公开(公告)号：US07560558B2

公开(公告)日：2009-07-14

申请号：US10525087

申请日：2003-08-22

申请人： Kiyoshi Shimizu ,  Toshiyuki Shimizu ,  Kaname Kimura ,  Kazuki Kawakami ,  Masayoshi Nakoji

发明人： Kiyoshi Shimizu ,  Toshiyuki Shimizu ,  Kaname Kimura ,  Kazuki Kawakami ,  Masayoshi Nakoji

IPC分类号： C07D215/44 ,  C07D239/72

CPC分类号： C07D215/233 ,  C07D401/14

摘要： The present invention provides compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof: wherein X represents CH or N; Z represents —O—, —NH— or —C(═O)—; R and R′ represent a hydrogen atom, hydroxyl, a halogen atom, optionally substituted alkyl, optionally substituted alkenyl optionally substituted alkoxy, amino, aminocarbonyl, or an optionally substituted heterocyclic group; and A represents an optionally substituted specific carbocyclic or heterocyclic group. The compounds according to the present invention have excellent TGFβ inhibitory activity.

摘要翻译： 本发明提供由式（I）表示的化合物及其药学上可接受的盐和溶剂合物：其中X表示CH或N; Z表示-O - ， - NH-或-C（ - O） - ; R和R'表示氢原子，羟基，卤素原子，任选取代的烷基，任选取代的烯基任选取代的烷氧基，氨基，氨基羰基或任选取代的杂环基; 并且A表示任选取代的特定碳环或杂环基。 根据本发明的化合物具有优异的TGFbeta抑制活性。

公开(公告)号：US07495104B2

公开(公告)日：2009-02-24

申请号：US10491898

申请日：2002-10-17

申请人： Atsushi Miwa ,  Tetsuya Yoshino ,  Tatsushi Osawa ,  Teruyuki Sakai ,  Toshiyuki Shimizu ,  Yasunari Fujiwara

发明人： Atsushi Miwa ,  Tetsuya Yoshino ,  Tatsushi Osawa ,  Teruyuki Sakai ,  Toshiyuki Shimizu ,  Yasunari Fujiwara

IPC分类号： C07D215/38 ,  C07D239/72 ,  A61K31/47

CPC分类号： C07D215/233 ,  C07D239/88 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02

摘要： An objective of the present invention is to provide novel compounds which have inhibitory activity against autophosphorylation of an FGF receptor family and, when orally or intraveneously administered, can suppress the growth of cancer cells. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X represents CH or N; Z represents O or S; Q represents NR10, CR11R2, carbonyl, O, S(═O)m, wherein m is 0 to 2, or urea; R1 to R3 each independently represent H, OH, halogen, nitro, amino, alkyl, alkoxy or the like in which the alkyl and alkoxy groups are optionally substituted; R4 represents H; R5 to R8 each independently represent H, halogen, alkyl, or alkoxy; and R9 represents an optionally substituted carbocyclic or heterocyclic group.

摘要翻译： 本发明的目的是提供对FGF受体家族的自磷酸化具有抑制活性的新型化合物，并且当口服或经受干预时可抑制癌细胞的生长。 本发明的化合物由式（I）表示或其药学上可接受的盐或溶剂合物：其中X表示CH或N; Z表示O或S; Q表示NR10，CR11R2，羰基，O，S（-O）m，其中m为0至2，或脲; R 1至R 3各自独立地表示其中烷基和烷氧基任选被取代的H，OH，卤素，硝基，氨基，烷基，烷氧基等; R4表示H; R5至R8各自独立地表示H，卤素，烷基或烷氧基; 并且R 9表示任选取代的碳环或杂环基。

公开(公告)号：US20080306845A1

公开(公告)日：2008-12-11

申请号：US12123737

申请日：2008-05-20

申请人： Midori MURAYAMA ,  Chikara Kishi ,  Hidenao Ubukata ,  Minoru Saito ,  Minoru Sakai ,  Naoki Wakasugi ,  Nobumitsu Samukawa ,  Toshiyuki Shimizu ,  Yasushi Ogawa ,  Yoshiroh Someya ,  Ryosuke Sako ,  Kazumi Hanada ,  Kentaroh Murakawa

发明人： Midori MURAYAMA ,  Chikara Kishi ,  Hidenao Ubukata ,  Minoru Saito ,  Minoru Sakai ,  Naoki Wakasugi ,  Nobumitsu Samukawa ,  Toshiyuki Shimizu ,  Yasushi Ogawa ,  Yoshiroh Someya ,  Ryosuke Sako ,  Kazumi Hanada ,  Kentaroh Murakawa

IPC分类号： G06Q10/00 ,  G06Q30/00

CPC分类号： G06Q40/10 ,  G06K15/00 ,  G06Q20/102 ,  G06Q30/0283 ,  G06Q30/04 ,  G06Q40/02

摘要： A charge managing system including an image forming apparatus and a charge managing server is provided. The image forming apparatus includes plural applications each configured for executing a specific process on input data, a counter unit that counts a number of result items output as a result of executing at least one of the applications, a count value storage unit that stores a count value corresponding to the number of result items counted by the counter unit, and a storage area setting unit that secures a plurality of storage areas within the count value storage unit each of which storage areas is configured for storing a corresponding count value obtained for each of the applications. The charge managing server manages charging a fee for using the image forming apparatus based on the corresponding count value stored in each of the storage areas secured for each of the applications.

摘要翻译： 提供了包括图像形成装置和电荷管理服务器的电荷管理系统。 图像形成装置包括多个应用，每个应用被配置用于对输入数据执行特定处理;对作为执行至少一个应用程序的结果输出的结果项数进行计数的计数器单元，存储计数的计数值存储单元 对应于由计数器单元计数的结果项目的数量的值;以及存储区域设置单元，其确保计数值存储单元内的多个存储区域，每个存储区域被配置为存储针对每个存储区域获得的相应计数值 应用程序。 收费管理服务器根据存储在为每个应用确保的每个存储区域中的相应计数值来管理使用图像形成装置的费用。

公开(公告)号：US20060264137A1

公开(公告)日：2006-11-23

申请号：US10924073

申请日：2004-08-23

申请人： Ken Ishihara ,  Hisao Namisaki ,  Yoshimi Tanaka ,  Shin-ichiro Morita ,  Katsuhiro Hori ,  Takahiro Yamazaki ,  Kenzo Ishikawa ,  Toshiyuki Shimizu

发明人： Ken Ishihara ,  Hisao Namisaki ,  Yoshimi Tanaka ,  Shin-ichiro Morita ,  Katsuhiro Hori ,  Takahiro Yamazaki ,  Kenzo Ishikawa ,  Toshiyuki Shimizu

IPC分类号： D04B21/00 ,  D04B21/14 ,  B32B15/14

CPC分类号： H05K9/009 ,  A41D31/26 ,  D04B1/14 ,  D04B1/24 ,  D10B2401/16 ,  D10B2403/0114 ,  D10B2501/02 ,  Y10T442/40 ,  Y10T442/413 ,  Y10T442/425 ,  Y10T442/475 ,  Y10T442/481

摘要： A garment made of a reversible electromagnetic wave shielding knitted material comprising a conductive fiber yarn and an elastic fiber yarn interknitted with each other as a surface side and a natural fiber yarn as a back side, wherein the proportion of the elastic fiber yarn is greater than 0 but not greater than 2/3 of the total amount of the conductive fiber yarn and the elastic fiber yarn interknitted with each other, the conductive fiber yarn is a silver-plated nylon yarn having a denier (d) of about 70 to about 210, the natural fiber yarn is a cotton yarn having a count of 30 to 150, and the material has a KES hand value (G-soft) of at least 6 and an electromagnetic wave shielding capability of at least 20 dB.

摘要翻译： 由可逆电磁波屏蔽针织物制成的衣服，其包含导电纤维纱线和作为表面侧相互编织的弹性纤维纱线和作为背面的天然纤维纱线，其中弹性纤维纱线的比例大于 0但不大于导电纤维纱线和彼此相互编织的弹性纤维纱线总量的2/3，导电纤维纱线是旦尼尔（d）为约70至约210的镀银尼龙纱线 天然纤维纱是计数为30〜150的棉纱，该材料的KES手值（G-soft）为6以上，电磁波屏蔽能力为20dB以上。

公开(公告)号：US20050120358A1

公开(公告)日：2005-06-02

申请号：US11032193

申请日：2005-01-11

申请人： Atsuyuki Nikami ,  Masaaki Nagatsuka ,  Toshiyuki Shimizu

发明人： Atsuyuki Nikami ,  Masaaki Nagatsuka ,  Toshiyuki Shimizu

IPC分类号： G06F7/38 ,  G06F9/48

CPC分类号： G06F13/24

摘要： An event notifying method notifies one or a plurality of events from a device to a processor by queuing to a queue in a processor system having one or a plurality of processors. A number of non-notified events existing in the queue is managed by a counter unit, and an inconsistent state of the counter unit caused by differences in updating timings of the counter unit from the device and the processor is temporarily permitted.

摘要翻译： 事件通知方法通过排队到具有一个或多个处理器的处理器系统中的队列来将一个或多个事件从设备通知给处理器。 存在于队列中的多个未通知的事件由计数器单元管理，并且临时允许由计数器单元更新定时与设备和处理器之间的差异引起的计数器单元的不一致状态。

公开(公告)号：US20050049264A1

公开(公告)日：2005-03-03

申请号：US10491898

申请日：2002-10-17

申请人： Atsushi Miwa ,  Tetsuya Yoshino ,  Tatsushi Osawa ,  Teruyuki Sakai ,  Toshiyuki Shimizu ,  Yasunari Fujiwara

发明人： Atsushi Miwa ,  Tetsuya Yoshino ,  Tatsushi Osawa ,  Teruyuki Sakai ,  Toshiyuki Shimizu ,  Yasunari Fujiwara

IPC分类号： A61P1/00 ,  A61P1/18 ,  A61P11/00 ,  A61P13/12 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00 ,  C07D215/22 ,  C07D215/233 ,  C07D239/88 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  A61K31/517 ,  A61K31/47

CPC分类号： C07D215/233 ,  C07D239/88 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02

摘要： An objective of the present invention is to provide novel compounds which have inhibitory activity against autophosphorylation of an FGF receptor family and, when orally or intraveneously administered, can suppress the growth of cancer cells. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X represents CH or N; Z represents O or S; Q represents NR10, CR11R2, carbonyl, O, S(═O)m, wherein m is 0 to 2, or urea; R1 to R3 each independently represent H, OH, halogen, nitro, amino, alkyl, alkoxy or the like in which the alkyl and alkoxy groups are optionally substituted; R4 represents H; R5 to R8 each independently represent H, halogen, alkyl, or alkoxy; and R9 represents an optionally substituted carbocyclic or heterocyclic group.

摘要翻译： 本发明的目的是提供对FGF受体家族的自磷酸化具有抑制活性的新型化合物，并且当口服或经受干预时可抑制癌细胞的生长。 本发明的化合物由式（I）表示或其药学上可接受的盐或溶剂合物：其中X表示CH或N; Z表示O或S; Q表示NR 10，CR 11 R 2，羰基，O，S（= O）m，其中m为0至2，或脲; R 1至R 3各自独立地表示其中烷基和烷氧基任选被取代的H，OH，卤素，硝基，氨基，烷基，烷氧基等; R 4表示H; R 5至R 8各自独立地表示H，卤素，烷基或烷氧基; 并且R 9表示任选取代的碳环或杂环基。

公开(公告)号：US06674362B2

公开(公告)日：2004-01-06

申请号：US09921626

申请日：2001-08-03

申请人： Kenji Yoshioka ,  Takeshi Inui ,  Takayuki Tanahashi ,  Toshiyuki Shimizu

发明人： Kenji Yoshioka ,  Takeshi Inui ,  Takayuki Tanahashi ,  Toshiyuki Shimizu

IPC分类号： G08B2900

CPC分类号： G08B25/016

摘要： A main controller for controlling an emergency informing terminal, and a sub controller for controlling communications with an external device are provided. The main controller and sub controller have microcomputers, and the main controller and sub controller monitor the operation of each other. If the other is abnormal, a reset signal is issued to initialize it, and if still abnormal, the history of abnormality is recorded, and the abnormality is informed to the user by means of sound or light. The power source device of this emergency informing terminal has a function of cutting off power supply to the emergency informing terminal when overheat or overcurrent occurs in the auxiliary battery which operate when supply from the main battery is interrupted, and if overheat or voltage drop occurs due to short circuit of the auxiliary battery or other trouble, power supply into the emergency informing terminal is cut off, so that spread of damage may be avoided.

摘要翻译： 提供了用于控制紧急通知终端的主控制器和用于控制与外部设备通信的子控制器。 主控制器和副控制器具有微型计算机，主控制器和副控制器监控对方的操作。 如果另一个异常，则发出复位信号进行初始化，如果仍然异常，则记录异常历史，并通过声光通知用户异常。该紧急通知的电源装置 终端具有在从主电池供电中断时在辅助电池中发生过热或过电流时切断向紧急通知终端供电的功能，并且如果由于辅助电池短路而发生过热或电压降或 其他故障，电源进入紧急通知终端被切断，从而可以避免传播损坏。

公开(公告)号：US06520484B1

公开(公告)日：2003-02-18

申请号：US09716996

申请日：2000-11-22

申请人： Toshiyuki Shimizu ,  Yasuhiro Miyazaki ,  Shiro Nakajima

发明人： Toshiyuki Shimizu ,  Yasuhiro Miyazaki ,  Shiro Nakajima

IPC分类号： B66D148

CPC分类号： B66D1/50 ,  F21V21/16 ,  F21V21/38

摘要： A hoisting apparatus is provided to facilitate maintenance of a load such as luminaires used at high elevations under safe working conditions. The apparatus comprises at least one cable, a load holder for holding the load, a base secured to a ceiling of a structure, and coupled to the load holder through the cable, and a drive unit for moving the load holder up and down by use of the cable between a top position where the load holder is located adjacent to the base, and a bottom position where the load holder is spaced from the base. The load holder has cable-length adjust unit for adjusting a length of the cable to stop the load holder at a desired position between the top and bottom positions.

摘要翻译： 提供一种起重设备以便于在安全工作条件下维护诸如在高海拔地使用的灯具之类的负载。 该装置包括至少一个电缆，用于保持负载的负载保持器，固定到结构的天花板上并通过电缆耦合到负载保持器的基座，以及用于通过使用来上下移动负载座的驱动单元 在负载保持器位于与基座相邻的顶部位置之间的电缆以及负载保持器与基座间隔开的底部位置。 负载支架具有电缆长度调节单元，用于调节电缆的长度以将负载保持器停止在顶部位置和底部位置之间的期望位置。

公开(公告)号：US06334356B1

公开(公告)日：2002-01-01

申请号：US09419101

申请日：1999-10-15

申请人： Toshiro Kita ,  Kenji Kawaguchi ,  Toshiyuki Shimizu

发明人： Toshiro Kita ,  Kenji Kawaguchi ,  Toshiyuki Shimizu

IPC分类号： G01N900

CPC分类号： G01N9/002 ,  G01N11/16 ,  G01N29/036 ,  G01N29/22 ,  G01N29/222 ,  G01N2291/02408 ,  G01N2291/02818

摘要： This invention relates to a method for deciding an amount of correction factor for the viscosity of a fluid test sample needed for correcting a calculation or measurement of the density based on the viscosity. The method for deciding the viscosity of the fluid test sample, during a density measurement performed by an oscillating densitometer where there is a peak point on the viscosity-attenuation constant characteristic of the test sample at the specific order oscillation, is to decide whether the attenuation constant of the viscosity-attenuation constant characteristic of the test sample at the other specific order oscillation is larger or smaller than that corresponding to the peak point, to decide according to said decision whether the viscosity detected by the attenuation constant obtained at the specific order oscillation belongs to either side larger or smaller than the peak point, and then to decide upon and determine the viscosity of the test sample according to the above two decisions.

摘要翻译： 本发明涉及一种用于基于粘度来确定校正密度的计算或测量所需的流体测试样品的粘度的校正因子的量的方法。用于确定流体测试样品的粘度的方法 通过振荡密度计进行的密度测量，其中在特定次序振荡下测试样品的粘度 - 衰减常数特征具有峰值点，是确定测试样品的粘度 - 衰减常数特性的衰减常数 其他特定顺序振荡大于或小于对应于峰值点的振荡，根据所述判定来确定由特定阶振荡获得的衰减常数所检测的粘度是否属于峰值点以上的任何一侧，然后 根据上述两个d来决定和确定测试样品的粘度 决定。

公开(公告)号：US06326824B1

公开(公告)日：2001-12-04

申请号：US09626963

申请日：2000-07-27

申请人： Koji Hosoe ,  Jun Funaki ,  Toshiyuki Shimizu ,  Michio Numata

发明人： Koji Hosoe ,  Jun Funaki ,  Toshiyuki Shimizu ,  Michio Numata

IPC分类号： H03L700

CPC分类号： H04J3/0682 ,  H04L7/0004 ,  H04L7/08

摘要： An initial value generation circuit generates an initial value taking into consideration the a time delay when a signal is transmitted through the signal wires between a pilot device and other devices, and a processing delay caused in respective devices. When a device receives a system synchronizing signal form another device, the device sets an initial value in a counter. Thereby, the counter value of a counter in a pilot device and counter values of counters in the other devices are made to coincide with each other.

摘要翻译： 考虑到通过导频装置和其他装置之间的信号线发送信号的时间延迟以及在各个装置中引起的处理延迟，初始值产生电路产生初始值。 当设备从另一个设备接收到系统同步信号时，设备在计数器中设置初始值。 由此，导频装置中的计数器的计数值和其他装置中的计数器的计数值相互一致。