公开(公告)号：US06351673B1

公开(公告)日：2002-02-26

申请号：US09661608

申请日：2000-09-14

申请人： Jiang Ding ,  Yinghong Yu ,  Andrew P. Kramer ,  Julio Spinelli

发明人： Jiang Ding ,  Yinghong Yu ,  Andrew P. Kramer ,  Julio Spinelli

IPC分类号： A61N1365

CPC分类号： E21B17/01 ,  A61N1/3627 ,  A61N1/3682 ,  E21B43/36

摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

公开(公告)号：US08792980B2

公开(公告)日：2014-07-29

申请号：US12980417

申请日：2010-12-29

申请人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

发明人： Yinghong Yu ,  Jiang Ding ,  Qingsheng Zhu

IPC分类号： A61N1/368 ,  A61N1/365

CPC分类号： A61N1/36578 ,  A61N1/3627 ,  A61N1/36542 ,  A61N1/3684

摘要： Methods and devices are disclosed for employing mechanical measurements to synchronize contractions of ventricular wall locations. Accelerometers that may be placed within electrode leads are positioned at ventricular wall locations, such as the left ventricle free wall, right ventricle free wall, and the anterior wall/septum wall. The accelerometers produce signals in response to the motion of the ventricular wall locations. A processor may then compare the signals to determine a difference in the synchronization of the ventricular wall location contractions. The difference in synchronization can be determined in various ways such as computing a phase difference and/or amplitude difference between the accelerometer signals. One or more stimulation pulses may be provided per cardiac cycle to resynchronize the contractions as measured by the accelerometers to thereby constantly and automatically optimize the cardiac resynchronization therapy.

摘要翻译： 公开了用于采用机械测量来同步心室壁位置收缩的方法和装置。 可以放置在电极引线内的加速度计定位在心室壁位置，例如左心室游离壁，右心室游离壁和前壁/隔膜壁。 加速度计响应于心室壁位置的运动产生信号。 然后，处理器可以比较信号以确定心室壁位置收缩的同步的差异。 可以以各种方式确定同步差异，例如计算加速度计信号之间的相位差和/或振幅差。 可以在每个心动周期提供一个或多个刺激脉冲，以重新同步由加速度计测量的收缩，从而不断地和自动地优化心脏再同步治疗。

公开(公告)号：US08588910B2

公开(公告)日：2013-11-19

申请号：US13154661

申请日：2011-06-07

申请人： David J. Ternes ,  Donald L. Hopper ,  Yinghong Yu

发明人： David J. Ternes ,  Donald L. Hopper ,  Yinghong Yu

IPC分类号： A61N1/00

CPC分类号： A61N1/3682 ,  A61N1/3627 ,  A61N1/365 ,  A61N1/3684

摘要： A non-linear dynamic specified AV delay can be used, such as to help maintain cardiac resynchronization therapy, such as in patients with one or more symptoms of congestive heart failure.

摘要翻译： 可以使用非线性动态指定的AV延迟，例如帮助维持心脏再同步治疗，例如患有一种或多种充血性心力衰竭症状的患者。

公开(公告)号：US08489204B2

公开(公告)日：2013-07-16

申请号：US13544007

申请日：2012-07-09

申请人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Jiang Ding ,  Yinghong Yu ,  Michael J. Stucky ,  Christopher Hartemink

发明人： Shantha Arcot-Krishnamurthy ,  Allan C. Shuros ,  Jiang Ding ,  Yinghong Yu ,  Michael J. Stucky ,  Christopher Hartemink

IPC分类号： A61N1/00 ,  A61B5/02

CPC分类号： A61N1/36585 ,  A61B5/02028 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3702 ,  G06F19/00

摘要： A method and apparatus is described for detecting and localizing areas of myocardial infarction or ischemia. By pacing sites in proximity to the infarcted or ischemic region with appropriately timed pacing pulses, the region is pre-excited in a manner that lessens the mechanical stress to which it is subjected, thus reducing the metabolic demand of the region and the stimulus for remodeling.

摘要翻译： 描述了用于检测和定位心肌梗死或缺血区域的方法和装置。 通过以适当的定时起搏脉冲对位于梗塞或缺血区域附近的部位进行起搏，该区域以减轻其受到的机械应力的方式预激发，从而降低该区域的代谢需求和重塑刺激 。

公开(公告)号：US20130172954A1

公开(公告)日：2013-07-04

申请号：US13542261

申请日：2012-07-05

申请人： Yinghong Yu ,  Shibaji Shome ,  Dan Li ,  Michael Gold ,  Jagmeet Singh

发明人： Yinghong Yu ,  Shibaji Shome ,  Dan Li ,  Michael Gold ,  Jagmeet Singh

IPC分类号： A61N1/365

CPC分类号： A61N1/36592 ,  A61B5/0006 ,  A61B5/0422 ,  A61B5/0456 ,  A61B5/0472 ,  A61B5/686 ,  A61N1/3684

摘要： A system comprises a cardiac signal sensing circuit and a processor circuit. The cardiac signal sensing circuit is configured to sense a cardiac signal segment using a set of electrodes connectable to the cardiac signal sensing circuit. The processor circuit is communicatively coupled to the cardiac signal sensing circuit and includes a peak detector circuit. The peak detector circuit is configured to identify, in the cardiac signal segment, a fiducial indicative of ventricular activation that is local to at least one electrode of the first set of electrodes. The fiducial includes a first large positive or negative peak greater than a specified percentage of a maximum peak of the first cardiac signal segment. The processor circuit is configured to provide an indication of local ventricular activation to at least one of a user or process.

摘要翻译： 一种系统包括心脏信号感测电路和处理器电路。 心脏信号感测电路被配置为使用可连接到心脏信号感测电路的一组电极来感测心脏信号段。 处理器电路通信地耦合到心脏信号感测电路并且包括峰值检测器电路。 峰值检测器电路被配置为在心脏信号段中识别指示心室激活的基准，其对于第一组电极的至少一个电极是局部的。 基准包括大于第一心脏信号段的最大峰值的指定百分比的第一大的正或负峰值。 处理器电路被配置为向用户或过程中的至少一个提供局部心室激活的指示。

公开(公告)号：US08473050B2

公开(公告)日：2013-06-25

申请号：US13185580

申请日：2011-07-19

申请人： Jonathan Kwok ,  Kent Lee ,  Jesse W. Hartley ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Jiang Ding

发明人： Jonathan Kwok ,  Kent Lee ,  Jesse W. Hartley ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Jiang Ding

IPC分类号： A61B5/053 ,  A61B5/0295

CPC分类号： A61B5/0205 ,  A61B5/053 ,  A61B5/0538 ,  A61N1/36185 ,  A61N1/36521 ,  A61N1/3686

摘要： Vector selection is automatically achieved via a thoracic or intracardiac impedance signal collected in a cardiac function management device or other implantable medical device that includes a test mode and a diagnostic mode. During a test mode, the device cycles through various electrode configurations for collecting thoracic impedance data. At least one figure of merit is calculated from the impedance data for each such electrode configuration. In one example, only non-arrhythmic beats are used for computing the figure of merit. A particular electrode configuration is automatically selected using the figure of merit. During a diagnostic mode, the device collects impedance data using the selected electrode configuration. In one example, the figure of merit includes a ratio of a cardiac stroke amplitude and a respiration amplitude. Other examples of the figure of merit are also described.

摘要翻译： 矢量选择通过收集在包括测试模式和诊断模式的心脏功能管理装置或其他可植入医疗装置中的胸部或心内阻抗信号自动实现。 在测试模式期间，器件循环通过各种电极配置来收集胸部阻抗数据。 从每个这样的电极配置的阻抗数据计算至少一个品质因数。 在一个例子中，仅使用非心律失常节拍来计算品质因数。 使用品质因数自动选择特定的电极配置。 在诊断模式下，设备使用所选择的电极配置收集阻抗数据。 在一个示例中，品质因数包括心搏幅度和呼吸振幅的比值。 还描述了品质因数的其它实例。

公开(公告)号：US20130158621A1

公开(公告)日：2013-06-20

申请号：US13716810

申请日：2012-12-17

申请人： Jiang Ding ,  Allan C. Shuros ,  Dan Li ,  Yinghong Yu ,  Stephen J. Hahn

发明人： Jiang Ding ,  Allan C. Shuros ,  Dan Li ,  Yinghong Yu ,  Stephen J. Hahn

IPC分类号： A61N1/365

CPC分类号： A61N1/36592 ,  A61B5/02152 ,  A61B5/0464 ,  A61B5/0468 ,  A61N1/365 ,  A61N1/37 ,  A61N1/371

摘要： Ectopic cardiac activity can be detected, such as in the absence of a diagnosed tachyarrhythmia episode. In response to the detected ectopic activity, electrostimulation can be provided to a para-Hisian region, such as to activate natural cardiac contraction mechanisms or to interrupt re-entrant cardiac activity. Subsequent ectopic cardiac activity can be detected, and subsequent electrostimulation can be provided to the para-Hisian region, such as according to one or more adjustable electrostimulation parameters.

摘要翻译： 可以检测异位心脏活动，例如在没有诊断的快速性心律失常发作时。 响应于检测到的异位活动，可以向对等神经区域提供电刺激，例如激活自然心脏收缩机制或中断再入心脏活动。 可以检测随后的异位心脏活动，并且可以根据一个或多个可调节的电刺激参数来向对 - Hisian区域提供随后的电刺激。

公开(公告)号：US08280512B2

公开(公告)日：2012-10-02

申请号：US12221650

申请日：2008-08-05

申请人： Jiang Ding ,  Yinghong Yu ,  Julio C. Spinelli

发明人： Jiang Ding ,  Yinghong Yu ,  Julio C. Spinelli

IPC分类号： A61N1/37

CPC分类号： A61B5/053 ,  A61B5/0452 ,  A61B5/0456 ,  A61B5/0472 ,  A61B34/20 ,  A61B2034/2072 ,  A61N1/3627 ,  A61N1/36592 ,  A61N1/3682

摘要： Methods and systems are disclosed for determining whether a patient is a responder to cardiac resynchronization therapy. The beginning and ending of the intrinsic ventricular depolarization are determined through signals measured from one or more electrodes implanted in the patient's heart. An interval between the beginning and ending of the intrinsic ventricular depolarization is computed and is compared to a threshold. The threshold may be determined empirically. The pacing parameters of a heart stimulation device, such as a pacemaker, may then be configured, for example, by setting the paced atrio-ventricular delay based on whether the patient responds positively to cardiac resynchronization therapy.

摘要翻译： 公开了用于确定患者是心脏再同步治疗的应答​​者的方法和系统。 通过从植入患者心脏的一个或多个电极测量的信号来确定内在性心室去极化的开始和结束。 计算内在心室去极化的开始和结束之间的间隔，并将其与阈值进行比较。 阈值可以凭经验确定。 然后可以例如通过基于患者是否对心脏再同步治疗作出积极响应来设定起搏心房延迟来配置诸如起搏器的心脏刺激装置的起搏参数。

公开(公告)号：US08271084B2

公开(公告)日：2012-09-18

申请号：US12259055

申请日：2008-10-27

申请人： Yinghong Yu ,  Jiang Ding

发明人： Yinghong Yu ,  Jiang Ding

IPC分类号： A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/3684

摘要： An earlier intrinsic activation and a later intrinsic activation of a right ventricle and a left ventricle are determined. This information is used for computing a biventricular pacing interval as a function of an interval from a pacing energy delivered to a ventricle corresponding to the later intrinsic activation and a depolarization sensed in a ventricle having earlier intrinsic activation, the depolarization evoked in response to the pacing energy.

摘要翻译： 确定右心室和左心室的早期内在激活和后期固有激活。 该信息用于计算作为从输送到心室的起搏能量对应于后来的内部激活的间隔的函数的计算双心室起搏间隔，以及在具有较早内在激活的心室中感测到的去极化，响应于起搏引起的去极化 能源。

公开(公告)号：US20120226328A1

公开(公告)日：2012-09-06

申请号：US13466431

申请日：2012-05-08

申请人： Yanting Dong ,  Yinghong Yu ,  Jiang Ding ,  Scott A. Meyer ,  Xuan Wei ,  Michael John Stucky

发明人： Yanting Dong ,  Yinghong Yu ,  Jiang Ding ,  Scott A. Meyer ,  Xuan Wei ,  Michael John Stucky

IPC分类号： A61N1/365 ,  A61N1/37

CPC分类号： A61N1/3627 ,  A61N1/36585 ,  A61N1/3684

摘要： Systems and methods involve determination of CRT parameters using a number of CRT optimization processes. Each CRT optimization process attempts to return recommended parameters. The CRT parameters are determined based on the recommended parameters returned by one or more of the CRT optimization processes. The CRT optimization processes may be sequentially implemented and the CRT parameters may be determined based on the recommended parameters returned by a first CRT optimization process to return recommended parameters. The CRT parameters may be determined based on a combination of the recommended parameters returned. The CRT optimization processes implemented may be selected from available CRT optimization processes based on patient conditions.

摘要翻译： 系统和方法涉及使用多个CRT优化过程来确定CRT参数。 每个CRT优化过程都会尝试返回推荐的参数。 CRT参数根据一个或多个CRT优化过程返回的推荐参数来确定。 可以顺序地实施CRT优化过程，并且可以基于由第一CRT优化过程返回的推荐参数来返回推荐参数来确定CRT参数。 可以基于返回的推荐参数的组合来确定CRT参数。 可以根据患者条件从可用的CRT优化过程中选择实现的CRT优化处理。