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公开(公告)号：US20240076801A1
公开(公告)日：2024-03-07
申请号：US18347010
申请日：2023-07-05
CPC分类号： C40B30/04 , C12N15/1065 , C12N15/1072 , C40B40/10 , C40B50/06
摘要： Disclosed herein include systems, methods, compositions, and kits for determining the expression of highly expressed proteins and lowly expressed proteins. In some embodiments, primers allowing generation of separate libraries for abundant AbSeq protein profiling oligonucleotides and scarce AbSeq protein profiling oligonucleotides are provided.
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公开(公告)号：US20240075270A1
公开(公告)日：2024-03-07
申请号：US17901005
申请日：2022-09-01
IPC分类号： A61M39/02
CPC分类号： A61M39/0247 , A61M2039/0258 , A61M2039/027 , A61M2039/0273 , A61M2205/0222 , A61M2205/6081
摘要： Provided herein is an instrument delivery device for advancing an instrument into a vascular access device. The instrument delivery device includes an outer housing, a connector coupled to the outer housing and including a projection member that mates with the vascular access device, and an inner housing having a distal end positioned within the outer housing and engaged with a proximal end of the instrument. The inner housing moves relative to the outer housing so that a distal movement thereof moves the instrument from a first position to a second position, with a distal end of the instrument moving from within the outer housing to out beyond the distal end of the outer housing and the projection member. A fluid flow preventing seal provided in or adjacent the connector prevents a transfer of fluid between the vascular access device and the inner volume of the outer housing.
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公开(公告)号：US20240075253A1
公开(公告)日：2024-03-07
申请号：US17901041
申请日：2022-09-01
发明人： Jonathan Karl Burkholz , Megan S. Scherich , Curtis H. Blanchard , Weston F. Harding , Adam J. Boud , Shaun Lauer
CPC分类号： A61M25/0606 , A61B5/150015 , A61B5/150992 , A61M2039/062
摘要： Provided herein is a medical device, including an instrument having a proximal end and a distal end, an introducer configured to moveably receive the instrument and having an outer housing having a proximal end, a distal end, and a sidewall therebetween defining an inner volume and an inner housing having a proximal end, a distal end, and a sidewall therebetween defining an inner volume, the inner housing slidably received within the outer housing, the distal end of the introducer configured to couple the introducer to an intravenous line. The inner housing is configured to move relative to the outer housing to move the instrument between a first position and a second position.
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公开(公告)号：US20240075249A1
公开(公告)日：2024-03-07
申请号：US17900995
申请日：2022-09-01
IPC分类号： A61M25/01
CPC分类号： A61M25/0113
摘要： Provided herein is an instrument delivery device for advancing an instrument into a vascular access device. The instrument delivery device includes an outer housing, an introducer portion positioned at the distal end of the outer housing and configured to mate with the vascular access device, and an inner housing having a distal end positioned within an inner volume of the outer housing and engaged with a proximal end of the instrument, with the inner housing moveable relative to the outer housing. A wheel member is positioned on the outer housing and rotatable relative thereto and is operably coupled to the inner housing to move the inner housing distally within the outer housing when the wheel member is rotated in a first direction, thereby also moving the instrument distally from to a position where the distal end of the instrument is disposed beyond the distal end of the outer housing.
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公开(公告)号：US20240066278A1
公开(公告)日：2024-02-29
申请号：US18237165
申请日：2023-08-23
CPC分类号： A61M39/04 , A61B5/150992 , A61M25/09 , A61M2039/0273
摘要： An instrument advancement device includes an access connector configured to be connected to a vascular access device, a primary lumen in fluid communication with the access connector, an instrument received within the primary lumen and having a retracted position and an extended position, an advancement member configured to move the instrument between the retracted position and the extended position, and a lumen seal received within the primary lumen and connected to the instrument. The lumen seal defines a space between the lumen seal and the primary lumen when the instrument is in the retracted portion. The lumen seal engages the primary lumen when the instrument is in the advanced position.
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96.发明公开公开(公告)号：US20240066216A1
公开(公告)日：2024-02-29
申请号：US18259649
申请日：2021-12-28
IPC分类号： A61M5/145
CPC分类号： A61M5/1452
摘要： A fluid delivery device has a syringe barrel with reservoir chamber for fluid, a plunger that translates along a longitudinal axis to expel fluid, and a pusher dimensioned to translate within the barrel and coupled to a drive mechanism to controllably contact and move the plunger. The pusher contacts the plunger at its mechanical center to reduce tilt in the plunger. Contact faces of the pusher and plunger cooperate as a ball joint to minimize non-axial forces on the plunger face. The pusher can have a protrusion of various lengths extending toward and being at least partially received in a recess of various depths in the plunger. The pusher is rigidly connected to a drive mechanism for anti-rotation. The pusher can have scalloped edges for air venting, and apertures for cooperating with protrusions on the drive mechanism to prevent bottoming out the plunger when filling.
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公开(公告)号：US11913083B2
公开(公告)日：2024-02-27
申请号：US17094908
申请日：2020-11-11
发明人： Chi Chen , Hugh J. Peck , Michael Porter , Gregory A. Richart , Ray A. McMillian
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708
摘要： A real time Taq-Man PCR assay for detecting multiple serotypes of human papillomavirus (HPV) wherein the number of serotypes detected exceeds the number of colorimetric channels for detection. A biological sample is combined with three oligonucleotide primer/probe sets such that the probes and primers anneal to a target sequence. Each primer/probe set is at least preferential for a specific serotype of an organism. The first and second primer/probe sets are degenerate with respect to each other. The third primer/probe set is not degenerate with respect to the first and second primer/probe sets and discriminates for a third serotype. The third primer/probe set has a signal moiety that emits signal at a wavelength that is the same or different from the wavelength emitted by the signal moiety of the degenerate primer/probe set probes. The target sequences, if present, are amplified and detected.
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公开(公告)号：US11911599B2
公开(公告)日：2024-02-27
申请号：US18102299
申请日：2023-01-27
发明人： Richard Cronenberg , Michael Quinn
CPC分类号： A61M5/31543 , A61M5/20 , A61M5/31553 , A61M5/31585 , A61M5/24 , A61M5/31551 , A61M5/31561 , A61M2005/2407 , A61M2005/3126 , A61M2205/581 , A61M2205/6018
摘要： An injection method is provided for using an injection pen, the injection pen comprising a housing, a lead screw axially moveable in the housing, a dose set member for dose setting and dose correcting, threadably connected to the housing and having a first mating feature, a setback member having a second mating feature for engaging the first mating feature, a clicker that generates an audible or tactile indication during operation, the clicker being operatively connected to the dose set member, and a push button operatively connected to the setback member to cause the second mating feature to engage the first mating feature during an injection, the push button receiving the clicker, wherein the first mating feature is disengaged from the second mating feature during the dose setting and the dose correcting and engaged with the second mating feature during the injection.
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公开(公告)号：US11911570B2
公开(公告)日：2024-02-27
申请号：US17217838
申请日：2021-03-30
CPC分类号： A61M25/00 , A61M25/02 , A61M2025/0246 , A61M2025/0253 , A61M2025/0266 , A61M2025/0273
摘要： An anchor system for securing a catheter to a patient may include an anchor pad, which may include a lower surface, an upper surface, and a window extending through the anchor pad. The lower surface may include an adhesive layer to adhere the anchor pad to skin of the patient. The upper surface may include a catheter securement mechanism. The window may provide access to the skin of the patient for application of a topical skin adhesive at a catheter insertion site disposed within the window.
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公开(公告)号：US20240057909A1
公开(公告)日：2024-02-22
申请号：US18236150
申请日：2023-08-21
CPC分类号： A61B5/150992 , A61B5/15003 , A61B5/153
摘要： A blood collection device including a distal end portion, a proximal end portion, an actuator, and a probe operably coupled to the actuator, wherein the actuator is configured to selectively advance the probe through a catheter of a vascular access device when the blood collection device is coupled to the vascular access device. The probe includes a distal portion and a proximal portion, wherein the distal portion and the proximal portion of the probe are formed of different materials, and wherein only the distal portion of the probe is configured to extend at least partially beyond a distal tip of the catheter of the vascular access device when the probe is in a fully advanced position.
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