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公开(公告)号：USD327493S
公开(公告)日：1992-06-30
申请号：US553765
申请日：1990-07-16
申请人： Masaki Hayashi
设计人： Masaki Hayashi
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公开(公告)号：USD311204S
公开(公告)日：1990-10-09
申请号：US112756
申请日：1987-10-22
申请人： Masaki Hayashi
设计人： Masaki Hayashi
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公开(公告)号：US4398169A
公开(公告)日：1983-08-09
申请号：US217692
申请日：1980-12-18
申请人： Masaki Hayashi
发明人： Masaki Hayashi
摘要： A ceramic thermometer resistance element comprises a coil-shaped resistor for measuring temperature inserted in a ceramic tube together with ceramic spherical filler particles of 40 to 150 .mu.m to thereby fix the resistor. The ceramic spherical filler particles are previously calcined at temperatures much higher than the upper limit of the temperature-measuring range of the element. The filler particles exhibit a liquid-like character and, accordingly, can fill up the gaps between the ceramic tube and the coil-shaped resistor and the gaps of the coils thereof, so that the filler particles hold the resistor statically in the ceramic tube.
摘要翻译： 陶瓷温度计电阻元件包括线圈形电阻器，用于测量插入陶瓷管中的温度以及40至150μm的陶瓷球形填料颗粒，从而固定电阻器。 陶瓷球形填料颗粒预先在远远高于元件温度测量范围的上限的温度下煅烧。 填料颗粒表现出类似液体的特征，因此可以填充陶瓷管和线圈形电阻器之间的间隙及其线圈的间隙，使得填料颗粒将电阻器静态地保持在陶瓷管中。
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公开(公告)号：US4317828A
公开(公告)日：1982-03-02
申请号：US233703
申请日：1981-02-12
IPC分类号： C07D213/18 , C07D213/30 , C07D213/48 , C07D213/55 , C07D213/57 , A61K31/435
CPC分类号： C07D213/30 , C07D213/18 , C07D213/48 , C07D213/55 , C07D213/57 , Y10S514/826
摘要： The pyridine derivatives of the general formula: ##STR1## [wherein A represents an alkylene group containing from 1 to 5 carbon atoms unsubstituted or substituted by a hydroxy group, B represents a single bond, or an oxygen or sulphur atom, or an alkylene group containing from 1 to 5 carbon atoms, D represents a single bond, or an alkylene group containing from 1 to 5 carbon atoms, E represents a grouping of the formula: ##STR2## (in which R.sup.6 represents a hydrogen atom, or an alkyl group containing from 1 to 4 carbon atoms), Z represents a single bond, or an ethynylene group, or a grouping of the formula: ##STR3## in which R.sup.2 represents a hydrogen atom, or an alkyl group containing from 1 to 4 carbon atoms, R.sup.3 represents a hydrogen, bromine or chlorine atom, or an alkyl group containing from 1 to 4 carbon atoms, the symbol represents a single or double bond, the carbon atom attached to R.sup.2 binds to B, and the carbon atom attached to R.sup.3 binds to D, R.sup.1 represents a hydroxy group, or a grouping of the formula: --COOR.sup.4 or --COSR.sup.4, in which R.sup.4 represents a hydrogen atom, or an alkyl group containing from 1 to 12 carbon atoms, or an aralkyl group containing from 7 to 13 carbon atoms, or a cycloalkyl group containing from 4 to 7 carbon atoms unsubstituted or substituted by at least one alkyl group containing from 1 to 4 carbon atoms, or a phenyl group unsubstituted or substituted by at least one halogen atom, trifluoromethyl group, alkyl or alkoxy or alkylthio group containing from 1 to 4 carbon atoms, nitro or phenyl group, R.sup.5 represents a hydrogen atom, or an alkyl group containing from 1 to 4 carbon atoms, with the proviso that, when B represents an oxygen or sulphur atom, Z represents a single bond and D represents an alkylene group containing from 1 to 5 carbon atoms], and non-toxic acid addition salts thereof and, when R.sup.1 represents a carboxy or thiocarboxy group, non-toxic salts thereof, possess a strong inhibitory activity on thromboxane synthetase from rabbit platelet microsomes, and are useful as therapeutically active agents in the prevention and treatment of inflammation, hypertension, thrombus, cerebral apoplexy, asthma, myocardial infarction, cardiostenosis, cerebral infarction and acute cardiac death.
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公开(公告)号：US4313954A
公开(公告)日：1982-02-02
申请号：US122704
申请日：1980-02-19
IPC分类号： A61K31/557 , A61P7/02 , A61P43/00 , C07C405/00 , C07D209/52 , A61K31/40
CPC分类号： C07C405/0041 , C07C405/00 , C07D209/52
摘要： Prostaglandin I.sub.2 analogues of the general formula ##STR1## [wherein R.sup.1 represents a hydrogen atom, an alkyl group containing from 1 to 12 carbon atoms, an aralkyl group containing from 7 to 13 carbon atoms, a cycloalkyl group containing from 4 to 7 carbon atoms unsubstituted or substituted by at least one alkyl group containing from 1 to 4 carbon atoms, a phenyl group unsubstituted or substituted by at least one halogen atom, trifluoromethyl or phenyl group, or by at least one alkyl, alkoxy or alkylthio group containing from 1 to 4 carbon atoms, or represents a group --C.sub.m H.sub.2m COOR.sup.6, --C.sub.n H.sub.2n OR.sup.7 or ##STR2## in which m represents an integer of 1 to 12, n represents an integer of 2 to 12, R.sup.6, R.sup.8 and R.sup.9, which may be the same or different, each represent an alkyl group containing from 1 to 4 carbon atoms, and R.sup.7 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms, R.sup.2 represents a hydrogen atom or a methyl or ethyl group, R.sup.3 represents an alkyl group containing from 1 to 4 carbon atoms, R.sup.4 represents a hydrogen atom, or an alkyl group containing from 1 to 4 carbon atoms, R.sup.5 represents an alkyl group containing from 1 to 10 carbon atoms, Y represents ethylene or trans-vinylene, the hydroxy group attached to the C-11 carbon atom is in .alpha.-configuration, and the wavy line attached to the C-15 carbon atom is in .alpha.- or .beta.-configuration or a mixture thereof] and non-toxic acid addition salts thereof and, when R.sup.1 represents a hydrogen atom, non-toxic salts thereof are new compounds possessing pharmacological properties typical of the prostaglandins.
摘要翻译： 具有通式
的前列腺素I2类似物[其中R1表示氢原子，含有1至12个碳原子的烷基，含有7至13个碳原子的芳烷基，含有4至7个碳原子的环烷基 未取代或被至少一个含有1至4个碳原子的烷基取代的苯基，未被取代或被至少一个卤素原子取代的苯基，三氟甲基或苯基，或至少一个含有1至4个碳原子的烷基，烷氧基或烷硫基 4个碳原子，或表示基团-C m H 2 mCOOR 6，-C n H 2n OR 7或其中m表示1至12的整数，n表示2至12的整数，R 6，R 8和R 9可以相同或不同 各自表示含有1至4个碳原子的烷基，R 7表示氢原子或含有1至4个碳原子的烷基，R 2表示氢原子或甲基或乙基，R 3表示含有 从1 至4个碳原子，R 4表示氢原子或含有1至4个碳原子的烷基，R 5表示含有1至10个碳原子的烷基，Y表示亚乙基或反式亚乙烯基， C-11碳原子为α-构型，连接至C-15碳原子的波浪线为α-或β-构型或其混合物）及其无毒的酸加成盐，当R1表示 氢原子，其无毒盐是具有典型的前列腺素的药理学性质的新化合物。 -
公开(公告)号：US4245099A
公开(公告)日：1981-01-13
申请号：US60113
申请日：1979-07-24
IPC分类号： A61K31/135 , A61K31/16 , A61K31/165 , A61P29/00 , C07C43/205 , C07C45/00 , C07C45/46 , C07C45/54 , C07C45/67 , C07C49/825 , C07C49/84 , C07C67/00 , C07C213/00 , C07C225/16 , C07C225/18 , C07C233/31 , C07C313/00 , C07C317/00 , C07C323/29 , C07C323/32 , C07C323/41 , C07D213/50
CPC分类号： C07D213/50 , C07C323/00 , C07C43/205 , C07C45/004 , C07C45/46 , C07C45/54 , C07C45/673 , C07C49/825 , C07C49/84 , Y10S514/87
摘要： A 2-acyl-6-aminomethylphenol derivative having the formula (I): ##STR1## wherein R.sup.1 represents a straight chain or branched chain alkyl group of 1 to 6 carbon atoms unsubstituted or substituted with 1 to 3 halogen atoms; a hydrogen atom or a group having the formula (II):--C.sub.n H.sub.2n --R.sup.7 (II)wherein n represents 0 or an integer of 1 to 6; R.sup.7 represents a cycloalkyl group of 3 to 8 carbon atoms unsubstituted or substituted with at least one lower alkyl group; a phenyl group unsubstituted or substituted with at least one lower alkyl group, a halogen atom, a lower alkoxy group or a lower alkylthio group; a lower alkoxy group; a lower alkylthio group; a lower alkylsulfinyl group; a lower alkylsulfonyl group; an N-lower alkylamino group; an N,N-di-lower alkylamino group; or a pyridyl, furyl or thienyl group; R.sup.2 represents a straight chain or branched chain alkyl group of 1 to 6 carbon atoms; a cycloalkyl group of 4 to 8 carbon atoms unsubstituted or substituted with at least one lower alkyl group; a phenyl group unsubstituted or substituted with at least one lower alkyl group, a lower alkoxy group, a lower alkylthio group or a halogen atom; or a lower alkylthio group; R.sup.3 and R.sup.4 each represents a hydrogen atom or R.sup.2 and R.sup.3 or R.sup.2 and R.sup.4 when taken together represent an alkylene group of 2 to 5 carbon atoms unsubstituted or substituted with 1 or 2 lower alkyl groups; R.sup.5 represents a hydrogen atom or a lower alkyl group; and R.sup.6 represents a hydrogen atom, a lower alkyl group or an acyl group, and the pharmaceutically acceptable acid addition salt thereof having anti-inflammatory, analgesic, antipyretic, diuretic and hypotensive effects that can be used for preventing and curing diseases caused by inflammation, edema, hypertension, etc. are disclosed. Also disclosed is a process for preparing such derivative or a pharmaceutically acceptable acid addition salt thereof.
摘要翻译： 具有式（I）的2-酰基-6-氨基甲基苯酚衍生物：其中R 1表示未被取代或被1至3个卤素原子取代的1至6个碳原子的直链或支链烷基; 氢原子或具有式（II）的基团：-C n H 2n-R 7（II）其中n表示0或1至6的整数; R7表示未被取代或被至少一个低级烷基取代的3-8个碳原子的环烷基; 未取代或被至少一个低级烷基，卤素原子，低级烷氧基或低级烷硫基取代的苯基; 低级烷氧基; 低级烷硫基; 低级烷基亚磺酰基; 低级烷基磺酰基; N-低级烷基氨基; N，N-二低级烷基氨基; 或吡啶基，呋喃基或噻吩基; R2表示1〜6个碳原子的直链或支链烷基; 未取代或被至少一个低级烷基取代的4-8个碳原子的环烷基; 未取代或被至少一个低级烷基，低级烷氧基，低级烷硫基或卤素原子取代的苯基; 或低级烷硫基; R 3和R 4各自表示氢原子或R 2，R 3或R 2和R 4一起表示未取代或被1或2个低级烷基取代的2至5个碳原子的亚烷基; R5表示氢原子或低级烷基; R6表示氢原子，低级烷基或酰基，及其药学上可接受的酸加成盐，其具有抗炎，镇痛，解热，利尿和降血压作用，可用于预防和治疗由炎症引起的疾病， 水肿，高血压等。 还公开了制备此类衍生物或其药学上可接受的酸加成盐的方法。
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公开(公告)号：US4234597A
公开(公告)日：1980-11-18
申请号：US20339
申请日：1979-03-14
申请人： Masaki Hayashi , Shuichi Ohuchida , Yoshinobu Arai
发明人： Masaki Hayashi , Shuichi Ohuchida , Yoshinobu Arai
IPC分类号： C07D209/94 , A61K31/557 , A61P7/02 , A61P9/00 , A61P9/10 , A61P43/00 , C07C405/00 , C07D209/52 , A61K31/40
CPC分类号： C07C405/00 , C07C405/0041 , C07D209/52
摘要： Prostaglandin I.sub.2 analogues of the formula: ##STR1## [wherein R.sup.1 represents hydrogen, alkyl of 1 to 12 carbon atoms, aralkyl of 7 to 12 carbon atoms, cycloalkyl of 4 to 7 carbon atoms optionally substituted by alkyl of 1 to 4 carbon atoms, phenyl optionally substituted by chlorine, trifluoromethyl, alkyl of 1 to 4 carbon atoms or phenyl, or represents a group --C.sub.p H.sub.2p COOR.sup.5, --C.sub.q H.sub.2q OR.sup.6 or ##STR2## (wherein R.sup.5, R.sup.7 and R.sup.8 represent alkyl of 1 to 4 carbon atoms, R.sup.6 represents hydrogen or alkyl of 1 to 4 carbon atoms, p represents an integer of from 1 to 12, and q represents an integer of from 2 to 12), R.sup.2, R.sup.3 and R.sup.4, represent hydrogen or alkyl of 1 to 8 carbon atoms, B represents a single bond, or alkylene of 1 to 4 carbon atoms, n represents 3, 4, 5 or 6, and the symbol represents a single or double bond] and, when appropriate, non-toxic salts, including acid addition salts, thereof are new compounds possessing pharmacological properties typical of the prostaglandins.
摘要翻译： 具有下式的前列腺素I2类似物：其中R 1表示氢，1至12个碳原子的烷基，7至12个碳原子的芳烷基，4至7个碳原子的环烷基，任选被1至4个碳原子的烷基取代 任选被氯，三氟甲基，1-4个碳原子的烷基或苯基取代的苯基，或代表基团-CpH2pCOOR5，-CqH2qOR6或者其中R5，R7和R8代表1-4个碳原子的烷基，R6代表 氢或1〜4个碳原子的烷基，p表示1〜12的整数，q表示2〜12的整数），R2，R3和R4表示氢或碳原子数为1〜8的烷基，B 表示单键，或1〜4个碳原子的亚烷基，n表示3,4,5或6，符号表示单键或双键]，适当时包括无毒盐，包括其酸加成盐 是具有典型的前列腺素的药理学特性的新化合物。
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公开(公告)号：US4215142A
公开(公告)日：1980-07-29
申请号：US940685
申请日：1978-09-08
IPC分类号： C08L5/00 , A61K31/20 , A61K31/215 , A61K31/557 , A61K31/5575 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07D307/937 , C07F1/02 , C07C177/00 , A61K31/14
CPC分类号： C07D307/935 , C07C405/00 , C07D307/937 , C07F1/02 , Y10S514/824 , Y10S514/826 , Y10S514/869 , Y10S514/926 , Y10S514/927
摘要： Prostaglandin E.sub.1 analogues of the general formula: ##STR1## [wherein Y represents ethylene or trans-vinylene, Z represents ethylene or trans-vinylene, R.sup.1 represents a hydrogen atom, an alkyl group containing from 1 to 12 carbon atoms, an aralkyl group containing from 7 to 12 carbon atoms, a cycloalkyl group containing from 4 to 7 carbon atoms and unsubstituted or substituted by at least one alkyl group containing from 1 to 6 carbon atoms, a phenyl group unsubstituted or substituted by at least one chlorine atom, trifluoromethyl group, alkyl group containing from 1 to 4 carbon atoms or phenyl group, a --C.sub.m H.sub.2m COOR.sup.5 group (wherein m represents an integer of from 1 to 12 and R.sup.5 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms), a --C.sub.n H.sub.2n OR.sup.6 group (wherein R.sup.6 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms and n represents an integer of from 2 to 12), or a ##STR2## group (wherein R.sup.7 and R.sup.8 each represent a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms and n is as hereinbefore defined), R.sup.2 represents a hydrogen atom or a methyl or ethyl group, R.sup.3 represents a single bond or an alkylene group containing from 1 to 4 carbon atoms, R.sup.4 represents a hydrogen atom, an alkyl group containing from 1 to 8 carbon atoms, a cycloalkyl group containing from 4 to 7 carbon atoms and unsubstituted or substituted by at least one alkyl group containing from 1 to 8 carbon atoms, or represents a phenyl or phenoxy group unsubstituted or substituted by at least one chlorine atom, trifluoromethyl group or alkyl group containing from 1 to 3 carbon atoms, and the wavy line attached to the C-11 and C-15 carbon atoms represents .alpha.- or .beta.- configuration or mixtures thereof] and cyclodextrin clathrates thereof, and, when R.sup.1 represents a hydrogen atom or a group C.sub.m H.sub.2m COOR.sup.5 in which R.sup.5 represents a hydrogen atom, non-toxic salts thereof and, when R.sup.1 represents a group ##STR3## non-toxic acid addition salts thereof, are new compounds and possess characteristic prostaglandin-like properties.
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公开(公告)号：US4140712A
公开(公告)日：1979-02-20
申请号：US547293
申请日：1975-02-05
申请人： Masaki Hayashi , Seiji Kori , Hajimu Miyake
发明人： Masaki Hayashi , Seiji Kori , Hajimu Miyake
IPC分类号： C07D317/72 , B01J31/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07D309/12 , C07F9/40 , C07C177/00
CPC分类号： C07D307/935 , C07C405/00 , C07D309/12 , C07F9/4006 , Y10S514/826 , Y10S514/929 , Y10S514/957 , Y10S514/962
摘要： The present invention relates to 20-hydroxy prostaglandins of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## and X represents ethylene or cis-vinylene and Y represents trans-vinylene, or X and Y each represent ethylene, R represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.1 , R.sup.2, R.sup.3, R.sup.4 and R.sup.5, which may be the same or different, each represent a hydrogen atom or a methyl or ethyl group, and n represents zero or an integer from 1 to 3 inclusive, and cyclodextrin clathrates of such acids and esters and, when R represents a hydrogen atom, the non-toxic salts thereof.These compounds exhibit characteristic prostaglandin activity.
摘要翻译： 本发明涉及下式的20-羟基前列腺素：其中A代表下式的组：其中X表示亚乙基或顺式 - 亚乙烯基，Y表示反式亚乙烯基，或X和Y各自表示 乙烯，R表示氢原子或含有1至12个碳原子的直链或支链烷基，可以相同或不同的R 1，R 2，R 3，R 4和R 5各自表示氢原子或 甲基或乙基，n表示0或1〜3的整数，以及这些酸和酯的环糊精包合物，当R表示氢原子时，为无毒性盐。
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公开(公告)号：US4133755A
公开(公告)日：1979-01-09
申请号：US818650
申请日：1977-07-25
申请人： Ryohkichi Tarao , Kanji Kaku , Masaki Hayashi , Takao Nakamura , Shigeo Ohishi , Hajime Yamano
发明人： Ryohkichi Tarao , Kanji Kaku , Masaki Hayashi , Takao Nakamura , Shigeo Ohishi , Hajime Yamano
摘要： As an agent for removing heavy metals such as mercury from waste waters containing the same, a composition and granule based on the composition are provided. Also a method for preparing the granule is provided. The composition consists mainly of a dithiocarbamate bond-containing low molecular weight compound, amorphous silica and active carbon powder. The granule consists mainly of said composition and a vinyl acetate polymer resin as a binder. The method is carried out by kneading and extruding the composition of the granule together with a clay as an excipient. Treated water through said agent can pass the current very severe effluent standards.
摘要翻译： 作为从含有该金属的废水中去除重金属如汞的试剂，提供了基于该组合物的组合物和颗粒。 还提供了制备颗粒的方法。 该组合物主要由含二硫代氨基甲酸酯键的低分子量化合物，无定形二氧化硅和活性炭粉末组成。 颗粒主要由所述组合物和作为粘合剂的乙酸乙烯酯聚合物树脂组成。 该方法通过将颗粒的组合物与作为赋形剂的粘土一起捏合和挤出来进行。 通过所述试剂处理的水可以通过目前非常严格的污水标准。
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