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公开(公告)号：US20180258501A1
公开(公告)日：2018-09-13
申请号：US15527930
申请日：2015-11-20
申请人： Nantomics, LLC
摘要： Systems and methods are provided for determination of primers for differentiation of at least two unspecified pathogens that belong to distinct pathogen (e.g., virus) families that comprise multiple distinct pathogen species and/or varieties.
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92.发明申请Systems, Compositions, And Methods For Discovery Of MSI And Neoepitopes That Predict Sensitivity To Checkpoint Inhibitors 审中-公开用于发现检测点抑制剂的MSI和Neoepitopes的系统，组合物和方法公开(公告)号：US20170032082A1
公开(公告)日：2017-02-02
申请号：US15292021
申请日：2016-10-12
申请人： NantOmics, LLC
CPC分类号： G16B20/00 , G01N33/56977 , G01N33/574 , G01N33/6878 , G01N2333/70532 , G01N2570/00 , G06F19/3481 , G16B30/00 , G16H50/20
摘要： Systems and methods are presented that allow for predicting treatment response of a tumor to a checkpoint inhibitor. In one exemplary aspect, the treatment response is directly associated with a relatively high number of patient- and tumor-specific immunologically visible neoepitopes. Specific mutational patterns in the nucleic acid encoding the neoepitope may be further indicative of treatment response.
摘要翻译： 提出了允许预测肿瘤对检查点抑制剂的治疗反应的系统和方法。 在一个示例性方面，治疗反应与相对高数量的患者和肿瘤特异性免疫可见的新表皮直接相关。 编码新表皮的核酸中的特异突变模式可进一步指示治疗反应。
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93.发明申请公开(公告)号：US20170017750A1
公开(公告)日：2017-01-19
申请号：US15015048
申请日：2016-02-03
申请人： NantOmics, LLC
发明人： Patrick Soon-Shiong , Shahrooz Rabizadeh , Stephen Charles Benz , John Zachary Sanborn , Charles Joseph Vaske
摘要： Contemplated panomic systems and methods significantly improve accuracy of genetic testing by taking into account matched normal data and expression levels of various genes in diseased tissue. Analysis and physician guidance is further improved by combining so identified clinically relevant changes with pathway analysis to thereby allow for classification of a tumor and/or identification of potentially druggable targets within affected pathways.
摘要翻译： 考虑到全基因系统和方法通过考虑到病变组织中各种基因的正常数据和表达水平的相关性，可以显着提高基因检测的准确性。 通过将所确定的临床相关变化与途径分析相结合，进一步改善分析和医师指导，从而允许在受影响的途径中分类肿瘤和/或鉴定潜在的可药用靶标。
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公开(公告)号：US20240233124A1
公开(公告)日：2024-07-11
申请号：US18616072
申请日：2024-03-25
申请人： NantOmics, LLC
CPC分类号： G06T7/0012 , G06T7/11 , G06T7/136 , G06T2207/10056 , G06T2207/20041 , G06T2207/20104 , G06T2207/20152 , G06T2207/30024 , G06T2207/30096 , G06T2207/30242
摘要： Techniques are provided for determining a cell count within a whole slide pathology image. The image is segmented using a global threshold value to define a tissue area. A plurality of patches comprising the tissue area are selected. Stain intensity vectors are determined within the plurality of patches to generate a stain intensity image. The stain intensity image is iteratively segmented to generate a cell mask using a local threshold value that is and gradually reduced after each iteration. A chamfer distance transform is applied to the cell mask to generate a distance map. Cell seeds are determined on the distance map. Cell segments are determined using a watershed transformation, and a whole cell count is calculated for the plurality of patches based on the cell segments. A client device may be configured for real-time cell counting based on the whole cell count.
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95.发明公开公开(公告)号：US20230307090A1
公开(公告)日：2023-09-28
申请号：US18163664
申请日：2023-02-02
申请人： Nantomics LLC
IPC分类号： G16B20/20 , G16B20/00 , G16B30/00 , G16H50/20 , G01N33/574 , G01N33/569 , G01N33/68 , G16H20/40 , G16H70/60 , G16B30/10
CPC分类号： G16B20/20 , G16B20/00 , G16B30/00 , G16H50/20 , G01N33/574 , G01N33/56977 , G01N33/6878 , G16H20/40 , G16H70/60 , G16B30/10 , G01N2570/00 , G01N2333/70532
摘要： Systems and methods are presented that allow for predicting treatment response of a tumor to a checkpoint inhibitor. In one exemplary aspect, the treatment response is directly associated with a relatively high number of patient- and tumor-specific immunologically visible neoepitopes. Specific mutational patterns in the nucleic acid encoding the neoepitope may be further indicative of treatment response.
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公开(公告)号：US20220375085A1
公开(公告)日：2022-11-24
申请号：US17881578
申请日：2022-08-04
申请人： NantOmics, LLC
摘要： Techniques are provided for determining a cell count within a whole slide pathology image. The image is segmented using a global threshold value to define a tissue area. A plurality of patches comprising the tissue area are selected. Stain intensity vectors are determined within the plurality of patches to generate a stain intensity image. The stain intensity image is iteratively segmented to generate a cell mask using a local threshold value that is and gradually reduced after each iteration. A chamfer distance transform is applied to the cell mask to generate a distance map. Cell seeds are determined on the distance map. Cell segments are determined using a watershed transformation, and a whole cell count is calculated for the plurality of patches based on the cell segments. A client device may be configured for real-time cell counting based on the whole cell count.
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公开(公告)号：US11443426B2
公开(公告)日：2022-09-13
申请号：US16957036
申请日：2019-01-15
申请人： NantOmics, LLC
摘要： Techniques are provided for determining a cell count within a whole slide pathology image. The image is segmented using a global threshold value to define a tissue area. A plurality of patches comprising the tissue area are selected. Stain intensity vectors are determined within the plurality of patches to generate a stain intensity image. The stain intensity image is iteratively segmented to generate a cell mask using a local threshold value that is and gradually reduced after each iteration. A chamfer distance transform is applied to the cell mask to generate a distance map. Cell seeds are determined on the distance map. Cell segments are determined using a watershed transformation, and a whole cell count is calculated for the plurality of patches based on the cell segments. A client device may be configured for real-time cell counting based on the whole cell count.
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公开(公告)号：US20220270709A1
公开(公告)日：2022-08-25
申请号：US17740040
申请日：2022-05-09
申请人： Nantomics LLC
发明人： Andrew Nguyen , John Zachary Sanborn , Stephen Charles Benz , Kayvan Niazi , Shahrooz Rabizadeh , Patrick Soon-Shiong , Charles Joseph Vaske
IPC分类号： G16B20/20 , G16B20/00 , A61K35/17 , A61K39/395 , A61K48/00 , C12Q1/6886 , A61K47/68 , A61K39/00 , A61K45/06
摘要： Systems and methods are presented that allow for selection of tumor neoepitopes that are filtered for various criteria. In particularly contemplated aspects, filtering includes a step in which the mutation leading to the neoepitope is ascertained as being located in a cancer driver gene.
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公开(公告)号：US20210363585A1
公开(公告)日：2021-11-25
申请号：US16639543
申请日：2018-08-17
申请人： NANTOMICS, LLC
发明人： Shahrooz Rabizadeh
IPC分类号： C12Q1/6886
摘要： Circulating free RNA (cfRNA) is used for monitoring status and/or treatment response for neural tumors, and especially glioma, glioblastoma, and neuroblastoma. Particularly preferred cfRNAs include those that encode a marker that is specific to a neural tumor, but also markers that are specific to DNA repair status and/or immune status.
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公开(公告)号：US20160070855A1
公开(公告)日：2016-03-10
申请号：US14846290
申请日：2015-09-04
发明人： John Zachary Sanborn , Charles Joseph Benz , Stephen Charles Benz , Shahrooz Rabizadeh , Patrick Soon-Shiong
IPC分类号： G06F19/22
摘要： Systems and methods for genomic analysis are contemplated in which idiosyncratic markers or marker constellations are employed to characterize and compare genomic sequences. In especially preferred aspects, the idiosyncratic markers are predetermined SNPs and a marker profile is used in a sample record to so allow cross reference to other marker profiles of other sequences.
摘要翻译： 考虑用于基因组分析的系统和方法，其中使用特异性标记或标记星座来表征和比较基因组序列。 在特别优选的方面，特异性标记是预定的SNP，并且在样品记录中使用标记谱，以允许与其他序列的其他标记谱的交叉参考。
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