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公开(公告)号：US07910086B1
公开(公告)日：2011-03-22
申请号：US12799283
申请日：2010-04-21
申请人： Hsing-Wen Sung , Hosheng Tu
发明人： Hsing-Wen Sung , Hosheng Tu
CPC分类号： A61K49/0093 , A61K9/19 , A61K9/4808 , A61K9/4891 , A61K9/5161 , A61K47/61 , A61K47/645 , A61K47/6455 , A61K47/6935 , A61K49/0043 , A61K49/0054
摘要： The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
摘要翻译： 本发明公开了一种由壳聚糖，聚谷氨酸和用于口服递送的生物活性剂组成的生物活性纳米粒子的药物组合物。 基于壳聚糖的纳米颗粒的特征在于具有正的表面电荷和增强的口服药物递送的渗透性。
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公开(公告)号：US07879312B1
公开(公告)日：2011-02-01
申请号：US12454803
申请日：2009-05-23
申请人： Hsing-Wen Sung , Shu-Fen Peng , Hosheng Tu
发明人： Hsing-Wen Sung , Shu-Fen Peng , Hosheng Tu
CPC分类号： A61K31/13 , A61K9/0043 , A61K9/5146 , A61K9/5161 , A61K31/445 , A61K31/55
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one DNA/RNA or bioactive agent characterized with a positive surface charge and their enhanced permeability for gene delivery and bioactive agent delivery.
摘要翻译： 本发明公开了由壳聚糖，聚谷氨酸和至少一种DNA / RNA或生物活性剂组成的纳米颗粒，其特征在于具有阳性表面电荷及其增强的基因递送和生物活性剂递送的渗透性。
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公开(公告)号：US20100330167A1
公开(公告)日：2010-12-30
申请号：US12807084
申请日：2010-08-27
申请人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
CPC分类号： A61K9/5146 , A61K9/0019 , A61K9/5161 , A61K9/5192 , A61K31/13 , A61K31/473 , A61K31/55 , A61K31/7008 , A61K31/704 , A61K31/727 , A61K33/24 , A61K38/28 , A61K45/06 , A61K47/61 , Y10S977/773 , A61K2300/00
摘要： The invention discloses the nanoparticles composed of chitosan, poly-γ-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
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公开(公告)号：US20090011008A1
公开(公告)日：2009-01-08
申请号：US12221897
申请日：2008-08-07
申请人： Hsing-Wen Sung , Yu-Hsin Lin , Hosheng Tu
发明人： Hsing-Wen Sung , Yu-Hsin Lin , Hosheng Tu
CPC分类号： A61K9/5161 , A61K9/19 , A61K9/5169 , A61K38/28
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
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公开(公告)号：US20090004266A1
公开(公告)日：2009-01-01
申请号：US12229929
申请日：2008-08-28
申请人： Hsing-Wen Sung , Hosheng Tu
发明人： Hsing-Wen Sung , Hosheng Tu
CPC分类号： A61K9/0056 , A61K9/145 , A61K9/19 , A61K9/5161 , A61K9/5169 , A61K38/23 , A61K38/27 , A61K38/28
摘要： The invention discloses a chewable composition for oral delivery of bioactive agents having nanoparticles that are composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
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公开(公告)号：US07449200B2
公开(公告)日：2008-11-11
申请号：US11405066
申请日：2006-04-17
申请人： Hsing-Wen Sung , Mei-Chin Chen , Po-Wei Lee , Hosheng Tu
发明人： Hsing-Wen Sung , Mei-Chin Chen , Po-Wei Lee , Hosheng Tu
CPC分类号： A61K9/5146 , A61K9/5153 , A61K9/5161 , A61K9/5192 , A61K31/727 , A61K38/14 , A61K38/18 , A61K38/23 , A61K38/28
摘要： The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering proteins or peptides to an animal subject. The nanoparticles are composed of positively charged shell substrate, negatively charged core substrate with encapsulated bioactive agents of proteins or peptides.
摘要翻译： 本发明公开了用于纳米颗粒弹丸轰击的生物可降解纳米颗粒，作为向动物对象施用蛋白质或肽的载体。 纳米颗粒由带正电荷的壳底物，带有带蛋白质或肽的封装生物活性剂的带负电荷的核心底物组成。
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公开(公告)号：US20080213354A1
公开(公告)日：2008-09-04
申请号：US11881217
申请日：2007-07-26
申请人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
IPC分类号： A61K9/14 , A61K38/22 , A61K38/08 , A61K9/48 , A61K39/395
CPC分类号： A61K9/5146 , A61K9/0019 , A61K9/5161 , A61K9/5192 , A61K31/13 , A61K31/473 , A61K31/55 , A61K31/7008 , A61K31/704 , A61K31/727 , A61K33/24 , A61K38/28 , A61K45/06 , A61K47/61 , Y10S977/773 , A61K2300/00
摘要： The invention discloses the nanoparticles composed of chitosan, poly-γ-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
摘要翻译： 本发明公开了由壳聚糖，聚-γ-谷氨酸和至少一种生物活性剂组成的纳米颗粒，其特征在于具有阳性表面电荷及其对细胞旁药物递送的增强的渗透性。
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公开(公告)号：US20080166329A1
公开(公告)日：2008-07-10
申请号：US11986708
申请日：2007-11-26
申请人： Hsing-Wen Sung , Hosheng Tu
发明人： Hsing-Wen Sung , Hosheng Tu
CPC分类号： A61L27/3633 , A61K35/28 , A61K35/34 , A61K35/545 , A61L27/20 , A61L27/24 , A61L27/367 , A61L27/3804 , A61L27/3843 , A61L27/3873 , A61L27/52 , A61L2430/20 , C08L1/00
摘要： A novel method, using a thermoreversible MC/PBS/Collagen hydrogel coated on the TCPS dish, for harvesting a living cell sheet or spheroid with ECM. In one application, the obtained living cell sheet/spheroid is administered to a joint adapted for implantation and for cartilage regeneration. In another application, the living cell sheet/spheroid is administered, preferably via percutaneous injection, to an infarcted cardiac tissue as a novel therapy for treating myocardial infarction.
摘要翻译： 一种新颖的方法，使用涂覆在TCPS皿上的热可逆MC / PBS /胶原水凝胶，用ECM收集活细胞片或球体。 在一个应用中，将获得的活细胞片/球体施用于适于植入和软骨再生的关节。 在另一个应用中，优选通过经皮注射将活细胞片/球体施用于梗死心脏组织，作为治疗心肌梗死的新疗法。
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公开(公告)号：US07348030B1
公开(公告)日：2008-03-25
申请号：US11267848
申请日：2005-11-04
申请人： Hsing-Wen Sung , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Hsiang-Fa Liang , Hosheng Tu
CPC分类号： A61K9/5153 , A61K31/7008 , A61K31/704 , A61K47/549 , A61K47/593 , A61K47/645 , A61K47/6931 , A61K47/6937 , B82Y5/00 , C08G81/00
摘要： The nanoparticles composed of γ-PGA-PLA block copolymers that are conjugated with galactosamine as a potential drug delivery system and loaded with anticancer drugs for treating liver cancers.
摘要翻译： 由与β-半乳糖胺缀合的γ-PGA-PLA嵌段共聚物作为潜在药物递送系统并装载用于治疗肝癌的抗癌药物的纳米颗粒。
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公开(公告)号：US20070243259A1
公开(公告)日：2007-10-18
申请号：US11405066
申请日：2006-04-17
申请人： Hsing-Wen Sung , Mei-Chin Chen , Po-Wei Lee , Hosheng Tu
发明人： Hsing-Wen Sung , Mei-Chin Chen , Po-Wei Lee , Hosheng Tu
IPC分类号： A61K38/28 , A61K38/18 , A61K38/14 , A61K31/727 , A61K9/14
CPC分类号： A61K9/5146 , A61K9/5153 , A61K9/5161 , A61K9/5192 , A61K31/727 , A61K38/14 , A61K38/18 , A61K38/23 , A61K38/28
摘要： The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering proteins or peptides to an animal subject. The nanoparticles are composed of positively charged shell substrate, negatively charged core substrate with encapsulated bioactive agents of proteins or peptides.
摘要翻译： 本发明公开了用于纳米颗粒弹丸轰击的生物可降解纳米颗粒，作为向动物对象施用蛋白质或肽的载体。 纳米颗粒由带正电荷的壳底物，带有带蛋白质或肽的封装生物活性剂的带负电荷的核心底物组成。
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