摘要:
The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula 1, and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要:
A signal source for use as a frequency source or time keeping signal source includes a radioactive emission source generating a substantially periodic signal corresponding to a radioactive material's disintegration rate. A radioactive emission detector generates a radioactive emission detection signal and, to stabilize the detected periodic signal, a dead time controlling attenuator blanks or shuts off the radioactive emission detection signal for a selected dead time interval in response to each detected radioactive emission (i.e., a detected signal pulse or signal component) generated by the source. The dead time controlling attenuator output provides a long-term and short-term a stable periodic signal.
摘要:
A new transcriptional co-activator that interacts with steroid/nuclear receptors has been identified. The peptide and its nucleic acid sequences are useful for modulating the activity of steroid/nuclear receptors and biochemical processes in which steroid/nuclear receptors play a role.
摘要:
In the field of data storage on limited rewritability storage media, handling frequently changing databases may lead to unequal wear of storage segments. The invention discloses a method for modifying a database file, which ensures maximally distributed segment wear in that any writing of data records uses a next available segment after the last written segment; and a reading method. A data carrier according to the method, containing a database file with records having version numbers is also disclosed.
摘要:
A data transfer in a network comprises a first node sending out a request for a particular data unit, a second node receiving and analysing the request, detecting that it may provide the requested data unit and sending to the first node a message indicating that it may provide the requested data unit, the first node receiving and selecting the message and sending a second request to the second node to request transfer of the particular data unit, and the second node transferring the particular data unit upon reception of the second request. A method for assigning a priority to such data transfer in a network comprises the first node assigning an identifier corresponding to a first priority to the request, the second node evaluating the identifier and, based on the identifier, calculating a second priority and assigning the calculated second priority to said transfer.
摘要:
A mounting apparatus for mounting a planar member (10) comprises a base (200), a pair of locking members (160) secured on the base, a supporting tray (130) secured on a bottom of the planar member and an operating shaft (110) pivotally attached to the supporting tray. A plurality of mounting holes (143) is defined in the supporting tray and each comprises an accommodating hole (142) and a retaining hole (144). A plurality of standoffs (210) formed on the base and each comprises a head portion (214) and a neck portion (212). A pair of arms is formed on the operating shaft and each defines a cutout for receiving the locking member. After the head portions of the standoffs are received in corresponding accommodating holes, the operating shaft is pushed towards the base. The planar member is attached to the base when the neck portions are received in corresponding retaining holes.
摘要:
In a radio system having stations which are at least partially provided with a directional antenna, a first emitting station is provided with a directional antenna in a first spatial radio area. The first emitting station sends a direction information message indicating the spatial direction in which the data is to be transmitted. Transmission resources can be advantageously occupied based on the direction information message.
摘要:
Communications with an implantable device are conducted using a physical telemetry link dynamically selected from multiple physical telemetry links based on selected criteria including, for example, bandwidth, security, data throughput, channel availability and reliability.
摘要:
A method performs synchronization in an at least partly self-organizing radio communication system with a number of mobile stations which lie across an air interface within two-way radio range. Al least some mobile stations from the number of mobile stations transmit synchronization sequences, by which a part or all the mobile stations of the number of mobile stations synchronize.
摘要:
The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.