Natural killer cell activating factor II
    91.
    发明授权
    Natural killer cell activating factor II 失效
    自然杀伤细胞激活因子II

    公开(公告)号:US07078482B2

    公开(公告)日:2006-07-18

    申请号:US10192611

    申请日:2002-07-11

    CPC分类号: C07K16/28 A61K38/00 C07K14/52

    摘要: The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

    摘要翻译: 本发明涉及NKAF II多肽,编码多肽的多核苷酸,产生多肽的方法,特别是通过表达多核苷酸,多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸,多肽,激动剂和拮抗剂的方法,其部分涉及研究,诊断和临床领域。

    Cytostatin II
    97.
    发明授权
    Cytostatin II 失效
    细胞抑素II

    公开(公告)号:US06746674B2

    公开(公告)日:2004-06-08

    申请号:US09971187

    申请日:2001-10-05

    IPC分类号: A61K3900

    摘要: The invention relates to cytostatin II growth modulatory polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

    摘要翻译: 本发明涉及细胞抑素II生长调节性多肽,编码多肽的多核苷酸,特别是通过表达多核苷酸产生多肽的方法,多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸,多肽,激动剂和拮抗剂的方法,其部分涉及研究,诊断和临床领域。

    Use of an antibody that binds human tumor necrosis factor receptor-like 2
    100.
    发明授权
    Use of an antibody that binds human tumor necrosis factor receptor-like 2 有权
    使用结合人类肿瘤坏死因子受体的抗体2

    公开(公告)号:US07824675B2

    公开(公告)日:2010-11-02

    申请号:US12241203

    申请日:2008-09-30

    IPC分类号: A61K39/00 A61K39/395

    摘要: The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.

    摘要翻译: 本发明涉及肿瘤坏死因子家族受体的新成员。 本发明提供编码人TR2受体的分离的核酸分子及其两个剪接变体。 还提供TR2多肽,载体,宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR2受体活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测与TR2受体的异常表达相关的疾病状态的诊断方法。 还提供了治疗与表达TR2受体的细胞的异常增殖和分化相关的疾病状态的治疗方法。