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110 条记录 (耗时 0.047 秒)

    Polyoxometalate compounds as antiviral agents
    96.
    发明授权
    Polyoxometalate compounds as antiviral agents 失效

    公开(公告)号：US06911470B1

    公开(公告)日：2005-06-28

    申请号：US08140885

    申请日：1993-10-25

    申请人： Raymond F. Schinazi ,  Craig L. Hill

    发明人： Raymond F. Schinazi ,  Craig L. Hill

    IPC分类号： C07C229/26 ,  C07C279/14 ,  C07D233/54 ,  A61K31/28

    CPC分类号： C07D233/64 ,  C07C229/26 ,  C07C279/14

    摘要： Polyoxometalate compounds which exhibit anti-retroviral activity are disclosed. Compounds with anti-retroviral activity include those having the following general molecular formulas: M7PW11O39 M8SiW11O39 M9HSiW9O34 M8HPW9O34 M10(TM)4(PW9O34)2 M16(TM)4(P2W15O56)2 M14[NaP5W30O110] M12(TM)3(PW9O34)2 M6P2W18O62 wherein M is an alkali metal, NH4+ or other common monocation or soluble dication, or any combination of the above provided adequate water solubility is exhibited, or histidinium ion, argininium ion, or lysinium ion or any dication of a dipeptide or oligopeptide with 2 protonated basic amino acid residues, or any combination of these monocations or dications with each other or with any common inorganic cation, and TM is a divalent transition metal ion, such as Mn, Fe, Co, Ni, Cu and Zn.

    3′,5-difluoro-2′,3′-didehydropyrimidine nucleosides and methods of treatment therewith
    97.
    发明授权
    3′,5-difluoro-2′,3′-didehydropyrimidine nucleosides and methods of treatment therewith 失效
    3'，5-二氟-2'，3'-二脱氢嘧啶核苷及其处理方法

    公开(公告)号：US06680303B2

    公开(公告)日：2004-01-20

    申请号：US10146779

    申请日：2002-05-15

    申请人： Raymond F. Schinazi ,  Dennis C. Liotta

    发明人： Raymond F. Schinazi ,  Dennis C. Liotta

    IPC分类号： A61K3170

    CPC分类号： A61K31/7068 ,  A61K31/70 ,  A61K45/06 ,  C07H19/06 ,  A61K2300/00

    摘要： A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or 5-fluoro]-2′,3′-dideoxy-2′,3′-didehydro-pyrimidine nucleoside or a [5-carboxamido or 5-fluoro]-3′-modified-pyrimidine nucleoside, or a mixture or a pharmaceutically acceptable derivative thereof, including a 5′ or N4 alkylated or acrylated derivative, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier.

    摘要翻译： 公开了用于治疗人和其他宿主动物中的HIV和HBV感染的方法和组合物，其包括给予有效量的[5-甲酰氨基或5-氟] -2'，3'-二脱氧-2' ，3'-二脱氢嘧啶核苷或[5-甲酰氨基或5-氟] -3'-修饰的嘧啶核苷或其混合物或药学上可接受的衍生物，包括5'或N 4烷基化或丙烯酸酯化 衍生物或其药学上可接受的盐在药学上可接受的载体中。