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公开(公告)号：US10532228B2
公开(公告)日：2020-01-14
申请号：US15901770
申请日：2018-02-21
申请人： Maureen Petterson , W. Davis Lee
发明人： Maureen Petterson , W. Davis Lee
摘要： The invention comprises a method and apparatus for using a multi-layer multi-color scintillation based detector element to image a tumor of a patient using a process of determining residual energies of positively charged particles after passing through the patient, the process comprising the steps of: (1) transmitting the positively charged particles at known energies through the patient and into a multi-layer detector element; (2) detecting first and second secondary photons, resultant from passage of the positively charged particles, respectively from a first layer of a first scintillation material and a second layer of a second scintillation material at two respective layer depths, where the first wavelength range differs from the second wavelength range; (4) determining residual energies of the positively charged particles, using output from the step of detecting; and (5) relating the residual energies to body densities to generate an image.
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公开(公告)号：US10166408B2
公开(公告)日：2019-01-01
申请号：US15823070
申请日：2017-11-27
申请人： Susan L. Michaud , W. Davis Lee
发明人： Susan L. Michaud , W. Davis Lee
摘要： The invention comprises a method and apparatus for treating a tumor with positively charged particles, comprising the steps of: (1) transporting the positively charged particles sequentially from an accelerator, along a beam transport path, through a nozzle system, and along a treatment beam path and (2) while scanning the treatment beam path along each of a set of vectors for treating the tumor, on average for the set of vectors, intentionally deviating the treatment beam path from a current vector of the set of vectors off of the current vector by at least one-eighth of a treatment beam diameter at least once for every twenty movements of the treatment beam.
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93.发明授权公开(公告)号：US10092776B2
公开(公告)日：2018-10-09
申请号：US15280999
申请日：2016-09-29
摘要： The invention comprises a method and apparatus for imaging a tumor of a patient using one or more imaging systems positionable about the tumor and treating the tumor using positively charged particles, such as a process of: (1) rotating a gantry support and/or gantry, connected to at least a portion of a beam transport system configured to pass a charged particle treatment beam, circumferentially about the patient and a gantry rotation axis; (2) translating a translatable imaging system past the patient on a path parallel to an axis perpendicular to the gantry rotation axis; (3) imaging the tumor using the translatable imaging system; and (4) treating the tumor using the rotatable treatment beam.
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公开(公告)号：US10029122B2
公开(公告)日：2018-07-24
申请号：US15176025
申请日：2016-06-07
摘要： The invention comprises a system for controlling a charged particle beam shape and direction relative to a controlled and dynamically positioned patient and/or an imaging surface, such as a scintillation plate of a tomography system and/or a first two-dimensional imaging system coupled to a second two-dimensional imaging system. Multiple interlinked beam/patient/imaging control stations allow safe zone operation and clear interaction with the charged particle beam system and the patient. Both treatment and imaging are facilitated using automated sequences controlled with a work-flow control system.
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公开(公告)号：US20180169441A1
公开(公告)日：2018-06-21
申请号：US15892282
申请日：2018-02-08
申请人： Stephen L. Spotts , W. Davis Lee
发明人： Stephen L. Spotts , W. Davis Lee
CPC分类号： A61N5/1077 , A61B6/03 , A61B6/032 , A61B6/037 , A61B6/4085 , A61N5/103 , A61N5/1043 , A61N5/1044 , A61N5/1049 , A61N5/1067 , A61N5/107 , A61N5/1081 , A61N5/1082 , A61N2005/1061 , A61N2005/1074 , A61N2005/1087 , A61N2005/1097 , G21K1/087 , G21K1/093 , G21K5/04 , G21K5/10 , H01J35/14
摘要： The invention comprises a method and apparatus for controlling tumor treatment, comprising the steps of: (1) a control system controlling a cancer therapy system, the control system comprising a set of modular control units, the cancer therapy system comprising a set of subsystem elements, (2) altering a first subsystem of the set of subsystem elements; and (3) updating a first modular control unit, of the set of modular control units, corresponding to the first subsystem without a necessitated change of remaining code elements of the set of modular control units corresponding to non-altered subsystem elements of the set of subsystem elements with an optional step of altering main subsystem controller code configured to control the set of subsystem control modules. Optionally the control system directly controls each of the subsystem elements and/or communicates with each of the set of subsystem elements without direct communication between the set of subsystem elements.
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公开(公告)号：US20170150933A1
公开(公告)日：2017-06-01
申请号：US15430008
申请日：2017-02-10
申请人： James P. Bennett , W. Davis Lee
发明人： James P. Bennett , W. Davis Lee
CPC分类号： A61B6/4258 , A61B6/032 , A61B6/037 , A61B6/12 , A61B6/4014 , A61B6/4085 , A61B6/4216 , A61B6/4266 , A61B6/4417 , A61B6/482 , A61B6/485 , A61B6/487 , A61B6/5205 , A61B6/5211 , A61B6/582 , A61N5/1037 , A61N5/1049 , A61N5/1067 , A61N5/107 , A61N5/1077 , A61N5/1082 , A61N2005/1051 , A61N2005/1054 , A61N2005/1061 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K1/08 , G21K5/04
摘要： The invention comprises a multiplexed proton tomography imaging apparatus and method of use thereof. In one embodiment, a method for imaging a tumor of a patient comprises the steps of: (1) simultaneously detecting spatially resolved positively charged particle positions passing through each of a set of cross-section planes, where the cross-section planes are both prior to and posterior to the patient along a path of the positively charged particles; (2) determining a prior vector for each of the individual positively charged particles entering a patient using the detected positions; (3) determining a posterior vector for each of the individual positively charged particles exiting the patient using the detected positions; (4) generating a probable path of each positively charged particle through the patient; and (5) generating an image of the patient using the n probable proton paths and optionally a detected residual energy of each proton.
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97.发明申请INTEGRATED TRANSLATION/ROTATION CHARGED PARTICLE IMAGING/TREATMENT APPARATUS AND METHOD OF USE THEREOF 审中-公开集成翻译/旋转充电颗粒成像/处理设备及其使用方法公开(公告)号：US20170014647A1
公开(公告)日：2017-01-19
申请号：US15280999
申请日：2016-09-29
CPC分类号： A61N5/1067 , A61B6/032 , A61B6/4092 , A61B6/4216 , A61B6/4258 , A61B6/4266 , A61B6/467 , A61B6/5205 , A61N5/1037 , A61N5/1039 , A61N5/1049 , A61N5/1069 , A61N5/107 , A61N5/1077 , A61N5/1081 , A61N5/1082 , A61N2005/1052 , A61N2005/1054 , A61N2005/1087 , A61N2005/1095 , A61N2005/1097 , G21K5/04
摘要： The invention comprises a method and apparatus for imaging a tumor of a patient using one or more imaging systems positionable about the tumor and treating the tumor using positively charged particles, such as a process of: (1) rotating a gantry support and/or gantry, connected to at least a portion of a beam transport system configured to pass a charged particle treatment beam, circumferentially about the patient and a gantry rotation axis; (2) translating a translatable imaging system past the patient on a path parallel to an axis perpendicular to the gantry rotation axis; (3) imaging the tumor using the translatable imaging system; and (4) treating the tumor using the rotatable treatment beam.
摘要翻译： 本发明包括用于使用可定位在肿瘤周围的一个或多个成像系统使用带正电荷的颗粒来治疗肿瘤的患者肿瘤成像的方法和装置，例如：（1）旋转支架和/或龙门架 连接到梁传输系统的至少一部分，其配置成使带电粒子处理束沿周向围绕患者和台架旋转轴线传递; （2）在平行于垂直于所述台架旋转轴的轴的路径上翻译可翻译成像系统经过所述患者; （3）使用可翻译成像系统对肿瘤进行成像; 和（4）使用可旋转治疗束治疗肿瘤。
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公开(公告)号：US12042672B2
公开(公告)日：2024-07-23
申请号：US17391886
申请日：2021-08-02
IPC分类号： A61N5/10
CPC分类号： A61N5/1078 , A61N5/1049 , A61N2005/1087
摘要： The invention comprises a method and apparatus for treating a tumor of a patient, in a beam treatment center comprising a floor, with positively charged particles, comprising: (1) a synchrotron mounted to an elevated floor section above the floor of the beam treatment center; (2) a beam transport system, comprising: at least three fixed-position beam transport lines, where none of the synchrotron and the beam transport system penetrate through the floor of the beam treatment center; (3) the positively charged particles transported from the synchrotron, through the beam transport system, to a position above a patient positioning system during use; and (4) an optional repositionable nozzle system connected to a first, second, and third fixed-position beam transport line at a first, second, and third time, respectively, where the nozzle track forms an arc of a circle and the repositionable nozzle system moves along the nozzle track.
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公开(公告)号：US20210393988A1
公开(公告)日：2021-12-23
申请号：US17391886
申请日：2021-08-02
IPC分类号： A61N5/10
摘要： The invention comprises a method and apparatus for treating a tumor of a patient, in a beam treatment center comprising a floor, with positively charged particles, comprising: (1) a synchrotron mounted to an elevated floor section above the floor of the beam treatment center; (2) a beam transport system, comprising: at least three fixed-position beam transport lines, where none of the synchrotron and the beam transport system penetrate through the floor of the beam treatment center; (3) the positively charged particles transported from the synchrotron, through the beam transport system, to a position above a patient positioning system during use; and (4) an optional repositionable nozzle system connected to a first, second, and third fixed-position beam transport line at a first, second, and third time, respectively, where the nozzle track forms an arc of a circle and the repositionable nozzle system moves along the nozzle track.
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公开(公告)号：US10555710B2
公开(公告)日：2020-02-11
申请号：US15430208
申请日：2017-02-10
申请人： James P. Bennett , W. Davis Lee
发明人： James P. Bennett , W. Davis Lee
摘要： The invention comprises a method and apparatus for imaging a tumor with X-rays while, simultaneously or alternatingly, treating or imaging the tumor with positively charged particles. An X-ray imaging system, such as one or two sets of a cone beam X-ray source coupled to an X-ray detector, is rotatable about a first axis and a patient. The X-ray imaging system is positioned off axis a path of charged particles delivered through an exit port of a nozzle system from a synchrotron and does not block a path of the positively charged particles from the exit nozzle to the patient or an imaging path from the patient to a scintillation detector. Fiducial indicators are used to confirm an unobstructed path of the positively charged particles in a treatment room comprising many movable elements, such as the X-ray imaging system and a patient positioning system/couch.
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