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161 条记录 (耗时 0.048 秒)

    MAGE-C2 ANTIGENIC PEPTIDES AND USES THEREOF
    91.
    发明申请
    MAGE-C2 ANTIGENIC PEPTIDES AND USES THEREOF 有权
    MAGE-C2抗原肽及其用途

    公开(公告)号：US20110305722A1

    公开(公告)日：2011-12-15

    申请号：US13182037

    申请日：2011-07-13

    申请人： Wenbin MA ,  Benoit Van Den Eynde ,  Thierry Boon-Falleur ,  Catherine Germeau ,  Pierre Coulie

    发明人： Wenbin MA ,  Benoit Van Den Eynde ,  Thierry Boon-Falleur ,  Catherine Germeau ,  Pierre Coulie

    IPC分类号： A61K39/385 ,  A61P37/04 ,  C07K14/76 ,  A61P35/00 ,  C07K7/06 ,  G01N33/566

    CPC分类号： C07K14/4748 ,  A61K38/00

    摘要： This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, ∃2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.

    摘要翻译： 本发明涉及衍生自MAGE-C2的分离的肽，编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽，包含核酸分子的表达载体，用核酸分子转化或转染的宿主细胞 表达载体和包含肽，HLA分子，∃2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽，核酸分子，表达载体，四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。

    MAGE-C2 antigenic peptides and uses thereof
    95.
    发明申请
    MAGE-C2 antigenic peptides and uses thereof 有权
    MAGE-C2抗原肽及其用途

    公开(公告)号：US20080311652A1

    公开(公告)日：2008-12-18

    申请号：US12011726

    申请日：2008-01-29

    申请人： Aline Van Pel ,  Daniele Godelaine ,  Javier Carrasco ,  Francis Brasseur ,  Thierry Boon-Falleur

    发明人： Aline Van Pel ,  Daniele Godelaine ,  Javier Carrasco ,  Francis Brasseur ,  Thierry Boon-Falleur

    IPC分类号： C12N5/00 ,  C07H21/04 ,  C12N15/63

    CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K2039/57

    摘要： This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, β2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.

    摘要翻译： 本发明涉及衍生自MAGE-C2的分离的肽，编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽，包含核酸分子的表达载体，用核酸分子转化或转染的宿主细胞 表达载体和包含肽，HLA分子，β2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽，核酸分子，表达载体，四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。

    Isolated nucleic acid molecules coding for tumor rejection antigen precursors of members of the MAGE-C and MAGE-B FAMILIES and uses thereof
    99.
    发明授权
    Isolated nucleic acid molecules coding for tumor rejection antigen precursors of members of the MAGE-C and MAGE-B FAMILIES and uses thereof 有权
    编码MAGE-C和MAGE-B家族成员的肿瘤排斥抗原前体的分离的核酸分子及其用途

    公开(公告)号：US06680191B1

    公开(公告)日：2004-01-20

    申请号：US09468433

    申请日：1999-12-17

    申请人： Sophie Lucas ,  Thierry Boon-Falleur

    发明人： Sophie Lucas ,  Thierry Boon-Falleur

    IPC分类号： C12M120

    CPC分类号： G01N33/56977 ,  C07K14/4748

    摘要： The invention relates to isolated nucleic acid molecules which code for antigens expressed by tumor cells which maybe recognized by cytotoxic T cells, leading to lysis of the tumor cells which express it. This invention also relates to vectors which are designed to encode the antigen expressed by tumor cells and also to cells transfected by the nucleic acid molecules or vectors which comprise the nucleic acid molecules. Various therapeutic and diagnostic uses arising out of the properties of the nucleic acid molecules and the antigens for which these code are also part of this invention.

    摘要翻译： 本发明涉及分离的核酸分子，其编码由细胞毒性T细胞识别的肿瘤细胞表达的抗原，导致表达它的肿瘤细胞的裂解。 本发明还涉及被设计用于编码由肿瘤细胞表达的抗原以及由核酸分子转染的细胞或包含核酸分子的载体的载体。 由于这些代码也是本发明的一部分的核酸分子和抗原的性质引起的各种治疗和诊断用途。

    Tumor associated nucleic acids and uses therefor
    100.
    发明授权
    Tumor associated nucleic acids and uses therefor 有权
    肿瘤相关核酸及其用途

    公开(公告)号：US06303756B1

    公开(公告)日：2001-10-16

    申请号：US09567995

    申请日：2000-05-10

    申请人： Valérie Martelange ,  Charles De Smet ,  Thierry Boon-Falleur

    发明人： Valérie Martelange ,  Charles De Smet ,  Thierry Boon-Falleur

    IPC分类号： C07K1600

    CPC分类号： C07K14/4748

    摘要： The invention describes sdp3.8 tumor associated nucleic acids, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such nucleic acids, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a sdp3.8 gene product.

    摘要翻译： 本发明描述了sdp3.8肿瘤相关核酸，包括其片段和生物功能变体。 还包括由这种核酸编码的多肽及其片段，以及与之相关的抗体。 还提供了用于诊断和治疗以sdp3.8基因产物表达为特征的病症的方法和产品。