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公开(公告)号：US20110305722A1
公开(公告)日：2011-12-15
申请号：US13182037
申请日：2011-07-13
IPC分类号： A61K39/385 , A61P37/04 , C07K14/76 , A61P35/00 , C07K7/06 , G01N33/566
CPC分类号： C07K14/4748 , A61K38/00
摘要： This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, ∃2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.
摘要翻译： 本发明涉及衍生自MAGE-C2的分离的肽，编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽，包含核酸分子的表达载体，用核酸分子转化或转染的宿主细胞 表达载体和包含肽，HLA分子，∃2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽，核酸分子，表达载体，四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。
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公开(公告)号：US07547517B2
公开(公告)日：2009-06-16
申请号：US10670472
申请日：2003-09-26
CPC分类号： C07K14/4748 , A61K38/00
摘要： This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, β2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.
摘要翻译： 本发明涉及衍生自MAGE-C2的分离的肽，编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽，包含核酸分子的表达载体，用核酸分子转化或转染的宿主细胞 表达载体和包含肽，HLA分子，β2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽，核酸分子，表达载体，四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。
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公开(公告)号：US08143011B2
公开(公告)日：2012-03-27
申请号：US13182037
申请日：2011-07-13
申请人： Wenbin Ma , Benoit Van Den Eynde , Thierry Boon-Falleur , Catherine Germeau , Pierre Coulie , Nathalie Vigneron
发明人： Wenbin Ma , Benoit Van Den Eynde , Thierry Boon-Falleur , Catherine Germeau , Pierre Coulie , Nathalie Vigneron
CPC分类号： C07K14/4748 , A61K38/00
摘要： This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, ∃2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.
摘要翻译： 本发明涉及衍生自MAGE-C2的分离的肽，编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽，包含核酸分子的表达载体，用核酸分子转化或转染的宿主细胞 表达载体和包含肽，HLA分子，∃2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽，核酸分子，表达载体，四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。
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公开(公告)号：US20090233315A1
公开(公告)日：2009-09-17
申请号：US12387884
申请日：2009-05-08
IPC分类号： G01N33/567 , C07K7/06
CPC分类号： C07K14/4748 , A61K38/00
摘要： This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA molecules, ∃2 microglobulin and a first and second binding partner. This invention also relates to methods for using the peptides, nucleic acid molecules, expression vectors, tetramers and complexes of this invention as well as to cytolytic T cells which recognize the peptides in complex with an HLA molecule.
摘要翻译： 本发明涉及衍生自MAGE-C2的分离的肽，编码MAGE-C2的核酸分子和来自MAGE-C2的分离的肽，包含核酸分子的表达载体，用核酸分子转化或转染的宿主细胞 表达载体和包含肽，HLA分子，∃2微球蛋白和第一和第二结合配偶体的四聚体。 本发明还涉及使用本发明的肽，核酸分子，表达载体，四聚体和复合物以及识别与HLA分子复合的肽的细胞溶解性T细胞的方法。
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5.发明授权Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-2 and uses thereof 失效编码肿瘤排斥抗原前体MAGE-2的分离的核酸分子及其用途公开(公告)号：US06552180B1
公开(公告)日：2003-04-22
申请号：US09579197
申请日：2000-05-26
IPC分类号： C07H2104
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , C07K14/4748
摘要： Isolated nucleic acid molecules are described, which have complements that hybridize to a nucleic acid molecule referred to as MAGE-2. The isolated nucleic acid molecules are expressed in some melanoma cells, as well as other types of cancer cells. The invention also relates to nucleic acid molecules which encode fragments of the proteins encoded by these nucleic acid molecules, and nucleic acid molecules which encode the ultimate product, the so-called tumor rejection antigens.
摘要翻译： 描述了分离的核酸分子，其具有与被称为MAGE-2的核酸分子杂交的互补序列。 分离的核酸分子在一些黑素瘤细胞以及其它类型的癌细胞中表达。 本发明还涉及编码由这些核酸分子编码的蛋白质的片段的核酸分子和编码最终产物的核酸分子，所谓的肿瘤排斥抗原。
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6.发明授权Isolated, truncated nucleic acid which are members of the gage, and uses thereof 有权作为量规成员的分离的截短的核酸及其用途公开(公告)号：US06509172B1
公开(公告)日：2003-01-21
申请号：US09163748
申请日：1998-09-30
IPC分类号： C12P2106
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/158
摘要： The invention relates to new members of the GAGE family referred to as GAGE-7B and GAGE-8. There are differences between these two molecules and the previously described members of the GAGE family on the genomic DNA, complementary DNA, and amino acid level.
摘要翻译： 本发明涉及GAGE家族的新成员，称为GAGE-7B和GAGE-8。 在基因组DNA，互补DNA和氨基酸水平上，这两个分子和前述GAGE家族成员之间存在差异。
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7.发明授权Isolated, truncated nucleic acid molecules which code for gage tumor rejection antigen, the tumor rejection antigen, and uses thereof 失效编码计量肿瘤排斥抗原的分离的截短的核酸分子，肿瘤排斥抗原及其用途
公开(公告)号：US6069001A
公开(公告)日：2000-05-30
申请号：US602039
申请日：1996-02-15
IPC分类号： G01N33/566 , A61K35/12 , A61K38/00 , A61K48/00 , A61K49/00 , A61P35/00 , C07H21/04 , C07K14/47 , C07K14/74 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/4748 , A61K38/00 , Y10S530/828
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as GAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described. Tumor rejection antigens are also shown.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为GAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为GAGE编码分子。 描述了编码序列和肿瘤排斥抗原及其前体分子的各种诊断和治疗用途。 还显示肿瘤排斥抗原。
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8.发明授权Isolated, nucleic acid molecules which code for gage tumor rejection antigen, the tumor rejection antigen, and uses thereof 失效分离的编码计量肿瘤排斥抗原的核酸分子，肿瘤排斥抗原及其用途
公开(公告)号：US06013481A
公开(公告)日：2000-01-11
申请号：US669161
申请日：1996-06-24
IPC分类号： C12N15/09 , A61K38/00 , C07K7/00 , C07K14/47 , C07K14/82 , C12N1/15 , C12N1/19 , C12N5/10 , C12N15/00 , C12N15/12
CPC分类号： C07K14/4748 , A61K38/00
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as GAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described. Tumor rejection antigens are also shown.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为GAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为GAGE编码分子。 描述了编码序列和肿瘤排斥抗原及其前体分子的各种诊断和治疗用途。 还显示肿瘤排斥抗原。
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9.发明授权Isolated RAGE-1 derived peptides which complex with HLA-B7 molecules and uses thereof 失效与HLA-B7分子复合的分离的RAGE-1衍生肽及其用途
公开(公告)号：US5939526A
公开(公告)日：1999-08-17
申请号：US530569
申请日：1995-09-20
申请人： Beatrice Gaugler , Benoit Van den Eynde , Peter Schrier , Nathalie Brouwenstijn , Thierry Boon-Falleur
发明人： Beatrice Gaugler , Benoit Van den Eynde , Peter Schrier , Nathalie Brouwenstijn , Thierry Boon-Falleur
CPC分类号： C07K14/4748 , A61K38/00 , Y10S530/828
摘要： The invention describes the RAGE tumor rejection antigen precursor family, including nucleic acids encoding such tumor rejection antigen precursors, tumor rejection antigen peptides or precursors thereof and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a RAGE tumor rejection antigen precursor.
摘要翻译： 本发明描述了RAGE肿瘤排斥抗原前体家族，包括编码这种肿瘤排斥抗原前体的核酸，肿瘤排斥抗原肽或其前体以及与之相关的抗体。 还提供了用于诊断和治疗以RAGE肿瘤排斥抗原前体的表达为特征的病症的方法和产品。
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10.发明授权
公开(公告)号：US5648226A
公开(公告)日：1997-07-15
申请号：US370648
申请日：1995-01-10
IPC分类号： G01N33/566 , A61K35/12 , A61K38/00 , A61K48/00 , A61K49/00 , A61P35/00 , C07H21/04 , C07K14/47 , C07K14/74 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/574 , C07K7/00 , C07K14/82
CPC分类号： C07K14/4748 , A61K38/00 , Y10S530/828
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as GAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described. Tumor rejection antigens are also shown.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为GAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为GAGE编码分子。 描述了编码序列和肿瘤排斥抗原及其前体分子的各种诊断和治疗用途。 还显示肿瘤排斥抗原。
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