公开(公告)号：US20060077382A1

公开(公告)日：2006-04-13

申请号：US10964523

申请日：2004-10-13

Applicant: Shih-Yuan Wang ,  Zhiyong Li ,  M. Islam

Inventor： Shih-Yuan Wang ,  Zhiyong Li ,  M. Islam

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658

Abstract: Devices, systems, and methods using Surface Enhanced Raman Spectroscopy (SERS) are disclosed. A device for generating Raman scattered radiation comprises a laser source and a SERS-active structure. The laser source may be configured for emanating radiation from an emanating surface or by forming a depression in the laser source, which creates a region of increased evanescent field from the laser source. SERS systems and methods include a device for generating Raman scattered radiation with a detector configured to receive the Raman scattered radiation.

Abstract translation: 公开了使用表面增强拉曼光谱（SERS）的器件，系统和方法。 用于产生拉曼散射辐射的装置包括激光源和SERS-活性结构。 激光源可以被配置用于从发射表面发射辐射，或者通过在激光源中形成凹陷，其产生从激光源增加的渐逝场的区域。 SERS系统和方法包括用配置成接收拉曼散射辐射的检测器产生拉曼散射辐射的装置。

公开(公告)号：US20060055922A1

公开(公告)日：2006-03-16

申请号：US10942482

申请日：2004-09-16

Applicant: Zhiyong Li ,  Shih-Yuan Wang

Inventor： Zhiyong Li ,  Shih-Yuan Wang

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658

Abstract: SERS-active structures including features having nanoscale dimensions are disclosed, including methods for forming such SERS-active structures and methods for forming a plurality of such SERS-active structures. Methods for performing SERS using SERS-active structures also are disclosed.

Abstract translation: 公开了包括具有纳米级尺寸的特征的SERS活性结构，包括形成这种SERS-活性结构的方法和形成多个这样的SERS-活性结构的方法。 还公开了使用SERS活性结构来执行SERS的方法。

公开(公告)号：US06567861B1

公开(公告)日：2003-05-20

申请号：US08931979

申请日：1997-09-17

Applicant: Manoj V. S. Kasichainula ,  Zhiyong Li

Inventor： Manoj V. S. Kasichainula ,  Zhiyong Li

IPC: G06F946

CPC classification number: G06F9/548

Abstract: Proxy data stream handling and complex object parameter handling allow object oriented programs to be run as distributed programs without any explicit networking code, and without using an interface definition language (IDL). Two proxies are generated dynamically that allow method calls written for local invocation to be invoked over a network. These dynamically-generated proxies allow calls to flow across a network as if they were local, and contain support for using data stream and complex objects as parameters.

Abstract translation: 代理数据流处理和复杂的对象参数处理允许面向对象的程序作为分布式程序运行，而不需要任何明确的联网代码，而不使用接口定义语言（IDL）。 动态生成两个代理，允许通过网络调用为本地调用编写的方法调用。 这些动态生成的代理允许调用通过网络流动，就像它们是本地的，并且包含使用数据流和复杂对象作为参数的支持。

公开(公告)号：US09442071B2

公开(公告)日：2016-09-13

申请号：US14394287

申请日：2012-04-24

Applicant: Steven Barcelo ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Ansoon Kim

Inventor： Steven Barcelo ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Ansoon Kim

IPC: G01J3/44 ,  G01B11/16 ,  G01N21/00 ,  G01N33/566 ,  G01N30/96 ,  G01N21/65 ,  B82Y15/00

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01N2201/06113 ,  Y10S977/954

Abstract: An apparatus for performing a sensing application includes a reservoir to contain a solution, a dispenser to dispense the solution from the reservoir, and a substrate having a plurality of nano-fingers positioned to receive the dispensed solution, in which the plurality of nano-fingers are flexible, such that the plurality of nano-fingers are configurable with respect to each other. The apparatus also includes an illumination source to illuminate the received solution, an analyte introduced around the plurality of nano-fingers, and the plurality of nano-fingers, in which light is to be emitted from the analyte in response to being illuminated. The apparatus further includes a detector to detect the light emitted from the analyte.

Abstract translation: 用于执行感测应用的装置包括容纳溶液的储存器，用于从储存器分配溶液的分配器以及具有多个纳米手指的基板，该多个纳米手指定位成接收分配的溶液，其中多个纳米手指 是柔性的，使得多个纳米手指可相对于彼此配置。 所述装置还包括照亮所接收的溶液的照明源，围绕所述多个纳米手指引入的分析物和所述多个纳米手指，其中光将响应于被照亮从分析物发射。 该装置还包括检测器，用于检测从分析物发射的光。

公开(公告)号：US09176467B2

公开(公告)日：2015-11-03

申请号：US13548981

申请日：2012-07-13

Applicant: Weidong Gu ,  Geming Ding ,  Yonghong Li ,  Zhiyong Li ,  Jianxin Cao ,  Xiong Li ,  Xiaobing Liu

Inventor： Weidong Gu ,  Geming Ding ,  Yonghong Li ,  Zhiyong Li ,  Jianxin Cao ,  Xiong Li ,  Xiaobing Liu

IPC: G03G21/00 ,  G03G21/18

CPC classification number: G03G21/1857 ,  G03G21/186

Abstract: The invention relates to a process cartridge, which comprises a process cartridge housing, a photosensitive member, a driving force receiving opening, a retractable mechanism and a control mechanism, wherein the photosensitive member is arranged inside the process cartridge housing; the driving force receiving opening is connected with the photosensitive member and provides a driving force for the photosensitive member; the retractable mechanism allows the driving force receiving opening to extend or retract in the axial direction of the photosensitive member; and the control mechanism controls the extension and retraction of the retractable mechanism.

Abstract translation: 本发明涉及一种处理盒，其包括处理盒壳体，感光构件，驱动力接收开口，可伸缩机构和控制机构，其中感光构件布置在处理盒壳体内; 驱动力接收开口与感光构件连接，并为感光构件提供驱动力; 可伸缩机构允许驱动力接收开口在感光构件的轴向方向上延伸或缩回; 并且控制机构控制伸缩机构的伸缩。

公开(公告)号：US09084807B2

公开(公告)日：2015-07-21

申请号：US13816105

申请日：2011-08-04

Applicant: Chunshan Tang ,  Ning Xie ,  Xiaoling Yang ,  Wuqing Lv ,  Zhiyong Li ,  Jingying Ye ,  Difa Liu ,  Fan Cheng

Inventor： Chunshan Tang ,  Ning Xie ,  Xiaoling Yang ,  Wuqing Lv ,  Zhiyong Li ,  Jingying Ye ,  Difa Liu ,  Fan Cheng

IPC: A61K31/7048 ,  A61K9/00 ,  A61K31/352 ,  A61K45/06 ,  A61K47/18 ,  A61K36/185

CPC classification number: A61K31/7048 ,  A61K9/00 ,  A61K9/0095 ,  A61K31/352 ,  A61K36/185 ,  A61K45/06 ,  A61K47/18 ,  A61K2236/30 ,  A61K2300/00

Abstract: Disclosed is a composition comprising ligustroflavone, rhoifolin and hyperin, which is prepared according to rational weight ratio: 40% to 80% ligustroflavone, 5% to 45% rhoifolin and 1% to 40% hyperin. The composition can be used as a neuraminidase inhibitor for preventing and treating influenza, and can be formulated into pharmaceutically acceptable dosage forms.

Abstract translation: 公开了一种组合物，其包含根据合理的重量比：40％至80％的连翘黄酮，5％至45％的罗霍林和1％至40％的高辛酸制备的顺黄酮，罗霍林和羟乙酸。 该组合物可以用作预防和治疗流感的神经氨酸酶抑制剂，并且可以配制成药学上可接受的剂型。

公开(公告)号：US09080980B2

公开(公告)日：2015-07-14

申请号：US14233957

申请日：2011-07-27

Applicant: Alexandre M Bratkovski ,  Zhiyong Li

Inventor： Alexandre M Bratkovski ,  Zhiyong Li

IPC: G01J3/44 ,  G01N21/65 ,  G01N21/01

CPC classification number: G01N21/658 ,  G01N21/01

Abstract: A surface enhanced Raman spectroscopy (SERS) apparatus employs a nanorod in an indentation in a surface of a substrate. The SERS apparatus includes the nanorod having a tip at a free end opposite to an end of the nanorod that is supported by the substrate indentation. The indentation has a tapered profile and supports the nanorod at a bottom of the indentation. The free end of the nanorod extends away from the indentation bottom. The SERS apparatus further includes a Raman-active material at a surface of one or both of the nanorod and the indentation. The indentation and the nanorod facilitate one or both of production and detection of a Raman scattering signal emitted by an analyte in a vicinity of the nanorod and indentation.

Abstract translation: 表面增强拉曼光谱（SERS）装置在衬底的表面中采用在压痕中的纳米棒。 SERS装置包括在由衬底压痕支撑的纳米棒的端部相对的自由端处具有尖端的纳米棒。 压痕具有锥形轮廓并且支撑在压痕底部的纳米棒。 纳米棒的自由端延伸远离压痕底部。 SERS装置还包括在纳米棒和凹陷中的一个或两个的表面处的拉曼活性材料。 压痕和纳米棒促进由纳米棒和压痕附近的分析物发射的拉曼散射信号的生成和检测中的一个或两个。

公开(公告)号：US20150103340A1

公开(公告)日：2015-04-16

申请号：US14405334

申请日：2012-07-29

Applicant: Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Shih-Yuan Wang ,  Huei Pei Kuo ,  Steven Barcelo ,  Zhang-Lin Zhou

Inventor： Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Shih-Yuan Wang ,  Huei Pei Kuo ,  Steven Barcelo ,  Zhang-Lin Zhou

IPC: G01N21/65

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01J3/4412 ,  G01N2021/651 ,  G01N2201/06113 ,  Y10S977/902

Abstract: A scattering spectroscopy nanosensor includes a nanoscale-patterned sensing substrate to produce an optical scattering response signal indicative of a presence of an analyte when interrogated by an optical stimulus. The scattering spectroscopy nanosensor further includes a protective covering to cover and protect the nanoscale-patterned sensing substrate. The protective covering is to be selectably removed by exposure to an optical beam incident on the protective covering. The protective covering is to prevent the analyte from interacting with the nanoscale-patterned sensing substrate prior to being removed.

Abstract translation: 散射光谱纳米传感器包括纳米级图案化的感测衬底，以产生指示当通过光学刺激询问的分析物存在时的光学散射响应信号。 散射光谱纳米传感器还包括覆盖并保护纳米级图案化感测基板的保护覆盖层。 通过暴露在入射到保护罩上的光束可选地去除保护罩。 保护性覆盖物是在去除之前防止分析物与纳米级图案化的感测基板相互作用。

公开(公告)号：US08994937B2

公开(公告)日：2015-03-31

申请号：US13449612

申请日：2012-04-18

Applicant: Devin Alexander Mourey ,  James William Stasiak ,  Zhiyong Li

Inventor： Devin Alexander Mourey ,  James William Stasiak ,  Zhiyong Li

IPC: G01J3/44 ,  G01N21/27 ,  G01N21/65

CPC classification number: G01N21/274 ,  G01N21/278 ,  G01N21/658

Abstract: A surface enhanced Raman spectroscopy calibration curve generating system includes a SERS sensor, which includes a substrate and a plurality of sensing members formed on the substrate. Each of the sensing members includes a plurality of SERS signal amplifying structures. An inkjet dispensing device is to dispense different concentrations of a solution including a known analyte of interest onto the respective sensing members to form a concentration dependent array. A Raman spectrometer is to interrogate the concentration dependent array. A processor is operatively connected to each of the inkjet dispensing device and the Raman spectrometer. Computer-readable instructions are embedded on a non-transitory, tangible computer-readable medium and are executable by the processor. The computer-readable instructions are to automatically generate an intensity profile as a function of concentration for the concentration dependent array.

Abstract translation: 表面增强拉曼光谱校准曲线生成系统包括SERS传感器，其包括衬底和形成在衬底上的多个感测构件。 每个感测构件包括多个SERS信号放大结构。 喷墨分配装置是将不同浓度的包括已知分析物的溶液分配到相应的感测构件上以形成浓度依赖阵列。 拉曼光谱仪是询问浓度依赖阵列。 处理器可操作地连接到每个喷墨分配装置和拉曼光谱仪。 计算机可读指令嵌入在非暂时有形的计算机可读介质中，并且可由处理器执行。 计算机可读指令是自动生成作为浓度依赖阵列的浓度的函数的强度分布。

公开(公告)号：US08993339B2

公开(公告)日：2015-03-31

申请号：US14006721

申请日：2011-03-23

Applicant: Ansoon Kim ,  Zhiyong Li ,  R Stanley Williams

Inventor： Ansoon Kim ,  Zhiyong Li ,  R Stanley Williams

IPC: G01N21/00 ,  G01N21/65 ,  G01N21/552 ,  G01N21/64

CPC classification number: G01N21/00 ,  G01N21/554 ,  G01N21/648 ,  G01N21/658

Abstract: A hybrid nanostructure for molecular analysis is disclosed. The structure includes a plurality of nanofingers wherein each nanofinger is coated with a metal coating, is attached at one end to a substrate, and is freely bendable along its length such that the second ends of each nanofinger are capable of movement toward each other to form a cavity. The structure further includes a nanoparticle trapped in the cavity. An array of hybrid nanostructures and a method for fabricating the hybrid nanostructures are also disclosed.

Abstract translation: 公开了用于分子分析的杂化纳米结构。 该结构包括多个纳米针，其中每个纳米针涂覆有金属涂层，其一端连接到基底，并且可沿其长度自由弯曲，使得每个纳米针的第二端能够朝向彼此移动以形成 一个空腔。 该结构还包括捕获在空腔中的纳米颗粒。 还公开了一系列混合纳米结构和制备混合纳米结构的方法。