Multi-spike release formulation for oral drug delivery
    97.
    发明授权
    Multi-spike release formulation for oral drug delivery 失效
    用于口服药物递送的多穗释放制剂

    公开(公告)号:US06555127B2

    公开(公告)日:2003-04-29

    申请号:US09766394

    申请日:2001-01-19

    IPC分类号: A61K4700

    摘要: Methylphenidate or other drugs are provided in a formulation for oral administration that releases the drug in two or more pharmacokinetic spikes, by combining different release forms in a single formulation. In a preferred embodiment for methylphenidate, the first pharmacokinetic spike is achieved by the release of taste-masked methylphenidate which is not enterically coated, while a second pharmacokinetic spike is achieved by the release of methylphenidate in a finely divided form from enterically coated pellets or microparticles formulated for rapid release following dissolution of the enteric coating. A critical aspect of the formulation is the inclusion of excipients that create a burst release following the initial rapid release and uptake. The formulation can be administered as a paste, jelly, suspension, or fast dissolving wafer. To manipulate the dose, the formulation can be provided, for example, as a paste packaged in a tube similar to those used to dispense toothpaste.

    摘要翻译: 在用于口服给药的制剂中提供哌甲酯或其它药物,其通过在单一制剂中组合不同的释放形式将药物释放在两种或更多种药代动力学尖峰中。 在哌甲酯的优选实施方案中,通过释放没有肠溶包衣的味觉掩蔽的哌甲酯来实现第一药代动力学峰值,而通过从肠溶包衣的丸粒或微粒释放精细分散形式的哌甲酯达到第二药代动力学峰值 配制用于肠溶衣溶解后的快速释放。 制剂的关键方面是包含在初始快速释放和摄取后产生爆发释放的赋形剂。 制剂可以作为糊剂,果冻,悬浮液或快速溶解的晶片来施用。 为了操作剂量,可以提供例如作为与用于分配牙膏的管相似的管中包装的糊剂的制剂。

    Use of a composition
    99.
    发明授权
    Use of a composition 有权
    使用组合物

    公开(公告)号:US06528085B2

    公开(公告)日:2003-03-04

    申请号:US09780880

    申请日:2001-02-12

    IPC分类号: A61K4700

    摘要: There is provided use of a pectin composition to prepare an aqueous composition having high yield stress characteristics without substantial gelation, wherein the pectin composition comprises at least a population of pectin that is calcium sensitive; wherein the pectin composition is capable of imparting high yield stress characteristics to an aqueous composition without causing substantial gelation of the aqueous composition.

    摘要翻译: 提供了使用果胶组合物来制备具有高屈服应力特性而没有实质胶凝的含水组合物,其中果胶组合物至少含有钙敏感的果胶群; 其中所述果胶组合物能够赋予水性组合物高的屈服应力特性,而不引起含水组合物的实质胶凝。

    Composition and method
    100.
    发明授权
    Composition and method 失效
    组成和方法

    公开(公告)号:US06528084B2

    公开(公告)日:2003-03-04

    申请号:US09745130

    申请日:2000-12-21

    IPC分类号: A61K4700

    摘要: An aqueous gel suitable for ingestion by a cat or dog comprising, a. an effective amount of a gelling agent, b. an effective amount of a cat or dog palatability enhancing agent, and c. at least about 85 wt. % water.

    摘要翻译: 适用于由猫或狗摄入的水性凝胶,其包含:a。 有效量的胶凝剂,b。 有效量的猫或狗适口性增强剂,和c。 至少约85重量% % 水。