公开(公告)号：US20070098734A1

公开(公告)日：2007-05-03

申请号：US11580358

申请日：2006-10-13

申请人： Zeling Cai ,  Michael Jackson ,  Per Peterson ,  Wei-Xing Shi ,  Yan Kong ,  Juli DeGraw

发明人： Zeling Cai ,  Michael Jackson ,  Per Peterson ,  Wei-Xing Shi ,  Yan Kong ,  Juli DeGraw

IPC分类号： A61K39/00 ,  C12N5/08

CPC分类号： A61K39/0008 ,  A61K2035/122 ,  C12N5/0636 ,  C12N2501/23 ,  C12N2501/51 ,  C12N2501/58 ,  C12N2502/50 ,  C12N2502/99

摘要： Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cells loaded with IgE peptides in vitro and inhibit antigen specific IgE response in vivo. In addition, adoptive transfer of the IgE specific CTL to an asthmatic mouse model can inhibit the development of lung inflammation and airway hypersensitivity. IgE specific CTL provides a treatment for allergic asthma and other IgE-mediated allergic diseases. Antigenic peptides identified from non-tumor self-antigens induce specific cytotoxic T lymphocyte (CTL) in vitro. The CTL induced by peptides identified from CD40L can kill activated CD4 T cells. In vitro generated CTL specific for CD40L inhibit CD4-dependent antibody responses of all isotypes in vivo. In contrast, CTL induced by antigenic peptides derived from IgE specifically inhibit IgE responses, and adoptive transfer of CD40L-specific CTL to NOD mice at early age delay the development of diabetes in NOD mice. In vitro generated CTL specific for non-tumor self-antigens expressed on activated CD4 T cells regulate immune responses in vivo.

摘要翻译： 可以通过用人造抗原呈递细胞呈递的IgE肽刺激静息幼稚CD8T细胞在体外产生来自IgE分子的抗原肽特异性的细胞毒性T淋巴细胞（CTL）。 IgE特异性CTL在体外裂解装载有IgE肽的靶细胞，并在体内抑制抗原特异性IgE反应。 此外，将IgE特异性CTL过继转移至哮喘小鼠模型可以抑制肺部炎症和气道超敏反应的发展。 IgE特异性CTL提供过敏性哮喘和其他IgE介导的过敏性疾病的治疗。 从非肿瘤自身抗原鉴定的抗原肽在体外诱导特异性细胞毒性T淋巴细胞（CTL）。 由CD40L鉴定的肽诱导的CTL可以杀死活化的CD4T细胞。 体外产生的CD40L特异性CTL可抑制体内所有同种型的CD4依赖性抗体反应。 相比之下，来自IgE的抗原肽诱导的CTL特异性抑制IgE应答，CD40L特异性CTL过早转移到NOD小鼠早期延迟NOD小鼠的糖尿病发展。 在活化的CD4T细胞上表达的非肿瘤自身抗原的体外产生的CTL调节体内的免疫应答。

公开(公告)号：US20060223953A1

公开(公告)日：2006-10-05

申请号：US11375450

申请日：2006-03-14

申请人： James Drescher ,  Michael Jackson ,  Lisa Muller ,  Frank Stubbs ,  Robert Tokash

发明人： James Drescher ,  Michael Jackson ,  Lisa Muller ,  Frank Stubbs ,  Robert Tokash

IPC分类号： C08L29/00 ,  C08L61/28

CPC分类号： C09D133/14 ,  C08L33/00 ,  C08L61/26 ,  C08L61/28 ,  C08L67/00 ,  C08L2666/04 ,  C08L2666/16 ,  C08L2666/02

摘要： The present invention provides reactive aqueous or solvent borne compositions comprising one or more low-temperature curing alkylether functional aminoplast resins having an average degree of polymerization of from 1.0 to 2.0, preferably alkylether group containing melamines, one or more hydroxyl group containing resins or polymers, such as acrylics and polyesters, one or more unblocked acid catalysts each having a pKa of 0.25 to 1.0, such as organic sulfonic acids, and one or more volatile amines, e.g. N-dipropylamine, that have a relative evaporation rate (RER) of 50-500, wherein, RER equals (p)(M)/11.6, with p being the vapor pressure of the amine in mm Hg and M being the molecular weight of the amine. The compositions cure at from 60° C. to 135° C., e.g. below 105° C., to form durable coatings suitable for plastic substrates, such as automotive plastics. The present invention also provides methods of forming the compositions comprising mixing the said aminoplast resins, hydroxyl group containing resins or polymers, unblocked acids and volatile amines to form a mixture, wherein the acids and the amines are added separately into the mixture.

公开(公告)号：US20060134125A1

公开(公告)日：2006-06-22

申请号：US11219967

申请日：2005-09-06

申请人： Alain Luxembourg ,  Michael Jackson ,  Per Peterson

发明人： Alain Luxembourg ,  Michael Jackson ,  Per Peterson

IPC分类号： A61K39/00

CPC分类号： A61K39/39 ,  A61K2039/5158 ,  C07K16/2818 ,  C12N5/0636 ,  C12N2501/51 ,  G01N33/5094 ,  G01N33/54326 ,  G01N33/56977

摘要： A new method to capture, purify and expand antigen-specific T lymphocytes has been developed using magnetic beads coated with recombinant MHC class I molecules. This method was optimized using homogenous populations of naive T cells purified from mice transgenic for the 2C T cell receptor (TCR). These T cells were captured on beads coated with MHC class I molecules and the relevant antigenic peptides. MHC and peptide specificity was confirmed by the usage of irrelevant MHC peptide combinations. An enrichment of 800 to 1600 fold was measured, using 2C T cells mixed with irrelevant T cells, starting from a 2C T cell frequency of 1/3000. The same approach was used to purify antigen-specific CD8+ T cells from total CD8+ T cells from naive mice. The recovered cells could be expanded and specifically kill target cells in vitro; they had a significant effect in vivo as well. We expect this procedure to be suitable to purify and expand in vitro tumor- and virus-specific killer T cells for use in cell therapy.

公开(公告)号：US20060010725A1

公开(公告)日：2006-01-19

申请号：US10890519

申请日：2004-07-14

申请人： Michael Jackson

发明人： Michael Jackson

IPC分类号： E02F9/28

CPC分类号： E02F9/2841

摘要： An excavating tooth has an adapter, a point and a locking device. The adapter has a forwardly protruding nose, a channel and a body. The body of the adapter is configured to be secured to excavating equipment. The point has a rearwardly opening socket for receiving the adapter nose therein, a forward digging member, and an ear extending from a side wall of the point, the ear having a recess. The locking device has a rigid body and a depressible protrusion. The rigid body is configured for receipt in the channel of the point and the depressible protrusion is configured for receipt in the recess of the adapter. The protrusion resiliently engages the recess for tightening the point to the adapter. The nose of the adapter has a plurality of tongues and the socket of the point has a plurality of grooves for receiving the plurality of tongues.

摘要翻译： 挖掘齿具有适配器，点和锁定装置。 适配器具有向前突出的鼻子，通道和身体。 适配器的主体被配置为固定到挖掘设备。 该点具有用于接收其中的适配器鼻部的向后开口的插座，前向挖掘构件和从该点的侧壁延伸的耳朵，耳部具有凹部。 锁定装置具有刚体和可压下的突起。 刚体被构造成用于容纳在该点的通道中，并且可压下的突起构造成用于容纳在适配器的凹部中。 突出部弹性地接合凹部以将点紧固到适配器。 适配器的鼻部具有多个舌片，并且该点的插座具有用于容纳多个舌片的多个凹槽。

公开(公告)号：US20050144862A1

公开(公告)日：2005-07-07

申请号：US10740017

申请日：2003-12-18

申请人： Michael Jackson ,  Jonathan Price

发明人： Michael Jackson ,  Jonathan Price

IPC分类号： B32B17/10 ,  E05F11/38 ,  E06B3/00

CPC分类号： B32B17/10036 ,  B32B17/10293 ,  B32B17/10761 ,  E05F11/385 ,  E05F2011/387 ,  E05Y2900/55

摘要： A laminated automobile side glass includes an insert for engaging the window opening mechanism. The insert is molded for integration into the lamination layers, with a mechanism interface section, having a maximum thickness equal to the overall thickness of the glass. This mechanism interface section is arranged in a cutout of the window, so that the window presents a substantially continuous sheet without protrusions. The insert is formed to constitute substantially the entire engagement of the window with the opening mechanism, and to absorb the stresses imposed by vibration, opening and closing of the window, and the slamming of the automobile door.

摘要翻译： 层压汽车侧玻璃包括用于接合窗口打开机构的插入件。 模制插入件用于与层压层一体化，具有机构接口部分，其最大厚度等于玻璃的总厚度。 该机构接口部分布置在窗口的切口中，使得窗口呈现出没有突起的基本上连续的片材。 插入件被形成为基本上构成窗口与打开机构的整个接合，并且吸收由振动，窗口的打开和关闭以及汽车门的砰击所施加的应力。

公开(公告)号：US06894275B2

公开(公告)日：2005-05-17

申请号：US10849923

申请日：2004-05-21

申请人： Martin Green ,  Michael Jackson

发明人： Martin Green ,  Michael Jackson

IPC分类号： H01J49/06 ,  H01J49/40

CPC分类号： H01J49/067 ,  H01J49/0031 ,  H01J49/40

摘要： A way of increasing the dynamic range of a mass spectrometer which incorporates a time to digital converter such as commonly used with a time of flight mass analyser is disclosed. A z-lens upstream of the analyser can be switched between a high sensitivity mode wherein a beam of ions passing therethrough is substantially focused on to the entrance slit of the analyser, and a low sensitivity mode wherein the beam of ions is defocused so that the diameter of the beam substantially exceeds that of the entrance slit of the analyser. Obtaining data in the low sensitivity mode in combination with obtaining data in the high sensitivity mode enable an order of magnitude increase in the dynamic range to be obtained.

公开(公告)号：US06878929B2

公开(公告)日：2005-04-12

申请号：US09823992

申请日：2001-04-03

申请人： Martin Green ,  Michael Jackson

发明人： Martin Green ,  Michael Jackson

IPC分类号： H01J49/06 ,  H01J49/40 ,  G01K1/08 ,  H01J3/14 ,  H01J3/26

CPC分类号： H01J49/067 ,  H01J49/0031 ,  H01J49/40

摘要： A way of increasing the dynamic range of a mass spectrometer which incorporates a time to digital converter such as commonly used with a time of flight mass analyser is disclosed. A z-lens upstream of the analyser can be switched between a high sensitivity mode wherein a beam of ions passing therethrough is substantially focused on to the entrance slit of the analyser, and a low sensitivity mode wherein the beam of ions is defocused so that the diameter of the beam substantially exceeds that of the entrance slit of the analyser. Obtaining data in the low sensitivity mode in combination with obtaining data in the high sensitivity mode enable an order of magnitude increase in the dynamic range to be obtained.

摘要翻译： 公开了一种增加包括时间到数字转换器的质谱仪的动态范围的方法，例如通常用于飞行时间质量分析器的方式。 分析仪上游的z-透镜可以在其中通过其中的离子束基本上聚焦到分析仪的入口狭缝的高灵敏度模式和低灵敏度模式之间切换，其中离子束散焦，使得 梁的直径基本上超过分析器的入口狭缝的直径。 以低灵敏度模式获取数据与获得高灵敏度模式下的数据相结合，可以获得要获得的动态范围的数量级。

公开(公告)号：US20050054090A1

公开(公告)日：2005-03-10

申请号：US10822173

申请日：2004-04-08

申请人： Susan Webb ,  Ola Winqvist ,  Lars Karlsson ,  Michael Jackson ,  Per Peterson

发明人： Susan Webb ,  Ola Winqvist ,  Lars Karlsson ,  Michael Jackson ,  Per Peterson

IPC分类号： C12N15/09 ,  A61K31/00 ,  A61K35/26 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61P3/00 ,  A61P3/10 ,  A61P21/00 ,  A61P21/04 ,  A61P37/00 ,  A61P37/04 ,  A61P37/08 ,  C07K14/705 ,  C12N5/07 ,  C12N5/10 ,  C12N15/12 ,  C12N5/06 ,  C12N5/08

CPC分类号： C07K14/70596 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  C12N5/0601 ,  C12N2510/00 ,  Y10S424/81

摘要： The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+ T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.

摘要翻译： 本发明涉及合成抗原呈递矩阵，其制备方法及其使用方法。 一种这样的基质是已被转染以产生具有一种或多种辅助分子的MHC抗原呈递分子的细胞。 这些基质用于激活幼稚的CD4 + T细胞，并将正在进行的激活状态转移到Th1或Th2细胞的优选分化群体中。

公开(公告)号：US20050021782A1

公开(公告)日：2005-01-27

申请号：US10462244

申请日：2003-06-16

申请人： Dale Malik ,  Michael Jackson ,  Jeffrey Lord

发明人： Dale Malik ,  Michael Jackson ,  Jeffrey Lord

IPC分类号： G06F15/16 ,  H04L29/06

CPC分类号： H04L63/083

摘要： Inconveniences in switching from one Internet service provider (ISP) to another ISP are remedied by providing streamlined approaches that facilitate the migration from one ISP to another ISP. In one embodiment, user information is validated prior to migrating from the old ISP to the new ISP, thereby ensuring proper transfer of information from the old ISP to the new ISP.

摘要翻译： 从一个互联网服务提供商（ISP）切换到另一个ISP的不便之处是通过提供简化的方法来解决，从而便于从一个ISP迁移到另一个ISP。 在一个实施例中，在从旧的ISP迁移到新的ISP之前验证用户信息，从而确保从旧的ISP到新的ISP的信息的正确传送。

公开(公告)号：USD499374S1

公开(公告)日：2004-12-07

申请号：US29191915

申请日：2003-10-16

申请人： Michael Jackson ,  Gianni Mario Zannoni ,  Chris Michael Zawistowski

设计人： Michael Jackson ,  Gianni Mario Zannoni ,  Chris Michael Zawistowski