
    94.
    发明申请
    ULTRASONIC DETECTION MEASUREMENT SYSTEM USING A TUNABLE DIGITAL FILTER WITH 4X INTERPOLATOR 有权
    超声波检测测量系统使用带4X插入式的数字滤波器

    公开(公告)号：US20090205428A1

    公开(公告)日：2009-08-20

    申请号：US12172863

    申请日：2008-07-14

    申请人： Andrew Thomas ,  Steven Besser ,  Jason Toomey

    发明人： Andrew Thomas ,  Steven Besser ,  Jason Toomey

    IPC分类号： G01N29/04

    CPC分类号： G01N29/262 ,  G01N29/043 ,  G01N29/42 ,  G01N29/44 ,  G01N29/4463 ,  G01N29/449 ,  G01N2291/044 ,  G01N2291/102

    摘要： An ultrasonic inspection system utilizes a tunable digital filter with 4× interpolation. The system is used for scanning objects to be tested and includes a transmit/receive device to generate a test signal and receive an echo signal. A signal processing circuit processes the echo signal with one or more digital to analog converters for converting an analog version of the echo signal to a digital echo signal in the form of streaming digital data which is stored in a memory. The data is stored at a first data rate and read out at the second, slower data rate. An averaging decimator receives and processes the data from the memory and supplies it to an IIR filter and subsequently to an FIR filter and ultimately to a box car filter to effect processing thereon which increases the perceived resolution of the data by a given factor, preferably by a factor of 4.

    摘要翻译： 超声波检测系统采用4x插值的可调数字滤波器。 该系统用于扫描要测试的对象，并且包括发射/接收装置以产生测试信号并接收回波信号。 信号处理电路用一个或多个数模转换器来处理回波信号，用于将回波信号的模拟版本转换成存储在存储器中的流式数字数据形式的数字回波信号。 数据以第一数据速率存储，并以第二个较慢的数据速率读出。 平均抽取器接收并处理来自存储器的数据并将其提供给IIR滤波器并随后提供给FIR滤波器并且最终提供给盒式汽车滤波器以对其进行处理，从而将数据的感知分辨率提高给定因子，优选地通过 一个因素4。

    Aryl-isoxazol-4-yl-imidazole derivatives
    96.
    发明授权
    Aryl-isoxazol-4-yl-imidazole derivatives 失效
    芳基异恶唑-4-基 - 咪唑衍生物

    公开(公告)号：US07414061B2

    公开(公告)日：2008-08-19

    申请号：US11640622

    申请日：2006-12-18

    申请人： Bernd Buettelmann ,  Bo Han ,  Henner Knust ,  Andrew Thomas

    发明人： Bernd Buettelmann ,  Bo Han ,  Henner Knust ,  Andrew Thomas

    IPC分类号： A61K31/506 ,  A61K31/4439 ,  A61K31/42 ,  C07D413/14

    CPC分类号： C07D413/04

    摘要： The present invention is concerned with aryl-isoxazol-4-yl-imidazole derivatives of formula I: wherein R1 to R6 are as defined in the specification and pharmaceutically acceptable acid addition salts thereof. This class of compounds has high affinity and selectivity for GABA A α5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.

    摘要翻译： 本发明涉及式I的芳基 - 异恶唑-4-基 - 咪唑衍生物：其中R 1至R 6如本说明书和药学上可接受的酸所定义 其加成盐。 这类化合物对GABA Aα5受体结合位点具有高亲和力和选择性，可用作认知增强剂或用于治疗认知障碍如阿尔茨海默病。

    Aryl-isoxazole-4-carbonyl-indole-carboxylic acid amide derivatives
    97.
    发明授权
    Aryl-isoxazole-4-carbonyl-indole-carboxylic acid amide derivatives 失效
    芳基异恶唑-4-羰基 - 吲哚羧酸酰胺衍生物

    公开(公告)号：US07378435B2

    公开(公告)日：2008-05-27

    申请号：US11543178

    申请日：2006-10-04

    申请人： Bernd Buettelmann ,  Bo Han ,  Henner Knust ,  Matthias Nettekoven ,  Andrew Thomas

    发明人： Bernd Buettelmann ,  Bo Han ,  Henner Knust ,  Matthias Nettekoven ,  Andrew Thomas

    IPC分类号： A61K31/42 ,  C07D413/02

    CPC分类号： C07D413/14

    摘要： The present invention is concerned with aryl-isoxazole-4-carbonyl-indole-carboxylic acid amide derivatives of formula I wherein R1, R2, R3, R4, and R5 are as defined in the specification and claims and with their pharmaceutically acceptable acid addition salts. The invention also relates to methods for preparing such compounds. This class of compounds has a high affinity and selectivity for GABA A α5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease. Thus, the invention also is concerned with pharmaceutical compositions containing compounds of formula I or their pharmaceutically acceptable acid addition salts and methods for the treatment of GABA Aα5 mediated diseases, including Alzheimer's disease.

    摘要翻译： 本发明涉及式I的芳基 - 异恶唑-4-羰基 - 吲哚 - 羧酸酰胺衍生物，其中R 1，R 2，R 3， R 4，R 4和R 5如说明书和权利要求书及其药学上可接受的酸加成盐所定义。 本发明还涉及制备这些化合物的方法。 这类化合物对GABA Aα5受体结合位点具有高亲和力和选择性，可能作为认知增强剂或治疗阿尔茨海默病等认知障碍。 因此，本发明还涉及含有式I化合物或其药学上可接受的酸加成盐和用于治疗包括阿尔茨海默病在内的GABA Aalpha5介导的疾病的方法的药物组合物。

    Cylinder head for rotary valve internal combustion engine
    98.
    发明申请
    Cylinder head for rotary valve internal combustion engine 失效
    旋转阀内燃机气缸盖

    公开(公告)号：US20080072852A1

    公开(公告)日：2008-03-27

    申请号：US11659725

    申请日：2005-08-31

    申请人： Andrew Thomas

    发明人： Andrew Thomas

    IPC分类号： F02F1/40 ,  F01L7/00

    CPC分类号： F01L7/02 ,  F01L7/023 ,  F01L7/16 ,  Y10T29/4927

    摘要： A cylinder head (3) for an axial flow rotary valve (1). The head comprises a bore (2) having an axis and adapted to house an axial flow rotary valve (1), a window (8) in the bore through which at least one port (12, 13) in the valve periodically communicates with a combustion chamber (9) as the valve rotates, at least two axially extending slots (21) in the bore, adjacent opposite sides of the window, each of the slots being adapted to locate a floating elongate gas sealing element (20), and at least one spark plug hole (7) adjacent to the bore and adapted for mounting a spark plug associated with the valve. The head further comprises at least one elongate axially extending cooling passage (24, 25 26) disposed between the bore and the spark plug hole, adjacent to one of the slots, the passage having a substantially constant cross section and extending axially at least over the length of the slots.

    摘要翻译： 一种用于轴流式旋转阀（1）的气缸盖（3）。 头部包括具有轴线并适于容纳轴向流动旋转阀（1）的孔（2），在孔中的窗口（8），阀中的至少一个端口（12,13）通过该窗口周期性地与一个 当阀门旋转时，燃烧室（9）中的孔中的至少两个轴向延伸的槽（21），邻近窗口的相对侧，每个槽适于定位浮动的细长气体密封元件（20） 至少一个邻近所述孔的火花塞孔（7），并适于安装与所述阀相关联的火花塞。 头部还包括设置在孔和火花塞孔之间的至少一个细长的轴向延伸的冷却通道（24,25 26），邻近其中一个狭槽，该通道具有基本上恒定的横截面并且至少在 插槽的长度。

    Aryl-4-ethynyl-isoxazole derivatives
    99.
    发明申请
    Aryl-4-ethynyl-isoxazole derivatives 失效
    芳基-4-乙炔基 - 异恶唑衍生物

    公开(公告)号：US20070287739A1

    公开(公告)日：2007-12-13

    申请号：US11805640

    申请日：2007-05-24

    申请人： Bernd Buettelmann ,  Henner Knust ,  Andrew Thomas

    发明人： Bernd Buettelmann ,  Henner Knust ,  Andrew Thomas

    IPC分类号： A61K31/42 ,  C07D261/06

    CPC分类号： C07D413/06 ,  C07D261/08 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14 ,  C07D471/04

    摘要： The present invention is concerned with aryl-4-ethynyl-isoxazole derivatives of formula I wherein R1 to R5 are as described in the specification and pharmaceutically acceptable salt thereof. This class of compounds has high affinity and selectivity for GABA A α5 receptor binding sites, being useful as a cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.

    摘要翻译： 本发明涉及式I的芳基-4-乙炔基 - 异恶唑衍生物，其中R 1至R 5如说明书及其药学上可接受的盐所述。 这类化合物对GABA Aα5受体结合位点具有高亲和力和选择性，可用作认知增强剂或用于治疗认知障碍如阿尔茨海默病。

    Aryl-isoxazolo-4-yl-oxadiazole derivatives
    100.
    发明申请
    Aryl-isoxazolo-4-yl-oxadiazole derivatives 失效
    芳基异恶唑-4-基 - 恶二唑衍生物

    公开(公告)号：US20070161686A1

    公开(公告)日：2007-07-12

    申请号：US11639695

    申请日：2006-12-15

    申请人： Bernd Buettelmann ,  Bo Han ,  Henner Knust ,  Andreas Koblet ,  Andrew Thomas

    发明人： Bernd Buettelmann ,  Bo Han ,  Henner Knust ,  Andreas Koblet ,  Andrew Thomas

    IPC分类号： A61K31/4245 ,  C07D413/02

    CPC分类号： C07D413/04 ,  C07D413/14

    摘要： The present invention is concerned with isoxazol-4-yl-oxadiazole derivatives of formula wherein R1, R2, and R3, are as defined in the specification and pharmaceutically acceptable acid addition salts thereof. This class of compounds has high affinity and selectivity for GABA A α5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.

    摘要翻译： 本发明涉及下式的异恶唑-4-基 - 恶二唑衍生物其中R 1，R 2，R 3和R 3为 在本说明书中定义及其药学上可接受的酸加成盐。 这类化合物对GABA Aα5受体结合位点具有高亲和力和选择性，可用作认知增强剂或用于治疗认知障碍如阿尔茨海默病。