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公开(公告)号：US07317108B2
公开(公告)日：2008-01-08
申请号：US10956781
申请日：2004-10-01
IPC分类号： C07D207/00
CPC分类号： C07D207/335 , C07D487/22 , C07F5/02 , C07F5/022
摘要： A method of making a metal complex comprises combining a 1-monoacyldipyrromethane with a compound of the formula R1R2MX, wherein M is boron, R1 and R2 are each independently organic substituents; and X is an anion leaving group; to produce a metal complex of the formula DMR1R2 wherein DH is a 1-monoacyldipyrromethane. The methods and complexes are useful for the purification and synthesis of dipyrromethanes and porphyrins.
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公开(公告)号：US06946552B2
公开(公告)日：2005-09-20
申请号：US10140654
申请日：2002-05-08
申请人： Jonathan S. Lindsey , Masahiko Taniguchi , Doyoung Ra , Guoning M , Thiagarajan Balasubramanian
发明人： Jonathan S. Lindsey , Masahiko Taniguchi , Doyoung Ra , Guoning M , Thiagarajan Balasubramanian
IPC分类号： C07D207/32 , C07D207/33 , C07D207/335 , C07D207/34 , C07D207/46 , C07D487/22
CPC分类号： C07D207/33 , C07D207/335 , C07D207/34 , C07D207/46
摘要： A method of making chlorins comprises the steps of reacting (e.g. condensing) a dipyrrin western half intermediate with an eastern half intermediate to form a tetrahydrobilene, and then cyclizing the tetrahydrobilene to form a chlorin. Intermediates including tetrahydrobilenes useful in such reactions are also described.
摘要翻译： 制备二氢卟酚的方法包括使双吡啶西半中间体与东半中间体反应（例如缩合）以形成四氢苯乙烯的步骤，然后环化四氢苯并形成二氢卟酚。 还描述了包括在这种反应中有用的四氢噻吩的中间体。
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公开(公告)号：US06921475B2
公开(公告)日：2005-07-26
申请号：US10098996
申请日：2002-03-14
IPC分类号： G01N27/416 , G01N27/49
CPC分类号： B82Y30/00 , B82Y10/00 , G01N27/3277
摘要： This invention provides approaches to improve the signal to noise ratio (S/N) in electrochemical measurements (e.g. amperometry, voltammetry, etc.). In particular, a method is described wherein the faradaic current is temporally dissociated from the charging current associated with reading the charge of a redox-active species (e.g. a self-assembled monolayer (SAM)). This method, designated herein as open circuit potential amperometry (OCPA), quantitatively reads the charge of the redox species bound to (electrically coupled to) an electrode surface, while discriminating against both charging current(s) and amperometric signal(s) that arise, e.g. from diffusion-based species in solution.
摘要翻译： 本发明提供了改善电化学测量（例如电流分析法，伏安法等）中的信噪比（S / N）的方法。 特别地，描述了一种方法，其中法拉第电流与读取氧化还原活性物质（例如自组装单层（SAM））的电荷相关的充电电流暂时解离。 该方法在本文中指定为开路电位电流分析法（OCPA），定量地读取结合到（电耦合到）电极表面的氧化还原物质的电荷，同时区分出现的充电电流和电流测量信号 ，例如 从溶液中的基于扩散的物种。
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公开(公告)号：US20140154186A1
公开(公告)日：2014-06-05
申请号：US14117212
申请日：2012-05-30
CPC分类号： C07D487/22 , A61K41/0071 , A61K49/0036 , A61N5/062 , C09B47/00 , G01N15/1404 , G01N33/582
摘要： Compound of Formula I: are described, along with compositions containing the same and methods of use thereof.
摘要翻译： 描述了式I化合物，以及含有其的组合物及其使用方法。
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公开(公告)号：US08304561B2
公开(公告)日：2012-11-06
申请号：US13456482
申请日：2012-04-26
IPC分类号： C07D207/333 , C07D207/36
CPC分类号： C07D487/22 , C07D207/34 , C07D207/36 , Y02P20/55
摘要： A method of making a metalloporphyrin is carried out by reacting (i) a linear tetrapyrrole, said linear tetrapyrrole having a 19-acyl group and a 1-protecting group, with (ii) a metal salt under basic conditions to produce the metalloporphyrin. Products produced by such methods and intermediates useful for carrying out such methods are also described.
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96.发明申请SYNTHESIS OF CHLORINS AND PHORBINES WITH ENHANCED RED SPECTRAL FEATURES 审中-公开具有增强的红色光谱特征的氯离子和磷酸盐的合成公开(公告)号：US20120245508A1
公开(公告)日：2012-09-27
申请号：US13480796
申请日：2012-05-25
IPC分类号： C07D487/22 , A61M37/00 , A61K31/409
CPC分类号： C07D487/22
摘要： The present invention provides compounds of the general Formula DI: along with methods of making such compounds, formulations containing the same, and methods of using the same (e.g., in photodynamic therapy, for the production of solar cells, etc.).
摘要翻译： 本发明提供了通式DI的化合物，以及制备此类化合物的方法，含有该化合物的制剂及其使用方法（例如，在光动力疗法中，用于生产太阳能电池等）。
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公开(公告)号：US08212023B2
公开(公告)日：2012-07-03
申请号：US13014914
申请日：2011-01-27
IPC分类号： C07D487/22 , C07B47/00
CPC分类号： C07D403/04 , C07D487/22
摘要： A method of making a porphyrin is carried out by: (a) condensing (i) a 1,9-bis(N,N-)dialkylaminomethyl)dipyrromethane of Formula II: with (ii) a dipyrromethane to produce a reaction product; then (b) oxidizing the reaction product; and then (c) optionally demetallating said reaction product to produce the porphyrin. The reaction is particularly useful for making substituted porphyrins with a wide range of substituents at the A and/or B (the 5 and/or 15) positions.
摘要翻译： 通过以下方法进行卟啉的制备方法：（a）将（ⅰ）式Ⅱ的1,9-双（N，N-）二烷基氨基甲基）二吡咯烷与（ⅱ）二吡咯甲烷缩合生成反应产物; 然后（b）氧化反应产物; 然后（c）任选地使所述反应产物脱金属以产生卟啉。 该反应对于在A和/或B（5和/或15）位置制备具有宽范围取代基的取代卟啉是特别有用的。
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98.发明授权公开(公告)号：US08207329B2
公开(公告)日：2012-06-26
申请号：US12095435
申请日：2006-11-30
IPC分类号： C07D487/00 , C07B47/00
CPC分类号： C07D487/22
摘要： The present invention provides compounds of the general Formula DI: along with methods of making such compounds, formulations containing the same, and methods of using the same (e.g., in photodynamic therapy, for the production of solar cells, etc.).
摘要翻译： 本发明提供了通式DI的化合物，以及制备此类化合物的方法，含有该化合物的制剂及其使用方法（例如，在光动力疗法中，用于生产太阳能电池等）。
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公开(公告)号：US07994312B2
公开(公告)日：2011-08-09
申请号：US12029070
申请日：2008-02-11
IPC分类号： C07D487/22 , C07D207/335 , C07F15/00
CPC分类号： C07D487/22 , C07D207/34 , C07D207/36 , Y02P20/55
摘要： A method of making a metalloporphyrin is carried out by reacting (i) a linear tetrapyrrole, said linear tetrapyrrole having a 19-acyl group and a 1-protecting group, with (ii) a metal salt under basic conditions to produce the metalloporphyrin. Products produced by such methods and intermediates useful for carrying out such methods are also described.
摘要翻译： 通过使（i）在碱性条件下使（I）线性四吡咯，具有19-酰基的所述直链四吡咯和1-保护基与（ii）金属盐反应，制备金属卟啉来进行制备金属卟啉的方法。 还描述了通过这种方法生产的产品和用于实施这些方法的中间体。
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公开(公告)号：US07947829B2
公开(公告)日：2011-05-24
申请号：US12780151
申请日：2010-05-14
IPC分类号： C07B47/00 , C07D487/22
CPC分类号： C07D487/04
摘要： A method of making a compound of Formula I: is carried out by condensing a pair of compounds of Formula II (which pair may be the same or different), or by condensing a compound of Formula III with a compound Formula IV, to produce a compound of Formula I. The condensing step may be carried out with a metal salt under basic conditions.
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