公开(公告)号：US07430946B2

公开(公告)日：2008-10-07

申请号：US11497488

申请日：2006-08-01

Applicant: Daniel Studer

Inventor： Daniel Studer

IPC: B26D5/00

CPC classification number: B26D7/086 ,  G01N1/06 ,  G01N1/36 ,  G01N2001/063 ,  Y10T83/04 ,  Y10T83/0538 ,  Y10T83/6508 ,  Y10T83/97

Abstract: In a process for cutting sections from a probe for microscopic analysis, an ultramicrotome device is used having a blade with a cutting edge, the cutting edge extending at least approximately in a first direction. The process includes the steps of: vibrating the blade in the first direction; and moving the blade relative to the probe to be cut in a second direction, the second direction being perpendicular to the first direction. This eliminates, or at least strongly reduces, compression of the cut sections.

Abstract translation: 在用于从用于显微镜分析的探针切割切片的过程中，使用具有切割刃的刀片的切割机装置，切割刃至少大致沿第一方向延伸。 该方法包括以下步骤：在第一方向上振动叶片; 并且相对于待切割的探针沿着第二方向移动所述刀片，所述第二方向垂直于所述第一方向。 这消除或至少强烈地减少了切割部分的压缩。

公开(公告)号：US20080202308A1

公开(公告)日：2008-08-28

申请号：US12033474

申请日：2008-02-19

Applicant: Hirohito Fujiwara ,  Tetsumasa Ito ,  Koji Fujimoto ,  Tatsuya Miyatani

Inventor： Hirohito Fujiwara ,  Tetsumasa Ito ,  Koji Fujimoto ,  Tatsuya Miyatani

IPC: B26D7/06

CPC classification number: G01N1/06 ,  Y10T83/6492 ,  Y10T83/9459

Abstract: An automatic thin-section manufacturing system for manufacturing thin sections by thinly cutting out an embedded block having embedded therein a biological sample while setting said embedded block at a predetermined rake angle, and said system comprising: a long cutting blade having a cutting edge on one end; a holder disposed in such a manner that it makes the rake angle with respect to the surface of the embedded block; a mounting plane which is provided to the front end of the holder, on which plural cutting blades are mounted and aligned with their cutting edges exposed to the outer side; an adsorptive member provided along the mounting plane, which maintains the posture of the cutting blades by adsorbing the base end side of the cutting blades mounted on the mounting plane; a first pressing member provided to the holder, which presses, among the plural cutting blades that are mounted and aligned on the mounting plane, the cutting blade allocated to the predetermined position against the mounting plane; a conveyor unit which slides out the cutting blades that are linearly aligned on the mounting plane, by sequentially conveying the plural cutting blades to feed them one by one on the mounting plane; a transportation unit which moves the embedded block relative to the holder, such that the cutting blade pressed by the first pressing member cuts out the thin section from the embedded block; and a control unit which, after performing thin sectioning for a predetermined time, exchanging the cutting blade used for the thin sectioning by operating the conveyor unit to slide out the cutting blades.

Abstract translation: 一种自动薄片制造系统，用于通过在将所述嵌入块设置在预定前角处的同时，将嵌入其中的嵌入块嵌入生物样品中而将其切割出来，制造薄片，并且所述系统包括：长切割刀片， 结束; 保持器，其以相对于嵌入块的表面形成前角的方式设置; 安装平面，其设置在所述保持器的前端，多个切割刀片安装在所述保持器的前端上并与其暴露于所述外侧的切割刃对齐; 沿着安装平面设置的吸附构件，其通过吸附安装在安装平面上的切割刀片的基端侧而保持切割刀片的姿势; 设置在所述保持器上的第一按压构件，其在安装和对准所述安装面上的所述多个切割刀片之间按照相对于所述安装平面分配到所述预定位置的所述切割刀片; 输送单元，其通过依次输送多个切割刀片，在安装平面上一个接一个地滑出沿着安装平面线性对准的切割刀片; 运送单元，其使所述嵌入块相对于所述保持架移动，使得由所述第一按压构件按压的所述切割刀片从所述嵌入块切出所述薄部; 以及控制单元，在经过预定时间的薄切片之后，通过操作所述输送单元来更换用于薄切割的切割刀片以滑出切割刀片。

公开(公告)号：US20080148913A1

公开(公告)日：2008-06-26

申请号：US11693656

申请日：2007-03-29

Applicant: Jan-Hao Chen ,  Yeou-Bin Guu ,  Yung-Feng Nien ,  Wann-Hsin Chen ,  Lih-Tao Hsu

Inventor： Jan-Hao Chen ,  Yeou-Bin Guu ,  Yung-Feng Nien ,  Wann-Hsin Chen ,  Lih-Tao Hsu

IPC: G01N1/06

CPC classification number: G01N1/06 ,  Y10T83/0448 ,  Y10T83/6668

Abstract: A dissection device for organisms includes a table bearing an organism and at least one blade lifted or lowered to approach the table. The blade includes a connecting portion, a cutting portion having a curved edge, and a neck portion connecting the connecting portion and the cutting portion. When the blade is lowered to contact the table, the cutting portion is rotated with respect to the neck portion to have rolling contact with the table from a first point to a second point of the edge.

Abstract translation: 用于生物体的解剖装置包括具有生物体的桌子和至少一个升降的叶片以接近桌子。 刀片包括连接部分，具有弯曲边缘的切割部分和连接连接部分和切割部分的颈部。 当叶片降低以接触桌子时，切割部分相对于颈部部分旋转以与台面滚动接触，从边缘的第一点到第二点。

公开(公告)号：US20080115640A1

公开(公告)日：2008-05-22

申请号：US11940430

申请日：2007-11-15

Applicant: Robert Ranner

Inventor： Robert Ranner

IPC: B26D7/08 ,  B26D1/12

CPC classification number: B28D1/003 ,  B23D45/003 ,  G01N1/06 ,  G01N2001/063 ,  Y10T83/2066 ,  Y10T407/1906

Abstract: An apparatus (1) for processing specimens (15), comprises an observation device (2) for observing a specimen (15), a specimen holder (3) for receiving the specimen (15) to be processed, and a tool holder (6), which is suitable for the reception of tools (5) for different processing steps.

Abstract translation: 一种用于加工试样（15）的装置（1），包括用于观察试样（15）的观察装置（2），用于接收待加工试样（15）的试样支架（3）和工具架 ），其适用于接收用于不同处理步骤的工具（5）。

公开(公告)号：US20080072723A1

公开(公告)日：2008-03-27

申请号：US11902357

申请日：2007-09-20

Applicant: Daisuke Nakajima ,  Yoshihiko Isagawa ,  Hiroaki Iida ,  Toshiyuki Murakami

Inventor： Daisuke Nakajima ,  Yoshihiko Isagawa ,  Hiroaki Iida ,  Toshiyuki Murakami

IPC: G01N1/06 ,  G02B21/34

CPC classification number: G01N1/06 ,  B26D3/28 ,  B26D5/02 ,  B26D7/32 ,  G01N1/312 ,  G01N35/00029 ,  G01N35/02 ,  G01N2001/065 ,  Y10T83/2074 ,  Y10T83/536 ,  Y10T83/6577 ,  Y10T436/2575

Abstract: Sliced specimens can be automatically and continuously prepared and burdens of an operator can be reduced while accuracy required for the sliced specimen is maintained. The sliced specimen is prepared by relatively moving a specimen block transfer section and a cutter, and when a slicing operation to adjust the height position of the specimen block is continuously performed so that the cutting surface of the specimen block is located at a sliceable position, the cutter is moved so that a contacting area of a blade edge of the cutter that firstly contacts the specimen block after the height position adjustment is sequentially changed, every time previously set number of times of slicing operation is completed. Thereafter, the height position of the blade edge of the cutter after the change is measured by a detector, and based on the measurement information of the detector, the sliceable position is corrected and the slicing operation is resumed.

Abstract translation: 切片样品可以自动连续地制备，并且可以减少操作者的负担，同时保持切片试样的精度。 通过相对移动样品块转移部和切割器来制备切片样品，并且当连续进行调整样品块的高度位置的切片操作，使得样品块的切割面位于切割位置时， 移动切割器，使得在每次预先设定的切片操作次数完成之后，在高度位置调整之后，切割器的叶片边缘的接触区域顺序地改变。 此后，通过检测器测量切换器的刀刃的高度位置，并且基于检测器的测量信息，校正切片位置并恢复切片操作。

公开(公告)号：US20080072722A1

公开(公告)日：2008-03-27

申请号：US11847861

申请日：2007-08-30

Applicant: Siegfried Tanki ,  Felix Redl

Inventor： Siegfried Tanki ,  Felix Redl

IPC: B26D5/00

CPC classification number: G01B11/2408 ,  G01N1/06 ,  G01N2001/065 ,  Y10T83/0333 ,  Y10T83/141 ,  Y10T83/148 ,  Y10T83/929

Abstract: In a vibrating microtome (1), a knife (6) is caused to vibrate during a sectioning operation in a direction parallel to a section plane and substantially parallel to the knife's edge, during which a transverse offset can occur as a consequence of a potentially present inclination of the cutting edge with respect to the section plane. A measuring device (3) for measuring the transverse offset comprises a light barrier (9) into which the cutting edge is placeable so as to partially cover the light of the light barrier. The vibrating microtome (1) generates, from the motion of the knife, a control application signal (pklo, pkhi) that describes the time course of the vibration of the knife (6), and the electronic measurement system of the measuring device (3) measures the coverage of the light barrier as a consequence of the vibration of the knife as an oscillating signal (tpm), and determines the transverse offset from the signal values at points in time that are defined by the control application signal.

Abstract translation: 在振动切片机（1）中，使刀（6）在切片操作期间沿平行于截面的方向基本上平行于刀的边缘振动，在此过程中由于潜在的可能会发生横向偏移 切割刃相对于截面的当前倾斜度。 用于测量横向偏移的测量装置（3）包括光栅（9），切割边缘可放置在其中以部分地覆盖光屏障的光。 振动切片机（1）从刀的运动产生描述刀（6）的振动时间过程的控制应用信号（pklo，pkhi）和测量装置（3）的电子测量系统 ）测量作为振荡信号（tpm）的刀的振动的光栅的覆盖范围，并且确定由由控制应用信号定义的时间点处的信号值的横向偏移。

公开(公告)号：US20080067382A1

公开(公告)日：2008-03-20

申请号：US11809661

申请日：2007-05-31

Applicant: Robert Arthur Harker

Inventor： Robert Arthur Harker

IPC: G21K7/00

CPC classification number: G01N1/286 ,  G01N1/06

Abstract: The subject invention pertains to an apparatus and method for collecting 2-D data slices of a specimen. Embodiments can incorporate a lapidary platen and an image recording system to image a specimen. The lapidary wheel platen can provide an imaging plane such that an image can be taken as the lapidary wheel platen abrades a surface of the specimen. A specimen mount can maintain the surface of the specimen properly aligned in the image plane. The imaging system can be a continuous recording system such as a video camera, a discrete recording system such as a flatbed scanner, or combinations of continuous and discrete recording systems to simultaneously collect two distinct data sets. The 2-D data set(s) can then be processed to create intricate 3-D color models.

Abstract translation: 本发明涉及用于收集样本的2-D数据切片的装置和方法。 实施例可以包括平板印刷机和图像记录系统以对试样成像。 凸轮轮压板可以提供成像平面，使得当研磨轮台板磨损样品的表面时可以拍摄图像。 样品支架可以将样品的表面保持在图像平面中正确对准。 成像系统可以是诸如摄像机，诸如平板扫描仪的离散记录系统或连续和离散记录系统的组合的连续记录系统，以同时收集两个不同的数据集。 然后可以处理2-D数据集以创建复杂的3-D颜色模型。

公开(公告)号：US20080041069A1

公开(公告)日：2008-02-21

申请号：US11575352

申请日：2005-09-16

Applicant: David Vicar ,  Graham Dawson ,  Mark Barratt ,  John Cox

Inventor： David Vicar ,  Graham Dawson ,  Mark Barratt ,  John Cox

IPC: F25B19/00

CPC classification number: G01N1/42 ,  G01N1/06

Abstract: According to an aspect of the present invention, a cryostat includes two separate cooling means, one for reducing the temperature in a cooling chamber (2) and the other arranged to cool a freezing plate (8). In one embodiment, there may be a single cooling circuit, with e.g. a single reservoir of refrigerant, but with a separate compressor provided for each of the cooling means i.e. one compressor to control the temperature within the cooling chamber (2) and a separate compressor for the cooling circuit associated with the freezing plate (8). In accordance with another aspect of the present invention, the freezing plate (8) includes means for retaining some liquid on the surface of the freezing plate. In an embodiment, these means are provided by a lip (12). In a further aspect a friction generating means provides resistance to the movement of the microtome head, for example by providing a spring loaded collar on rotatable shaft. In a further aspect a cryostat is provided with a touch screen display.

Abstract translation: 根据本发明的一个方面，低温恒温器包括两个单独的冷却装置，一个用于降低冷却室（2）中的温度，另一个用于冷却冷冻板（8）。 在一个实施例中，可以存在单个冷却回路。 单个制冷剂储存器，但是具有为每个冷却装置设置的单独的压缩机，即一个用于控制冷却室（2）内的温度的压缩机和用于与冷冻板（8）相关联的冷却回路的单独的压缩机。 根据本发明的另一方面，冷冻板（8）包括用于将一些液体保持在冷冻板的表面上的装置。 在一个实施例中，这些装置由唇缘（12）提供。 在另一方面，摩擦产生装置提供对切片机头的运动的阻力，例如通过在可旋转的轴上设置弹簧加载的环。 在另一方面，低温恒温器设置有触摸屏显示器。

公开(公告)号：US20070261429A1

公开(公告)日：2007-11-15

申请号：US11718958

申请日：2005-11-08

Applicant: David Teehan

Inventor： David Teehan

IPC: F25B19/00 ,  F25D25/00

CPC classification number: A01N1/02 ,  A01N1/0257 ,  F17C2270/0509 ,  F25D19/006 ,  G01N1/06 ,  G01N1/42 ,  G01N2001/065

Abstract: A cryostat includes a rotatable mounting arranged to rotate about a first rotational axis, the mounting extending substantially in a first plane, a sample plate arranged in use to support a sample, located on the rotatable mounting, and a heat sink located adjacent the side of the mounting distant from the sample plate. A thermal conductor extends between the sample plate and the heat sink. The conductor extends through an aperture in the rotatable mounting. A rotatable sample holder for a cryostat includes a sample plate having a first side arranged in use to support a sample, a drive gear arranged to rotate about a first rotational axis, and a driven gear arranged to rotate about a second rotational axis, engaged with the drive gear and coupled to the sample plate such that rotation of the drive gear causes the driven gear and sample holder to rotate. The first rotational axis does not intersect the second rotational axis.

Abstract translation: 低温恒温器包括可旋转的安装件，其布置成围绕第一旋转轴线旋转，所述安装件基本上在第一平面中延伸;样品板，其布置用于支撑位于所述可旋转安装件上的样品;以及散热器， 远离样品板的安装。 导热体在样品板和散热片之间延伸。 导体延伸穿过可旋转安装件中的孔。 用于低温恒温器的可旋转样品保持器包括样品板，其具有布置成用于支撑样品的第一侧，布置成围绕第一旋转轴线旋转的驱动齿轮和布置成围绕第二旋转轴线旋转的从动齿轮， 驱动齿轮并联接到样品板，使得驱动齿轮的旋转导致从动齿轮和样品保持器旋转。 第一旋转轴线不与第二旋转轴线相交。

公开(公告)号：US20070204740A1

公开(公告)日：2007-09-06

申请号：US11642475

申请日：2006-12-20

Applicant: Tatsuya Miyatani ,  Tetsumasa Ito ,  Koji Fujimoto ,  Eiji Nakano ,  Hirohito Fujiwara

Inventor： Tatsuya Miyatani ,  Tetsumasa Ito ,  Koji Fujimoto ,  Eiji Nakano ,  Hirohito Fujiwara

IPC: G01N1/00 ,  G01N1/04

CPC classification number: G01N1/312 ,  G01N1/06 ,  G01N1/31 ,  G01N35/00722 ,  G01N35/0099 ,  G01N2001/362

Abstract: To be able to alleviate burden on an operator and automatically fabricate a necessary number of sheets of prepared slides from respective embedded blocks while pertinently interchanging the respective embedded blocks, there is provided an automatic instrument for fabricating prepared slide of tissue section including a store house for storing a plurality of embedded blocks embedded with a living body sample by an embedding medium, cutting means for cutting out a section by cutting the embedded block by a predetermined thickness, first carrying means for putting in and out a selected one of the embedded block to and from the store house and carrying the selected one of the embedded block to a position of being cut by the cutting means, second carrying means for carrying the section to a storage tank stored with a liquid to be floated on a liquid surface, transcribing means for fabricating a prepared slide by transcribing the section floated on the liquid surface onto a base plate, and a control portion for controlling the first carrying means to cut out a necessary number of the sections from the embedded block, thereafter, return the embedded block to the store house, and take out a successively selected one of the embedded block from the store house to be carried to the cut position.

Abstract translation: 为了能够减轻操作者的负担，并且在相应的嵌入块相应地互换的同时自动地制造必要数量的准备好的幻灯片片材，提供了一种用于制造组织部分的准备的幻灯片的自动仪器，其包括存储室 通过嵌入介质存储嵌入生物体样本的多个嵌入块，切割装置，用于通过将嵌入块切割预定厚度来切割部分;第一传送装置，用于将嵌入块中的所选一个插入到所述嵌入块中 并且从储藏室将所选择的嵌入块中的一个运送到由切割装置切割的位置，第二承载装置，用于将存储于待浮动的液体的储存罐运送到液体表面上的转录装置 用于通过将浮在液面上的部分转印到基板上来制造制备的载玻片，以及a 控制部分，用于控制第一携带装置从嵌入块切出必要数量的部分，然后将嵌入块返回到存储室，并从存储器中取出连续选择的嵌入块中的一个 携带到切割位置。