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公开(公告)号：US20220401574A1
公开(公告)日：2022-12-22
申请号：US17773974
申请日：2020-11-13
摘要： The presently disclosed drug-loaded liposomal conjugated to polymer microbubbles showed: i) increased tumor drug concentration; ii) reduced tumor growth; and ii) increased survival time in a mouse cancer model when exposed to concurrent high and low acoustic pressure ultrasonic pulses as compared to individual high or low acoustic pressure ultrasonic pulses. Notably, when unconjugated drug-loaded liposome were administered with free microbubbles and exposed to concurrent high and low acoustic pressure ultrasonic pulses, a superior tumor growth inhibition was also seen. Three weeks after treatments, DoxLPX+US group showed significantly better left ventricular function indices from echocardiography imaging than the free Dox group. Clinical methods using these liposomal conjugated microbubbles permit an increased therapeutic drug delivery and improved safety profile, respectively due to enhanced, preferential drug accumulation in target tumor tissue and simultaneously reduced drug delivery to non-target tissue.
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公开(公告)号：US11531877B2
公开(公告)日：2022-12-20
申请号：US16164964
申请日：2018-10-19
发明人： Youtao Zhang , Lei Zhao , Jun Yang , Shuai Ding
摘要： A method of deploying a neural network on a target device method includes extracting a number of device dependent error masks from the target device, using the number of device dependent error masks in a training phase of the neural network to generate a device dependent weight matrix for the neural network, and storing the device dependent weight matrix in the target device for use by the target device to perform inference tasks using the neural network.
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公开(公告)号：US11530388B2
公开(公告)日：2022-12-20
申请号：US16485771
申请日：2018-02-13
发明人： Alejandro Soto-Gutierrez , Tomoji Mashimo , Alexandra Sylvie Collin de l'Hortet , Eduardo Cervantes Alvarez , Jorge Guzman Lepe , Kan Handa , Kazuki Takeishi , Yang Wang , Branimir Popovic
IPC分类号： C12N5/00 , C12N5/071 , A01K67/027 , C12N5/074
摘要： Methods are disclosed herein for producing human hepatocytes from human induced pluripotent stem cells. Also provided are transgenic rats for the expansion of human hepatocytes, such as those produced using the methods disclosed herein.
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94.发明授权公开(公告)号：US11529122B2
公开(公告)日：2022-12-20
申请号：US16726089
申请日：2019-12-23
申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education , The Regents of the University of Michigan
发明人： Kang Kim , Jingping Xu , Jonathan M Rubin
摘要： A method of evaluating tissue stiffness of a target area includes positioning an ultrasound elasticity imaging apparatus adjacent a surface of an area of tissue where the target area is located and applying a dynamic range of force to the tissue. A plurality of ultrasound beams can be directed at the tissue and a plurality of ultrasound echoes can be acquired from the strained tissue in the target area to calculate an amount of developed strain within the target area.
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公开(公告)号：US20220395612A1
公开(公告)日：2022-12-15
申请号：US17872467
申请日：2022-07-25
摘要： The present invention relates to an ovarian-derived hydrogel material, which can be useful for three-dimensional in vitro culturing of cells, cell therapy, fertility preservation, drug delivery, site-specific remodeling and repair of damaged tissue, and/or diagnostic kits.
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公开(公告)号：US11517234B2
公开(公告)日：2022-12-06
申请号：US15956461
申请日：2018-04-18
发明人： Xinyan Cui , Nicolas Alexander Alba , Mingui Sun
摘要： An electrode system include a flowable and cohesive surface contact element comprising a hydrophilic polymer swollen with an electrolyte fluid, the contact element having a Q′ ratio of at least 5 as defined by the equation Q ′ = W W W G wherein WG is the dry weight of the hydrophilic polymer and WW is weight of water in the sample after absorption of the electrolyte fluid comprising water and an electrolyte salt. The surface contact element can consist essentially of the hydrophilic polymer swollen by the electrolyte fluid. Another electrode system includes a contact element including a crosslinked hydrophilic polymer matrix. The contact element has a Q′ ratio of at least 5 as defined by the equation Q ′ = W W W G . The contact elements can also have a Q′ ratio of at least 6, at least 7, at least 10 or even at least 11.
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公开(公告)号：US11513100B2
公开(公告)日：2022-11-29
申请号：US16479675
申请日：2018-01-26
申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , UNITED STATES DEPARTMENT OF ENERGY
摘要： A gas sensor (100,200) includes at least one sensor device including a surface acoustic wave (SAW) device (110) or a quartz crystal microbalance (QCM) device (210), and a layer of metal organic framework (MOF) material (120,220) disposed on each of the at least one sensor device. The at least one sensor device is structured to sense a change in mass of the MOF material.
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公开(公告)号：US20220364449A1
公开(公告)日：2022-11-17
申请号：US17734713
申请日：2022-05-02
申请人： Chevron U.S.A. Inc. , University of Pittsburgh - Of the Commonwealth System of Higher Education
摘要： A dissipation equilibrium value for a well operation may be determined based on a height of a fracture within a layer and a limit on the change of the height of the fracture (fracture height change limit). A pressure limit for the well operation may be determined based on the dissipation equilibrium value, stress in the layer, and stress in a bounding layer. The pressure limit may be used to control the pressure of the well during the well operation, and prevent growth of the fracture beyond the fracture height change limit.
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公开(公告)号：US20220362340A1
公开(公告)日：2022-11-17
申请号：US17773373
申请日：2020-10-30
申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , WISCONSIN ALUMNI RESEARCH FOUNDATION
IPC分类号： A61K38/20 , A61K35/747 , A61K35/741 , A61K38/21 , A61K38/19 , A61K31/4184 , A61K31/4468 , A61K31/4178 , A61K31/352 , A61K31/341 , A61P1/00
摘要： Disclosed herein are gastrointestinal tract (G1) bacteria and methods for treating or preventing an irradiation-induced intestinal damage in a subject, the methods comprising administering a G1 bacterium to the subject, wherein the G1 bacterium comprises a vector that comprises a polynucleotide encoding IL-22 and/or IFN-P, or a functional fragment thereof.
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公开(公告)号：US20220355540A1
公开(公告)日：2022-11-10
申请号：US17621115
申请日：2020-06-22
IPC分类号： B29C64/129 , B33Y10/00
摘要： A four-dimensional (“4D”)-printing or 4D-additive manufacturing method for producing anisotropic macroscopic structures and/or anisotropic macroscopic materials having a plurality of voxels, comprising: providing or forming a first layer of a photocurable first liquid crystalline (LC) monomer; wherein the first layer of the first LC monomer has been provided or formed at a temperature falling within a nematic phase range of the first LC monomer; applying a magnetic field, having a first three-dimensional (“3D”) magnetic field vector with respect to an origin point of a 3D coordinate system, to the first layer of first LC monomer or one or more of the plurality of voxels within the first layer of first LC monomer for a first dwell time, to produce in alignment with the first 3D magnetic field vector a first molecular director and/or first nematic alignment vector within the first layer of first LC monomer or within each of the one or more of the plurality of voxels within the first layer of first LC monomer; exposing the first layer of first LC monomer or the one or more of the plurality of voxels within the first layer of first LC monomer to a first dose of light radiation.
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